Adaptogenic and anti-amnesic properties of in rodents
Abstract
Evolvulus alsinoides (EA) is well known for its memory enhancement, antiepileptic and immunomodulatory properties in the traditional Indian system of medicine, Ayurveda. In view of the increasing attention towards plants offering non-specific resistance (adaptogens) towards stress, we have evaluated crude ethanolic extract of EA for its adaptogenic and memory enhancing properties in rodents. Adaptogenic activity was assessed in rats subjected to acute and chronic unpredictable stress. Male Sprague-Dawley rats, weighing 180-200 g were immobilized for 150 min once only in acute stress (AS) model, whereas in chronic unpredictable stress (CUS) model rats were subjected to different types of stressors daily for 7 days. Stress exposure has induced gastric ulceration with increase in adrenal gland weight, plasma creatine kinase (CK), and corticosterone level in AS and CUS. However plasma glucose was increased only in AS. Rats were treated with graded doses of crude ethanolic extract of EA (100, 200 and 400 mg/kg p.o.) for 3 days and subjected to AS on 3 day after 45 min of last dose. In CUS, EA at a dose of 200 mg/kg p.o. found effective in acute studies was administered 45 min prior to stress regimen for 7 days. EA reduced the stress induced perturbations similar to Panax quinquefolium (PQ) (100 mg/kg p.o.), a well known adaptogen. EA (100 mg/kg) administered orally for 3 days in adult male Swiss mice, was effective in decreasing scopolamine induced deficit in passive avoidance test. The improvement in the peripheral stress markers and scopolamine induced dementia by EA in the present study indicates the adaptogenic and anti-amnesic properties of EA.
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The ethanolic extract of E. alsinoides (100 mg/kg, p.o) protected against scopolamine induced dementia in rats.
“The ethanolic extract (100 mg/kg, p.o) also protected against scopolamine induced dementia in rats [188].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [188]
Three days oral treatment with E. alsinoides (100 mg/kg) was effective in decreasing scopolamine induced deficit in adult male Swiss mice.
“Three days oral treatment with E. alsionoides (100 mg/kg) was effective in decreasing scopolamine induced deficit in adult male Swiss mice [188].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [188]
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- Authors
- SIRIPURAPU, K., GUPTA, P., BHATIA, G., MAURYA, R., NATH, C., & PALIT, G.
- Affiliations
- Central Drug Research Institute (IN)
- Corresponding author
- PALIT, G
- ORCID
- NATH, C
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 81
- Issue
- 3
- Pages
- 424-432
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W1600555363
- Cited by
- 51
- References
- 42
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Evolvulus alsinoides, adaptogenic activity, memory enhancement, chronic unpredictable mild stress, acute immobilization stress, stress-induced gastric ulcer, corticosterone, plasma creatine kinase, scopolamine-induced amnesia, passive avoidance, Panax quinquefolius, ethanolic plant extract, Ayurvedic medicinal plants
- MeSH terms
- Adaptation, Psychological, Adrenal Glands, Amnesia, Animals, Avoidance Learning, Blood Glucose, Corticosterone, Creatine Kinase, Dose-Response Relationship, Drug, Panax, Male, Phytotherapy, Memory, Organ Size, Restraint, Physical, Stress, Psychological, Rats, Sprague-Dawley, Convolvulaceae, Plant Preparations, Rats
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