Cited by 98Neurotransmitter Receptor Influence on BehaviorPsychopathy, Forensic Psychiatry, Sexual OffendingCrime Patterns and Interventions

Preliminary evidence that specific candidate genes are associated with adolescent‐onset antisocial behavior

Burt, S. Alexandra, Mikolajewski, Amy J.·2008·Aggressive Behavior

Abstract

Though initially conceptualized as resulting from peer imitation of child‐onset or life‐course‐persistent youth [Moffitt, 1993], there is mounting evidence from twin studies that adolescent‐onset or adolescent‐limited antisocial behavior may also be genetically influenced. This study sought to provide preliminary molecular genetic evidence in support of these findings. We further evaluated whether genetic associations varied between behavioral subtypes of ASB (i.e., physical aggression and nonaggressive rule‐breaking), given that only the latter has been found to characterize adolescent‐onset ASB. The sample consisted of 211 undergraduate men of European‐American ancestry. Three polymorphisms with theoretical and/or empirical ties to ASB or related traits (i.e., tryptophan hydroxylase‐A218C, 5HT 2A His452Tyr, and the DAT1 variable nucleotide tandem repeat) were genotyped. Analyses revealed that two of the three polymorphisms (i.e., His452Tyr and DAT1) were associated with adolescent ASB. Moreover, these associations appeared to be specific to the nonaggressive, rule‐breaking form of ASB, and did not extend to physical aggression, further supporting ties to adolescent ASB in particular. Such results thus constructively replicate earlier findings of genetic influence on adolescent ASB. They also offer preliminary evidence that the genetic processes underlying aggressive and nonaggressive antisocial behavior may be (at least partially) distinct. Aggr. Behav. 34:437–445, 2008. © 2008 Wiley‐Liss, Inc.

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Crossref · 10.1002/ab.20251

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Authors
Burt, S. A., & Mikolajewski, A. J.
Affiliations
Michigan State University (US)
Corresponding author
Burt, S. Alexandra
Venue
Aggressive Behavior
Publisher
Wiley
Published
2008-03-25
Volume
34
Issue
4
Pages
437-445
ISSN
  • 0096-140X (ISSN-L)
  • 1098-2337
OpenAlex
W2032886932
Cited by
98
References
40
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 9 · 2015: 10 · 2014: 11 · 2013: 14 · 2012: 6
FWCI
3.90
Type
journal article
Language
en
Open access
closed
Locations
  • Aggressive Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Social Sciences › Sociology and Political Science › Crime Patterns and Interventions
Keywords
genetic association, candidate genes, tryptophan hydroxylase, physical aggression, heritability, European American men
MeSH terms
Adolescent, Adult, Aggression, Alleles, Antisocial Personality Disorder, Genetic Markers, Genotype, Humans, Internal-External Control, Male, Polymorphism, Genetic, Social Conformity, Tryptophan Hydroxylase, Minisatellite Repeats, Conduct Disorder, Genetic Predisposition to Disease, Receptor, Serotonin, 5-HT2A, Dopamine Plasma Membrane Transport Proteins

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