Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats

Diergaarde, Leontien; Pattij, Tommy; Poortvliet, Ingmar; Hogenboom, François; de Vries, Wendy; Schoffelmeer, Anton N.M.; De Vries, Taco J.

doi:10.1016/j.biopsych.2007.07.011

Cited by 391Smoking Behavior and CessationNeurotransmitter Receptor Influence on BehaviorNicotinic Acetylcholine Receptors Study

Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats

Diergaarde, Leontien, Pattij, Tommy, Poortvliet, Ingmar, Hogenboom, François, de Vries, Wendy, Schoffelmeer, Anton N.M., De Vries, Taco J.·2008·Biological Psychiatry

DOI 10.1016/j.biopsych.2007.07.011

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Abstract

Background Although heavy smoking has been associated with impulsivity in humans, it is not clear whether poor impulse control represents a risk factor in the etiology of nicotine dependence.Methods To address this issue, rats were selected on the basis of individual differences in impulsivity in the delayed reward task (impulsive choice) and the 5-choice serial reaction time task (impulsive action). Subsequently, rats were subjected to a nicotine self-administration (SA) paradigm tailored to measure the motivational properties of nicotine and nicotine-associated stimuli. In separate groups, differences in electrically evoked dopamine release in slice preparations obtained from several mesolimbic brain regions were determined.Results Impulsive action was associated with an enhanced motivation to initiate and maintain nicotine SA. In contrast, impulsive choice predicted a diminished ability to inhibit nicotine seeking during abstinence and an enhanced vulnerability to relapse upon re-exposure to nicotine cues. Impulsive action was associated with reduced dopamine release in the accumbens core and impulsive choice with reduced dopamine release in accumbens core, shell, and medial prefrontal cortex.Conclusions The strong association between sub-dimensions of impulsivity and nicotine SA implies that interventions aimed to improve impulse control might help to reduce susceptibility to nicotine dependence and/or lead to successful smoking cessation.

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Enhanced impulsive responding in the 5CSRTT is predictive of enhanced nicotine self-administration and resistance to extinction.
“Similarly, enhanced impulsive responding in the 5CSRTT is predictive of enhanced nicotine self-administration and resistance to extinction (Diergaarde et al., 2008).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Diergaarde et al., 2008

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Authors: Diergaarde, L., Pattij, T., Poortvliet, I., Hogenboom, F., de Vries, W., Schoffelmeer, A. N. M., & De Vries, T. J.
Affiliations: Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
ORCID: Pattij, Tommy
Schoffelmeer, Anton N.M.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2008-02
Volume: 63
Issue: 3
Pages: 301-308
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2007.07.011
OpenAlex: W2008233347
Cited by: 391
References: 54
Citations by year: 2026: 4 · 2025: 9 · 2024: 4 · 2023: 13 · 2022: 10 · 2021: 13 · 2020: 20 · 2019: 18 · 2018: 24 · 2017: 22 · 2016: 29 · 2015: 26 · 2014: 39 · 2013: 38 · 2012: 25
FWCI: 14.25
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
VU Research Portal (publishedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: impulsivity, impulsive choice, impulsive action, nicotine seeking, nicotine dependence, nicotine self-administration, dopamine release, accumbens, medial prefrontal cortex, relapse, smoking cessation, individual differences
MeSH terms: Analysis of Variance, Animals, Behavior, Animal, Choice Behavior, Conditioning, Operant, Disease Models, Animal, Impulsive Behavior, Male, Nicotine, Predictive Value of Tests, Reinforcement Schedule, Reward, Self Administration, Rats, Wistar, Substance-Related Disorders, Rats

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Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats

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