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Cited by 123Retinal Diseases and TreatmentsCardiovascular Health and Risk FactorsRetinal Imaging and Analysis

Age-Related Macular Degeneration and Risk of Coronary Heart Disease

Wong, Tien Yin, Tikellis, Gabriella, Sun, Cong, Klein, Ronald, Couper, David J., Sharrett, A. Richey·2007·Ophthalmology
DOI 10.1016/j.ophtha.2006.06.039
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Abstract

Objective To examine the association of age-related macular degeneration (AMD) with incident coronary heart disease (CHD) and all-cause mortality.Design Population-based prospective cohort study.Participants From the Atherosclerosis Risk in Communities Study (n = 12 536; age range, 49-73 years).Methods Participants had retinal photographs of one eye taken between 1993 and 1995. Photographs were evaluated for the presence of early and late AMD signs according to the Wisconsin grading system. Incident CHD events (acute myocardial infarction, silent myocardial infarction, fatal CHD, and cardiac revascularization procedures) and all-cause mortality were identified prospectively using standardized methods.Main outcome measures Incident CHD events and all-cause mortality.Results Of 11,414 persons at risk of CHD, there were 555 (4.9%) with AMD at baseline, of whom 540 were early AMD and 15 were late AMD cases. Over a 10-year follow-up, 922 persons developed an incident CHD event. After controlling for age, gender, race, systolic and diastolic blood pressure, pack-years of cigarette smoking, and other variables, early AMD was not associated with incident CHD (relative risk, 1.08; 95% confidence interval, 0.82-1.42). However, individuals with late AMD were significantly more likely to have an incident CHD event, with 4 CHD events among the 15 participants with late AMD at baseline (10-year cumulative incidence, 30.9%) as compared with 918 CHD events among the 11 399 participants without late AMD (incidence of 10.0%; P = 0.049, Fisher exact test). In the full cohort (n = 12 536), early AMD was not significantly associated with all-cause mortality. However, individuals with late AMD were more likely to die (10-year cumulative mortality rate, 23.5%) than those without late AMD (mortality rate, 8.9%; P = 0.088, Fisher exact test).Conclusions These data provide no evidence of an association between early AMD signs with incident CHD and all-cause mortality in middle-aged persons. Individuals with late AMD appear to have a higher rate of CHD events than those without late AMD, but due to a small number of late AMD cases, this finding should be interpreted cautiously.

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  • The finding of increased myocardial infarction risk in patients with age-related macular degeneration was not confirmed in other studies, although these studies included fewer individuals with advanced age-related macular degeneration.

    “These findings were not confirmed in other studies, although these studies included fewer individuals with advanced age-related macular degeneration.77–79”

    From Age-related macular degeneration (2008) · cites this paper as [77]

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Authors
Wong, T. Y., Tikellis, G., Sun, C., Klein, R., Couper, D. J., & Sharrett, A. R.
Affiliations
  • The University of Melbourne (AU)
  • University of Wisconsin–Madison (US)
  • University of North Carolina at Chapel Hill (US)
  • Johns Hopkins University (US)
Corresponding author
Wong, Tien Yin
ORCID
Venue
Ophthalmology
Publisher
Elsevier BV
Published
2007-01
Volume
114
Issue
1
Pages
86-91
ISSN
0161-6420 (ISSN-L)
DOI
10.1016/j.ophtha.2006.06.039
OpenAlex
W2129914553
Cited by
123
References
35
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 1 · 2018: 7 · 2017: 12 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 5 · 2012: 10
FWCI
6.79
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Funders
  • National Institutes of Health (n01hc55021-47-0-1, n01hc55020-39-0-0, n01hc55016-37-0-0, n01hc055022-024, n01hc55019-35-0-1, n01hc55018-38-0-1, n01hc55015-48-0-1)
  • U.S. Public Health Service (EYO13939)
  • National Heart, Lung, and Blood Institute (N01-HC55022, N01-HC-55018, N01 HC 55020, N01 HC 55019, ­N01-HC55016, N01‐HC‐55015, N01-HC55021)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords
age-related macular degeneration, coronary artery disease, late AMD, early AMD, all-cause mortality, fundus images, middle-aged adults, cardiovascular risk factors, Atherosclerosis Risk in Communities Study, myocardial infarction, cardiac revascularization, silent myocardial infarction, coronary heart disease mortality, smoking, blood pressure, hyperlipidemia
MeSH terms
Aged, Cause of Death, Cholesterol, Coronary Disease, Female, Humans, Macular Degeneration, Male, Middle Aged, Myocardial Infarction, Myocardial Revascularization, Prospective Studies, Risk Factors, Triglycerides, United States, Cohort Studies, Incidence, Proportional Hazards Models

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