African trypanosome infections of the nervous system: Parasite entry and effects on sleep and synaptic functions

Kristensson, Krister; Nygård, Mikael; Bertini, Giuseppe; Bentivoglio, Marina

doi:10.1016/j.pneurobio.2009.12.001

Cited by 140Trypanosoma species research and implicationsSleep and Wakefulness ResearchTryptophan and brain disorders

African trypanosome infections of the nervous system: Parasite entry and effects on sleep and synaptic functions

Kristensson, Krister, Nygård, Mikael, Bertini, Giuseppe, Bentivoglio, Marina·2010·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2009.12.001

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Abstract

The extracellular parasite Trypanosoma brucei causes human African trypanosomiasis (HAT), also known as sleeping sickness. Trypanosomes are transmitted by tsetse flies and HAT occurs in foci in sub-Saharan Africa. The disease, which is invariably lethal if untreated, evolves in a first hemo-lymphatic stage, progressing to a second meningo-encephalitic stage when the parasites cross the blood-brain barrier. At first, trypanosomes are restricted to circumventricular organs and choroid plexus in the brain outside the blood-brain barrier, and to dorsal root ganglia. Later, parasites cross the blood-brain barrier at post-capillary venules, through a multi-step process similar to that of lymphocytes. Accumulation of parasites in the brain is regulated by cytokines and chemokines. Trypanosomes can alter neuronal function and the most prominent manifestation is represented by sleep alterations. These are characterized, in HAT and experimental rodent infections, by disruption of the sleep-wake 24h cycle and internal sleep structure. Trypanosome infections alter also some, but not all, other endogenous biological rhythms. A number of neural pathways and molecules may be involved in such effects. Trypanosomes secrete prostaglandins including the somnogenic PGD2, and they interact with the host's immune system to cause release of pro-inflammatory cytokines. From the sites of early localization of parasites in the brain and meninges, such molecules could affect adjacent brain areas implicated in sleep-wakefulness regulation, including the suprachiasmatic nucleus and its downstream targets, to cause the changes characteristic of the disease. This raises challenging issues on the effects of cytokines on synaptic functions potentially involved in sleep-wakefulness alterations.

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IL-1 and TNF are substances involved in the homeostatic regulation of sleep.
“These findings established both cytokines, IL-1 and TNF, as substances involved in the homeostatic regulation of sleep (for review, see Refs. 299, 411).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [299]
Increasing the availability of IL-1 and TNF promotes NREM sleep amount and intensity and suppresses REM sleep amount.
“increasing the availability of those cytokines promoted NREM sleep amount and intensity and suppressed REM sleep amount.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [299]
Blocking the biological actions of IL-1 and TNF reduces physiological NREM sleep amount or NREM sleep rebound after sleep deprivation.
“blocking the biological actions of the cytokines IL-1 and TNF resulted in a reduction of physiological NREM sleep amount or NREM sleep rebound after sleep deprivation.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [299]
Pathogens, including bacteria, viruses, fungi, and parasites, increase the amount and intensity of NREM sleep while decreasing the amount of REM sleep.
“pathogens, including bacteria, viruses, fungi, and parasites increase the amount and intensity of NREM sleep while decreasing the amount of REM sleep (for comprehensive review, see Refs. 299, 353).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [299]

Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works
Brain stem reticular formation and activation of the EEG
Moruzzi, G., & Magoun, H. W. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90219-9 · Cited by 4,307 · see citing works
Two-Process Model of Sleep Regulation
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6166 · Cited by 3,895 · see citing works
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804 · see citing works
FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE
Reese, T. S., & Karnovsky, M. J. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.1.207 · Cited by 2,629 · see citing works
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151 · see citing works
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., et al. (2000) · Nature Medicine · doi:10.1038/79690 · Cited by 2,118 · see citing works
Reduced Number of Hypocretin Neurons in Human Narcolepsy
Thannickal, T. C., Moore, R. Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., & Siegel, J. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00058-1 · Cited by 2,089 · see citing works
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · see citing works
The sleep switch: hypothalamic control of sleep and wakefulness
Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656 · see citing works
The human nervous system
Paxinos, G., & Jürgen, K. (2004) · Cited by 1,478 · see citing works
Timing of human sleep: recovery process gated by a circadian pacemaker
Daan, S., Beersma, D. G. M., & Borbély, A. A. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.2.r161 · Cited by 1,424 · see citing works
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Sakurai, T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2092 · Cited by 1,276 · see citing works
A putative flip–flop switch for control of REM sleep
Lu, J., Sherman, D. L., Devor, M. G., & Saper, C. B. (2006) · Nature · doi:10.1038/nature04767 · Cited by 1,219 · see citing works
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206 · see citing works
Practice Parameters for the Use of Actigraphy in the Assessment of Sleep and Sleep Disorders: An Update for 2007
Morgenthaler, T., Alessi, C., Friedman, L., Owens, J., Kapur, V., Boehlecke, B., Brown, T., Chesson, A., Coleman, J., Lee-Chiong, T., et al. (2007) · Sleep · doi:10.1093/sleep/30.4.519 · Cited by 1,142 · see citing works
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias
Mignot, E., Lammers, G. J., Ripley, B., Okun, M., Nevsimalova, S., Overeem, S., Vankova, J., Black, J., Harsh, J., Bassetti, C., et al. (2002) · Archives of Neurology · doi:10.1001/archneur.59.10.1553 · Cited by 1,126 · see citing works
The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization
Bittencourt, J. C., Presse, F., Arias, C. M., Peto, C. A., Vaughan, J. M., Nahon, J., Vale, W., & Sawchenko, P. E. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190204 · Cited by 1,075 · see citing works
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
Pace-Schott, E. F., & Hobson, J. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn895 · Cited by 937 · see citing works
Pathobiology of neuropathic pain
Zimmermann, M. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01303-6 · Cited by 935 · see citing works
Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function
Raivich, G., Bohatschek, M., Kloss, C. U. A., Werner, A., Jones, L. L., & Kreutzberg, G. W. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00007-7 · Cited by 843 · see citing works
Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837 · see citing works
