Increased serum levels of anti-ganglioside m1 auto-antibodies in autistic children: Relation to the disease severity
Open accessAbstract
BACKGROUND: Autoimmunity to the central nervous system (CNS) may play a pathogenic role in a subgroup of patients with autism. This study aimed to investigate the frequency of serum anti-ganglioside M1 auto-antibodies, as indicators of the presence of autoimmunity to CNS, in a group of autistic children. We are the first to measure the relationship between these antibodies and the degree of the severity of autism. METHODS: Serum anti-ganglioside M1 antibodies were measured, by ELISA, in 54 autistic children, aged between 4 and 12 years, in comparison to 54 healthy-matched children. Autistic severity was assessed by using the Childhood Autism Rating Scale (CARS). RESULTS: Autistic children had significantly higher serum levels of anti-ganglioside M1 antibodies than healthy children (P < 0.001). The seropositivity of anti-ganglioside M1 antibodies was found in 74% (40/54) of autistic children. Serum levels of anti-ganglioside M1 antibodies were significantly higher in autistic children with severe autism (63%) than those with mild to moderate autism (37%), P = 0.001. Moreover, serum anti-ganglioside M1 antibodies had significant positive correlations with CARS (P < 0.001). CONCLUSIONS: Serum levels of anti-ganglioside M1 antibodies were increased in many autistic children. Also, their levels had significant positive correlations with the degree of the severity of autism. Thus, autism may be, in part, one of the pediatric autoimmune neuropsychiatric disorders. Further wide-scale studies are warranted to shed light on the possible etiopathogenic role of anti-ganglioside M1 auto-antibodies in autism. The role of immunotherapy in autistic patients who have increased serum levels of anti-ganglioside M1 antibodies should also be studied.
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Mostafa and Al-Ayadi reported significantly higher proportion of children with ASD having anti-MAG antiautoantibodies, anti-ganglioside M1, anti-neuronal and anti-nuclear antibodies than typically developing controls.
“Mostafa and Al-Ayadi reported significantly higher proportion of children with ASD having anti-MAG antiautoantibodies, anti-ganglioside M1, anti-neuronal and anti-nuclear antibodies than typically developing controls, that positively correlated with the severity of autism symptoms (CARS scores) [109,165,166,167].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [165]
These antibodies positively correlated with the severity of autism symptoms (CARS scores).
“Mostafa and Al-Ayadi reported significantly higher proportion of children with ASD having anti-MAG antiautoantibodies, anti-ganglioside M1, anti-neuronal and anti-nuclear antibodies than typically developing controls, that positively correlated with the severity of autism symptoms (CARS scores) [109,165,166,167].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [165]
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Cites
1 retracted
Enterocolitis in children with developmental disorders
Wakefield, A. J., Anthony, A., MURCH, S. H., Thomson, M. A., Montgomery, S., Davies, S. E., O’Leary, J. J., Berelowitz, M., & Walker-Smith, J. A. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03248.x · Cited by 244 · see citing works
RetractedDiagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
(1976) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1976.tb115280.x · Cited by 5,225 · see citing works
Ariga, T., McDonald, M. P., & Yu, R. K. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800007-jlr200 · Cited by 317 · see citing works
Immunological Findings in Autism
Cohly, H., & Panja, A. B. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)71013-8 · Cited by 263 · see citing works
Increased Prevalence of Familial Autoimmunity in Probands With Pervasive Developmental Disorders
Sweeten, T. L., Bowyer, S. L., Posey, D. J., Halberstadt, G. M., & McDougle, C. J. (2003) · PEDIATRICS · doi:10.1542/peds.112.5.e420 · Cited by 248 · see citing works
Jyonouchi, H., Sun, S., & Itokazu, N. (2002) · Neuropsychobiology · doi:10.1159/000065416 · Cited by 225 · see citing works
Vojdani, A., Campbell, A. W., Anyanwu, E., Kashanian, A., Bock, K., & Vojdani, E. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00180-7 · Cited by 197 · see citing works
Mercury and autism: accelerating evidence?
