Insular cortex volume and impulsivity in teenagers with first-presentation borderline personality disorder
Abstract
Fronto-limbic neural dysfunction has been implicated in the emotional dysregulation and impulsivity seen in borderline personality disorder (BPD). However, it remains unclear whether affected individuals exhibit morphologic changes of the insular cortex, a fronto-limbic integration cortex engaged in emotional regulation and impulse control. This magnetic resonance imaging study examined the insular cortex volume and its relationship to clinical characteristics in a first-presentation teenage BPD sample. No significant difference was found in the insular volume between 20 BPD participants (5 males) and 20 healthy control participants (5 males). There was no association between the insular volume and parasuicidal episodes, trauma exposure, or comorbid Axis I disorders, but the BPD participants with violent episodes during the previous 6 months had a smaller insular volume bilaterally compared with those without such episodes. Furthermore, right anterior insular volume in the BPD participants was negatively correlated with impulsivity score. These preliminary findings suggest that insular cortex volume does not significantly differ in early BPD, but that there might be a relationship with violent and impulsive behavior that is often seen in the disorder. Further studies are needed to clarify whether the potential relationship between the insular cortex volume and impulsivity is specific to BPD.
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Compared with healthy controls, self-injurers show reduced insula gray matter volume, but this is not substantiated in BPD youth reporting parasuicidal behaviors.
“In comparison to healthy controls, self-injurers show reduced insula GMV (62, 64), but this is not substantiated in BPD youth reporting parasuicidal behaviors (65).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [65]
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“Furthermore, given the heterogeneity of the disorder (Skodol et al., 2002a,b) and the fact that dysfunction of the insular cortex has not been consistently demonstrated in BPD (Lis et al., 2007), studies in BPD patients with pathologic impulsivity raise the possibility that decreased metabolism…”
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Neural correlates associated with suicide and nonsuicidal self-injury in youth
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- Authors
- Takahashi, T., Chanen, A. M., Wood, S. J., Yücel, M., Tanino, R., Suzuki, M., Velakoulis, D., Pantelis, C., & McGorry, P. D.
- Affiliations
- The University of Melbourne (AU)
- University of Toyama (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Takahashi, Tsutomu
- ORCID
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 33
- Issue
- 8
- Pages
- 1395-1400
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2052591023
- Cited by
- 36
- References
- 37
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 3 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- borderline personality disorder, impulsivity, adolescents, violent behavior, trauma exposure, emotional dysregulation, anterior insula
- MeSH terms
- Adolescent, Analysis of Variance, Borderline Personality Disorder, Brain Mapping, Cerebral Cortex, Female, Humans, Impulsive Behavior, Magnetic Resonance Imaging, Male, Statistics as Topic, Young Adult
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