Pain and analgesia: the value of salience circuits
Open accessAbstract
Evaluating external and internal stimuli is critical to survival. Potentially tissue-damaging conditions generate sensory experiences that the organism must respond to in an appropriate, adaptive manner (e.g., withdrawal from the noxious stimulus, if possible, or seeking relief from pain and discomfort). The importance we assign to a signal generated by a noxious state, its salience, reflects our belief as to how likely the underlying situation is to impact our chance of survival. Importantly, it has been hypothesized that aberrant functioning of the brain circuits which assign salience values to stimuli may contribute to chronic pain. We describe examples of this phenomenon, including 'feeling pain' in the absence of a painful stimulus, reporting minimal pain in the setting of major trauma, having an 'analgesic' response in the absence of an active treatment, or reporting no pain relief after administration of a potent analgesic medication, which may provide critical insights into the role that salience circuits play in contributing to numerous conditions characterized by persistent pain. Collectively, a refined understanding of abnormal activity or connectivity of elements within the salience network may allow us to more effectively target interventions to relevant components of this network in patients with chronic pain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A higher stimulus intensity is likely to be more salient, and thus have more importance assigned to it which could increase its influence on perceived pain.
“A higher stimulus intensity is likely to be more salient, and thus have more importance assigned to it which could increase its influence on perceived pain54.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [54]
Emotional distress and psychosocial stress increase the likelihood of transition from acute to chronic musculoskeletal pain.
“emotional distress and psychosocial stress have been shown to increase the likelihood of transitioning from acute to chronic musculoskeletal pain 18, 36, 37, 41, 42.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [36]
Prospective studies suggest that pre-morbid psychological dysfunction is a risk factor for later development of many chronic pain conditions, including musculoskeletal pain and functional pain disorders.
“prospective studies suggest that pre-morbid psychological dysfunction represents a risk factor for the future development of numerous chronic pain conditions including musculoskeletal pain and functional pain disorders 14, 36–39.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Feeling and thinking: Preferences need no inferences.
Zajonc, R. B. (1980) · American Psychologist · doi:10.1037/0003-066x.35.2.151 · Cited by 8,094 · see citing works
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426 · see citing works
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 2× · see citing works
“and attentional processing of pain stimuli (Craig, 2009).”
BackgroundCognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259 · see citing works
Saliency, switching, attention and control: a network model of insula function
Menon, V., & Uddin, L. Q. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0262-0 · Cited by 5,592 · see citing works
Correspondence of the brain's functional architecture during activation and rest
Smith, S. M., Fox, P. T., Miller, K. L., Glahn, D. C., Fox, P. M., Mackay, C. E., Filippini, N., Watkins, K. E., Toro, R., Laird, A. R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905267106 · Cited by 5,150 · see citing works
The precuneus: a review of its functional anatomy and behavioural correlates
Cavanna, A. E., & Trimble, M. R. (2006) · Brain · doi:10.1093/brain/awl004 · Cited by 5,128 · see citing works
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929 · see citing works
Does Rejection Hurt? An fMRI Study of Social Exclusion
Eisenberger, N. I., Lieberman, M. D., & Williams, K. D. (2003) · Science · doi:10.1126/science.1089134 · Cited by 3,849 · see citing works
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377 · see citing works
Gusnard, D. A., Akbudak, E., Shulman, G. L., & Raichle, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043098 · Cited by 2,997 · see citing works
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347 · see citing works
Memory systems of the brain: A brief history and current perspective
Squire, L. R. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.06.005 · Cited by 2,269 · see citing works
Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network
Greicius, M. D., Supekar, K., Menon, V., & Dougherty, R. F. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn059 · Cited by 2,175 · see citing works
Pain demands attention: A cognitive–affective model of the interruptive function of pain.
Eccleston, C., & Crombez, G. (1999) · Psychological Bulletin · doi:10.1037/0033-2909.125.3.356 · Cited by 1,718 · see citing works
Multisensory integration: current issues from the perspective of the single neuron
Stein, B. E., & Stanford, T. R. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2331 · Cited by 1,598 · see citing works
Rethinking the Emotional Brain
LeDoux, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.004 · Cited by 1,594 · cited 1× · see citing works
“As such, these areas that contribute to the emotional brain processes, ‘‘reflect functions and circuits related to survival’’ that integrate ‘‘motivation, reinforcement, and arousal’’ (LeDoux, 2012).”
BackgroundPlacebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002) · Science · doi:10.1126/science.1067176 · Cited by 1,488 · see citing works
Meredith, M. A., & Stein, B. E. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.56.3.640 · Cited by 1,183 · see citing works
“Liking” and “wanting” food rewards: Brain substrates and roles in eating disorders
Berridge, K. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.044 · Cited by 1,147 · see citing works
Distinct cerebellar contributions to intrinsic connectivity networks
Habas, C., Kamdar, N., Nguyen, D., Prater, K., Beckmann, C. F., Menon, V., & Greicius, M. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1868-09.2009 · Cited by 1,115 · see citing works
Redelmeier, D. A., & Kahneman, D. (1996) · Pain · doi:10.1016/0304-3959(96)02994-6 · Cited by 1,078 · see citing works
Corticostriatal functional connectivity predicts transition to chronic back pain
Baliki, M. N., Petre, B., Torbey, S., Herrmann, K. M., Huang, L., Schnitzer, T. J., Fields, H. L., & Apkarian, A. V. (2012) · Nature Neuroscience · doi:10.1038/nn.3153 · Cited by 1,050 · see citing works
Eisenberger, N. I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3231 · Cited by 1,016 · see citing works
Striatal Plasticity and Basal Ganglia Circuit Function
Kreitzer, A. C., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.005 · Cited by 1,009 · see citing works
Balancing Structure and Function at Hippocampal Dendritic Spines
Bourne, J. N., & Harris, K. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125646 · Cited by 916 · see citing works
Pain catastrophizing and neural responses to pain among persons with fibromyalgia
Gracely, R. H. (2004) · Brain · doi:10.1093/brain/awh098 · Cited by 892 · see citing works
Functional characteristics of the midbrain periaqueductal gray.
