Cited by 44Muscle metabolism and nutritionProtein Hydrolysis and Bioactive PeptidesMuscle Physiology and Disorders

The role of protein hydrolysates for exercise-induced skeletal muscle recovery and adaptation: a current perspective

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Morgan, Paul T., Breen, Leigh·2021·Nutrition & Metabolism

Abstract

The protein supplement industry is expanding rapidly and estimated to have a multi-billion market worth. Recent research has centred on understanding how the manufacturing processes of protein supplements may impact muscle recovery and remodeling. The hydrolysed forms of protein undergo a further heating extraction process during production which may contribute to amino acids (AA) appearing in circulation at a slightly quicker rate, or greater amplitude, than the intact form. Whilst the relative significance of the rate of aminoacidemia to muscle protein synthesis is debated, it has been suggested that protein hydrolysates, potentially through the more rapid delivery and higher proportion of di-, tri- and smaller oligo-peptides into circulation, are superior to intact non-hydrolysed proteins and free AAs in promoting skeletal muscle protein remodeling and recovery. However, despite these claims, there is currently insufficient evidence to support superior muscle anabolic properties compared with intact non-hydrolysed proteins and/or free AA controls. Further research is warranted with appropriate protein controls, particularly in populations consuming insufficient amounts of protein, to support and/or refute an important muscle anabolic role of protein hydrolysates. The primary purpose of this review is to provide the reader with a current perspective on the potential anabolic effects of protein hydrolysates in individuals wishing to optimise recovery from, and maximise adaptation to, exercise training.

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  • Differences in protein absorbability are ameliorated after protein purification through removal of nonprotein constituents to produce protein isolates.

    “However, differences in protein absorbability are ameliorated after protein purification through removal of nonprotein constituents to produce protein isolates [[80], [81], [82]].”

    From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [82]

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  1. [43]Reitelseder S Agergaard J Doessing S Helmark IC Lund P Kristensen NB Whey and casein labeled with L-[1–13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion Am J Physiol Metab. 2011 300 E231 E242 10.1152/ajpendo.00513.2010 21045172 · DOI · Paper page

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Authors
Morgan, P. T., & Breen, L.
Affiliations
University of Birmingham (GB)
Corresponding author
Morgan, Paul T.
Venue
Nutrition & Metabolism
Published
2021-04-21
Volume
18
Issue
1
Pages
44-44
ISSN
1743-7075 (ISSN-L)
OpenAlex
W3156035391
Cited by
44
References
177
Citations by year
2026: 4 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 5 · 2021: 3
FWCI
0.95
Type
journal article
Language
en
Open access
Locations
  • Nutrition & Metabolism (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • e-space (Manchester Metropolitan University) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
protein hydrolysates, exercise-induced muscle damage, skeletal muscle recovery, muscle protein synthesis, protein supplements, oligopeptides, exercise adaptation, protein intake

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