The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Impulsivity predicts the escalation of cocaine self-administration in rats
Open accessAbstract
Impulsivity, as measured by the delay-discounting task, predicts the acquisition of cocaine self-administration and reinstatement of cocaine seeking in rats. The purpose of this study was to extend these results to the escalation phase of drug self-administration. Female rats were initially screened for high (HiI) or low (LoI) impulsivity for food reinforcement using a delay-discounting procedure. They were then implanted with i.v. catheters and trained to lever press for cocaine infusions (0.8 mg/kg). Once cocaine intake stabilized, rats were allowed to self-administer cocaine (0.4 mg/kg) under a fixed-ratio 1 (FR 1) schedule during three, 2 h short-access sessions. Subsequently, performance was briefly assessed under a progressive ratio (PR) schedule for 3 doses of cocaine (0.2, 0.8, and 3.2 mg/kg). Following PR testing, the cocaine dose was then changed to 0.4 mg/kg. Session length was then extended to 6 h for 21 days (extended access), and 0.4 mg/kg cocaine was available under a FR 1 schedule. After the 21-day extended access phase, responses and infusions under the short access FR and PR dose-response conditions were reassessed. The results indicated that HiI rats escalated cocaine-reinforced responding during the extended access condition, but LoI rats did not. HiI rats also earned significantly more infusions than LoI rats under the post-escalation short access FR condition. However, HiI and LoI rats did not differ under the pre- and post-extended access PR conditions. This study suggests that individual differences in impulsivity predict escalation of cocaine self-administration in female rats, which may have implications in the prediction of binge-like patterns of cocaine intake in women.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“some evidence suggests impulsive choice is predictive of higher cocaine or methylphenidate intake”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Anker et al., 2009
In the citing paper
“prospective studies suggest that high discounting rates may indicate vulnerability for the development of such problems across species”
From DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls (2010) · cites this paper as Anker et al, 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Psychiatric Aspects of Impulsivity
Moeller, F. G., Barratt, E. S., Dougherty, D. M., Schmitz, J. M., & Swann, A. C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1783 · Cited by 2,747
An adjusting procedure for studying delayed reinforcement.
Commons, M. L., Mazur, J., Nevin, J. A., & Rachlin, H. C. (1987) · doi:10.4324/9781315825502-11 · Cited by 1,842
Verdejo‐García, A., Lawrence, A. J., & Clark, L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.11.003 · Cited by 1,502
Impulsivity as a determinant and consequence of drug use: a review of underlying processes
de Wit, H. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00129.x · Cited by 1,415
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S. J., Theobald, D. E. H., Lääne, K., Peña, Y., Murphy, E. R., Shah, Y., Probst, K., et al. (2007) · Science · doi:10.1126/science.1137073 · Cited by 1,188
Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point
Ahmed, S. H., & Koob, G. F. (1998) · Science · doi:10.1126/science.282.5387.298 · Cited by 1,186
Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005) · Nature Neuroscience · doi:10.1038/nn1583 · Cited by 1,024
The place of impulsiveness in a dimensional system of personality description
Eysenck, S. B. G., & Eysenck, H. J. (1977) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1977.tb01003.x · Cited by 902
Psychological heterogeneity in AD/HD—a dual pathway model of behaviour and cognition
Sonuga-Barke, E. J. S. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00432-6 · Cited by 901
The role of impulsive behavior in drug abuse
Perry, J. L., & Carroll, M. E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1173-0 · Cited by 805
Self-citationNeurobiological mechanisms for opponent motivational processes in addiction
Koob, G. F., & Moal, M. L. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0094 · Cited by 743
Kirby, K., & Petry, N. (2004) · Addiction · doi:10.1111/j.1360-0443.2003.00669.x · Cited by 737
Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals.
Coffey, S., Gudleski, G., Saladin, M., & Brady, K. (2003) · Experimental and clinical psychopharmacology · doi:10.1037//1064-1297.11.1.18 · Cited by 655
Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals.