Behbehani, M. M. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00009-k · Cited by 879 · see citing works
Control over brain activation and pain learned by using real-time functional MRI
deCharms, R. C., Maeda, F., Glover, G. H., Ludlow, D., Pauly, J. M., Soneji, D., Gabrieli, J. D. E., & Mackey, S. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505210102 · Cited by 876 · see citing works
Legrain, V., Iannetti, G. D., Plaghki, L., & Mouraux, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.005 · Cited by 854 · see citing works
Bingel, U., Wanigasekera, V., Wiech, K., Ni Mhuircheartaigh, R., Lee, M. C., Ploner, M., & Tracey, I. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001244 · Cited by 810 · see citing works
Functional connectivity of the insula in the resting brain
Cauda, F., D'Agata, F., Sacco, K., Duca, S., Geminiani, G., & Vercelli, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.049 · Cited by 793 · see citing works
High-cost, high-capacity backbone for global brain communication
van den Heuvel, M. P., Kahn, R. S., Goñi, J., & Sporns, O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203593109 · Cited by 781 · see citing works
Neurobiological Mechanisms of the Placebo Effect
Benedetti, F., Mayberg, H., Wager, T., Stohler, C., & Zubieta, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3458-05.2005 · Cited by 771 · see citing works
The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain
Maddock, R. J. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01374-5 · Cited by 733 · see citing works
Social rejection shares somatosensory representations with physical pain
Kross, E., Berman, M. G., Mischel, W., Smith, E. E., & Wager, T. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102693108 · Cited by 689 · see citing works
Two systems of resting state connectivity between the insula and cingulate cortex
Taylor, K. S., Seminowicz, D. A., & Davis, K. D. (2009) · Human Brain Mapping · doi:10.1002/hbm.20705 · Cited by 665 · see citing works
Placebo and Nocebo Effects Are Defined by Opposite Opioid and Dopaminergic Responses
Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.34 · Cited by 637 · see citing works
Reward deficiency syndrome: genetic aspects of behavioral disorders
Comings, D. E., & Blum, K. (2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26022-6 · Cited by 621 · see citing works
I feel how you feel but not always: the empathic brain and its modulation
Hein, G., & Singer, T. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.07.012 · Cited by 607 · see citing works
Reward Changes Salience in Human Vision via the Anterior Cingulate
Hickey, C., Chelazzi, L., & Theeuwes, J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1026-10.2010 · Cited by 606 · cited 2× · see citing works
“…in salience networks is observed in detecting and/or planning responses to salient events (Downar et al., 2002) and the cingulate is involved in: rewardrelated activation of mesolimbic circuits (Hickey et al., 2010), commission errors (Ham et al., 2012), and fluid reasoning (Yuan et al., 2012).”
BackgroundSalience network integrity predicts default mode network function after traumatic brain injury
Bonnelle, V., Ham, T. E., Leech, R., Kinnunen, K. M., Mehta, M. A., Greenwood, R. J., & Sharp, D. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113455109 · Cited by 606 · see citing works
Pain, catastrophizing, and depression in the rheumatic diseases
Edwards, R. R., Cahalan, C., Mensing, G., Smith, M., & Haythornthwaite, J. A. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.2 · Cited by 596 · cited 2× · see citing works
“, 2010), and cognitive processes such as catastrophizing, a pain-specific psychosocial construct comprised of cognitive and emotional processes such as helplessness, pessimism, rumination about pain-related symptoms, and magnification of pain complaints (Edwards et al., 2011).”
