Cited by 140Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorBiochemical Analysis and Sensing Techniques

The gut–brain dopamine axis: a regulatory system for caloric intake

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de Araujo, Ivan E., Ferreira, Jozélia G., Tellez, Luis A., Ren, Xueying, Yeckel, Catherine W.·2012·Physiology & Behavior

Abstract

Post-ingestive factors are known to strongly modulate feeding behavior by providing feedback signals to the central nervous system on the current physiological state of the organism. Of particular interest is the identification of the physiological pathways that permit the brain to sense post-ingestive signals. We will review recent evidence supporting the concept that direct stimulation of the gastrointestinal tract with nutrients induces release of the catecholamine neurotransmitter dopamine. In addition, changes in dopamine efflux produced by direct stimulation of the gastrointestinal tract were found to reflect the caloric load of the infusates, suggesting that dopamine signaling may function as a central caloric sensor that mediates adjustments in intake according to the caloric density of a meal. Consistent with the above, blockade of dopamine signaling disrupts flavor-nutrient associations and impairs the regulatory capacity to maintain constant caloric intake during intra-gastric feeding. Future research must determine the exact pathways linking gut nutrient administration to dopamine efflux. Current evidence points to parallel contributions by pre- and post-absorptive pathways, indicating that dopamine systems constitute a site of convergence through which distinct physiological signals can exert control over ingestive behaviors.

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Crossref · 10.1016/j.physbeh.2012.02.026

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Authors
de Araujo, I. E., Ferreira, J. G., Tellez, L. A., Ren, X., & Yeckel, C. W.
Affiliations
Yale University (US)
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2012-06
Volume
106
Issue
3
Pages
394-399
ISSN
0031-9384 (ISSN-L)
OpenAlex
W2050866793
Cited by
140
References
72
Citations by year
2026: 9 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 18 · 2020: 14 · 2019: 4 · 2018: 12 · 2017: 11 · 2016: 14 · 2015: 9 · 2014: 8 · 2013: 7 · 2012: 2
FWCI
0.94
Type
journal article
Language
en
Open access
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
NIH (DC009997)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords
dopamine efflux, nutrient sensing, feeding behavior, gut-brain signaling
MeSH terms
Animals, Brain, Energy Intake, Dopamine, Eating, Feeding Behavior, Humans, Sensation, Gastrointestinal Tract

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