Cited by 64COVID-19 and Mental HealthMindfulness and Compassion InterventionsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Is psychological flexibility a mediator between perceived stress and general anxiety or depression among suspected patients of the 2019 coronavirus disease (COVID-19)?

Open access
Huang, Chi, Xie, Jiaying, Owusua, Theresah, Chen, Zhiheng, Wang, Jiangang, Qin, Chunxiang, He, Qingnan·2021·Personality and Individual Differences

Abstract

This study is aimed to investigate the status of general anxiety and depression among suspected patients of COVID-19 and explore whether psychological flexibility can serve as a mediator between perceived stress and general anxiety or depression. Total of 180 participants completed the online questionnaire which comprised demographic information, the Perceived Stress Scale (PSS), the 7-item Generalized Anxiety Disorder scale (GAD-7), the 9-item Patients Health Questionnaire (PHQ-9), the Acceptance and Action Questionnaire-II (AAQ-II) and the Cognitive Fusion Questionnaire (CFQ). Statistical methods including correlation analysis, multiple linear regression analysis and structural equation model were used in this study. The scores of 23.9% (43/180) and 34.4% (62/180) of participants were higher than the cut points of GAD-7 and PHQ-9 respectively. Psychological flexibility was significantly correlated with perceived stress, general anxiety and depression. Multiple regression analyses showed the possible mediation effect of psychological flexibility between perceived stress and general anxiety or depression. The structural equation model confirmed that psychological flexibility partially mediated between perceived stress and general anxiety or depression. Our findings suggested the potential benefit of Acceptance and Commitment Therapy (ACT) as a psychological support approach in suspected patients of COVID-19 because ACT targets psychological flexibility. © 2021 Elsevier Ltd

Integrity signals

Registry

Crossref · 10.1016/j.paid.2021.111132

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

4 of 10 cited sources checked · 2 supported · 0 flagged · accuracy not yet measured

  • Premisecitation

    Online ACT interventions and ACT self-help books have been shown to improve psychological flexibility in other populations.

    “online ACT interventions or ACT self-help books could be used in suspected patients of COVID-19, which were proven to improve psychological flexibility in other populations (Pots et al., 2016; Wersebe et al., 2018).”
    Quote in the paperSubstantial claim2 of 2 sources checked
    • cites Pots et al., 2016 source

      The Outcomes section reports significantly greater improvement across measured outcomes, including psychological flexibility, for the web-based ACT group than for the waiting-list and expressive-writing groups. The Acceptance and commitment therapy section also reports earlier evidence for a guided ACT self-help intervention, but this paper does not show that ACT self-help books improve psychological flexibility. Page numbers are unavailable in our copy. (LLM, conf=0.86)

      Experimental — accuracy not yet measured
    • cites Wersebe et al., 2018 source
  • Findingown data

    The indirect effect of perceived stress on depression through psychological flexibility represented 65.5% of the total effect.

    “The indirect effect of perceived stress on depression through psychological flexibility accounted for 65.5% (0.372/0.568) of the total effect.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: The mediation analysis assumes that the observed associations are not due to unmeasured confounding and that the temporal ordering is as modeled, so that perceived stress causally affects anxiety and depression through psychological flexibility.
  • Findingown data

    Individuals who reported greater perceived stress also reported lower psychological flexibility.

    “The results indicated that individuals who had experienced higher perceived stress reported lower levels of psychological flexibility.”
    Quote in the paperSubstantial claim
  • Findingown data

    Among people suspected of having COVID-19, 23.9% (43 of 180) had GAD-7 scores at or above the screening cut point.

    “The scores of 23.9% (43/180) and 34.4% (62/180) of participants were higher than the cut points of GAD-7 and PHQ-9 respectively.”
    • Also stated in: § Preliminary analyses · plain
      “Of the total, 23.9% (43/180) fell at or above the cut points of GAD-7 and 34.4% (62/180) fell at or above the cut points of PHQ-9.”
    Quote in the paperNot a substantial claim
  • Findingown data

    The rates of general anxiety and depression among suspected COVID-19 patients were much higher than the normative rates of 7.8% and 13.4% reported for general residents in China.

    “The positive rates of screening general anxiety and depression among suspected patients of COVID-19 were 23.9% and 34.4%, which were much higher than the normative data from general residents in China (7.8% and 13.4%) (Qi, 2014).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Qi, 2014

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims. 9
  • Classified as probably not a substantial claim. 11
  • May combine two claims.