BackgroundSelf-citationA multisensory investigation of the functional significance of the “pain matrix”
Mouraux, A., Diukova, A., Lee, M., Wise, R. G., & Iannetti, G. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.084 · Cited by 556 · see citing works
Overt versus covert treatment for pain, anxiety, and Parkinson's disease
Colloca, L., Lopiano, L., Lanotte, M., & Benedetti, F. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00908-1 · Cited by 551 · see citing works
(2011) · Springer eBooks · doi:10.1007/springerreference_44317 · Cited by 549 · see citing works
Downar, J., Crawley, A. P., Mikulis, D. J., & Davis, K. D. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00636.2001 · Cited by 544 · see citing works
Chronic pain patients are impaired on an emotional decision-making task
Apkarian, V. A., Sosa, Y., Krauss, B. R., Thomas, S. P., Fredrickson, B. E., Levy, R. E., Harden, N. R., & Chialvo, D. R. (2004) · Pain · doi:10.1016/j.pain.2003.12.015 · Cited by 536 · see citing works
Absolute Coding of Stimulus Novelty in the Human Substantia Nigra/VTA
Bunzeck, N., & Düzel, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.021 · Cited by 503 · see citing works
D'Argembeau, A., Ruby, P., Collette, F., Degueldre, C., Balteau, E., Luxen, A., Maquet, P., & Salmon, E. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.6.935 · Cited by 495 · see citing works
Anterior insula integrates information about salience into perceptual decisions about pain
Wiech, K., Lin, C.-S., Brodersen, K. H., Bingel, U., Ploner, M., & Tracey, I. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2087-10.2010 · Cited by 470 · see citing works
The pulvinar and visual salience
Robinson, D. L., & Petersen, S. E. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90354-b · Cited by 469 · see citing works
Individual differences in reward responding explain placebo-induced expectations and effects
Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.028 · Cited by 466 · see citing works
Role of the anterior insula in task-level control and focal attention
Nelson, S. M., Dosenbach, N. U. F., Cohen, A. L., Wheeler, M. E., Schlaggar, B. L., & Petersen, S. E. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0260-2 · Cited by 435 · see citing works
A computational substrate for incentive salience
McClure, S. M., Daw, N. D., & Montague, P. R. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00177-2 · Cited by 416 · see citing works
Dopaminergic dysfunction in schizophrenia: Salience attribution revisited
Heinz, A., & Schlagenhauf, F. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq031 · Cited by 412 · see citing works
Thalamic sensitization transforms localized pain into widespread allodynia
Burstein, R., Jakubowski, M., Garcia-Nicas, E., Kainz, V., Bajwa, Z. H., Hargreaves, R., Becerra, L. R., & Borsook, D. (2010) · Annals of Neurology · doi:10.1002/ana.21994 · Cited by 408 · see citing works
Self-citationCortical responses to pain in healthy individuals depends on pain catastrophizing
Seminowicz, D. A., & Davis, K. D. (2006) · Pain · doi:10.1016/j.pain.2005.11.008 · Cited by 407 · see citing works
Neuroimaging of the periaqueductal gray: State of the field
Linnman, C., Moulton, E. A., Barmettler, G., Becerra, L. R., & Borsook, D. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.095 · Cited by 402 · see citing works
Self-citationDopamine, affordance and active inference
Friston, K. J., Shiner, T., FitzGerald, T., Galea, J. M., Adams, R., Brown, H., Dolan, R. J., Moran, R., Stephan, K. E., & Bestmann, S. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002327 · Cited by 381 · see citing works
Nociceptive Laser-Evoked Brain Potentials Do Not Reflect Nociceptive-Specific Neural Activity
Mouraux, A., & Iannetti, G. D. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91181.2008 · Cited by 373 · see citing works
Burgess, S. E., Gardell, L. R., Ossipov, M. H., Malan, T. P., Vanderah, T. W., Lai, J. Y., & Porreca, F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05129.2002 · Cited by 356 · see citing works
Nocebo hyperalgesia: how anxiety is turned into pain
Colloca, L., & Benedetti, F. (2007) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e3282b972fb · Cited by 350 · see citing works
Functional resting-state networks are differentially affected in schizophrenia
Woodward, N. D., Rogers, B. P., & Heckers, S. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.03.010 · Cited by 342 · see citing works
Borsook, D., Upadhyay, J., Chudler, E. H., & Becerra, L. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-27 · Cited by 326 · see citing works
Self-citationAddiction related alteration in resting-state brain connectivity
Ma, N., Liu, Y., Li, N., Wang, C.-X., Zhang, H., Jiang, X., Xu, H.-S., Fu, X., Hu, X. P., & Zhang, D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.08.037 · Cited by 322 · see citing works
Influence of the method of drug administration on analgesic response
