Repeated restraint stress alters sensitivity to the social consequences of ethanol differentially in early and late adolescent rats
Open accessAbstract
In rats, considerable differences in the social consequences of acute ethanol are seen across ontogeny, with adolescents being more sensitive to low dose ethanol-induced social facilitation and less sensitive to the social inhibition evident at higher ethanol doses relative to adults. Stressor exposure induces social anxiety-like behavior, indexed via decreases in social preference, and alters responsiveness to the social consequences of acute ethanol by enhancing ethanol-associated social facilitation and anxiolysis regardless of age. Given that substantial ontogenetic differences in the social consequences of ethanol are evident even within the adolescent period, the present study was designed to investigate whether similar stress-associated alterations in social behavior and ethanol responsiveness are evident in early and late adolescents. Juvenile-early adolescent [postnatal days (P) 24-28] and mid-late adolescent (P38-42) male and female Sprague-Dawley rats were repeatedly restrained (90 min/day) for 5 days, followed by examination of ethanol-induced (0, 0.25, 0.5, or 1.0 g/kg) alterations in social behaviors on the last day. Responsiveness to restraint stress in terms of both stress-induced behavioral alterations and stress-associated changes in sensitivity to the social consequences of acute ethanol challenge differed drastically at the two ages. Repeated restraint increased anxiety-like behavior in a social context in older adolescents, whereas previously stressed young adolescent males showed substantial increases in play fighting - an effect of stress not evident in P28 females or P42 adolescents of either sex. Unexpectedly, repeated restraint eliminated sensitivity to ethanol-induced social facilitation in P28 adolescent males and made their female counterparts less sensitive to this effect. In contrast, previously stressed late adolescents became sensitive to the socially facilitating and anxiolytic effects of acute ethanol.
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Early-life stress has been shown to alter play fighting in rats and hamsters and to increase aggressive behaviors at adulthood.
“Early-life stress has been shown to alter play fighting in rats and hamsters as well as to increase aggressive behaviors at adulthood.”
From Peripubertal stress increases play fighting at adolescence and modulates nucleus accumbens CB1 receptor expression and mitochondrial function in the amygdala (2018) · cites this paper as [10]
The Results (§3.2; page not provided) report that juvenile restraint stress increased play fighting in early-adolescent male rats. The paper provides no finding about hamsters or increased aggression in adulthood; Methods (§2.6; page not provided) says serious fighting was not analyzed. (LLM, conf=0.90)
Experimental — accuracy not yet measuredSocial play is modulated by early life experiences.
“Importantly, social play has been shown to be modulated by early life experiences.”
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Self-citation
- Authors
- Varlinskaya, E. I., Truxell, E. M., & Spear, L. P.
- Affiliations
- Binghamton University (US)
- Corresponding author
- Varlinskaya, Elena I.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 113
- Pages
- 38-45
- ISSN
- 0091-3057 (ISSN-L)
- PMC
- PMC3889217
- OpenAlex
- W2011356610
- Cited by
- 21
- References
- 70
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 3
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA012453, U01AA019972, R01AA017355, R01AA012453)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- repeated restraint stress, adolescent development, ontogeny, social facilitation, social inhibition, anxiolysis, anxiety-like behavior, social preferences, play fighting, sex differences, age differences, acute ethanol administration
- MeSH terms
- Ethanol, Animals, Behavior, Animal, Dose-Response Relationship, Drug, Female, Immobilization, Male, Stress, Physiological, Rats, Sprague-Dawley, Rats
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