The gut–brain dopamine axis: a regulatory system for caloric intake
Open accessAbstract
Post-ingestive factors are known to strongly modulate feeding behavior by providing feedback signals to the central nervous system on the current physiological state of the organism. Of particular interest is the identification of the physiological pathways that permit the brain to sense post-ingestive signals. We will review recent evidence supporting the concept that direct stimulation of the gastrointestinal tract with nutrients induces release of the catecholamine neurotransmitter dopamine. In addition, changes in dopamine efflux produced by direct stimulation of the gastrointestinal tract were found to reflect the caloric load of the infusates, suggesting that dopamine signaling may function as a central caloric sensor that mediates adjustments in intake according to the caloric density of a meal. Consistent with the above, blockade of dopamine signaling disrupts flavor-nutrient associations and impairs the regulatory capacity to maintain constant caloric intake during intra-gastric feeding. Future research must determine the exact pathways linking gut nutrient administration to dopamine efflux. Current evidence points to parallel contributions by pre- and post-absorptive pathways, indicating that dopamine systems constitute a site of convergence through which distinct physiological signals can exert control over ingestive behaviors.
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DA is a catecholamine that to a large extent is synthesized in the gut and plays a crucial role in the reward system in the brain.
“DA is a catecholamine that to a large extent is synthesized in the gut and plays a crucial role in the reward system in the brain (98).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [98]
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- Authors
- de Araujo, I. E., Ferreira, J. G., Tellez, L. A., Ren, X., & Yeckel, C. W.
- Affiliations
- Yale University (US)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 106
- Issue
- 3
- Pages
- 394-399
- ISSN
- 0031-9384 (ISSN-L)
- PMC
- PMC3348418
- OpenAlex
- W2050866793
- Cited by
- 140
- References
- 72
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 18 · 2020: 14 · 2019: 4 · 2018: 12 · 2017: 11 · 2016: 14 · 2015: 9 · 2014: 8 · 2013: 7 · 2012: 2
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- NIH (DC009997)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- dopamine efflux, nutrient sensing, feeding behavior, gut-brain signaling
- MeSH terms
- Animals, Brain, Energy Intake, Dopamine, Eating, Feeding Behavior, Humans, Sensation, Gastrointestinal Tract
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