Levine, J. D., & Gordon, N. C. (1984) · Nature · doi:10.1038/312755a0 · Cited by 322 · see citing works
Self-citationHuman striatal response to salient nonrewarding stimuli
Zink, C. F., Pagnoni, G., Martin, M. E., Dhamala, M., & Berns, G. S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-22-08092.2003 · Cited by 312 · see citing works
Regional Gray Matter Density Changes in Brains of Patients With Irritable Bowel Syndrome
Seminowicz, D. A., Labus, J. S., Bueller, J. A., Tillisch, K., Naliboff, B. D., Bushnell, M. C., & Mayer, E. A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.049 · Cited by 298 · see citing works
Berna, C., Leknes, S., Holmes, E. A., Edwards, R. R., Goodwin, G. M., & Tracey, I. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.014 · Cited by 287 · see citing works
Self-citationRoles of the Insular Cortex in the Modulation of Pain: Insights from Brain Lesions
Starr, C. J., Sawaki, L. A., Wittenberg, G. F., Burdette, J. H., Oshiro, Y., de Quevedo, A. S., & Coghill, R. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5173-08.2009 · Cited by 283 · see citing works
Spence, C. J., & Parise, C. (2009) · Consciousness and Cognition · doi:10.1016/j.concog.2009.12.001 · Cited by 279 · see citing works
Resting State Networks and Consciousness
Heine, L., Soddu, A., Gómez, F., Vanhaudenhuyse, A., Tshibanda, L., Thonnard, M., Charland-Verville, V., Kirsch, M., Laureys, S., & Demertzi, A. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00295 · Cited by 272 · see citing works
Strigo, I. A., Simmons, A. N., Matthews, S. C., Craig, A. D. B., & Paulus, M. P. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1275 · Cited by 272 · see citing works
As-Sanie, S., Harris, R. E., Napadow, V., Kim, J., Neshewat, G., Kairys, A., Williams, D., Clauw, D. J., & Schmidt-Wilcke, T. (2012) · Pain · doi:10.1016/j.pain.2012.01.032 · Cited by 268 · see citing works
Porreca, F., Burgess, S. E., Gardell, L. R., Vanderah, T. W., Malan, T. P., Ossipov, M. H., Lappi, D. A., & Lai, J. Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05281.2001 · Cited by 266 · see citing works
Responses of striatal neurons in the behaving monkey. 1. Head of the caudate nucleus
Rolls, E. T., Thorpe, S. J., & Maddison, S. P. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90191-2 · Cited by 256 · see citing works
Valence and salience contribute to nucleus accumbens activation
Cooper, J. C., & Knutson, B. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.08.009 · Cited by 256 · see citing works
Her versus his migraine: multiple sex differences in brain function and structure
Maleki, N., Linnman, C., Brawn, J., Burstein, R., Becerra, L. R., & Borsook, D. (2012) · Brain · doi:10.1093/brain/aws175 · Cited by 255 · see citing works
Self-citationLuerding, R., Weigand, T., Bogdahn, U., & Schmidt‐Wilcke, T. (2008) · Brain · doi:10.1093/brain/awn229 · Cited by 253 · see citing works
Identifying Neurobiological Phenotypes Associated with Alcohol Use Disorder Severity
Claus, E. D., Ewing, S. W. F., Filbey, F. M., Sabbineni, A., & Hutchison, K. E. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.99 · Cited by 249 · see citing works
MATTE, H. O., Rodriguez, O., & CASTRO, E. A. (1955) · PubMed · Cited by 231 · see citing works
The development of hub architecture in the human functional brain network
Hwang, K., Hallquist, M. N., & Luna, B. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs227 · Cited by 226 · see citing works
Choosing to make an effort: The role of striatum in signaling physical effort of a chosen action
Kurniawan, I. T., Seymour, B., Talmi, D., Yoshida, W., Chater, N., & Dolan, R. J. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00027.2010 · Cited by 225 · see citing works
Aversion-Related Circuitry in the Cerebellum: Responses to Noxious Heat and Unpleasant Images
Moulton, E. A., Elman, I., Pendse, G., Schmahmann, J. D., Becerra, L. R., & Borsook, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6709-10.2011 · Cited by 224 · see citing works
Self-citationAlterations of the brain reward system in antipsychotic naïve schizophrenia patients.
Nielsen, M., Rostrup, E., Wulff, S., Bak, N., Lublin, H., Kapur, S., & Glenthøj, B. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.02.007 · Cited by 222 · see citing works
Neural Encoding in Ventral Striatum during Olfactory Discrimination Learning
Setlow, B., Schoenbaum, G. M., & Gallagher, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00264-2 · Cited by 220 · see citing works
Blum, K., Gardner, E., Oscar-Berman, M., & Gold, M. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212798919110 · Cited by 218 · see citing works
Danziger, N., Faillenot, I., & Peyron, R. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.023 · Cited by 215 · see citing works
Altered Resting State in Diabetic Neuropathic Pain
Cauda, F., Sacco, K., Duca, S., Cocito, D., D’Agata, F., Geminiani, G. C., & Canavero, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004542 · Cited by 214 · see citing works
