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Cited by 416Regulation of Appetite and ObesityMuscle metabolism and nutritionPharmacology and Obesity Treatment

Protein-induced satiety: Effects and mechanisms of different proteins

Veldhorst, M., Smeets, A., Soenen, S., Hochstenbach-Waelen, A., Hursel, R., Diepvens, K., Lejeune, M., Luscombe-Marsh, N. +1 more·2008·Physiology & Behavior
DOI 10.1016/j.physbeh.2008.01.003
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Abstract

Relatively high protein diets, i.e. diets that maintain the absolute number of grams of protein ingested as compared to before dieting, are a popular strategy for weight loss and weight maintenance. Research into multiple mechanisms regulating body weight has focused on the effects of different quantities and types of dietary protein. Satiety and energy expenditure are important in protein-enhanced weight loss and weight maintenance. Protein-induced satiety has been shown acutely, with single meals, with contents of 25% to 81% of energy from protein in general or from specific proteins, while subsequent energy intake reduction was significant. Protein-induced satiety has been shown with high protein ad libitum diets, lasting from 1 to 6 days, up to 6 months. Also significantly greater weight loss has been observed in comparison with control. Mechanisms explaining protein-induced satiety are nutrient-specific, and consist mainly of synchronization with elevated amino acid concentrations. Different proteins cause different nutrient related responses of (an)orexigenic hormones. Protein-induced satiety coincides with a relatively high GLP-1 release, stimulated by the carbohydrate content of the diet, PYY release, while ghrelin does not seem to be especially affected, and little information is available on CCK. Protein-induced satiety is related to protein-induced energy expenditure. Finally, protein-induced satiety appears to be of vital importance for weight loss and weight maintenance. With respect to possible adverse events, chronic ingestion of large amounts of sulphur-containing amino acids may have an indirect effect on blood pressure by induction of renal subtle structural damage, ultimately leading to loss of nephron mass, and a secondary increase in blood pressure. The established synergy between obesity and low nephron number on induction of high blood pressure and further decline of renal function identifies subjects with obesity, metabolic syndrome and diabetes mellitus II as particularly susceptible groups.

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Authors
Veldhorst, M., Smeets, A., Soenen, S., Hochstenbach-Waelen, A., Hursel, R., Diepvens, K., Lejeune, M., Luscombe-Marsh, N., & Westerterp-Plantenga, M.
Affiliations
Maastricht University (NL)
Corresponding author
Veldhorst, M.
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2008-05
Volume
94
Issue
2
Pages
300-307
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2008.01.003
OpenAlex
W2048447383
Cited by
416
References
6
Citations by year
2026: 7 · 2025: 14 · 2024: 23 · 2023: 14 · 2022: 35 · 2021: 24 · 2020: 27 · 2019: 23 · 2018: 19 · 2017: 27 · 2016: 27 · 2015: 29 · 2014: 23 · 2013: 20 · 2012: 27
FWCI
2.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords
dietary protein, weight loss, weight maintenance, energy expenditure, amino acids, glucagon-like peptide-1, peptide YY, ghrelin, cholecystokinin, appetite-regulating hormones, sulfur-containing amino acids, nephron mass, blood pressure, obesity, metabolic syndrome, type 2 diabetes
MeSH terms
Dietary Proteins, Gluconeogenesis, Humans, Hypertension, Renal, Kidney Diseases, Nephrons, Satiety Response, Weight Loss

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