The DOI matches its Crossref record; 67 of the 70 references it cites were found in a registry or an index.
Consumption of a healthy dietary pattern results in significant reductions in C-reactive protein levels in adults: a meta-analysis
Abstract
Consumption of healthy dietary patterns has been associated with reduced risk of cardiovascular disease and metabolic syndrome. Dietary intervention targets disease prevention, so studies increasingly use biomarkers of underlying inflammation and metabolic syndrome progression to examine the diet-health relationship. The extent to which these biomarkers contribute to the body of evidence on healthy dietary patterns is unknown. The aim of this meta-analysis was to determine the effect of healthy dietary patterns on biomarkers associated with adiposity, insulin resistance, and inflammation in adults. A systematic search of Scopus, PubMed, Web of Science, and Cochrane Central Register of Controlled Trials (all years to April 2015) was conducted. Inclusion criteria were randomized controlled trials; effects of dietary patterns assessed on C-reactive protein (CRP), total adiponectin, high-molecular-weight adiponectin, tumor necrosis factor-α, adiponectin:leptin, resistin, or retinol binding protein 4. Random effects meta-analyses were conducted to assess the weighted mean differences in change or final mean values for each outcome. Seventeen studies were included in the review. These reflected research on dietary patterns associated with the Mediterranean diet, Nordic diet, Tibetan diet, and the Dietary Approaches to Stop Hypertension diet. Consumption of a healthy dietary pattern was associated with significant reductions in CRP (weighted mean difference, -0.75 [-1.16, -0.35]; P = .0003). Non-significant changes were found for all other biomarkers. This analysis found evidence for favorable effects of healthy dietary patterns on CRP, with limited evidence for other biomarkers. Future research should include additional randomized controlled trials incorporating a greater range of dietary patterns and biomarkers.
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“Alternatively, the absolute change in levels of CRP or IL-6 with a healthy diet intervention (Neale et al, 2016), or aerobic exercise (Hayashino et al, 2014), is comparable to the absolute difference found in association with sleep disturbance.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Neale et al, 2016
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Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
Dietary pattern analysis: a new direction in nutritional epidemiology
Hu, F. B. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00002 · Cited by 4,029
Ridker, P. M., Buring, J. E., Cook, N. R., & Rifai, N. (2003) · Circulation · doi:10.1161/01.cir.0000055014.62083.05 · Cited by 2,292
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- Higgins, 2011, Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 [updated March 2011], Cochrane Collaboration
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Items 201–220 of 220
Zhou, Q., Gong, Z., Yongjia, L. I., Pang, L., Bai, Y., Chen, T., & Lian, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-15970-1
“Neale et al. 31 conducted a meta-analysis of 18 articles and discovered a negative correlation between a plant-based healthy dietary pattern (mostly fruits, vegetables, and whole grains, with little red meat) and CRP levels.”
Carrera‐Bastos, P., Rydhög, B., Granfeldt, Y. E., Sundquist, K., Sonestedt, E., Nilsson, P. M., & Jönsson, T. (2025) · European Journal of Nutrition · doi:10.1007/s00394-025-03838-z
Talebi, S., Mehrabani, S., Ghoreishy, S. M., Wong, A., Moghaddam, A., Rahimi-Feyli, P., Amirian, P., Zarpoosh, M., Kermani, M. A. H., & Moradi, S. (2024) · Figshare · doi:10.6084/m9.figshare.26721156
Talebi, S., Mehrabani, S., Ghoreishy, S. M., Wong, A., Moghaddam, A., Rahimi-Feyli, P., Amirian, P., Zarpoosh, M., Kermani, M. A. H., & Moradi, S. (2024) · Figshare · doi:10.6084/m9.figshare.26721165