Stone, A. A., Schwartz, J. E., Broderick, J. E., & Shiffman, S. S. (2005) · Personality and Social Psychology Bulletin · doi:10.1177/0146167205275615 · Cited by 206 · see citing works
Shine, J. M., Halliday, G. M., Naismith, S. L., & Lewis, S. J. G. (2011) · Movement Disorders · doi:10.1002/mds.23896 · Cited by 205 · see citing works
Neural correlates of the prolonged salience of painful stimulation
Downar, J. H., Mikulis, D. J., & Davis, K. D. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00407-5 · Cited by 200 · see citing works
Impairments of attention after cingulotomy
Cohen, R. A., Kaplan, R. F., Moser, D. J., Jenkins, M. A., & Wilkinson, H. A. (1999) · Neurology · doi:10.1212/wnl.53.4.819 · Cited by 192 · see citing works
Becerra, L. R., Morris, S., Bazes, S., Gostic, R., Sherman, S. J., Gostic, J., Pendse, G., Moulton, E. A., Scrivani, S. J., Keith, D. A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2305-06.2006 · Cited by 191 · see citing works
Self-citationAberrant temporal and spatial brain activity during rest in patients with chronic pain
Malinen, S., Vartiainen, N. V., Hlushchuk, Y., Koskinen, M., Ramkumar, P., Forss, N., Kalso, E. A., & Hari, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001504107 · Cited by 186 · see citing works
Anhedonia and Emotional Experience in Schizophrenia: Neural and Behavioral Indicators
Dowd, E. C., & Barch, D. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.020 · Cited by 184 · see citing works
A prefrontal non-opioid mechanism in placebo analgesia
Petrovic, P., Kalso, E., Petersson, K. M., Andersson, J., Fransson, P., & Ingvar, M. (2010) · Pain · doi:10.1016/j.pain.2010.03.011 · Cited by 182 · see citing works
Elsenbruch, S., Rosenberger, C., Bingel, U., Forsting, M., Schedlowski, M., & Gizewski, E. R. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.054 · Cited by 180 · see citing works
Moore, J. W., & Stickney, K. J. (1980) · Physiological Psychology · doi:10.3758/bf03337464 · Cited by 179 · see citing works
Functional network connectivity in the behavioral variant of frontotemporal dementia
Filippi, M., Agosta, F., Scola, E., Canu, E., Magnani, G., Marcone, A., Valsasina, P., Caso, F., Copetti, M., Comi, G., et al. (2013) · Cortex · doi:10.1016/j.cortex.2012.09.017 · Cited by 177 · see citing works
Campbell, C. M., & Edwards, R. R. (2009) · Translational research · doi:10.1016/j.trsl.2008.12.002 · Cited by 175 · see citing works
Hedonic and incentive signals for body weight control
Egecioglu, E., Skibicka, K. P., Hansson, C., Álvarez-Crespo, M., Friberg, P. A., Jerlhag, E., Engel, J. A., & Dickson, S. L. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9166-4 · Cited by 173 · see citing works
Dissociable Influences of Opiates and Expectations on Pain
Atlas, L. Y., Whittington, R. A., Lindquist, M. A., Wielgosz, J., Sonty, N., & Wager, T. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0383-12.2012 · Cited by 172 · see citing works
Unconscious attentional orienting to exogenous cues: A review of the literature
Mulckhuyse, M., & Theeuwes, J. (2010) · Acta Psychologica · doi:10.1016/j.actpsy.2010.03.002 · Cited by 168 · see citing works
Kruit, M. C., Launer, L. J., Overbosch, J., et al. (2008) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01723.x · Cited by 164 · see citing works
Migraine Attacks the Basal Ganglia
Maleki, N., Becerra, L. R., Nutile, L. M., Pendse, G., Brawn, J., BIGAL, M. E., Burstein, R., & Borsook, D. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-71 · Cited by 159 · see citing works
Self-citationStarr, C. J., Sawaki, L. A., Wittenberg, G. F., Burdette, J. H., Oshiro, Y., de Quevedo, A. S., McHaffie, J. G., & Coghill, R. C. (2011) · Brain · doi:10.1093/brain/awr117 · Cited by 158 · see citing works
Characterization and consequences of pain variability in individuals with fibromyalgia
Harris, R. E., Williams, D. A., McLean, S. A., Sen, A., Hufford, M. R., Gendreau, R. M., Gracely, R. H., & Clauw, D. J. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21407 · Cited by 152 · see citing works
Distinct Tonic and Phasic Anticipatory Activity in Lateral Habenula and Dopamine Neurons
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.016 · Cited by 146 · see citing works
Habituation and sensitization to heat and cold pain in women with fibromyalgia and healthy controls
Smith, B. W., Tooley, E. M., Montague, E. Q., Robinson, A. E. R., Cosper, C. J., & Mullins, P. G. (2008) · Pain · doi:10.1016/j.pain.2008.09.018 · Cited by 145 · see citing works
Weissman-Fogel, I., Moayedi, M., Tenenbaum, H. C., Goldberg, M. B., Freeman, B. V., & Davis, K. D. (2011) · Pain · doi:10.1016/j.pain.2010.10.046 · Cited by 140 · see citing works
Altered resting state attentional networks in diabetic neuropathic pain
Cauda, F., D’Agata, F., Sacco, K., Duca, S., Cocito, D., Paolasso, I., Isoardo, G., & Geminiani, G. C. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.188631 · Cited by 133 · see citing works
Pain Insensitivity in Schizophrenia: Trait or State Marker?