Astrocyte dysfunction in neurological disorders: a molecular perspective
Seifert, G., Schilling, K., & Steinhäuser, C. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1870 · Cited by 798 · see citing works
A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms
Silver, R., LeSauter, J., Tresco, P. A., & Lehman, M. N. (1996) · Nature · doi:10.1038/382810a0 · Cited by 792 · see citing works
Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections
Abrahamson, E. E., & Moore, R. Y. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02890-6 · Cited by 788 · see citing works
The circadian visual system, 2005
Morin, L. P., & Allen, C. N. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.08.003 · Cited by 786 · see citing works
SLEEP AS A PROBLEM OF LOCALIZATION
von Economo, C. (1930) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-193003000-00001 · Cited by 687 · see citing works
A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons
Ericsson, A. B., Kovacs, K., & Sawchenko, P. E. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00897.1994 · Cited by 684 · see citing works
Efferent projections of the suprachiasmatic nucleus: I. Studies using anterograde transport of Phaseolus vulgaris leucoagglutinin in the rat
Watts, A. G., Swanson, L. W., & Sanchez‐Watts, G. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902580204 · Cited by 678 · see citing works
Fos Expression in Orexin Neurons Varies with Behavioral State
Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B., & Scammell, T. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01656.2001 · Cited by 654 · see citing works
DEVELOPMENTAL CYCLES AND BIOLOGY OF PATHOGENIC TRYPANOSOMES
Vickerman, K. (1985) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072036 · Cited by 621 · see citing works
Sleep as a fundamental property of neuronal assemblies
Krueger, J. M., Rector, D. M., Roy, S., Van Dongen, H. P. A., Belenky, G., & Panksepp, J. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2521 · Cited by 596 · see citing works
From waking to sleeping: neuronal and chemical substrates
Jones, B. E. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.09.009 · Cited by 577 · see citing works
Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
Chou, T. C., Scammell, T. E., Gooley, J. J., Gaus, S. E., Saper, C. B., & Lu, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10691.2003 · Cited by 576 · see citing works
Hypocretin (orexin) cell loss in Parkinson's disease
Thannickal, T. C., Lai, Y.-Y., & Siegel, J. M. (2007) · Brain · doi:10.1093/brain/awm097 · Cited by 566 · see citing works
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
Agrawal, S., Anderson, P., Durbeej, M., van Rooijen, N., Ivars, F., Opdenakker, G., & Sorokin, L. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051342 · Cited by 559 · see citing works
Sick and tired: does sleep have a vital role in the immune system?
Bryant, P. A., Trinder, J., & Curtis, N. (2004) · Nature Reviews Immunology · doi:10.1038/nri1369 · Cited by 551 · see citing works
Neurobiology of REM and NREM sleep
McCarley, R. W. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.005 · Cited by 538 · see citing works
Circadian Rhythm Sleep Disorders: Part II, Advanced Sleep Phase Disorder, Delayed Sleep Phase Disorder, Free-Running Disorder, and Irregular Sleep-Wake Rhythm
Sack, R. L., Auckley, D. H., Auger, R. R., Carskadon, M. A., Wright, K. P., Vitiello, M. V., & Zhdanova, I. V. (2007) · SLEEP · doi:10.1093/sleep/30.11.1484 · Cited by 530 · see citing works
The hypothalamic integrator for circadian rhythms
Saper, C. B., Lü, J., Chou, T. C., & Gooley, J. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2004.12.009 · Cited by 528 · see citing works
Toll‐like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram‐negative bacterial cell wall components
LAFLAMME, N., & RIVEST, S. (2001) · The FASEB Journal · doi:10.1096/fj.00-0339com · Cited by 501 · see citing works
Afferents to the Ventrolateral Preoptic Nucleus
Chou, T. C., Bjørkum, A. A., Gaus, S. E., Lu, J., Scammell, T. E., & Saper, C. B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00977.2002 · Cited by 493 · see citing works
SCN Outputs and the Hypothalamic Balance of Life
Kalsbeek, A., Palm, I. F., la Fleur, S., Scheer, F., Perreau‐Lenz, S., Ruiter, M., Kreier, F., Cailotto, C., & Buijs, R. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406293854 · Cited by 492 · see citing works
Orchestrating time: arrangements of the brain circadian clock
Antle, M. C., & Silver, R. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.01.003 · Cited by 463 · see citing works
A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
Verret, L., Goutagny, R., Fort, P., Cagnon, L., Salvert, D., Léger, L., Boissard, R., Salin, P. A., Peyron, C., & Luppi, P. (2003) · BMC Neuroscience · doi:10.1186/1471-2202-4-19 · Cited by 453 · see citing works
Eliminating Human African Trypanosomiasis: Where Do We Stand and What Comes Next?
Simarro, P. P., Jannin, J. G., & Cattand, P. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050055 · Cited by 439 · see citing works
The hypocretin/orexin ligand–receptor system: implications for sleep and sleep disorders
Kilduff, T. S., & Peyron, C. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01594-0 · Cited by 438 · see citing works
The Role of Cytokines in Physiological Sleep Regulation
Krueger, J. M., Obál, F., Fang, J., Kubota, T., & Taishi, P. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05826.x · Cited by 423 · see citing works
TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription
Cavadini, G., Petrzilka, S., Kohler, P. P., Jud, C., Tobler, I., Birchler, T., & Fontana, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701466104 · Cited by 421 · see citing works
The hypocretins: Setting the arousal threshold
Sutcliffe, J. G., & de Lecea, L. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn808 · Cited by 416 · see citing works
CSF hypocretin/orexin levels in narcolepsy and other neurological conditions
Ripley, B., Overeem, S., Fujiki, N., Nevsimalova, S., Uchino, M., Yesavage, J., Di Monte, D., Dohi, K., Melberg, A., Lammers, G. J., et al. (2001) · Neurology · doi:10.1212/wnl.57.12.2253 · Cited by 415 · see citing works
Homeostatic, circadian, and emotional regulation of sleep
Saper, C. B., Cano, G., & Scammell, T. E. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20770 · Cited by 405 · see citing works
Toll-Like Receptor 4 on Nonhematopoietic Cells Sustains CNS Inflammation during Endotoxemia, Independent of Systemic Cytokines
Chakravarty, S., & Herkenham, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4268-04.2005 · Cited by 396 · see citing works
Perivascular Spaces and the Two Steps to Neuroinflammation
Owens, T., Bechmann, I., & Engelhardt, B. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31818f9ca8 · Cited by 352 · see citing works
Arousal--Revisiting the Reticular Activating System
Steriade, M. (1996) · Science · doi:10.1126/science.272.5259.225 · Cited by 350 · see citing works
Contrasting Effects of Ibotenate Lesions of the Paraventricular Nucleus and Subparaventricular Zone on Sleep–Wake Cycle and Temperature Regulation
Lu, J., Zhang, Y.-H., Chou, T. C., Gaus, S. E., Elmquist, J. K., Shiromani, P. J., & Saper, C. B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04864.2001 · Cited by 335 · see citing works
Mini‐review: Transendothelial migration of leukocytes: through the front door or around the side of the house?
