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Safety of red yeast rice supplementation: A systematic review and meta-analysis of randomized controlled trials
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“In addition, the concomitant administration of red yeast rice extract with medications that are strong inhibitors of the P450 enzyme CYP3A4 could theoretically increase plasma levels of monacolin K, and therefore reduce the safety of red yeast and increase its statin like side effects [92].”
From The Use of Medications and Dietary Supplements by Masters Athletes—A Review (2022) · cites this paper as [92]
In the citing paper
“A recent review on the safety of red rice extract concluded that despite the overall lack of interaction data associated with red yeast rice extract, patients should be monitored when taking other medications, especially those that are considered to be at a higher risk of statin-associated muscle symptoms [92].”
From The Use of Medications and Dietary Supplements by Masters Athletes—A Review (2022) · cites this paper as [92]
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2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.018 · Cited by 1,582
Self-citationLu, Z., Kou, W., Du, B., Wu, Y., Zhao, S., Brusco, O. A., Morgan, J. M., & Capuzzi, D. M. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.056 · Cited by 315
Resistance and intolerance to statins
Reiner, Ž. (2014) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.05.009 · Cited by 225
Self-citationGerards, M. C., Terlou, R. J., Yu, H., Koks, C. H. W., & Gerdes, V. E. A. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.04.004 · Cited by 169
Pirro, M., Vetrani, C., Bianchi, C., Mannarino, M. R., Bernini, F., & Rivellese, A. A. (2017) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.11.122 · Cited by 99
EFSA Panel on Dietetic Products, N. A. A. (. (2011) · EFSA Journal · doi:10.2903/j.efsa.2011.2304 · Cited by 84
Moriarty, P. M., Roth, E. M., Karns, A., Ye, P., Zhao, S.-P., Liao, Y., Capuzzi, D. M., Bays, H. E., Zhang, F., Liu, S., et al. (2014) · Journal of clinical lipidology · doi:10.1016/j.jacl.2014.09.002 · Cited by 65
Cicero, A. F. G., Fogacci, F., Rosticci, M., Parini, A., Giovannini, M., Veronesi, M., D’Addato, S., & Borghi, C. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0214-2 · Cited by 41
Self-citationMarazzi, G., Campolongo, G., Pelliccia, F., Quattrino, S., Vitale, C., Cacciotti, L., Massaro, R., Volterrani, M., & Rosano, G. (2017) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2017.06.015 · Cited by 36
Cicero, A. F. G., Colletti, A., Fogacci, F., Bove, M., Rosticci, M., & Borghi, C. (2017) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-016-0163-2 · Cited by 35
Self-citationBarrat, E., Zaïr, Y., Sirvent, P., Chauveau, P., Maudet, C., Housez, B., Derbord, E., Lescuyer, J.-F., Bard, J.-M., Cazaubiel, M., et al. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0486-2 · Cited by 31
Karl, M., Rubenstein, M., Rudnick, C., & Brejda, J. (2012) · Journal of clinical lipidology · doi:10.1016/j.jacl.2011.09.004 · Cited by 21
Research works printed but not linked: 73
- Sahebkar, 2016, Lipid-modifying effects of nutraceuticals: an evidence-based approach, Nutrition, 32, 1179, 10.1016/j.nut.2016.04.007 · DOI · Paper page
- Ma, 2000, Constituents of red yeast rice, a traditional Chinese food and medicine, J. Agric. Food Chem., 48, 5220, 10.1021/jf000338c · DOI · Paper page