    Premisecitation

    The Chinese version of the PSS-14 has satisfactory content validity and reliability.

    “A Chinese version of PSS-14 with satisfactory content validity and reliability (Leung, Lam, & Chan, 2010) was adopted.”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites Leung, Lam, & Chan, 2010 source

      The Results (Reliability analysis) report satisfactory internal consistency for the Chinese PSS-14. The Discussion and Conclusion support its construct and concurrent validity, but our copy does not establish the distinct claim of content validity; the study examined Chinese cardiac patients who smoke. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductcitation

    A power calculation using G*Power determined that 107 participants were needed to achieve 95% power to detect a medium effect size (f2=0.15) in multiple linear regression with two predictors at an alpha of 0.05.

    “Sample size calculations (using G*Power version 3.1 (Faul, Erdfelder, Buchner, & Lang, 2009) determined that 107 participants were needed to provide sufficient power (1-β = 0.95) to detect medium effect size (f 2 = 0.15) associations using multiple linear regression analyses with two presumed predictors (perceived stress and psychological flexibility), and an alpha level of 0.05.”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites Faul, Erdfelder, Buchner, & Lang, 2009 source
  • May combine two claims.

    Findingown data

    The regression model for general anxiety explained 59.9% of the variance, with 22.6% of that variance explained after psychological flexibility was added.

    “the multiple linear regression accounted for 59.9% variance of general anxiety, a total of 22.6% of which was explained after psychological flexibility was added”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    The regression model for depression explained 50.7% of the variance, with 16.0% of that variance explained after psychological flexibility was added.

    “the multiple linear regression accounted for 50.7% variance of depression, a total of 16.0% of which was explained after psychological flexibility was added”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Interpretationown data

    Higher psychological flexibility acts as a protective factor that reduces the psychological impact of stress and serves as a protective mediator between perceived stress and general anxiety or depression.

    “These results suggest that higher psychological flexibility plays a protective role in reducing the psychological impact of stress on individuals and it is a protective mediator between perceived stress and general anxiety or depression.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: The mediation analysis assumes that the observed associations are not due to unmeasured confounding and that the temporal ordering is as modeled, so that perceived stress causally affects anxiety and depression through psychological flexibility.
  • Classified as probably not a substantial claim. May combine two claims.

    Premisecitation

    The Chinese version of the PHQ-9 has satisfactory content validity and reliability.

    “A Chinese version of PHQ-9 with satisfactory content validity and reliability (Wang et al., 2014) was adopted.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Wang et al., 2014 source
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductown data

    The Cronbach's alpha for the CFQ-F in this study was 0.950.

    “Cronbach's alpha of AAQ-II and CFQ-F in this study was 0.930 and 0.950 respectively.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductreasoning

    The psychological assessments captured only a single time point of how suspected COVID-19 patients felt during the early outbreak.

    “Lastly, the psychological assessments provide a single snapshot of how suspected patients of COVID-19 were feeling during the early outbreak”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation

    The Chinese version of the CFQ-F is a reliable and valid measure of cognitive fusion.

    “However, CFQ-F is a reliable and valid assessment of cognitive fusion (Zhang, Ji et al., 2014).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Zhang, Ji et al., 2014 source
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductreasoning

    After adding 15% for non-response, the required sample size was 126.

    “The addition of 15% of non-response rate resulted in the required sample size of 126.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductreasoning

    The time at which participants submitted their questionnaires could not be standardized because data were collected online during the pandemic.

    “Secondly, because questionnaires could only be collected through the internet during the pandemic, the time for participants to submit questionnaires cannot be unified.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductown data

    The Cronbach's alpha for the PHQ-9 in this study was 0.899.

    “Cronbach's alpha in this study was 0.899.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Study design and conductown data

    The two structural equation models showed good fit, with CFI=1.000 and SRMR values of 0.002 and 0.001.

    “The standardized indices of two models presented good model fits: χ 2 = 0.047(P = 0.828), χ 2/df = 0.047, CFI = 1.000, SRMR = 0.002; χ 2 = 0.014(P = 0.907), χ 2/df = 0.014, CFI = 1.000, SRMR = 0.001.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductown data

    The Cronbach's alpha for the AAQ-II in this study was 0.930.