Mutter, J., Naumann, J., Schneider, R., Walach, H., & Haley, B. E. (2005) · PubMed · Cited by 172 · see citing works
Sugiura, Y., Shimma, S., Konishi, Y., Yamada, M., & Setou, M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003232 · Cited by 141 · see citing works
Vojdani, A., Pangborn, J. B., Vojdani, E., & Cooper, E. L. (2003) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200301600302 · Cited by 130 · see citing works
High-dose rituximab and anti-MAG–associated polyneuropathy
Renaud, S., Fuhr, P., Gregor, M., Schweikert, K., Lorenz, D., Daniels, C., Deuschl, G., Gratwohl, A. A., & Steck, A. J. (2006) · Neurology · doi:10.1212/01.wnl.0000201193.00382.b3 · Cited by 126 · see citing works
Autoantibodies in Neuropsychiatric Lupus
Greenwood, D. L. V., Gitlits, V. M., Alderuccio, F., Sentry, J. W., & Toh, B. (2002) · Autoimmunity · doi:10.1080/08916930290016547 · Cited by 113 · see citing works
Confirmation of the association of the C4B null allelle in autism
Odell, D., Maciulis, A., Cutler, A., Warren, L., McMahon, W. M., Coon, H., Stubbs, G., Henley, K., & Torres, A. (2005) · Human Immunology · doi:10.1016/j.humimm.2004.11.002 · Cited by 110 · see citing works
Anti-myelin-associated glycoprotein neuropathy
Steck, A. J., Stalder, A. K., & Renaud, S. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000245368.36576.0d · Cited by 108 · see citing works
Enstrom, A. M., de Water, J. V., & Ashwood, P. (2009) · PubMed · Cited by 107 · see citing works
Benedetti, L., Briani, C., Grandis, M., Vigo, T., Gobbi, M., Ghiglione, E., Carpo, M., Cocito, D., Caporale, C. M., Sormani, M. P., et al. (2007) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2007.00129.x · Cited by 106 · see citing works
Mostafa, G. A., Al Shehab, A., & Fouad, N. R. (2010) · Journal of Child Neurology · doi:10.1177/0883073809339393 · Cited by 105 · see citing works
Self-citationOxidative stress in egyptian children with autism: Relation to autoimmunity
Mostafa, G. A., El-Hadidi, E. S., Hewedi, D. H., & Abdou, M. M. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.12.003 · Cited by 101 · see citing works
Self-citationMitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children
Zhang, B., Angelidou, A., Alysandratos, K., Vasiadi, M., Francis, K., Asadi, S., Theoharides, A., Sideri, K., Lykouras, L., Kalogeromitros, D. C., et al. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-80 · Cited by 93 · see citing works
Plomp, J. J., & Willison, H. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.171702 · Cited by 86 · see citing works
Mostafa, G. A., & Shehab, A. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.03.025 · Cited by 84 · see citing works
Self-citationAntibodies against ganglioside complexes in Guillain‐Barré syndrome and related disorders
Kusunoki, S., & Kaida, K. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07029.x · Cited by 83 · see citing works
Serum anti-nuclear antibodies as a marker of autoimmunity in egyptian autistic children
Mostafa, G. A., & Kitchener, N. (2009) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2008.10.017 · Cited by 69 · see citing works
Self-citationGaleazzi, M., Annunziata, P., Sebastiani, G. D., et al. (2000) · PubMed · Cited by 60 · see citing works
Serum anti-myelin-associated glycoprotein antibodies in egyptian autistic children
Mostafa, G. A., Awad El-Sayed, Z., Mohamed Abd El-Aziz, M., & Farouk El-Sayed, M. (2008) · Journal of Child Neurology · doi:10.1177/0883073808319321 · Cited by 57 · cited 2× · see citing works
“The presence of other brain auto-antibodies such as anti-myelin basic protein antibodies and anti-myelinassociated glycoprotein antibodies have been observed in some autistic children [3,4].”
BackgroundSelf-citationMostafa, G. A., Ibrahim, D. H., Shehab, A., et al. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.07.014 · Cited by 56 · see citing works
Self-citationThe association of MHC genes with autism
Anthony, R. T. (2001) · Frontiers in bioscience · doi:10.2741/torres · Cited by 48 · see citing works
Pervasive Developmental Disorders and Childhood Psychosis
Raviola, G. J., Gosselin, G. J., Walter, H. J., & DeMaso, D. R. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0755-7.00028-2 · Cited by 36 · see citing works
Human Antiganglioside Autoantibodies: Validation of ELISA
Ravindranath, M. H., Muthugounder, S., Saravanan, T. S., et al. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1313.024 · Cited by 26 · see citing works
Neuromuscular synaptic function in mice lacking major subsets of gangliosides
Zitman, F. M. P., Todorov, B., Jacobs, B. C., Verschuuren, J. J. G. M., Furukawa, K., Furukawa, K., Willison, H. J., & Plomp, J. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.034 · Cited by 25 · see citing works
The association of MHC genes with autism
Torres, A. (2001) · Frontiers in bioscience · doi:10.2741/a655 · Cited by 20 · see citing works
Neuromuscular synaptic transmission in aged ganglioside-deficient mice
Zitman, F. M. P., Todorov, B., Verschuuren, J. J. G. M., Jacobs, B. C., Furukawa, K., Furukawa, K., Willison, H. J., & Plomp, J. J. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.01.007 · Cited by 19 · see citing works
Purification of gangliosides by liquid-liquid partition chromatography
Kato, T., & Hatanaka, K. (2008) · Journal of Lipid Research · doi:10.1194/jlr.d800033-jlr200 · Cited by 19 · see citing works
Autism spectrum disorders – Exogenous protein insult
Dochniak, M. J. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.01.060 · Cited by 17 · see citing works
Total ganglioside ablation at mouse motor nerve terminals alters neurotransmitter release level
Zitman, F. M. P., Todorov, B., Furukawa, K., Furukawa, K., Willison, H. J., & Plomp, J. J. (2009) · Synapse · doi:10.1002/syn.20747 · Cited by 13 · see citing works
Panjwani, C. M. B. R. G., Vasconcelos, B. C. D. E., Neto, J. C. D. S., et al. (2008) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-86502008000400011 · Cited by 12 · see citing works
[Pathomechanism of autoantibody production in neurological disorders].