- Lachenmeier, 2012, NMR evaluation of total statin content and HMG-CoA reductase inhibition in red yeast rice (Monascus spp.) food supplements, Chin. Med., 7, 8, 10.1186/1749-8546-7-8 · DOI
- Alberts, 1988, Discovery, biochemistry and biology of lovastatin, Am. J. Cardiol., 62, 10J, 10.1016/0002-9149(88)90002-1 · DOI · Paper page
- Liu, 2006, Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials, Chin. Med., 1, 4, 10.1186/1749-8546-1-4 · DOI
- Bianconi, 2018, Cholesterol-lowering nutraceuticals affecting vascular function and cardiovascular disease risk, Curr. Cardiol. Rep., 20, 53, 10.1007/s11886-018-0994-7 · DOI
- Cicero, 2017, Short-term effects of a combined nutraceutical on lipid level, fatty liver biomarkers, hemodynamic parameters, and estimated cardiovascular disease risk: a double-blind, placebo-controlled randomized clinical trial, Adv. Ther., 34, 1966, 10.1007/s12325-017-0580-1 · DOI
- Zhao, 2004, Xuezhikang, an extract of cholestin, protects endothelial function through anti-inflammatory and lipid-lowering mechanisms in patients with coronary heart disease, Circulation, 110, 915, 10.1161/01.CIR.0000139985.81163.CE · DOI
- Affuso, 2010, Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study, Nutr. Metab. Cardiovasc. Dis., 20, 656, 10.1016/j.numecd.2009.05.017 · DOI
- Cicero, 2016, Middle-term dietary supplementation with red yeast rice plus coenzyme Q10 improves lipid pattern, endothelial reactivity and arterial stiffness in moderately hypercholesterolemic subjects, Ann. Nutr. Metab., 68, 213, 10.1159/000445359 · DOI
- Russo, 2016, When nutraceuticals reinforce drugs side effects: a case report, Curr. Drug Saf., 11, 264, 10.2174/1574886311666160201152047 · DOI
- Polsani, 2008, A case report of myopathy from consumption of red yeast rice, J. Clin. Lipidol., 2, 60, 10.1016/j.jacl.2007.12.005 · DOI
- Raschi, 2018, Adverse events to food supplements containing red yeast rice: comparative analysis of FAERS and CAERS reporting systems, Drug Saf., 41, 745, 10.1007/s40264-018-0661-3 · DOI
- Moher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, BMJ, 339, b2535, 10.1136/bmj.b2535 · DOI · Paper page
- Simental-Mendía, 2018, Effect of fibrates on glycemic parameters: a systematic review and meta-analysis of randomized placebo-controlled trials, Pharmacol. Res., 132, 232, 10.1016/j.phrs.2017.12.030 · DOI
- Fogacci, 2019, Metabolic effect of berberine-silymarin association: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials, Phytother. Res.
- Bała, 2017, Effects of tibolone on fibrinogen and antithrombin III: a systematic review and meta-analysis of controlled trials, Pharmacol. Res., 124, 64, 10.1016/j.phrs.2017.07.024 · DOI
- Duval, 2000, Trim and fill: a simple funnel plot–based method of testing and adjusting for publication bias in meta-analysis, Biometrics, 56, 455, 10.1111/j.0006-341X.2000.00455.x · DOI · Paper page
- Ruscica, 2019, Nutraceutical approach for the management of cardiovascular risk - a combination containing the probiotic Bifidobacterium longum BB536 and red yeast rice extract: results from a randomized, double-blind, placebo-controlled study, Nutr. J., 18, 13, 10.1186/s12937-019-0438-2 · DOI
- Derosa, 2018, Effects on oral fat load of a nutraceutical combination of fermented red rice, sterol esters and stanols, curcumin, and olive polyphenols: a randomized, placebo controlled trial, Phytomedicine., 42, 75, 10.1016/j.phymed.2018.01.014 · DOI
- D’Addato, 2017, Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q(10) on lipid levels: a randomized, double-blind, placebo controlled study, Drug Des. Dev. Ther., 11, 1585, 10.2147/DDDT.S128623 · DOI