Coffey, S. F., Gudleski, G. D., Saladin, M. E., & Brady, K. T. (2003) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.11.1.18 · Cited by 625
Separate neural pathways process different decision costs
Rudebeck, P. H., Walton, M. E., Smyth, A. N., Bannerman, D. M., & Rushworth, M. F. S. (2006) · Nature Neuroscience · doi:10.1038/nn1756 · Cited by 580
Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research
National Research Council (2003) · National Academies Press eBooks · doi:10.17226/10732 · Cited by 530
Impaired inhibitory control of behavior in chronic cocaine users
Fillmore, M. T., & Rush, C. R. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(01)00206-x · Cited by 519
Chudasama, Y., Passetti, F., Rhodes, S. E. V., Lopian, D., Desai, A., & Robbins, T. W. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.020 · Cited by 518
The neuropharmacology of impulsive behaviour
Pattij, T., & Vanderschuren, L. J. M. J. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.01.002 · Cited by 479
Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry
Dalley, J. W., Mar, A. C., Economidou, D., & Robbins, T. W. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.12.021 · Cited by 467
Diergaarde, L., Pattij, T., Poortvliet, I., Hogenboom, F., de Vries, W., Schoffelmeer, A. N. M., & De Vries, T. J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.011 · Cited by 391
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
Ahmed, S. H., Kenny, P. J., Koob, G. F., & Markou, A. (2002) · Nature Neuroscience · doi:10.1038/nn872 · Cited by 389
Perry, J. L., Larson, E. B., German, J. P., Madden, G. J., & Carroll, M. E. (2005) · Psychopharmacology · doi:10.1007/s00213-004-1994-4 · Cited by 388
Self-citationEffects of THC on Behavioral Measures of Impulsivity in Humans
McDonald, J. M., Schleifer, L., Richards, J. B., & de Wit, H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300176 · Cited by 386
The estrous cycle affects cocaine self-administration on a progressive ratio schedule in rats
Roberts, D. C. S., Bennett, S. A. L., & Vickers, G. J. (1989) · Psychopharmacology · doi:10.1007/bf00451696 · Cited by 372
Winstanley, C. A., Dalley, J. W., Theobald, D. E., & Robbins, T. W. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300434 · Cited by 371
Heil, S. H., Johnson, M. W., Higgins, S. T., & Bickel, W. K. (2005) · Addictive Behaviors · doi:10.1016/j.addbeh.2005.09.005 · Cited by 334
Cognitive impulsivity in cocaine and heroin polysubstance abusers
Verdejo‐García, A., Perales, J. C., & Pérez-Garcı́a, M. (2006) · Addictive Behaviors · doi:10.1016/j.addbeh.2006.06.032 · Cited by 316
VERDEJO-GARCÍA, A., BECHARA, A., RECKNOR, E. C., & PÉREZ-GARCÍA, M. (2006) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617706060486 · Cited by 315
Long-lasting increase in the set point for cocaine self-administration after escalation in rats
Ahmed, S. H., & Koob, G. F. (1999) · Psychopharmacology · doi:10.1007/s002130051121 · Cited by 301
Winstanley, C. A., Theobald, D. E. H., Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi088 · Cited by 280
Moeller, F. G., Dougherty, D. M., Barratt, E. S., Oderinde, V., Mathias, C. W., Harper, R. A., & Swann, A. C. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(02)00106-0 · Cited by 268
Ersche, K. D., Roiser, J. P., Robbins, T. W., & Sahakian, B. J. (2008) · Psychopharmacology · doi:10.1007/s00213-007-1051-1 · Cited by 255
Impulsivity predicts individual susceptibility to high levels of alcohol self-administration
Poulos, C. X., Le, A. D., & Parker, J. L. (1995) · Behavioural Pharmacology · doi:10.1097/00008877-199512000-00006 · Cited by 234 · cited 2×
“Rats screened for high levels of impulsive choice on a delay-discounting task subsequently self-administered more ethanol (Poulos et al., 1995) and i.v. nicotine (Diergaarde et al., 2008), acquired cocaine self-administration faster (Perry et al., 2005, 2008), and exhibited greater reinstatement of…”
BackgroundBornovalova, M., Daughters, S., Hernandez, G. D., Richards, J., & Lejuez, C. (2005) · Experimental and clinical psychopharmacology · doi:10.1037/1064-1297.13.4.311 · Cited by 232
Increased motivation for self-administered cocaine after escalated cocaine intake
Paterson, N. E., & Markou, A. (2003) · Neuroreport · doi:10.1097/00001756-200312020-00019 · Cited by 203
Perry, J. L., Nelson, S. E., & Carroll, M. E. (2008) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.16.2.165 · Cited by 200
Self-citationActon, G. S. (2003) · Substance Use & Misuse · doi:10.1081/ja-120016566 · Cited by 186
Robinson, E. S. J., Eagle, D. M., Economidou, D., Theobald, D. E. H., Mar, A. C., Murphy, E. R., Robbins, T. W., & Dalley, J. W. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.021 · Cited by 184
Roth, M. E., & Carroll, M. E. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.03.018 · Cited by 182
Self-citationLynch, W. J., Arizzi, M. N., & Carroll, M. E. (2000) · Psychopharmacology · doi:10.1007/s002130000488 · Cited by 172
Self-citationPerformance monitoring and stop signal inhibition in abstinent patients with cocaine dependence
Li, C. R., Milivojevic, V., Kemp, K. A., Hong, K., & Sinha, R. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.04.008 · Cited by 169
Dual determinants of drug use in humans: reward and impulsivity.
de Wit, H., & Richards, J. B. (2004) · PubMed · Cited by 168
Risk factors in the relationship between gender and crack/cocaine.