Engelhardt, B., & Wolburg, H. (2004) · European Journal of Immunology · doi:10.1002/eji.200425327 · Cited by 334 · see citing works
Tumor necrosis factor alters synaptic transmission in rat hippocampal slices.
Tancredi, V., D'Arcangelo, G., Grassi, F., Tarroni, P., Palmieri, G., Santoni, A., & Eusebi, F. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90071-e · Cited by 326 · see citing works
Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain
Wan, W., Wetmore, L., Sorensen, C. M., Greenberg, A. H., & Nance, D. M. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90179-1 · Cited by 325 · see citing works
Sleep states alter activity of suprachiasmatic nucleus neurons
Deboer, T., Vansteensel, M. J., Détári, L., & Meijer, J. H. (2003) · Nature Neuroscience · doi:10.1038/nn1122 · Cited by 324 · see citing works
Phases and states of sleep in the rat
Timo-Iaria, C., Negrão, N., Schmidek, W. R., Hoshino, K., de Menezes, C. E. L., & Martinez, T. L. D. R. (1970) · Physiology & Behavior · doi:10.1016/0031-9384(70)90162-9 · Cited by 319 · see citing works
Circadian regulation of sleep in mammals: Role of the suprachiasmatic nucleus
Mistlberger, R. E. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.01.005 · Cited by 318 · see citing works
Circadian clock genes and sleep homeostasis
Franken, P., & Dijk, D. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06723.x · Cited by 302 · see citing works
The suprachiasmatic nucleus and the circadian time-keeping system revisited
van Esseveldt, L. E., Lehman, M. N., & Boer, G. J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00025-4 · Cited by 296 · see citing works
Topographic organization of suprachiasmatic nucleus projection neurons
Leak, R. K., & Moore, R. Y. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1142 · Cited by 295 · see citing works
Indirect projections from the suprachiasmatic nucleus to major arousal-promoting cell groups in rat: Implications for the circadian control of behavioural state
Deurveilher, S., & Semba, K. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.030 · Cited by 277 · see citing works
Loss of circadian rhythm in sleep-wakefulness cycle in the rat by suprachiasmatic nucleus lesions
Ibuka, N., & Kawamura, H. (1975) · Brain Research · doi:10.1016/0006-8993(75)90574-0 · Cited by 271 · see citing works
Orexin neuronal circuitry: Role in the regulation of sleep and wakefulness
Ohno, K., & Sakurai, T. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.08.001 · Cited by 269 · see citing works
An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons
Scammell, T. E., Gerashchenko, D., Mochizuki, T., McCarthy, M. T., Estabrooke, I. V., Sears, C., Saper, C. B., Urade, Y., & Hayaishi, O. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00383-9 · Cited by 269 · see citing works
Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease.
Raivich, G., & Banati, R. (2004) · Brain research. Brain research reviews · doi:10.1016/j.brainresrev.2004.06.006 · Cited by 263 · see citing works
Human African trypanosomiasis of the CNS: current issues and challenges
Kennedy, P. G. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21052 · Cited by 262 · see citing works
The Biological Clock Nucleus: A Multiphasic Oscillator Network Regulated by Light
Quintero, J. E., Kuhlman, S. J., & McMahon, D. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-22-08070.2003 · Cited by 259 · see citing works
Effects of Suprachiasmatic Transplants on Circadian Rhythms of Neuroendocrine Function in Golden Hamsters**This work was supported by NIH Grants MH-44132, KO2-MH-00914, and F32-HD-07673. A preliminary report of this research was presented at the 23rd Annual Meeting of the Society for Neuroscience (Neurosci Abstr 19:236.17, 1993).
Meyer-Bernstein, E. L., Jetton, A. E., Matsumoto, S., Markuns, J. F., Lehman, M. N., & Bittman, E. L. (1999) · Endocrinology · doi:10.1210/endo.140.1.6428 · Cited by 252 · see citing works
A Haptoglobin-Hemoglobin Receptor Conveys Innate Immunity to Trypanosoma brucei in Humans
Vanhollebeke, B., Muylder, G. D., Nielsen, M. J., et al. (2008) · Science · doi:10.1126/science.1156296 · Cited by 241 · see citing works
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice
Eguchi, N., Minami, T., Shirafuji, N., Kanaoka, Y., Tanaka, T., Nagata, A., Yoshida, N., Urade, Y., Ito, S., & Hayaishi, O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.726 · Cited by 236 · see citing works
Prostaglandins and adenosine in the regulation of sleep and wakefulness
Huang, Z., Urade, Y., & Hayaishi, O. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.09.004 · Cited by 224 · see citing works
Heterogeneity of rhythmic suprachiasmatic nucleus neurons: Implications for circadian waveform and photoperiodic encoding
Schaap, J., Albus, H., vanderLeest, H. T., Eilers, P. H. C., Détári, L., & Meijer, J. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436298100 · Cited by 216 · see citing works
Paradoxical (REM) sleep genesis: The switch from an aminergic–cholinergic to a GABAergic–glutamatergic hypothesis
Luppi, P., Gervasoni, D., Verret, L., Goutagny, R., Peyron, C., Salvert, D., Léger, L., & Fort, P. (2006) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2007.05.006 · Cited by 214 · see citing works
The continuing problem of human African trypanosomiasis (sleeping sickness)
Kennedy, P. G. E. (2008) · Annals of Neurology · doi:10.1002/ana.21429 · Cited by 213 · see citing works
Suprachiasmatic nucleus in sleep–wake regulation
Moore, R. Y. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.10.003 · Cited by 202 · see citing works
Cytokines and Neuronal Ion Channels in Health and Disease
Viviani, B., Gardoni, F., & Marinovich, M. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82013-7 · Cited by 195 · see citing works
Organization of circadian functions: interaction with the body
Buijs, R. M., Scheer, F. A. J. L., Kreier, F., Yi, C., Bos, N. P. A., Goncharuk, V. D., & Kalsbeek, A. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53020-1 · Cited by 189 · see citing works
Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep
Mizoguchi, A., Eguchi, N., Kimura, K., Kiyohara, Y., Qu, W., Huang, Z., Mochizuki, T., Lazarus, M., Kobayashi, T., Kaneko, T., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201398898 · Cited by 185 · see citing works
Ventromedial Arcuate Nucleus Communicates Peripheral Metabolic Information to the Suprachiasmatic Nucleus
Yi, C., van der Vliet, J., Dai, J., Guangfu, Y., Li-qiang, R., & Buijs, R. M. (2005) · Endocrinology · doi:10.1210/en.2005-1051 · Cited by 184 · see citing works
Resistance to the African trypanosomes is IFN-gamma dependent.
