Cited by 436Ferroptosis and cancer prognosisIron Metabolism and DisordersNeurological diseases and metabolism

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The Application of Ferroptosis in Diseases

Qiu, Yangmin, Cao, Yue, Cao, Wangjia, Jia, Yifei, Lu, Na·2020·Pharmacological Research

DOI 10.1016/j.phrs.2020.104919

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Abstract

Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron metabolism, lipid metabolism, oxidative stress and biosynthesis of nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH) and coenzyme Q10 (CoQ10). A growing body of evidence suggests that ferroptosis is associated with cancer and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and Huntington's disease). This finding has helped develop a novel cytoprotective strategy to protect cells in neurodegenerative, blood and heart diseases by inhibiting ferroptosis. Meanwhile, the selective induction of ferroptosis has been adopted as a potential treatment strategy in some kinds of cancer. This review aims to summarize the mechanism of ferroptosis regulation and relevance to pathological physiology.

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Authors: Qiu, Y., Cao, Y., Cao, W., Jia, Y., & Lu, N.
Affiliations: China Pharmaceutical University (CN)
University of Macau (MO)
Corresponding author: Lu, Na
ORCID: Qiu, Yangmin
Cao, Yue
Cao, Wangjia
Lu, Na
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2020-09
Volume: 159
Pages: 104919
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2020.104919
OpenAlex: W3032712286
Cited by: 415
References: 211
Citations by year: 2026: 18 · 2025: 65 · 2024: 90 · 2023: 113 · 2022: 87 · 2021: 34 · 2020: 8
FWCI: 8.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81872899,81903626)
Jiangsu Science and Technology Department (BE2018711)
Ministry of Science and Technology of the People's Republic of China (2017ZX09101003-005-023, 2017ZX09301014, 2018ZX09711001-003-007)
China Pharmaceutical University (CPU2018GY17)
Natural Science Foundation of Jiangsu Province (BK20180576)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: ferroptosis, regulated cell death, iron-dependent lipid peroxidation, iron metabolism, lipid metabolism, oxidative stress, NADPH, glutathione, coenzyme Q10, cancer, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, ferroptosis inhibitors, cytoprotection
MeSH terms: Ferroptosis, Animals, Antineoplastic Agents, Humans, Iron, Neoplasms, Lipid Peroxidation, Reactive Oxygen Species, Neuroprotective Agents, Neurodegenerative Diseases

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The Application of Ferroptosis in Diseases

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