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Cited by 64Autism Spectrum Disorder ResearchAutoimmune Neurological Disorders and TreatmentsSystemic Lupus Erythematosus Research

The relationship between the increased frequency of serum antineuronal antibodies and the severity of autism in children

Mostafa, Gehan Ahmed, Al-Ayadhi, Laila Yousef·2012·European Journal of Paediatric Neurology
DOI 10.1016/j.ejpn.2011.12.010
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Abstract

Background Autism may involve an autoimmune pathogenesis. Immunotherapy may have a role in autistic children who have brain auto-antibodies.Aim This study aimed to investigate the frequency of serum antineuronal auto-antibodies, as indicators of the presence of autoimmunity to brain, in a group of autistic children. We are the first to measure the relationship between these antibodies and the degree of the severity of autism.Methods Serum antineuronal antibodies were measured, by indirect immunofluorescence technique, in 80 autistic children, aged between 6 and 12 years, in comparison to 80 healthy-matched children. The severity of autism was assessed by using the Childhood Autism Rating Scale.Results Autistic children had significantly higher percent positivity of serum antineuronal antibodies (62.5%) than healthy controls (5%), P<0.001. The frequency of the positivity of serum antineuronal antibodies was significantly higher in children with severe autism (87.5%) than children with mild to moderate autism (25%), P<0.001. Similarly, the frequency of the positivity of these antibodies was significantly higher in female children with autism (90%) than male autistic children (53.3%), P=0.001.Conclusions Serum antineuronal antibodies were found in a subgroup of autistic children and they were significantly correlated to the severity of autism. Thus, autism may be, in part, one of the pediatric autoimmune neuropsychiatric disorders. Further wide-scale studies are warranted to shed light on the etiopathogenic role of antineuronal antibodies in autism. The role of immunotherapy in autistic patients, who are seropositive for antineuronal antibodies, should also be studied.

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Crossref · 10.1016/j.ejpn.2011.12.010

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  • The presence of anti-neuronal antibodies was higher in females (90%) than in males (53.3%).

    “as well as in females (90%) compared with males (53.3%).”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Mostafa and Al-Ayadhi (2012)

  • The presence of anti-neuronal antibodies was higher in severe diagnoses (87.5%) than in mild or moderate diagnoses (25%).

    “the presence of such antibodies was higher in severe diagnoses (87.5%) than mild/ moderate diagnoses (25%)”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Mostafa and Al-Ayadhi (2012)

  • In a cohort of 80 Saudi children with ASD versus 80 GP controls, anti-neuronal antibodies tested by immunofluorescence against monkey cerebellum were higher in the ASD group (62.5% vs 5%).

    “Mostafa and Al-Ayadhi (2012), who found a higher rate of anti-neuronal antibodies in a cohort of 80 Saudi children with ASD vs 80 -GP controls, as tested via immunofluorescence against monkey cerebellum (62.5 vs 5%)”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Mostafa and Al-Ayadhi (2012)

  • Offending antibodies of either origin appear to persist systemically for extended periods.

    “Offending antibodies of either origin appear to persist systemically for extended periods of time (Mostafa and Al-Ayadhi, 2012;Piras et al, 2014;Singer et al, 2006;Zimmerman et al, 2007)”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Mostafa and Al-Ayadhi, 2012

  • Reports indicate that the presence of these antibodies may correlate with adverse conditions in patients.

    “Although reports indicate the presence of these antibodies may correlate with adverse conditions in the patients (Braunschweig et al, 2012a;Goines et al, 2011a;Mostafa and Al-Ayadhi, 2012;Piras et al, 2014)”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Mostafa and Al-Ayadhi, 2012

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Authors
Mostafa, G. A., & Al-Ayadhi, L. Y.
Affiliations
  • Ain Shams University (EG)
  • King Saud University (SA)
ORCID
Al-Ayadhi, Laila Yousef
Venue
European Journal of Paediatric Neurology
Publisher
Elsevier BV
Published
2012-09
Volume
16
Issue
5
Pages
464-468
ISSN
1090-3798 (ISSN-L)
DOI
10.1016/j.ejpn.2011.12.010
OpenAlex
W2080216105
Cited by
64
References
44
Citations by year
2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 9 · 2012: 4
FWCI
4.41
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Journal of Paediatric Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • King Abdulaziz City for Science and Technology
  • King Khalid University
  • National Plan for Science, Technology and Innovation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Keywords
autism spectrum disorder, antineuronal antibodies, autoimmune disease pathogenesis, autism severity, autoimmune neuropsychiatric disorders, immunotherapy, sex differences
MeSH terms
Autistic Disorder, Autoantibodies, Brain, Child, Cross-Sectional Studies, Female, Humans, Male, Neurons, Autoimmunity

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