- Derosa, 2017, Effects of a combination of Berberis aristata, Silybum marianum and monacolin on lipid profile in subjects at low cardiovascular risk; a double-blind, randomized, placebo-controlled trial, Int. J. Mol. Sci., 18
- Spigoni, 2017, Effects of a new nutraceutical formulation (Berberine, RYR and chitosan) on Non-HDL cholesterol levels in individuals with dyslipidemia: results from a randomized, double blind, placebo-controlled study, Int. J. Mol. Sci., 18, 10.3390/ijms18071498 · DOI
- Xue, 2017, RYR induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trial, BMC Cardiovasc. Disord., 17, 127, 10.1186/s12872-017-0560-z · DOI
- Zheng, 2017, Xuezhikang reduced arterial stiffness in patients with essential hypertension: a preliminary study, Braz. J. Med. Biol. Res., 50, e6363, 10.1590/1414-431x20176363 · DOI
- Cicero, 2016, Effect of RYR combined with antioxidants on lipid pattern, hs-CRP level, and endothelial function in moderately hypercholesterolemic subjects, Ther. Clin. Risk Manag., 12, 281, 10.2147/TCRM.S91817 · DOI
- Cicero, 2016, Efficacy and tolerability of a combined lipid-lowering nutraceutical on cholesterolemia, hs-CRP level and endothelial function in moderately hypercholesterolemic subjects, J. Biol. Regul. Homeost. Agents, 30, 593
- Cicero, 2016, Effetto di un nutraceutico combinato a medio termine su controllo pressorio, ottimizzazione della colesterolemia LDL e rischio cardiovascolare stimato: follow-up di uno studio pilota, Pharmanutr. Funct. Foods, 3, 39
- Heinz, 2016, Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention, Nutr. Res., 36, 1162, 10.1016/j.nutres.2016.07.005 · DOI
- Kasliwal, 2016, ESSENS dyslipidemia: a placebo -controlled, randomized study of a nutritional supplement containing RYR in subjects with newly diagnosed dyslipidemia, Nutrition, 32, 767, 10.1016/j.nut.2016.01.012 · DOI · Paper page
- Gentile, 2015, Effects of Armolipid Plus on small dense LDL particles in a sample of patients affected by familial combined hyperlipidemia, Clin. Lipidol., 10, 475, 10.2217/clp.15.37 · DOI
- Verhoeven, 2015, Can RYR and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: a double blind, placebo controlled randomized trial, BMC Complement. Altern. Med., 15, 52, 10.1186/s12906-015-0576-9 · DOI
- Derosa, 2014, A randomized, placebo-controlled study on the effects of a nutraceutical combination of RYR, silybum marianum and octasonol on lipid profile, endothelial and inflammatory parameters, J. Biol. Regul. Homeost. Agents, 28, 317
- Gonnelli, 2014, Efficacy and tolerability of a nutraceutical combination (Red yeast rice, policosanols, and berberine) in patients with low-moderate risk hypercholesterolemia: a double-blind, placebo-controlled study, Curr. Ther. Res. Clin. Exp., 77, 1, 10.1016/j.curtheres.2014.07.003 · DOI
- Ruscica, 2014, Nutraceutical approach to moderate cardiometabolic risk: results of a randomized, double-blind and crossover study with Armolipid Plus, J. Clin. Lipidol., 8, 61, 10.1016/j.jacl.2013.11.003 · DOI
- Solà, 2014, Effects of poly-bioactive compounds on lipid profile and body weight in a moderately hypercholesterolemic population with low cardiovascular disease risk: a multicenter randomized trial, PLoS One, 9, 10.1371/journal.pone.0101978 · DOI
- Barrat, 2013, A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial, Int. J. Food Sci. Nutr., 64, 882, 10.3109/09637486.2013.809405 · DOI
- Cicero, 2013, RYR improves lipid pattern, high-sensitivity C-reactive protein, and vascular remodeling parameters in moderately hypercholesterolemic Italian subjects, Nutr. Res., 33, 622, 10.1016/j.nutres.2013.05.015 · DOI