Singh, M. K., Giles, L. L., & Nasrallah, H. A. (2006) · Journal of Psychiatric Practice · doi:10.1097/00131746-200603000-00004 · Cited by 130 · see citing works
Cortical and subcortical responses to high and low effective placebo treatments
Geuter, S., Eippert, F., Attar, C. H., & Büchel, C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.11.029 · Cited by 130 · see citing works
Melloni, L., van Leeuwen, S., Alink, A., & Müller, N. G. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr384 · Cited by 130 · see citing works
Cauda, F., Sacco, K., D’Agata, F., Duca, S., Cocito, D., Geminiani, G. C., Migliorati, F., & Isoardo, G. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-138 · Cited by 129 · see citing works
Are Patients With Schizophrenia Insensitive to Pain? A Reconsideration of the Question
Bonnot, O., Anderson, G., Cohen, D., Willer, J., & Tordjman, S. (2009) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e318192be97 · Cited by 126 · see citing works
Moore, J. W., & Stickney, K. J. (1980) · Physiological Psychology · doi:10.3758/bf03332852 · Cited by 126 · see citing works
Reward-Dependent Spatial Selectivity of Anticipatory Activity in Monkey Caudate Neurons
Takikawa, Y., Kawagoe, R., & Hikosaka, O. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00288.2001 · Cited by 124 · see citing works
Selective decreased grey matter volume of the pain-matrix network in cluster headache
Absinta, M., Rocca, M. A., Colombo, B., Falini, A., Comı, G., & Filippi, M. (2011) · Cephalalgia · doi:10.1177/0333102411431334 · Cited by 118 · see citing works
Stein, N., Sprenger, C., Scholz, J., Wiech, K., & Bingel, U. (2012) · Pain · doi:10.1016/j.pain.2012.07.010 · Cited by 116 · see citing works
The Missing P in Psychiatric Training
Elman, I., Zubieta, J.-K., & Borsook, D. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.174 · Cited by 115 · see citing works
Self-citationBrain networks predicting placebo analgesia in a clinical trial for chronic back pain
Hashmi, J. A., Baria, A. T., Baliki, M. N., Huang, L., Schnitzer, T. J., & Apkarian, V. A. (2012) · Pain · doi:10.1016/j.pain.2012.08.008 · Cited by 115 · see citing works
Contextual novelty changes reward representations in the striatum
Guitart-Masip, M., Bunzeck, N., Stephan, K. E., Dolan, R. J., & Düzel, E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5331-09.2010 · Cited by 104 · see citing works
Zhang, L., Zhang, Y., & Zhao, Z. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04302.x · Cited by 101 · see citing works
Pain and emotion in the insular cortex: evidence for functional reorganization in major depression
Mutschler, I., Tonio Ball, A., Wankerl, J., & Strigo, I. A. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.095 · Cited by 98 · see citing works
Multisensory interactions in primate auditory cortex: fMRI and electrophysiology
Kayser, C., Petkov, C. I., & Logothetis, N. K. (2009) · Hearing Research · doi:10.1016/j.heares.2009.02.011 · Cited by 95 · see citing works
Human cerebellar responses to brush and heat stimuli in healthy and neuropathic pain subjects
Borsook, D., Moulton, E. A., Tully, S., Schmahmann, J. D., & Becerra, L. R. (2008) · The Cerebellum · doi:10.1007/s12311-008-0011-6 · Cited by 95 · see citing works
Self-citationMcBeth, J., Morris, S., Benjamin, S., Silman, A. J., & Macfarlane, G. J. (2001) · PubMed · Cited by 94 · see citing works
Emotional and personality changes following cingulotomy
Cohen, R. A., Paul, R., Zawacki, T. M., Moser, D. J., Sweet, L., & Wilkinson, H. (2001) · Emotion · doi:10.1037/1528-3542.1.1.38 · Cited by 93 · see citing works
A pure salience response in posterior parietal cortex
Arcizet, F., Mirpour, K., & Bisley, J. W. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr035 · Cited by 90 · see citing works
Neural Mechanisms Underlying 5-HTTLPR-Related Sensitivity to Acute Stress
Drabant, E. M., Ramel, W., Edge, M. D., Hyde, L. W., Kuo, J. R., Goldin, P. R., Hariri, A. R., & Gross, J. J. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111699 · Cited by 90 · see citing works
Chapter 31 Functional contributions of the primate pulvinar
Robinson, D. L. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)60382-9 · Cited by 81 · see citing works
Mechanisms of Action Selection and Timing in Substantia Nigra Neurons
Fan, D., Rossi, M. A., & Yin, H. H. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5924-11.2012 · Cited by 78 · see citing works
Cortex Mediates Multisensory But Not Unisensory Integration in Superior Colliculus
Alvarado, J. C., Stanford, T. R., Vaughan, J. W., & Stein, B. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3524-07.2007 · Cited by 78 · see citing works
Baumgärtner, U., Tiede, W., Treede, R.-D., & Craig, A. D. (. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00512.2006 · Cited by 73 · see citing works
Eck, J., Richter, M., Straube, T., Miltner, W. H. R., & Weiß, T. (2011) · Pain · doi:10.1016/j.pain.2011.01.026 · Cited by 72 · see citing works
Cerebral Activation and Catastrophizing During Pain Anticipation in Patients With Fibromyalgia
Burgmer, M., Petzke, F. W., Giesecke, T., Gaubitz, M., Heuft, G., & Pfleiderer, B. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318236588a · Cited by 71 · see citing works
Thomason, M. E., Hamilton, J. P., & Gotlib, I. H. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02422.x · Cited by 69 · see citing works
Shimo, K., Ueno, T., Younger, J., Nishihara, M., Inoue, S., Ikemoto, T., Taniguchi, S., & Ushida, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026681 · Cited by 67 · see citing works
Yen, C.-P., Kuan, C.-Y., Sheehan, J. P., Kung, S., Wang, C.-C., Liu, C., & Kwan, A. L. (2008) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2008.04.008 · Cited by 65 · see citing works
Jongsma, M. L. A., Postma, S., Souren, P. M., Arns, M., Gordon, E., Vissers, K. C. P., Wilder‐Smith, O. H. G., van Rijn, C. M., & van Goor, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023363 · Cited by 64 · see citing works
Oxytocin and the salience of social cues
Averbeck, B. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004892107 · Cited by 64 · see citing works
Heightened central affective response to visceral sensations of pain and discomfort in IBS
Hall, G. B., Kamath, M. V., Collins, S. M., Ganguli, S. C., Spaziani, R., miranda, K. L., Bayati, A. I., & Bienenstock, J. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01436.x · Cited by 62 · see citing works
Abnormal Bodily Experiences May be a Marker of Early Schizophrenia?
