Preliminary evidence that specific candidate genes are associated with adolescent‐onset antisocial behavior
Abstract
Though initially conceptualized as resulting from peer imitation of child‐onset or life‐course‐persistent youth [Moffitt, 1993], there is mounting evidence from twin studies that adolescent‐onset or adolescent‐limited antisocial behavior may also be genetically influenced. This study sought to provide preliminary molecular genetic evidence in support of these findings. We further evaluated whether genetic associations varied between behavioral subtypes of ASB (i.e., physical aggression and nonaggressive rule‐breaking), given that only the latter has been found to characterize adolescent‐onset ASB. The sample consisted of 211 undergraduate men of European‐American ancestry. Three polymorphisms with theoretical and/or empirical ties to ASB or related traits (i.e., tryptophan hydroxylase‐A218C, 5HT 2A His452Tyr, and the DAT1 variable nucleotide tandem repeat) were genotyped. Analyses revealed that two of the three polymorphisms (i.e., His452Tyr and DAT1) were associated with adolescent ASB. Moreover, these associations appeared to be specific to the nonaggressive, rule‐breaking form of ASB, and did not extend to physical aggression, further supporting ties to adolescent ASB in particular. Such results thus constructively replicate earlier findings of genetic influence on adolescent ASB. They also offer preliminary evidence that the genetic processes underlying aggressive and nonaggressive antisocial behavior may be (at least partially) distinct. Aggr. Behav. 34:437–445, 2008. © 2008 Wiley‐Liss, Inc.
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Only a small handful of molecular genetic studies implicate DA candidate genes, including DAT1, DRD2, and DRD4, in the development of conduct problems.
“only a small handful of molecular genetic studies implicate DA candidate genes, including DAT1, DRD2, and DRD4, in the development of conduct problems [656-659]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [657]
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- Authors
- Burt, S. A., & Mikolajewski, A. J.
- Affiliations
- Michigan State University (US)
- Corresponding author
- Burt, S. Alexandra
- Venue
- Aggressive Behavior
- Publisher
- Wiley
- Published
- 2008-03-25
- Volume
- 34
- Issue
- 4
- Pages
- 437-445
- ISSN
- 0096-140X (ISSN-L)
- 1098-2337
- OpenAlex
- W2032886932
- Cited by
- 98
- References
- 40
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 9 · 2015: 10 · 2014: 11 · 2013: 14 · 2012: 6
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Aggressive Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Sociology and Political Science › Crime Patterns and Interventions
- Keywords
- genetic association, candidate genes, tryptophan hydroxylase, physical aggression, heritability, European American men
- MeSH terms
- Adolescent, Adult, Aggression, Alleles, Antisocial Personality Disorder, Genetic Markers, Genotype, Humans, Internal-External Control, Male, Polymorphism, Genetic, Social Conformity, Tryptophan Hydroxylase, Minisatellite Repeats, Conduct Disorder, Genetic Predisposition to Disease, Receptor, Serotonin, 5-HT2A, Dopamine Plasma Membrane Transport Proteins
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