- Ogier, 2013, Cardinault N. Eur J Nutr, 52, 547, 10.1007/s00394-012-0357-x · DOI · Paper page
- Verhoeven, 2013, RYR lowers cholesterol in physicians - a double blind, placebo controlled randomized trial, BMC Complement. Altern. Med., 13, 178, 10.1186/1472-6882-13-178 · DOI
- Affuso, 2012, A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome, World J. Cardiol., 4, 77, 10.4330/wjc.v4.i3.77 · DOI
- Cicero, 2012, Long-term efficacy and tolerability of a multicomponent lipid-lowering nutraceutical in overweight and normoweight patients, Nutrafoods, 11, 55, 10.1007/s13749-012-0018-y · DOI
- Lee, 2012, Combined extractives of red yeast rice, bitter gourd, chlorella, soy protein, and licorice improve total cholesterol, low-density lipoprotein cholesterol, and triglyceride in subjects with metabolic syndrome, Nutr. Res., 32, 85, 10.1016/j.nutres.2011.12.011 · DOI
- Guardamagna, 2011, The treatment of hypercholesterolemic children: efficacy and safety of a combination of RYR extract and policosanols, Nutr. Metab. Cardiovasc. Dis., 21, 424, 10.1016/j.numecd.2009.10.015 · DOI
- Marazzi, 2011, Long-term effects of nutraceuticals (berberine, RYR, policosanol) in elderly hypercholesterolemic patients, Adv. Ther., 28, 1105, 10.1007/s12325-011-0082-5 · DOI · Paper page
- Bogsrud, 2010, HypoCol (RYR) lowers plasma cholesterol - a randomized placebo controlled study, Scand. Cardiovasc. J., 44, 197, 10.3109/14017431003624123 · DOI
- Halbert, 2010, Tolerability of RYR (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance, Am. J. Cardiol., 105, 198, 10.1016/j.amjcard.2009.08.672 · DOI · Paper page
- Becker, 2009, Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial, Ann. Intern. Med., 150, 10.7326/0003-4819-150-12-200906160-00006 · DOI · Paper page
- Yang, 2009, Combined nattokinase with RYR but not nattokinase alone has potent effects on blood lipids in human subjects with hyperlipidemia, Asia Pac. J. Clin. Nutr., 18, 310
- Ye, 2009, Potential protective effect of long-term therapy with Xuezhikang on left ventricular diastolic function in patients with essential hypertension, J. Altern. Complement. Med., 15, 719, 10.1089/acm.2008.0599 · DOI
- Gheith, 2008, Efficacy and safety of Monascus purpureus went rice in subjects with secondary hyperlipidemia, Clin. Exp. Nephrol., 12, 189, 10.1007/s10157-008-0033-x · DOI
- Cicero, 2007, Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation, Arzneimittelforschung, 57, 26
- Huang, 2007, Efficacy of Monascus purpureus went rice on lowering lipid ratios in hypercholesterolemic patients, Eur. J. Cardiovasc. Prev. Rehabil., 14, 438, 10.1097/HJR.0b013e32801da137 · DOI
- Li, 2007, Xuezhikang, an extract of cholestin, decreases plasma inflammatory markers and endothelin-1, improve exercise-induced ischemia and subjective feelings in patients with cardiac syndrome X, Int. J. Cardiol., 122, 82, 10.1016/j.ijcard.2006.11.031 · DOI
- Shang, 2007, Clinical observation of Xuezhikang and atorvastatin for patients with coronary heart disease complicated with dyslipidemia on serum lipid and hemorheology, Guangxi Med. J., 29, 1158
- Hu, 2006, Effects of withdrawal of Xuezhikang, an extract of cholestin, on lipid profile and C-reactive protein: a short-term time course study in patients with coronary artery disease, Cardiovasc. Drugs Ther., 20, 185, 10.1007/s10557-006-7947-x · DOI