Stanghellini, G., Ballerini, M., Fusar‐Poli, P., & Cutting, J. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799316181 · Cited by 55 · see citing works
The salience network contributes to an individual's fluid reasoning capacity
Yuan, Z., Qin, W., Wang, D., Jiang, T., Zhang, Y., & Yu, C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.01.037 · Cited by 55 · see citing works
Autobiographical memory and chronic pain
Wright, J., & Morley, S. (1995) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.1995.tb01460.x · Cited by 52 · see citing works
Subthalamic nucleus stimulation affects incentive salience attribution in Parkinson's disease
Serranová, T., Jech, R., Dušek, P., Sieger, T., Růžička, F., Urgošík, D., & Růžička, E. (2011) · Movement Disorders · doi:10.1002/mds.23880 · Cited by 51 · see citing works
Habas, C., Guillevin, R., & Abanou, A. (2009) · The Cerebellum · doi:10.1007/s12311-009-0145-1 · Cited by 49 · see citing works
Nielsen, T., McGregor, D., Zadra, A. L., Ilnicki, D., & Ouellet, L. (1993) · SLEEP · doi:10.1093/sleep/16.5.490 · Cited by 48 · see citing works
Becker, S., Kleinböhl, D., Baus, D., & Hölzl, R. (2011) · Pain · doi:10.1016/j.pain.2011.02.027 · Cited by 48 · see citing works
The Effect of Dopamine Agonists on Adaptive and Aberrant Salience in Parkinson's Disease
Nagy, H., Levy-Gigi, E., Somlai, Z., Takáts, A., Bereczki, D., & Kéri, S. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.278 · Cited by 42 · see citing works
Increased cold and heat pain thresholds influence the thermal grill illusion in schizophrenia
Boettger, M. K., Grossmann, D., & Bär, K. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00188.x · Cited by 38 · see citing works
Placebo analgesia and beyond: a melting pot of concepts and ideas for neuroscience
Carlino, E., Pollo, A., & Benedetti, F. (2011) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e328349d0c2 · Cited by 36 · see citing works
Brain structures activated by overt and covert emotional visual stimuli
Sabatini, E., Penna, S. D., Franciotti, R., Ferretti, A., Zoccolotti, P., Rossini, P. M., Romani, G. L., & Gainotti, G. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.03.001 · Cited by 34 · see citing works
Kotsis, V., Benson, S., Bingel, U., Forsting, M., Schedlowski, M., Gizewski, E., & Elsenbruch, S. (2012) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2012.01968.x · Cited by 31 · see citing works
Insular lesions and smoking cessation after first-ever ischemic stroke: A 3-month follow-up
Bienkowski, P., Zatorski, P., Baranowska, A., Ryglewicz, D., & Sienkiewicz-Jarosz, H. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.008 · Cited by 29 · see citing works
Distinct Frontal Networks Are Involved in Adapting to Internally and Externally Signaled Errors
Ham, T. E., de Boissezon, X., Leff, A., Beckmann, C., Hughes, E., Kinnunen, K. M., Leech, R., & Sharp, D. J. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs056 · Cited by 29 · see citing works
Pain Facilitation Brain Regions Activated by Nalbuphine Are Revealed by Pharmacological fMRI
Gear, R. W., Becerra, L. R., Upadhyay, J., Bishop, J. H., Wallin, D. J., Pendse, G., Levine, J. D., & Borsook, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0050169 · Cited by 28 · see citing works
Self-citationAlbrecht, A., Bergado-Acosta, J. R., Pape, H., & Stork, O. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709991106 · Cited by 27 · see citing works
Recalling pain experienced during a colonoscopy: Pain expectation and variability
Gavaruzzi, T., Carnaghi, A., Lotto, L., Rumiati, R., Meggiato, T., Polato, F., & Lazzari, F. D. (2009) · British Journal of Health Psychology · doi:10.1348/135910709x458305 · Cited by 25 · see citing works
Löwenstein, L., Kenton, K. S., Mueller, E. R., Brubaker, L. T., Heneghan, M., Senka, J., & FitzGerald, M. P. (2009) · Neurourology and Urodynamics · doi:10.1002/nau.20676 · Cited by 23 · see citing works
Veilleux, S., & Melzack, R. (1976) · Experimental Neurology · doi:10.1016/0014-4886(76)90224-7 · Cited by 22 · see citing works
Malone, M. A. (2011) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2011.05.003 · Cited by 21 · see citing works
Sensitivity to expressions of pain in schizophrenia patients
Martins, M. J. D., Moura, B. M., Martins, I. P., Figueira, M. L., & Prkachin, K. M. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2011.03.007 · Cited by 20 · see citing works
Decreasing pain tolerance outside of awareness
Meerman, E. E., Verkuil, B., & BROSSCHOT, J. F. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.08.006 · Cited by 16 · see citing works
A positron emission tomography study of wind‐up pain in chronic postherniotomy pain
Kupers, R. C., Lonsdale, M. N., Aasvang, E. K., & Kehlet, H. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.01.003 · Cited by 13 · see citing works
Effects of Unilateral and Bilateral Invasion of Thalamic Pulvinar for Pain Relief
YOSHII, N., & FUKUDA, S. (1979) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.127.81 · Cited by 8 · see citing works
[The placebo mystery or neurobiology of the soul].