Hertz, C. J., Filutowicz, H. I., & Mansfield, J. M. (1998) · PubMed · Cited by 162 · see citing works
Immunostimulatory CpG-DNA Activates Murine Microglia
Dalpke, A. H., Schäfer, M. K.-H., Frey, M., Zimmermann, S., Tebbe, J. J., Weihe, E., & Heeg, K. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.4854 · Cited by 161 · see citing works
Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D 2
Scammell, T. E., Gerashchenko, D., Urade, Y., Onoe, H., Saper, C. B., & Hayaishi, O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7754 · Cited by 161 · see citing works
CSF hypocretin-1 assessment in sleep and neurological disorders
Bourgin, P., Zeitzer, J. M., & Mignot, E. J.-M. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70140-6 · Cited by 157 · see citing works
Sleeping sickness: a tale of two diseases
Welburn, S. C., Fèvre, E. M., Coleman, P. G., et al. (2001) · Trends in Parasitology · doi:10.1016/s1471-4922(00)01839-0 · Cited by 151 · see citing works
SCN Organization Reconsidered
Morin, L. P. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730406296749 · Cited by 151 · see citing works
Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A 1 receptors and promotes non-rapid eye movement sleep
Oishi, Y., Huang, Z., Fredholm, B. B., Urade, Y., & Hayaishi, O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810926105 · Cited by 151 · see citing works
Alternating vigilance states: new insights regarding neuronal networks and mechanisms
Fort, P., Bassetti, C. L., & Luppi, P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06722.x · Cited by 148 · see citing works
Differential induction of c-Fos immunoreactivity in hypothalamus and brain stem nuclei following central and peripheral administration of endotoxin
Wan, W., Janz, L., Vriend, C. Y., Sorensen, C. M., Greenberg, A. H., & Nance, D. M. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90158-8 · Cited by 143 · see citing works
Cerebral vessel laminins and IFN-γ define Trypanosoma brucei brucei penetration of the blood-brain barrier
Masocha, W., Robertson, B., Rottenberg, M. E., Mhlanga, J., Sorokin, L. M., & Kristensson, K. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22104 · Cited by 143 · see citing works
Self-citation
Long Term Effects of Sleep Deprivation on The Mammalian Circadian Pacemaker
Deboer, T., Détári, L., & Meijer, J. H. (2007) · SLEEP · doi:10.1093/sleep/30.3.257 · Cited by 142 · see citing works
Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease
Nikolskaia, O. V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27798 · Cited by 140 · see citing works
Spread of Trypanosoma brucei to the nervous system: Early attack on circumventricular organs and sensory ganglia
Schultzberg, M., Ambatsis, M., Samuelsson, E., Kristensson, K., & Meirvenne, N. V. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210109 · Cited by 139 · see citing works
Self-citation
The Induction of a Type 1 Immune Response following a Trypanosoma brucei Infection Is MyD88 Dependent
Drennan, M. B., Stijlemans, B., Abbeele, J. V. D., Quesniaux, V. F. J., Barkhuizen, M., Brombacher, F., BAETSELIER, P. D., Ryffel, B., & Magez, S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2501 · Cited by 135 · see citing works
Inhibition of nitric oxide synthesis inhibits rat sleep
Kapás, L., Fang, J., & Krueger, J. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91969-0 · Cited by 133 · see citing works
Regulation of Synaptic Efficacy in Hypocretin/Orexin-Containing Neurons by Melanin Concentrating Hormone in the Lateral Hypothalamus
Rao, Y., Lu, M., Ge, F., Marsh, D. J., Qian, S., Wang, A. H., Picciotto, M. R., & Gao, X. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1766-08.2008 · Cited by 131 · see citing works
Neuroimmunology of the circadian clock
Coogan, A. N., & Wyse, C. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.087 · Cited by 131 · see citing works
Efferent projections from the median preoptic nucleus to sleep- and arousal-regulatory nuclei in the rat brain
Uschakov, A., Gong, H., McGinty, D., & Szymusiak, R. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.055 · Cited by 130 · see citing works
Hypocretin (Orexin) Induces Calcium Transients in Single Spines Postsynaptic to Identified Thalamocortical Boutons in Prefrontal Slice
Lambe, E. K., & Aghajanian, G. K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00598-1 · Cited by 127 · see citing works
The dorsomedial hypothalamic nucleus is not necessary for food‐anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice
Moriya, T., Aida, R., Kudo, T., Akiyama, M., Doi, M., Hayasaka, N., Nakahata, N., Mistlberger, R. E., Okamura, H., & Shibata, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06697.x · Cited by 124 · see citing works
Controlling cytokine signaling by constitutive inhibitors
Rakesh, K., & Agrawal, D. K. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.04.042 · Cited by 122 · see citing works
Death of a trypanosome: a selfish altruism
Duszenko, M., Figarella, K., MacLeod, E. T., et al. (2006) · Trends in Parasitology · doi:10.1016/j.pt.2006.08.010 · Cited by 122 · see citing works
Regulation of innate and acquired immunity in African trypanosomiasis
Mansfield, J. M., & Paulnock, D. M. (2005) · Parasite Immunology · doi:10.1111/j.1365-3024.2005.00791.x · Cited by 117 · see citing works
