Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by Taq IA A1 Allele
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The dorsal striatum plays a role in consummatory food reward, and striatal dopamine receptors are reduced in obese individuals, relative to lean individuals, which suggests that the striatum and dopaminergic signaling in the striatum may contribute to the development of obesity. Thus, we tested whether striatal activation in response to food intake is related to current and future increases in body mass and whether these relations are moderated by the presence of the A1 allele of the Taq IA restriction fragment length polymorphism, which is associated with dopamine D2 receptor ( DRD2 ) gene binding in the striatum and compromised striatal dopamine signaling. Cross-sectional and prospective data from two functional magnetic resonance imaging studies support these hypotheses, which implies that individuals may overeat to compensate for a hypofunctioning dorsal striatum, particularly those with genetic polymorphisms thought to attenuate dopamine signaling in this region.
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Enhanced activity in brain regions that process palatability could make obese subjects favour food over other natural reinforcers, whereas decreased activation of dopaminergic targets by actual food consumption might lead to overconsumption to compensate for weak D2R-mediated signalling.
“An enhanced activity in brain regions that process palatability could make obese subjects favour food over other natural reinforcers, whereas decreased activation of dopaminergic targets by the actual food consumption might lead to overconsumption as a means to compensate for weak D2R-mediated signalling (93).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [93]
Blunted DA activation by consumption of drug or food could trigger overconsumption to compensate for the blunted reward circuit response.
“Since this is not what is seen in the clinic, it was suggested that blunted DA activation by consumption (of drug or food) could trigger overconsumption to compensate for the blunted response of the reward circuit (46).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [46]
In contrast to adult research, studies using only adolescent participants found the A1 allele is associated with decreased reward reactivity in ventral and dorsal striatum.
“In contrast to the adult research, the few studies using only adolescent participants found that the A1 allele is associated with decreased reward reactivity in ventral (Stice and Dagher 2010) and dorsal (Stice, Spoor et al. 2008) striatum.”
From Developmental imaging genetics: Linking dopamine function to adolescent behavior (2014) · cites this paper as Stice, Spoor et al. 2008
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- Authors
- Stice, E., Spoor, S., Bohon, C., & Small, D. M.
- Affiliations
- Oregon Research Institute (US)
- Corresponding author
- Stice, E.
- Venue
- Science
- Published
- 2008-10-17
- Volume
- 322
- Issue
- 5900
- Pages
- 449-452
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2681095
- OpenAlex
- W2092703117
- Cited by
- 786
- References
- 33
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 12 · 2023: 22 · 2022: 29 · 2021: 32 · 2020: 31 · 2019: 34 · 2018: 42 · 2017: 55 · 2016: 64 · 2015: 64 · 2014: 65 · 2013: 60 · 2012: 76
- FWCI
- 24.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (F31MH081588, R01MH064560)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- obesity, dorsal striatum, food reward, dopamine D2 receptor, DRD2 gene, dietary intake, body mass, genetic polymorphism, moderating effect, overeating
- MeSH terms
- Adolescent, Adult, Alleles, Basal Ganglia, Caudate Nucleus, Corpus Striatum, Cues, Dopamine, Eating, Female, Food, Humans, Hyperphagia, Magnetic Resonance Imaging, Obesity, Putamen, Regression Analysis, Polymorphism, Restriction Fragment Length, Reward, Deoxyribonucleases, Type II Site-Specific, Signal Transduction, Weight Gain, Body Mass Index, Receptors, Dopamine D2
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