Watanabe, O., & Arimura, K. (2008) · PubMed · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Sweeten TL Bowyer SL Posey DJ Halberstadt GM McDougle CJ Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders Pediatrics 2003 112 5 e420 10.1542/peds.112.5.e420 14595086 · DOI
Cited by
Sorted by citations
Mostafa, G. A., & AL-Ayadhi, L. Y. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-201 · Cited by 168 · see citing works
Self-citationImmune Dysregulation in Autism Spectrum Disorder: What Do We Know about It?
Robinson-Agramonte, M. D. L. A., Noris García, E., Fraga Guerra, J., Vega Hurtado, Y., Antonucci, N., Semprún-Hernández, N., Schultz, S., & Siniscalco, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063033 · Cited by 176 · see citing works
Prata, J., Santos, S. G., Almeida, M. I., Coelho, R., & Barbosa, M. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0938-y · Cited by 115 · see citing works
Vitamin D and Autism Spectrum Disorder: A Literature Review
Mazahery, H., Camargo, C., Conlon, C., Beck, K., Kruger, M., & Von Hurst, P. (2016) · Nutrients · doi:10.3390/nu8040236 · Cited by 110 · see citing works
Frye, R. E., & Rossignol, D. A. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38337 · Cited by 96 · see citing works
Severity of Autism Spectrum Disorders: Current Conceptualization, and Transition to DSM-5
Mehling, M. H., & Tassé, M. J. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2731-7 · Cited by 89 · see citing works
Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder
Napolioni, V., Ober-Reynolds, B., Szelinger, S., Corneveaux, J. J., Pawlowski, T., Ober-Reynolds, S., Kirwan, J., Persico, A. M., Melmed, R. D., Craig, D. W., et al. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-38 · Cited by 76 · see citing works
Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy
Marchezan, J., Winkler dos Santos, E. G. A., Deckmann, I., & Riesgo, R. D. S. (2018) · Neuroimmunomodulation · doi:10.1159/000492225 · Cited by 70 · see citing works
Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism
Connery, K., Tippett, M., Delhey, L. M., Rose, S., Slattery, J. C., Kahler, S. G., Hahn, J., Kruger, U., Cunningham, M. W., Shimasaki, C., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0214-7 · Cited by 64 · see citing works
Mostafa, G. A., & Al-Ayadhi, L. Y. (2012) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2011.12.010 · Cited by 64 · see citing works
Self-citationAutoantibodies against neuronal progenitors in sera from children with autism
Mazur-Kolecka, B., Cohen, I. L., Gonzalez, M., Jenkins, E. C., Kaczmarski, W., Brown, W. T., Flory, M., & Frackowiak, J. (2014) · Brain and Development · doi:10.1016/j.braindev.2013.04.015 · Cited by 29 · see citing works
- Authors
- Mostafa, G. A., & AL-ayadhi, L. Y.
- Affiliations
- Ain Shams University (EG)
- King Saud University (SA)
- Corresponding author
- Mostafa, Gehan A
- ORCID
- AL-ayadhi, Laila Y
- Venue
- Journal of Neuroinflammation
- Published
- 2011
- Volume
- 8
- Issue
- 1
- Pages
- 39
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC3104945
- OpenAlex
- W2015306125
- Cited by
- 85
- References
- 38
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 11 · 2012: 8
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- King Abdulaziz City for Science and Technology
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Keywords
- autism spectrum disorder, autoimmunity, autism severity, pediatric autoimmune neuropsychiatric disorders, serum autoantibodies, Childhood Autism Rating Scale, immunotherapy
- MeSH terms
- Autistic Disorder, Autoantibodies, Central Nervous System, Child, Child, Preschool, Female, G(M1) Ganglioside, Humans, Male, Severity of Illness Index
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