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Cited by 71Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsGastrointestinal motility and disorders

The DOI matches its Crossref record; 257 of the 263 references it cites were found in a registry or an index.

Animal models of fibromyalgia: What is the best choice?

Brum, Evelyne Silva, Becker, Gabriela, Fialho, Maria Fernanda Pessano, Oliveira, Sara Marchesan·2022·Pharmacology & Therapeutics
DOI 10.1016/j.pharmthera.2021.107959
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Abstract

Fibromyalgia (FM) is a complex syndrome, with an indefinite aetiology and intricate pathophysiology that affects 2 - 3% of the world population. From the beginning of the 2000s, experimental animal models have been developed to mimic clinical FM and help obtain a better understanding of the relevant neurobiology. These animal models have enabled a broad study of FM symptoms and mechanisms, as well as new treatment strategies. Current experimental FM models include the reserpine-induced systemic depletion of biogenic amines, muscle application of acid saline, and stress-based (cold, sound, or swim) approaches, among other emerging models. FM models should: (i) mimic the cardinal symptoms and complaints reported by FM patients (e.g., spontaneous nociception, muscle pain, hypersensitivity); (ii) mimic primary comorbidities that can aggravate quality of life and lead to worse outcomes (e.g., fatigue, sleep disturbance, depression, anxiety); (iii) mimic the prevalent pathological mechanisms (e.g., peripheral and central sensitization, inflammation/neuroinflammation, change in the levels of the excitatory and inhibitory neurotransmitters); and (iv) demonstrate a pharmacological profile similar to the clinical treatment of FM. However, it is difficult for any one of these models to include the entire spectrum of clinical FM features once even FM patients are highly heterogeneous. In the past six years (2015 - 2020), a wide range of experimental FM studies has amounted to the literature reinforcing the need for an updated review. Here we have described, in detail, several approaches used to experimentally study FM, with a focus on recent studies in the field and in previously less discussed mechanisms. We highlight each model's challenges, limitations, and future directions, intending to help preclinical researchers establish the correct experimental FM model to use depending on their goals.

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Citations

Cites

Research works printed but not linked: 4

  1. Ferrari, 2013, Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat, Journal of Pain, 14, 731, 10.1016/j.jpain.2013.01.779 · DOI
  2. Gamaro, 1998, 63, 693
  3. Gregory, 2013, Fatigue-enhanced hyperalgesia in response to muscle insult: Induction and development occur in a sex-dependent manner, Pain, 154, 2668, 10.1016/j.pain.2013.07.047 · DOI
  4. Häuser, 2015, Fibromyalgia, Nature Reviews | Disease Primers, 1, 1

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Metadata

Authors
Brum, E. S., Becker, G., Fialho, M. F. P., & Oliveira, S. M.
Affiliations
Universidade Federal de Santa Maria (BR)
Corresponding author
Oliveira, Sara Marchesan
ORCID
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2022-02
Volume
230
Pages
107959
ISSN
0163-7258 (ISSN-L)
DOI
10.1016/j.pharmthera.2021.107959
OpenAlex
W3182795747
Cited by
71
References
263
Citations by year
2026: 11 · 2025: 14 · 2024: 19 · 2023: 15 · 2022: 11
FWCI
2.05
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
fibromyalgia, animal models, cold stress, sound stress, swim stress, central sensitization, peripheral sensitization, neuroinflammation, fatigue, sleep disorders, depression, anxiety, neurotransmitters, model selection
MeSH terms
Animals, Anxiety Disorders, Disease Models, Animal, Fibromyalgia, Humans, Quality of Life, Sleep Wake Disorders

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