    “Cronbach's alpha of AAQ-II and CFQ-F in this study was 0.930 and 0.950 respectively.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductown data

    The Cronbach's alpha for the GAD-7 in this study was 0.939.

    “Cronbach's alpha in this study was 0.939.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductown data

    The Cronbach's alpha for the Perceived Stress Scale in this study was 0.796.

    “Cronbach's alpha in this study was 0.796.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductreasoning

    The study collected data exclusively through self-report questionnaires.

    “Thirdly, this study exclusively used self-report questionnaires for data collection.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation

    The Chinese version of the AAQ-II has satisfactory content validity and reliability.

    “A Chinese version of AAQ-II with satisfactory content validity and reliability (Zhang, Chung, Si, & Liu, 2014) was adopted.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Zhang, Chung, Si, & Liu, 2014 source
  • May combine two claims.

    Premisecitation

    The Chinese version of the GAD-7 has satisfactory content validity and reliability.

    “A Chinese version of GAD-7 with satisfactory content validity and reliability (Tong, An, McGonigal, Park, & Zhou, 2016) was adopted.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Tong, An, McGonigal, Park, & Zhou, 2016 source
19 of 19
  • The paper relies on this without support.

    It had not been reported whether perceived stress, anxiety, depression, and psychological flexibility are related in people suspected of COVID-19, nor whether psychological flexibility mediates the link between perceived stress and anxiety or depression.

    “However, the relationship between perceived stress, anxiety, depression and psychological flexibility among suspected patients of COVID-19 is unreported, and whether psychological flexibility acts as a mediating variable between perceived stress and anxiety or depression has not been confirmed.”
  • The paper relies on this without support.

    The mediation analysis assumes that the observed associations are not due to unmeasured confounding and that the temporal ordering is as modeled, so that perceived stress causally affects anxiety and depression through psychological flexibility.

    “perceived stress indirectly affects anxiety and depression through psychological flexibility from regression analysis results.”
2 of 2

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The findings support earlier research that lower psychological flexibility is linked with greater psychological distress among nursing students.

    “Our findings support earlier research by indicating that lower levels of flexibility are linked with greater psychological distress among nursing students”

    From Associations of psychological flexibility, mindfulness, and valued living with psychological distress among nursing students (2025) · cites this paper as [45]

    The Discussion reports that lower psychological flexibility was associated with higher general anxiety and depression, supporting the claimed link with distress. However, this study examined suspected COVID-19 patients, not nursing students; it does not establish that association in the population named in the claim. (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • Limited psychological flexibility may heighten vulnerability to emotional challenges in high-pressure academic and clinical environments.

    “This suggests that limited flexibility may heighten vulnerability to emotional challenges in high-pressure academic and clinical environments.”

    From Associations of psychological flexibility, mindfulness, and valued living with psychological distress among nursing students (2025) · cites this paper as [45]

    The Discussion reports that lower psychological flexibility was associated with higher anxiety and depression among suspected COVID-19 patients, supporting the suggested link to emotional challenges. The paper does not study high-pressure academic or clinical environments, so that setting is an extrapolation. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Cites

Flagged first, then by citations

5 of the 45 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. Mental Health Center of Gansu Province. (2020). Guidance manual on psychological protection against new coronavirus infections. Chen X.(Ed.) (pp. 164).
  2. Zhao, 2003, Psychological characteristics and psychological care of SARS and suspected SARS patients, Journal of General Hospital of Air Force, pla, 03, 48

Cited by

Sorted by citations

Authors
Huang, C., Xie, J., Owusua, T., Chen, Z., Wang, J., Qin, C., & He, Q.
Affiliations
Central South University (CN)
Corresponding author
  • Qin, Chunxiang
  • He, Qingnan
Venue
Personality and Individual Differences
Publisher
Elsevier BV
Published
2021-12
Volume
183
Pages
111132
ISSN
0191-8869 (ISSN-L)
OpenAlex
W3178918041
Cited by
64
References
45
Citations by year
2026: 17 · 2025: 10 · 2024: 16 · 2023: 11 · 2022: 10
FWCI
6.31
Type
journal article
Language
en
Open access
Locations
  • Personality and Individual Differences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
psychological flexibility, perceived stress, general anxiety, depression, mediating effect, acceptance and commitment therapy, cognitive fusion, psychological support

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