Lemoine, P. (2011) · PubMed · Cited by 6 · see citing works
Pharmacologie de l’âme ou le mystère du placebo
Lemoine, P. (2011) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)31946-6 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719 · see citing works
Self-citationMore than skin deep: Stress neurobiology and mental health consequences of racial discrimination
Berger, M., & Sarnyai, Z. (2015) · Stress · doi:10.3109/10253890.2014.989204 · Cited by 606 · see citing works
Placebo Analgesia: A Predictive Coding Perspective
Büchel, C., Geuter, S., Sprenger, C., & Eippert, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.042 · Cited by 505 · see citing works
Psychological processing in chronic pain: a neural systems approach
Simons, L. E., Elman, I., & Borsook, D. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.006 · Cited by 359 · see citing works
Self-citationHemington, K. S., Wu, Q., Kucyi, A., Inman, R. D., & Davis, K. D. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1161-1 · Cited by 220 · see citing works
As-Sanie, S., Kim, J., Schmidt-Wilcke, T., Sundgren, P. C., Clauw, D. J., Napadow, V., & Harris, R. E. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2015.09.008 · Cited by 199 · see citing works
Pain in the body. Altered interoception in chronic pain conditions: a systematic review
Di Lernia, D., Serino, S., & Riva, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.015 · Cited by 190 · see citing works
The Insula: A “Hub of Activity” in Migraine
Borsook, D., Veggeberg, R., Erpelding, N., Borra, R., Linnman, C., Burstein, R., & Becerra, L. (2016) · The Neuroscientist · doi:10.1177/1073858415601369 · Cited by 146 · see citing works
Self-citationCottam, W. J., Iwabuchi, S. J., Drabek, M. M., Reckziegel, D., & Auer, D. P. (2018) · Pain · doi:10.1097/j.pain.0000000000001209 · Cited by 110 · see citing works
Does the kappa opioid receptor system contribute to pain aversion?
Cahill, C. M., Taylor, A. M. W., Cook, C., Ong, E., Morón, J. A., & Evans, C. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00253 · Cited by 105 · see citing works
Structural basis of empathy and the domain general region in the anterior insular cortex
Mutschler, I., Reinbold, C., Wankerl, J., Seifritz, E., & Ball, T. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00177 · Cited by 92 · see citing works
Refractory dependence on opioid analgesics
Ballantyne, J. C., Sullivan, M. D., & Koob, G. F. (2019) · Pain · doi:10.1097/j.pain.0000000000001680 · Cited by 81 · see citing works
Boundary effects of expectation in human pain perception
Hird, E. J., Charalambous, C., El-Deredy, W., Jones, A. K. P., & Talmi, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-45811-x · Cited by 68 · see citing works
Brain network alterations in the inflammatory soup animal model of migraine
Becerra, L., Bishop, J., Barmettler, G., Kainz, V., Burstein, R., & Borsook, D. (2017) · Brain Research · doi:10.1016/j.brainres.2017.02.001 · Cited by 40 · see citing works
Self-citationPatient action as means and end for chronic pain care
Sullivan, M. D., & Vowles, K. E. (2017) · Pain · doi:10.1097/j.pain.0000000000000921 · Cited by 29 · see citing works
Yu, W., Caira, C. M., del R. Rivera Sanchez, N., Moseley, G. A., & Kash, T. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-91672-8 · Cited by 25 · see citing works
Subliminal (latent) processing of pain and its evolution to conscious awareness
Borsook, D., Youssef, A. M., Barakat, N., Sieberg, C. B., & Elman, I. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.015 · Cited by 21 · see citing works
Self-citationPain in an era of armed conflicts: prevention and treatment for warfighters and civilian casualties
George, E., Elman, I., Becerra, L., Berg, S., & Borsook, D. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.002 · Cited by 18 · see citing works
Self-citationKaracaoglu, M., Peerdeman, K. J., Numans, M. E., Stolk, M. R., Meijer, S., Klinger, R., Veldhuijzen, D. S., van Middendorp, H., & Evers, A. W. M. (2023) · The Journal of Pain · doi:10.1016/j.jpain.2023.05.003 · Cited by 5 · see citing works
- Authors
- Borsook, D., Edwards, R., Elman, I., Becerra, L., & Levine, J.
- Affiliations
- Boston Children's Hospital (US)
- Brigham and Women's Hospital (US)
- Cambridge Health Alliance (US)
- University of California, San Francisco (US)
- Corresponding author
- Borsook, David
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 104
- Pages
- 93-105
- ISSN
- 0301-0082 (ISSN-L)
- PMC
- PMC3644802
- OpenAlex
- W2008554353
- Cited by
- 215
- References
- 171
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 10 · 2023: 20 · 2022: 21 · 2021: 16 · 2020: 14 · 2019: 19 · 2018: 15 · 2017: 15 · 2016: 16 · 2015: 23 · 2014: 9 · 2013: 4 · 2012: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5r01ns065051-02)
- National Institute on Aging (R01AG034982)
- National Institute of Neurological Disorders and Stroke (R01-NS-065051, K24NS064050)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- salience network, chronic pain, pain perception, analgesia, placebo analgesia, pain catastrophizing, pain underreporting, noxious stimuli, brain circuits
- MeSH terms
- Analgesia, Analgesics, Animals, Humans, Pain, Pain Measurement, Pain Management
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review