Cited by 436Ferroptosis and cancer prognosisIron Metabolism and DisordersNeurological diseases and metabolism

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The Application of Ferroptosis in Diseases

Qiu, Yangmin, Cao, Yue, Cao, Wangjia, Jia, Yifei, Lu, Na·2020·Pharmacological Research

DOI 10.1016/j.phrs.2020.104919

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Abstract

Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron metabolism, lipid metabolism, oxidative stress and biosynthesis of nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH) and coenzyme Q10 (CoQ10). A growing body of evidence suggests that ferroptosis is associated with cancer and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and Huntington's disease). This finding has helped develop a novel cytoprotective strategy to protect cells in neurodegenerative, blood and heart diseases by inhibiting ferroptosis. Meanwhile, the selective induction of ferroptosis has been adopted as a potential treatment strategy in some kinds of cancer. This review aims to summarize the mechanism of ferroptosis regulation and relevance to pathological physiology.

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Additional file 3 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
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Additional file 2 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
Zhang, X., Zhou, L. Q., Lü, W., Du, W., Mi, X.-Y., Li, Z., Li, X., Wang, Z., Wang, Y., Duan, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14544832
Additional file 4 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
Zhang, X., Zhou, L. Q., Lü, W., Du, W., Mi, X.-Y., Li, Z., Li, X., Wang, Z., Wang, Y., Duan, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14544838
Additional file 1 of Construction of a ferroptosis-related five-lncRNA signature for predicting prognosis and immune response in thyroid carcinoma
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Additional file 7 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
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Additional file 6 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
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Additional file 11 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
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Additional file 9 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
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Additional file 8 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
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Additional file 10 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
Zhang, X.-J., Zhou, L., Lu, W.-J., Du, W.-X., Mi, X.-Y., Li, Z., Li, X.-Y., Wang, Z.-W., Wang, Y., Duan, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14544823
Additional file 6 of Lamprey immune protein triggers the ferroptosis pathway during zebrafish embryonic development
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Additional file 7 of Lamprey immune protein triggers the ferroptosis pathway during zebrafish embryonic development
Du, Z., Zhang, D., Li, J., Li, Q., & Pang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20508605
Additional file 3 of Lamprey immune protein triggers the ferroptosis pathway during zebrafish embryonic development
Du, Z., Zhang, D., Li, J., Li, Q., & Pang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20508593
Additional file 3 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s disease
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Additional file 6 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s disease
Liu, M., Zhao, J., Xue, C., Yang, J., & Ying, L. (2024) · Figshare · doi:10.6084/m9.figshare.26738763
Additional file 5 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
Zhang, X.-J., Zhou, L., Lu, W.-J., Du, W.-X., Mi, X.-Y., Li, Z., Li, X.-Y., Wang, Z.-W., Wang, Y., Duan, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14544841
Additional file 9 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s disease
Liu, M., Zhao, J., Xue, C., Yang, J., & Ying, L. (2024) · Figshare · doi:10.6084/m9.figshare.26738772
Additional file 3 of Construction of a ferroptosis-related five-lncRNA signature for predicting prognosis and immune response in thyroid carcinoma
Qin, Y., Zhang, D., Zhang, H., Hou, L., Wang, Z., Yang, L., Zhang, M., Zhao, G., Yao, Q., Ling, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21251786
Additional file 1 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s disease
Liu, M., Zhao, J., Xue, C., Yang, J., & Ying, L. (2024) · Figshare · doi:10.6084/m9.figshare.26103737
Additional file 2 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s disease
Liu, M., Zhao, J., Xue, C., Yang, J., & Ying, L. (2024) · Figshare · doi:10.6084/m9.figshare.26103836

Authors: Qiu, Y., Cao, Y., Cao, W., Jia, Y., & Lu, N.
Affiliations: China Pharmaceutical University (CN)
University of Macau (MO)
Corresponding author: Lu, Na
ORCID: Qiu, Yangmin
Cao, Yue
Cao, Wangjia
Lu, Na
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2020-09
Volume: 159
Pages: 104919
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2020.104919
OpenAlex: W3032712286
Cited by: 415
References: 211
Citations by year: 2026: 18 · 2025: 65 · 2024: 90 · 2023: 113 · 2022: 87 · 2021: 34 · 2020: 8
FWCI: 8.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81872899,81903626)
Jiangsu Science and Technology Department (BE2018711)
Ministry of Science and Technology of the People's Republic of China (2017ZX09101003-005-023, 2017ZX09301014, 2018ZX09711001-003-007)
China Pharmaceutical University (CPU2018GY17)
Natural Science Foundation of Jiangsu Province (BK20180576)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: ferroptosis, regulated cell death, iron-dependent lipid peroxidation, iron metabolism, lipid metabolism, oxidative stress, NADPH, glutathione, coenzyme Q10, cancer, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, ferroptosis inhibitors, cytoprotection
MeSH terms: Ferroptosis, Animals, Antineoplastic Agents, Humans, Iron, Neoplasms, Lipid Peroxidation, Reactive Oxygen Species, Neuroprotective Agents, Neurodegenerative Diseases

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The Application of Ferroptosis in Diseases

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