Talebi, S., Mehrabani, S., Ghoreishy, S. M., Wong, A., Moghaddam, A., Rahimi-Feyli, P., Amirian, P., Zarpoosh, M., Kermani, M. A. H., & Moradi, S. (2024) · Figshare · doi:10.6084/m9.figshare.26721159
Talebi, S., Mehrabani, S., Ghoreishy, S. M., Wong, A., Moghaddam, A., Rahimi-Feyli, P., Amirian, P., Zarpoosh, M., Kermani, M. A. H., & Moradi, S. (2024) · Figshare · doi:10.6084/m9.figshare.26721162
Talebi, S., Mehrabani, S., Ghoreishy, S. M., Wong, A., Moghaddam, A., Rahimi-Feyli, P., Amirian, P., Zarpoosh, M., Kermani, M. A. H., & Moradi, S. (2024) · Figshare · doi:10.6084/m9.figshare.26721168
Talebi, S., Mehrabani, S., Ghoreishy, S. M., Wong, A., Moghaddam, A., Rahimi-Feyli, P., Amirian, P., Zarpoosh, M., Kermani, M. A. H., & Moradi, S. (2024) · Figshare · doi:10.6084/m9.figshare.26721174
Talebi, S., Mehrabani, S., Ghoreishy, S. M., Wong, A., Moghaddam, A., Rahimi-Feyli, P., Amirian, P., Zarpoosh, M., Kermani, M. A. H., & Moradi, S. (2024) · Figshare · doi:10.6084/m9.figshare.26721171
Talebi, S., Mehrabani, S., Ghoreishy, S. M., Wong, A., Moghaddam, A., Rahimi-Feyli, P., Amirian, P., Zarpoosh, M., Kermani, M. A. H., & Moradi, S. (2024) · Figshare · doi:10.6084/m9.figshare.26721177
OBESITY AS A MODIFIABLE DETERMINANT OF THYROID DYSFUNCTION, STRUCTURAL CHANGES, AND THYROID CANCER
Baran, K., Grygorowicz, A., Ględa, M., Szyszka, M., Radecka, W., Kozak, W., Szreiber, A., Grela, K., Nowacka, K., Jabłoński, K., et al. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.4(48).2025.4647
Kim, J., Jeong, K., Lee, S. W., & Baek, Y. (2026) · Medicine · doi:10.1097/md.0000000000046422
“[38] Previous observational studies [39–41] have demonstrated the beneficial effects of healthy dietary sources, such as low salt and saturated fatty acid intake, high intake of fruit and vegetables, whole grains, and plant-based prudent diets and patterns.”
Wani, S., Kulkarni, S., Pingale, P. L., Rane, B. R., Bachhav, Y. G., & Dua, K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34003-1.00009-2
Lesani, A., Daneshzad, E., Calvo-Malvar, M., Clark, C. C. T., Zahedi, H., Vilela, S., & Mojani-Qomi, M. S. (2026) · Nutrition Journal · doi:10.1186/s12937-026-01280-3
“A central mechanism linking poor dietary quality to these conditions is the chronic low-grade inflammation it induces, both at the intestinal level and systemically [2].”
Shahzil, M., Kazmi, S. K., Shehzadi, M., Hasan, F. N., Danish, M. W., Faisal, M. S., Canakis, J. P., & Clarke, K. (2025) · Research Square · doi:10.21203/rs.3.rs-7035116/v1
Diet and nutrition considerations in integrative oncology
Price, L., Dearden, J., & Greenlee, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30194-0.00039-4
Shahzil, M., Kazmi, S. K., Shehzadi, M., Hasan, F. N., Danish, M. W., Faisal, M. S., Canakis, J. P., & Clarke, K. (2026) · Gastroenterology Research and Practice · doi:10.1155/grp/2994340
Ma, X., Rohani, P., & Sohouli, M. H. (2026) · Food & Function · doi:10.1039/d5fo04706d
Lee, Y. Q., Lim, C. G. Y., Sim, X., & Chong, M. F. (2026) · Clinical Nutrition · doi:10.1016/j.clnu.2026.106817
Metadata
- Authors
- Neale, E. P., Batterham, M. J., & Tapsell, L. C.
- Affiliations
- University of Wollongong (AU)
- Corresponding author
- Neale, E.P.
- Venue
- Nutrition Research
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 36
- Issue
- 5
- Pages
- 391-401
- ISSN
- 0271-5317 (ISSN-L)
- OpenAlex
- W2287836917
- Cited by
- 220
- References
- 70
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 31 · 2023: 17 · 2022: 16 · 2021: 22 · 2020: 24 · 2019: 30 · 2018: 25 · 2017: 22 · 2016: 4
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Research (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- healthy eating patterns, C-reactive protein, inflammation, Mediterranean diet, Nordic diet, Dietary Approaches to Stop Hypertension diet, adiponectin, TNF-α, resistin, retinol-binding protein 4, adiposity, insulin resistance, metabolic syndrome, cardiovascular disease prevention
- MeSH terms
- Red Meat, Diet, Healthy, Adult, C-Reactive Protein, Cardiovascular Diseases, Edible Grain, Diet, Fruit, Humans, Inflammation, Obesity, Vegetables, Biomarkers, Metabolic Syndrome
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