A comparative analysis of the distribution of immunoreactive orexin A and B in the brains of nocturnal and diurnal rodents
Nixon, J. P., & Smale, L. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-28 · Cited by 116 · see citing works
Electrophysiological and morphological heterogeneity of neurons in slices of rat suprachiasmatic nucleus
Pennartz, C. M. A., de Jeu, M. T. G., Geurtsen, A. M. S., Sluiter, A. A., & Hermes, M. L. H. J. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.775bv.x · Cited by 114 · see citing works
Regional pacemakers composed of multiple oscillator neurons in the rat suprachiasmatic nucleus
Nakamura, W., Honma, S., Shirakawa, T., & Honma, K.-I. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01684.x · Cited by 113 · see citing works
The Role of B-cells and IgM Antibodies in Parasitemia, Anemia, and VSG Switching in Trypanosoma brucei–Infected Mice
Magez, S., Schwegmann, A., Atkinson, R., Claes, F., Drennan, M., Baetselier, P. D., & Brombacher, F. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000122 · Cited by 110 · see citing works
Progress in Human African Trypanosomiasis, Sleeping Sickness
(1999) · Springer eBooks · doi:10.1007/978-2-8178-0857-4 · Cited by 107 · see citing works
Circadian responses to endotoxin treatment in mice
Marpegán, L., Bekinschtein, T. A., Costas, M. A., & Golombek, D. A. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.11.003 · Cited by 107 · see citing works
Identification of a Novel Prostaglandin F2α Synthase in Trypanosoma brucei
Kubata, B. K., Duszenko, M., Kabututu, Z. P., Rawer, M., Szallies, A., Fujimori, K., Inui, T., Nozaki, T., Yamashita, K., Horii, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1327 · Cited by 105 · see citing works
Trypanosoma brucei brucei crosses the blood–brain barrier while tight junction proteins are preserved in a rat chronic disease model
Mulenga, C., Mhlanga, J., Kristensson, K., & Robertson, B. (2001) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2001.00306.x · Cited by 102 · see citing works
Self-citation
Indirect projections from the suprachiasmatic nucleus to the ventrolateral preoptic nucleus: a dual tract‐tracing study in rat
Deurveilher, S., Burns, J., & Semba, K. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02196.x · Cited by 96 · see citing works
Sleep architecture of the melanin‐concentrating hormone receptor 1‐knockout mice
Adamantidis, A., Salvert, D., Goutagny, R., Lakaye, B., Gervasoni, D., Grisar, T. M., Luppi, P., & Fort, P. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06129.x · Cited by 92 · see citing works
Sleep structure: a new diagnostic tool for stage determination in sleeping sickness
Buguet, A., Bisser, S., Josenando, T., Chapotot, F., & Cespuglio, R. (2004) · Acta Tropica · doi:10.1016/j.actatropica.2004.10.001 · Cited by 91 · see citing works
Protease Activated Receptor Signaling Is Required for African Trypanosome Traversal of Human Brain Microvascular Endothelial Cells
Grab, D. J., Garcı́a-Garcı́a, J. C., Nikolskaia, O. V., Kim, Y. V., Brown, A. M., Pardo, C. A., Zhang, Y., Becker, K. G., Wilson, B. A., Lima, A. P. C. A., et al. (2009) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000479 · Cited by 89 · see citing works
Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology
Sternberg, J., Rodgers, J., Bradley, B., et al. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.06.017 · Cited by 86 · see citing works
Nitric Oxide Donors SIN-1 and SNAP Promote Nonrapid-Eye-Movement Sleep in Rats
Kapás, L., & Krueger, J. M. (1996) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00227-4 · Cited by 86 · see citing works
Diffusion pathways and retrograde axonal transport of protein tracers in peripheral nerves
Kristensson, K., & Olsson, Y. (1973) · Progress in Neurobiology · doi:10.1016/0301-0082(73)90017-8 · Cited by 86 · see citing works
Self-citation
Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes
Hutchings, N. R., Donelson, J. E., & Hill, K. L. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201036 · Cited by 86 · see citing works
Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form
Figarella, K., Rawer, M., Uzcategui, N. L., et al. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401564 · Cited by 85 · see citing works
Interferon-γ induces characteristics of central sensitization in spinal dorsal horn neurons in vitro
Vikman, K. S., Hill, R. H., Backström, E., Robertson, B., & Kristensson, K. (2003) · Pain · doi:10.1016/s0304-3959(03)00262-8 · Cited by 85 · see citing works
Self-citation
Interferon-γ receptors in nociceptive pathways
Robertson, B., Xu, X., Hao, J., Wiesenfeld‐Hallin, Z., Mhlanga, J., Grant, G., & Kristensson, K. (1997) · Neuroreport · doi:10.1097/00001756-199703240-00050 · Cited by 84 · see citing works
Self-citation
Expression and Role of CXCL10 during the Encephalitic Stage of Experimental and Clinical African Trypanosomiasis
Amin, D. N., Rottenberg, M. E., Thomsen, A. R., Ngoyi, D. M., Fenger, C., Kristensson, K., Büscher, P., Finsen, B. R., & Masocha, W. (2009) · The Journal of Infectious Diseases · doi:10.1086/644597 · Cited by 83 · see citing works
Self-citation
Astrocyte activation correlates with cytokine production in central nervous system of Trypanosoma brucei brucei-infected mice.
