Genetic variations in the serotoninergic system and environmental factors contribute to aggressive behavior in Chinese adolescents
Abstract
Aggressive behavior is a major public health problem worldwide and has been associated with many gene variants, especially those related to the serotonin (5-hydroxytryptamine, 5-HT) system, and environmental factors. However, the overall contribution of serotonin-related genes to aggressive behavior is not well understood. With a sample of 478 healthy Chinese volunteers, this study investigated the relation between aggressive behavior and genetic variations of the serotoninergic system (as characterized by 129 representative polymorphisms) interacting with environmental factors (parental warmth and acceptance; stressful life events). We adopted a system-level approach to identify SNPs and environmental factors associated with aggressive behavior, and estimated their overall contribution to aggressive behavior using multiple regression, which was then verified by permutation analysis. We identified 12 SNPs that made statistically significant contributions to aggressive behavior. Next, main effects, interactions among these SNPs, and interactions between these SNPs and environmental factors were assessed using multiple regression. The final model accounted for approximately 19% of the variance for aggressive behavior. Permutation analysis confirmed that the probability of obtaining these findings by chance was low (p=0.045, permuted for 1000 times). These results showed that genetic variations in the serotoninergic system, combined with environmental risk factors, made a moderate contribution to individual differences in aggressive behavior among a healthy population sample.
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Human aggression has a complex genetic architecture that interacts with environmental factors.
“Its complex genetic architecture interacts with environmental factors [7–9].”
From An integrated analysis of genes and functional pathways for aggression in human and rodent models (2019) · cites this paper as [7]
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- Authors
- Chen, C., Liu, C., Chen, C., Moyzis, R., Chen, W., & Dong, Q.
- Affiliations
- McGovern Institute for Brain Research (US)
- Pennsylvania State University (US)
- University of California, Irvine (US)
- Beijing Normal University (CN)
- Corresponding author
- Dong, Qi
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 138
- Pages
- 62-68
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2062970946
- Cited by
- 7
- References
- 77
- Citations by year
- 2019: 1 · 2018: 3 · 2017: 1 · 2015: 2
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31100807, 31221003)
- Ministry of Education of the People's Republic of China
- Fundamental Research Funds for the Central Universities (2012LYB05)
- Specialized Research Fund for the Doctoral Program of Higher Education of China (20110003120001)
- Higher Education Discipline Innovation Project (B07008)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- aggression, serotonergic system, serotonin genes, single nucleotide polymorphisms, gene-environment interaction, parental warmth, parental acceptance, life events, adolescents, Chinese population, individual differences
- MeSH terms
- Adolescent, Adolescent Behavior, Adult, Aggression, China, Computer Simulation, Female, Humans, Male, Models, Genetic, Models, Psychological, Monte Carlo Method, Parent-Child Relations, Surveys and Questionnaires, Stress, Psychological, Polymorphism, Single Nucleotide, Asian People, Gene-Environment Interaction, Genotyping Techniques
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