Cited by 57Mitochondrial Function and PathologyAutophagy in Disease and TherapyMetabolism, Diabetes, and Cancer

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Decoding the rosetta stone of mitonuclear communication

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English, Justin, Son, Jyung Mean, Cardamone, Maria Dafne, Lee, Changhan, Perissi, Valentina·2020·Pharmacological Research

DOI 10.1016/j.phrs.2020.105161PMC PMC7755734

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Abstract

Cellular homeostasis in eukaryotic cells requires synchronized coordination of multiple organelles. A key role in this stage is played by mitochondria, which have recently emerged as highly interconnected and multifunctional hubs that process and coordinate diverse cellular functions. Beyond producing ATP, mitochondria generate key metabolites and are central to apoptotic and metabolic signaling pathways. Because most mitochondrial proteins are encoded in the nuclear genome, the biogenesis of new mitochondria and the maintenance of mitochondrial functions and flexibility critically depend upon effective mitonuclear communication. This review addresses the complex network of signaling molecules and pathways allowing mitochondria-nuclear communication and coordinated regulation of their independent but interconnected genomes, and discusses the extent to which dynamic communication between the two organelles has evolved for mutual benefit and for the overall maintenance of cellular and organismal fitness.

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Authors: English, J., Son, J. M., Cardamone, M. D., Lee, C., & Perissi, V.
Affiliations: Boston University (US)
University of Southern California (US)
Corresponding author: Perissi, Valentina
ORCID: English, Justin
Cardamone, Maria Dafne
Lee, Changhan
Perissi, Valentina
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2020-11
Volume: 161
Pages: 105161
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2020.105161
PMC: PMC7755734
OpenAlex: W3081296598
Cited by: 55
References: 359
Citations by year: 2026: 10 · 2025: 7 · 2024: 17 · 2023: 8 · 2022: 4 · 2021: 8 · 2020: 1
FWCI: 0.50
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (R01GM127625, 5T32GM008541)
VP, NIH (R01AG052258)
AFAR fellowship
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: mitochondria, nuclear genome, mitochondrial biogenesis, cellular homeostasis, mitochondrial pathway, mitochondrial metabolism, apoptosis, organelle evolution
MeSH terms: Animals, Cell Communication, Cell Nucleus, Gene Expression Regulation, Humans, Mitochondria, Nuclear Proteins, Signal Transduction, Mitochondrial Proteins

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Decoding the rosetta stone of mitonuclear communication

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