Cited by 149Antioxidant Activity and Oxidative StressTreatment of Major DepressionTryptophan and brain disorders

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Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study

Kotan, Vahap Ozan, Sarandol, Emre, Kirhan, Emine, Ozkaya, Guven, Kirli, Selcuk·2011·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2011.03.021

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Abstract

Purpose Major depressive disorder (MDD) is a devastating disease that afflicts large populations and has also been accepted to be an independent risk factor for cardiovascular disease (CVD). Oxidative stress seems to play an essential role in the relationship of MDD and CVD. We aimed to determine the level of oxidative stress in patients with MDD and to investigate the effects of long-term antidepressant (AD) treatment on the oxidative-antioxidative system parameters and CVD risk factors.Method Fifty patients who fully met the fourth Diagnostic and Statistical Manual of Mental Disorders criteria for MDD and 44 healthy control subjects were included in the study. Control visits of the patients were repeated 6weeks, 12weeks and 24weeks after beginning of the AD treatment. Lipid profiles, oxidation and oxidizability of apolipoprotein B-containing lipoproteins (expressed as apo B-b-MDA and apo B-Δ-MDA, respectively), levels of plasma malondialdehyde (p-MDA), total antioxidative capacity (TAOC), antioxidant molecules and antioxidant enzyme activities including paraoxonase/arylesterase, red blood cell superoxide dismutase (RBC-SOD) and glutathione peroxidase were determined during 24-week of follow-up period.Results According to the results of the study, p-MDA, apo B-b-MDA and RBC-SOD activity were increased and arylesterase activity was decreased in MDD patients. Body mass index (BMI), vitamin A and total cholesterol levels in MDD patients increased after 24-weeks of AD treatment. RBC-SOD activity, TAOC, p-MDA and apo B-b-MDA levels were decreased; paraoxonase/arylesterase activities and apo B-Δ-MDA were increased at the end of 24th week.Conclusion Oxidative stress, demonstrated in MDD patients, was partly improved during 24weeks of AD treatment. Increase in paraoxonase/arylesterase activities and decrease in p-MDA and apo B-b-MDA levels after 24weeks seem to be beneficial for reduction of CVD risk in MDD patients. However increased BMI and apo B-Δ-MDA levels are negative cardiovascular effects of long-term AD treatment.

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Authors: Kotan, V. O., Sarandol, E., Kirhan, E., Ozkaya, G., & Kirli, S.
Corresponding author: Kotan, Vahap Ozan
ORCID: Kotan, Vahap Ozan
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2011-07
Volume: 35
Issue: 5
Pages: 1284-1290
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2011.03.021
OpenAlex: W2016056242
Cited by: 149
References: 53
Citations by year: 2026: 3 · 2025: 9 · 2024: 9 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 16 · 2019: 9 · 2018: 5 · 2017: 16 · 2016: 11 · 2015: 13 · 2014: 11 · 2013: 11 · 2012: 9
FWCI: 6.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Bursa Uludag University - AVESIS (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, antidepressant treatment, oxidative stress, malondialdehyde, apolipoprotein B, lipid peroxidation, superoxide dismutase, glutathione peroxidase, total antioxidant capacity, cardiovascular risk, body mass index, vitamin A, cholesterol
MeSH terms: Adult, Antidepressive Agents, Antioxidants, Apolipoproteins, Blood Cell Count, Carboxylic Ester Hydrolases, Cardiovascular Diseases, Major Depressive Disorder, Female, Follow-Up Studies, Hormones, Humans, Lipids, Liver Function Tests, Long-Term Care, Male, Malondialdehyde, Psychiatric Status Rating Scales, Risk Factors, Superoxide Dismutase, Body Mass Index, Oxidative Stress, Aryldialkylphosphatase, Young Adult

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Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study

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