- Liu, 2003, Xuezhikang decreases serum lipoprotein(a) and C-reactive protein concentrations in patients with coronary heart disease, Clin. Chem., 49, 1347, 10.1373/49.8.1347 · DOI
- Keithley, 2002, A pilot study of the safety and efficacy of cholestin in treating HIV-related dyslipidemia, Nutrition, 18, 201, 10.1016/S0899-9007(01)00688-8 · DOI
- Yu, 2002, Effect of Xuezhikang for patients with coronary heart disease complicated with hyperlipidemia on fibrinolytic function, Chin. J. Coal Ind. Med., 5, 61
- Heber, 1999, Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement, Am. J. Clin. Nutr., 69, 231, 10.1093/ajcn/69.2.231 · DOI · Paper page
- Banach, 2018, International lipid expert panel (ILEP). The role of nutraceuticals in statin intolerant patients, J. Am. Coll. Cardiol., 72, 96, 10.1016/j.jacc.2018.04.040 · DOI · Paper page
- Gulizia, 2017, ANMCO/ISS/AMD/ANCE/ARCA/FADOI/GICR-IACPR/SICI-GISE/SIBioC/SIC/SICOA/SID/SIF/SIMEU /SIMG/SIMI/SISA Joint ConsensusDocument on cholesterol and cardiovascular risk: diagnostic-therapeutic pathway in Italy, Eur. Heart J. Suppl., 19, D3, 10.1093/eurheartj/sux029 · DOI
- Cicero, 2017, Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel, Nutr. Rev., 75, 731, 10.1093/nutrit/nux047 · DOI · Paper page
- Authors/Task Force Members, 2016, Atherosclerosis, 2016, 281
- EFSA, Scientific opinion on the safety of monacolins in red yeast rice, 2018, EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). European Food Safety Authority (EFSA), Parma, Italy, EFSA J., 16, 5368
- Banach, 2015, Statin intolerance - an attempt at a unified definition. Position paper from an International Lipid Expert Panel, Arch. Med. Sci., 11, 1, 10.5114/aoms.2015.49807 · DOI · Paper page
- Banach, 2018, Statin intolerance: some practical hints, Cardiol. Clin., 36, 225
- Rosenson, 2017, The statin-associated muscle symptom clinical index (SAMS-CI): revision for clinical use, content validation, and inter-rater reliability, Cardiovasc. Drugs Ther., 31, 179, 10.1007/s10557-017-6723-4 · DOI
- Prasad, 2002, Rhabdomyolysis due to red yeast rice (Monascus purpureus) in a renal transplant recipient, Transplantation, 74, 1200, 10.1097/00007890-200210270-00028 · DOI
- Cicero, 2018, An update on the safety of nutraceuticals and effects on lipid parameters, Expert Opin. Drug Saf., 17, 303, 10.1080/14740338.2018.1429404 · DOI
- Avula, 2014, Chemical profiling and quantification of monacolins and citrinin in red yeast rice commercial raw materials and dietary supplements using liquid chromatography-accurate QToF mass spectrometry: chemometrics application, J. Pharm. Biomed. Anal., 100, 243, 10.1016/j.jpba.2014.07.039 · DOI
- Chan, 2008, Effects of citrinin on maturation of mouse oocytes, fertilization, and fetal development in vitro and in vivo, Toxicol. Lett., 180, 28, 10.1016/j.toxlet.2008.05.011 · DOI
- EFSA, 2012, Scientific Opinion on the risks for public and animal health related to the presence of citrinin in food and feed. EFSA Panel on Contaminants in the Food Chain (CONTAM). European Food Safety Authority (EFSA), Parma, italy, EFSA J., 10, 2605
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Self-citation
Metadata
- Authors
- Fogacci, F., Banach, M., Mikhailidis, D. P., Bruckert, E., Toth, P. P., Watts, G. F., Reiner, Ž., Mancini, J., Rizzo, M., Mitchenko, O., Pella, D., Fras, Z., Sahebkar, A., Vrablik, M., & Cicero, A. F. G.
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 143
- Pages
- 1-16
- ISSN
- 1043-6618
- Cited by
- 117
- References
- 12
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
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