Hunter, C. A., Jennings, F. W., Kennedy, P. G. E., & Murray, M. (1992) · PubMed · Cited by 82 · see citing works
Interleukin (IL)-6, IL-8 and IL-10 in serum and CSF of Trypanosoma brucei gambiense sleeping sickness patients before and after treatment
Lejon, V., Lardon, J., Kenis, G., et al. (2002) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(02)90115-x · Cited by 80 · see citing works
Persistent Changes in Spontaneous Firing of Purkinje Neurons Triggered by the Nitric Oxide Signaling Cascade
Smith, S. L., & Otis, T. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00367.2003 · Cited by 79 · see citing works
Macrophages as Mediators of Immunosuppression in Murine African Trypanosomiasis
Askonas, B. A. (1985) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-70538-0_6 · Cited by 77 · see citing works
The duality of sleeping sickness: focusing on sleep
Buguet, A., Bourdon, L., Bouteille, B., Cespuglio, R., Vincendeau, P., Radomski, M. W., & Dumas, M. (2001) · Sleep Medicine Reviews · doi:10.1053/smrv.2000.0130 · Cited by 77 · see citing works
Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress
Figarella, K., Uzcategui, N. L., Beck, A., et al. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401862 · Cited by 74 · see citing works
Human recombinant tumor necrosis factor and interferon affect the activity of neurons in the organum vasculosum laminae terminalis
Shibata, M., & Blatteis, C. M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90639-d · Cited by 74 · see citing works
Spatially and Genetically Distinct African Trypanosome Virulence Variants Defined by Host Interferon‐γ Response
MacLean, L. M., Odiit, M., MacLeod, A., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/522011 · Cited by 74 · see citing works
Interferon-γ-induced changes in synaptic activity and AMPA receptor clustering in hippocampal cultures
Vikman, K. S., Owe‐Larsson, B., Brask, J., Kristensson, K., & Hill, R. H. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03238-8 · Cited by 73 · see citing works
Self-citation
Traversal of human and animal trypanosomes across the blood-brain barrier
Grab, D. J., & Kennedy, P. G. E. (2008) · Journal of NeuroVirology · doi:10.1080/13550280802282934 · Cited by 71 · see citing works
Disruption of Circadian Rhythms in Synaptic Activity of the Suprachiasmatic Nuclei by African Trypanosomes and Cytokines
Lundkvist, G. B. S., Hill, R. H., & Kristensson, K. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0536 · Cited by 70 · see citing works
Self-citation
The thalamic paraventricular nucleus relays information from the suprachiasmatic nucleus to the amygdala: A combined anterograde and retrograde tracing study in the rat at the light and electron microscopic levels
Peng, Z., & Bentivoglio, M. (2004) · Journal of Neurocytology · doi:10.1023/b:neur.0000029651.51195.f9 · Cited by 68 · see citing works
Self-citation
Interferon-γ Alters Electrical Activity and Clock Gene Expression in Suprachiasmatic Nucleus Neurons
Kwak, Y., Lundkvist, G. B. S., Brask, J., Davidson, A. J., Menaker, M., Kristensson, K., & Block, G. D. (2008) · Journal of Biological Rhythms · doi:10.1177/0748730407313355 · Cited by 68 · see citing works
Self-citation
Trypanosoma brucei brucei:A Long-Term Model of Human African Trypanosomiasis in Mice, Meningo-Encephalitis, Astrocytosis, and Neurological Disorders
Keita, M., Bouteille, B., Enanga, B., et al. (1997) · Experimental Parasitology · doi:10.1006/expr.1996.4136 · Cited by 67 · see citing works
Expression of an oscillating interferon-γ receptor in the suprachiasmatic nuclei
Lundkvist, G. B. S., Robertson, B., Mhlanga, J., Rottenberg, M. E., & Kristensson, K. (1998) · Neuroreport · doi:10.1097/00001756-199804200-00018 · Cited by 65 · see citing works
Self-citation
CpG Oligodeoxynucleotide Treatment Enhances Innate Resistance and Acquired Immunity to African Trypanosomes
Harris, T. H., Mansfield, J. M., & Paulnock, D. M. (2007) · Infection and Immunity · doi:10.1128/iai.01649-06 · Cited by 64 · see citing works
Blood-brain barrier damage in experimental African trypanosomiasis
Philip, K. A., Dascombe, M. J., Fraser, P. A., et al. (1994) · Annals of Tropical Medicine and Parasitology · doi:10.1080/00034983.1994.11812911 · Cited by 64 · see citing works
Molecular basis for prostaglandin production in hosts and parasites
Kubata, B. K., Duszenko, M., Martin, K. S., et al. (2007) · Trends in Parasitology · doi:10.1016/j.pt.2007.05.005 · Cited by 61 · see citing works
The Gene for a T Lymphocyte Triggering Factor from African Trypanosomes
Vaidya, T. B., Bakhiet, M., Hill, K. L., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.3.433 · Cited by 61 · see citing works
Electrophysiological actions of orexins on rat suprachiasmatic neurons in vitro
Brown, T. M., Coogan, A. N., Cutler, D. J., et al. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.10.058 · Cited by 57 · see citing works
Rods and cones project to the inner plexiform layer during development
Johnson, P. T., Williams, R. R., Cusato, K., & Reese, B. E. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991108)414:1 · Cited by 56 · see citing works
A circulating ghrelin mimetic attenuates light‐induced phase delay of mice and light‐induced Fos expression in the suprachiasmatic nucleus of rats
Yi, C., Challet, É., Pévet, P., Kalsbeek, A., Escobar, C., & Buijs, R. M. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06181.x · Cited by 55 · see citing works
Suprachiasmatic astrocytes as an interface for immune‐circadian signalling
Leone, M. J., Marpegán, L., Bekinschtein, T. A., Costas, M. A., & Golombek, D. A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21042 · Cited by 55 · see citing works
Clinical aspects of human African trypanosomiasis
Dumas, M., & Bisser, S. (1999) · Springer eBooks · doi:10.1007/978-2-8178-0857-4_13 · Cited by 53 · see citing works
Inducible Nitric Oxide Synthase and Nitrotyrosine in the Central Nervous System of Mice Chronically Infected with Trypanosoma brucei brucei
Keita, M., Vincendeau, P., Buguet, A., Cespuglio, R., Vallat, J., Dumas, M., & Bouteille, B. (2000) · Experimental Parasitology · doi:10.1006/expr.2000.4505 · Cited by 53 · see citing works
Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice
Olivadoti, M. D., & Opp, M. R. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.008 · Cited by 53 · see citing works