Lejuez, C., Bornovalova, M., Reynolds, E., Daughters, S., & Curtin, J. (2007) · Experimental and clinical psychopharmacology · doi:10.1037/1064-1297.15.2.165 · Cited by 147
Patkar, A. A., Murray, H. W., Mannelli, P., Gottheil, E., Weinstein, S. P., & Vergare, M. J. (2004) · Journal of Addictive Diseases · doi:10.1300/j069v23n02_08 · Cited by 147
Larson, E. B., Anker, J. J., Gliddon, L. A., Fons, K. S., & Carroll, M. E. (2007) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.15.5.461 · Cited by 141
Self-citationTreatment Outcome Predictors for Cocaine Dependence
Poling, J. C., Kosten, T. R., & Sofuoglu, M. (2007) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990701199416 · Cited by 132
Selective breeding for differential saccharin intake as an animal model of drug abuse
Carroll, M. E., Morgan, A. D., Anker, J. J., Perry, J. L., & Dess, N. K. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830c3632 · Cited by 118
Self-citationInhibitory Control Deficits in Childhood and Risk for Substance Use Disorders: A Review
Ivanov, I., Schulz, K. P., London, E. D., & Newcorn, J. H. (2008) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990802013334 · Cited by 114
The nature of the relationship between attention-deficit/hyperactivity disorder and substance use.
Wilens, T. E. (2007) · PubMed · Cited by 110
Perry, J. L., Nelson, S. E., Anderson, M. M., Morgan, A. D., & Carroll, M. E. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.03.012 · Cited by 100
Self-citationCarroll, M. E., Campbell, U. C., & Heideman, P. D. (2001) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.9.3.307 · Cited by 98
Self-citationIncreased intravenous drug self-administration during deprivation of other reinforcers
Carroll, M. E., & Boe, I. N. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90319-7 · Cited by 88
Self-citationPatkar, A. A., Berrettini, W. H., Hoehe, M. R., Thornton, C. C., Gottheil, E., Hill, K. P., & Weinstein, S. P. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00098-7 · Cited by 87
Perry, J. L., Morgan, A. D., Anker, J. J., Dess, N. K., & Carroll, M. E. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0371-x · Cited by 85
Self-citationLiu, Y., Roberts, D. C. S., & Morgan, D. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2089-y · Cited by 72
Evolving conceptualizations of cocaine dependence.
Fh, G., & Hd, K. (1988) · PubMed · Cited by 68
Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine
Morgan, D., Liu, Y., & Roberts, D. C. S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300773 · Cited by 62
Wheel running as a predictor of cocaine self-administration and reinstatement in female rats
Larson, E. B., & Carroll, M. E. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.10.015 · Cited by 60
Self-citationDelay Discounting and Impulsive Choice in the Rat
Mar, A. C., & Robbins, T. W. (2007) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0822s39 · Cited by 50
Delay discounting as a predictor of drug abuse.
Carroll, M., Anker, J. J., Mach, J., Newman, J. L., & Perry, J. (2010) · American Psychological Association eBooks · doi:10.1037/12069-009 · Cited by 46
Self-citationSubstance abuse patterns reveal contrasting personal traits
Rosenthal, T. L., Edwards, N. B., Ackerman, B. J., KNOTT, D. H., & Rosenthal, R. H. (1990) · Journal of Substance Abuse · doi:10.1016/s0899-3289(05)80060-4 · Cited by 40
Carroll, M. E., Anderson, M. M., & Morgan, A. D. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0600-3 · Cited by 35
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
Delayed reward discounting and addictive behavior: a meta-analysis
MacKillop, J., Amlung, M. T., Few, L. R., Ray, L. A., Sweet, L. H., & Munafò, M. R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2229-0 · Cited by 1,021
The behavioral economics of substance use disorders: reinforcement pathologies and their repair
Bickel, W. K., Johnson, M. W., Koffarnus, M. N., MacKillop, J., & Murphy, J. G. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153724 · Cited by 655
Bickel, W. K., Koffarnus, M. N., Moody, L., & Wilson, A. G. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.013 · Cited by 386
Rung, J. M., & Madden, G. J. (2018) · Journal of Experimental Psychology: General · doi:10.1037/xge0000462 · Cited by 358
Metadata
- Authors
- Anker, J. J., Perry, J. L., Gliddon, L. A., & Carroll, M. E.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Anker, Justin J.
- ORCID
- Anker, Justin J.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 93
- Issue
- 3
- Pages
- 343-348
- ISSN
- 0091-3057 (ISSN-L)
- PMC
- PMC2734915
- OpenAlex
- W2083570864
- Cited by
- 188
- References
- 62
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 7 · 2016: 10 · 2015: 13 · 2014: 19 · 2013: 21 · 2012: 21
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (K05 015267-07)
- National Institute on Drug Abuse (R01DA003240, K05DA015267, F31DA023301)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- impulsivity, cocaine self-administration, delay discounting, individual differences, female rats, progressive ratio schedule, extended access
- MeSH terms
- Animals, Conditioning, Operant, Data Interpretation, Statistical, Female, Impulsive Behavior, Prognosis, Reinforcement Schedule, Self Administration, Rats, Wistar, Disease Progression, Cocaine-Related Disorders, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