IFN-γ-Induced Chemokines Synergize with Pertussis Toxin to Promote T Cell Entry to the Central Nervous System
Millward, J. M., Caruso, M. P., Campbell, I. L., Gauldie, J., & Owens, T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.8175 · Cited by 52 · see citing works
Induced neuronal expression of class I major histocompatibility complex mRNA in acute and chronic inflammation models
Foster, J. A., Quan, N., Stern, E. L., Kristensson, K., & Herkenham, M. A. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00258-8 · Cited by 51 · see citing works
Self-citation
Interferon-γ-responsive neuronal sites in the normal rat brain: receptor protein distribution and cell activation revealed by Fos induction
Robertson, B., Kong, G., Peng, Z., Bentivoglio, M., & Kristensson, K. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00240-9 · Cited by 51 · see citing works
Self-citation
Minocycline Impedes African Trypanosome Invasion of the Brain in a Murine Model
Masocha, W., Rottenberg, M. E., & Kristensson, K. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.5.1798-1804.2006 · Cited by 51 · see citing works
Self-citation
Melatonin and its new agonist S-20098 restore synchronized sleep fragmented by experimental trypanosome infection in the rat
Grassi-Zucconi, G., Semprevivo, M., Mocaër, E., Kristensson, K., & Bentivoglio, M. (1996) · Brain Research Bulletin · doi:10.1016/0361-9230(95)02032-2 · Cited by 50 · see citing works
Self-citation
Disruption of Endocrine Rhythms in Sleeping Sickness With Preserved Relationship Between Hormonal Pulsatility and the REM-NREM Sleep Cycles
BRANDENBERGER, G., Buguet, A., Spiegel, K., Stanghellini, A., Muanga, G., Bogui, P., & Dumas, M. (1996) · Journal of Biological Rhythms · doi:10.1177/074873049601100307 · Cited by 50 · see citing works
Indirect projections from the suprachiasmatic nucleus to the median preoptic nucleus in rat
Deurveilher, S., & Semba, K. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03295-5 · Cited by 49 · see citing works
Suppressors, receptors and effects of cytokines on the aging mouse biological clock
Sadki, A., Bentivoglio, M., Kristensson, K., & Nygård, M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.007 · Cited by 49 · see citing works
Self-citation
Interferon-γ induced disruption of GABAergic inhibition in the spinal dorsal horn in vivo
Vikman, K. S., Duggan, A. W., & Siddall, P. J. (2007) · Pain · doi:10.1016/j.pain.2007.02.010 · Cited by 48 · see citing works
Sleep fragmentation, and changes in locomotor activity and body temperature in trypanosome-infected rats
Grassi-Zucconi, G., Harris, J. A., Mohammed, A. H., et al. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(94)00265-3 · Cited by 44 · see citing works
Sleep during Experimental Trypanosomiasis in Rabbits
Toth, L. A., Tolley, E. A., Broady, R. C., Blakely, B. W., & Krueger, J. M. (1994) · Experimental Biology and Medicine · doi:10.3181/00379727-205-43694 · Cited by 42 · see citing works
VASCULAR LESIONS IN RABBITS INFECTED WITH TRYPANOSOMA (TRYPANOZOON) BRUCEI
Goodwin, L. G., & HOOK, S. V. M. (1968) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1968.tb00451.x · Cited by 41 · see citing works
A link between chemokine levels and disease severity in human African trypanosomiasis
Courtioux, B., Boda, C., Vatunga, G., et al. (2006) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.04.011 · Cited by 41 · see citing works
Type I IFNs Play a Role in Early Resistance, but Subsequent Susceptibility, to the African Trypanosomes
Lopez, R., Demick, K. P., Mansfield, J. M., & Paulnock, D. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4908 · Cited by 40 · see citing works
Early major histocompatibility complex (MHC) class I antigen induction in hypothalamic supraoptic and paraventricular nuclei in trypanosome-infected rats
Schultzberg, M., Olsson, T. P., Samuelsson, E., et al. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90104-5 · Cited by 40 · see citing works
Chronic inflammation affects the photic response of the suprachiasmatic nucleus
Palomba, M. L., & Bentivoglio, M. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.09.002 · Cited by 37 · see citing works
Self-citation
Co-localization of hypocretin-1 and hypocretin-2 in the cat hypothalamus and brainstem
Zhang, J.-H., Sampogna, S. L., Morales, F. R., & Chase, M. H. (2002) · Peptides · doi:10.1016/s0196-9781(02)00084-0 · Cited by 37 · see citing works
Role of nitric oxide in sleep regulation: effects of l-NAME, an inhibitor of nitric oxide synthase, on sleep in rats
Monti, J. M., Hantos, H., Ponzoni, A., et al. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00131-4 · Cited by 36 · see citing works
Microglia activation in a model of sleep disorder: an immunohistochemical study in the rat brain during Trypanosoma brucei infection
Chianella, S., Semprevivo, M., Peng, Z.-C., Zaccheo, D., Bentivoglio, M., & Grassi-Zucconi, G. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01449-3 · Cited by 35 · see citing works
Self-citation
Participation of transcription factors from the Rel/NF-κB family in the circadian system in hamsters
Marpegán, L., Bekinschtein, T., Freudenthal, R., et al. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.112 · Cited by 35 · see citing works
Twenty-Four—Hour Disruption of the Sleep-Wake Cycle and Sleep-Onset REM-Like Episodes in a Rat Model of African Trypanosomiasis
Darsaud, A., Bourdon, L., Mercier, S., et al. (2004) · SLEEP · doi:10.1093/sleep/27.1.42 · Cited by 34 · see citing works
Differential Mechanisms Underlying the Modulation of Delayed-Rectifier K+Channel in Mouse Neocortical Neurons by Nitric Oxide
Han, N.-L. R., Ye, J., Yu, A. C. H., et al. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01185.2004 · Cited by 32 · see citing works
Pathology of African trypanosomiasis
Kristensson, K., & Bentivoglio, M. (1999) · Springer eBooks · doi:10.1007/978-2-8178-0857-4_9 · Cited by 31 · see citing works
Self-citation
Neural–immune interactions in disorders of sleep-wakefulness organization
Bentivoglio, M., & Kristensson, K. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.09.004 · Cited by 31 · see citing works
Self-citation
Rapid nitric oxide-dependent effects of tumor necrosis factor-&agr; on suprachiasmatic nuclei neuronal activity
Nygård, M., Lundkvist, G., Hill, R., & Kristensson, K. (2009) · NeuroReport · doi:10.1097/wnr.0b013e32831f1ca2 · Cited by 31 · see citing works
Self-citation
Twenty-Four-Hour Plasma Cortisol and Prolactin in Human African Trypanosomiasis Patients and Healthy African Controls
Radomski, M. W., Buguet, A., Montmayeur, A., et al. (1995) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1995.52.281 · Cited by 30 · see citing works
Hypocretin and Human African Trypanosomiasis
Dauvilliers, Y. A., Bisser, S., Chapotot, F., Vatunga, G., Cespuglio, R., Josenando, T., & Buguet, A. (2008) · SLEEP · doi:10.1093/sleep/31.3.348 · Cited by 30 · see citing works
A Screen for Secreted Factors of the Suprachiasmatic Nucleus
Kramer, A., Yang, F.-C., Kraves, S., & Weitz, C. J. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)93034-6 · Cited by 29 · see citing works
Trypanosomes cause dysregulation of c-fos expression in the rat suprachiasmatic nucleus
Bentivoglio, M., Grassi-Zucconi, G., Peng, Z. C., et al. (1994) · Neuroreport · doi:10.1097/00001756-199402000-00013 · Cited by 29 · see citing works
Self-citation
African trypanosomiasis in the rat alters melatonin secretion and melatonin receptor binding in the suprachiasmatic nucleus
Kristensson, K., Claustrat, B., Mhlanga, J., et al. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00084-7 · Cited by 29 · see citing works
Self-citation
Plasma Melatonin Rhythm is Maintained in Human African Trypanosomiasis
Claustrat, B., Buguet, A., Geoffriau, M., et al. (1998) · Neuroendocrinology · doi:10.1159/000054351 · Cited by 28 · see citing works
Is Sleeping Sickness a Orcadian Disorder? The Serotonergic Hypothesis
Buguet, A. (1999) · Chronobiology International · doi:10.3109/07420529908998722 · Cited by 28 · see citing works
Differential effects of tumor necrosis factor-alpha and -beta on rat ventromedial hypothalamic neurons in vitro
Katafuchi, T., Motomura, K., Baba, S., Ota, K., & Hori, T. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.6.r1966 · Cited by 28 · see citing works
Relationship of Plasma Growth Hormone to Slow-Wave Sleep in African Sleeping Sickness
Radomski, M. W., Buguet, A., Doua, F., et al. (2008) · Neuroendocrinology · doi:10.1159/000126980 · Cited by 27 · see citing works
Time-related changes in the sleep-wake cycle of rats infected with Trypanosoma brucei brucei
Montmayeur, A., & Buguet, A. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90443-x · Cited by 27 · see citing works
Differential Invasion of Trypanosoma brucei brucei and Lymphocytes into the Brain of C57BL/6 and 129Sv/Ev Mice
Masocha, W., Amin, D. N., Kristensson, K., et al. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02170.x · Cited by 26 · see citing works
Self-citation
Cachectin - Tumour necrosis factor: A cytokine that mediates injury initiated by invasive parasites
Beutler, B., & Cerami, A. (1987) · Parasitology Today · doi:10.1016/0169-4758(87)90119-0 · Cited by 26 · see citing works
Electrical Signaling in Central Orexin/Hypocretin Circuits: Tuning Arousal and Appetite to Fit the Environment
Burdakov, D. (2004) · The Neuroscientist · doi:10.1177/1073858404263597 · Cited by 26 · see citing works
Neurobiology of Cerebral Malaria and African Sleeping Sickness
Mhlanga, J., Bentivoglio, M., & Kristensson, K. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00309-2 · Cited by 25 · see citing works
Self-citation
Dysregulation of photic induction of Fos-related protein in the biological clock during experimental trypanosomiasis
Peng, Z., Kristensson, K., & Bentivoglio, M. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90217-8 · Cited by 24 · see citing works
Self-citation
Different effects of spinally applied prostaglandin D2 on responses of dorsal horn neurons with knee input in normal rats and in rats with acute knee inflammation
Telleria-Diaz, A., Ebersberger, A., Vásquez, E., et al. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.017 · Cited by 24 · see citing works
Reversal of the sleep/wake cycle disorder of sleeping sickness after trypanosomicide treatment
Buguet, A., Tapie, P., & Bert, J. (1999) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1999.00160.x · Cited by 24 · see citing works
The roles of prostanoids in infection and sickness behaviors
Matsuoka, T., & Narumiya, S. (2008) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-008-0622-3 · Cited by 21 · see citing works
Production of prostaglandins D2 and E2 by mouse fibroblasts and astrocytes in culture caused byTrypanosoma brucei brucei products and endotoxin
Alafiatayo, R., Cookson, M., & Pentreath, V. W. (1994) · Parasitology Research · doi:10.1007/bf00932678 · Cited by 21 · see citing works
The use of azathioprine to ameliorate post‐treatment encephalopathy associated with African trypanosomiasis
Hunter, C. A., Jennings, F. W., Kennedy, P. G. E., et al. (1992) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1992.tb00833.x · Cited by 20 · see citing works

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“…brucei, associated in humans with human African trypanosomiasis or ‘‘sleeping sickness’’, show reduced amplitude circadian activity rhythms, mirroring effects in humans infected with this parasite who show diurnal somnolence and nocturnal insomnia (Kristensson et al., 2010; Lundkvist et al., 2010).”

Authors: Kristensson, K., Nygård, M., Bertini, G., & Bentivoglio, M.
Affiliations: Karolinska Institutet (SE)
University of Verona (IT)
Corresponding author: Kristensson, Krister
ORCID: Bertini, Giuseppe
Bentivoglio, Marina
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2010-06
Volume: 91
Issue: 2
Pages: 152-171
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2009.12.001
OpenAlex: W2024288031
Cited by: 140
References: 208
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 10 · 2021: 6 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 13 · 2013: 17 · 2012: 13
FWCI: 6.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: Trypanosoma brucei, sleeping sickness, blood-brain barrier penetration, sleep-wake cycle disruption, sleep disorders, prostaglandin D2, inflammatory cytokines, chemokines, suprachiasmatic nucleus, circadian rhythm, synaptic function, dorsal root ganglia, choroid plexus, circumventricular organs
MeSH terms: Animals, Brain, Humans, Synaptic Transmission, Sleep, Sleep Wake Disorders, Trypanosomiasis, African, Central Nervous System Protozoal Infections

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African trypanosome infections of the nervous system: Parasite entry and effects on sleep and synaptic functions

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