Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment

Cumurcu, Birgul Elbozan; Ozyurt, Huseyin; Etikan, Ilker; Demir, Suleyman; Karlidag, Rifat

doi:10.1111/j.1440-1819.2009.02004.x

Cited by 165Treatment of Major DepressionAntioxidant Activity and Oxidative StressTryptophan and brain disorders

Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment

Cumurcu, Birgul Elbozan, Ozyurt, Huseyin, Etikan, Ilker, Demir, Suleyman, Karlidag, Rifat·2009·Psychiatry and Clinical Neurosciences

DOI 10.1111/j.1440-1819.2009.02004.x

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Abstract

Aim: The purpose of the present study was to investigate whether total antioxidant capacity (TAC) and total oxidant status (TOS) are associated with major depressive disorder (MDD) and to evaluate the impact of antidepressant treatment on TAC and TOS in MDD. Methods: Fifty‐seven MDD patients and 40 healthy controls participated in the study. Serum TAC and TOS were measured both in patients and controls using Erel's methods. Patients were treated with antidepressant drugs for 12 weeks. The treatment course was evaluated using the Montgomery–Asberg Depression Rating Scale (MADRS) in all patients. Results: TOS and oxidative stress index (OSI) were higher (P = 0.0001 for both) and TAC was lower (P = 0.0001) in the MDD group compared with those of the controls. After 3 months of antidepressant treatment, TOS and OSI were decreased and TAC was increased compared with the pretreatment values (P = 0.0001, for all). Furthermore, there were significant positive correlations between the severity of the disease and serum TOS and OSI (r = 0.584,P = 0.0001; r = 0.636,P = 0.0001, respectively). A negative correlation was found between the severity of the disease and serum TAC (r = −0.553,P = 0.0001) at the pre‐treatment stage. Conclusion: Treatment administered for 3 months to MDD patients increases TAC while decreasing TOS and OSI.

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Individuals with MDD display lower serum/plasmatic total antioxidant potentials than matched controls.
“Individuals who suffer with MDD display lower serum/plasmatic total antioxidant potentials [28, 32, 48] and reduced brain GSH levels [31] as compared to matched controls.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [32]
Cumurcu et al. (2009) found TOS and OSI were higher and TAC level was lower in the MDD group compared with controls (n = 40).
“TOS and OSI were higher and TAC level was lower in the MDD group compared with controls (n = 40).”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [32]
There was a positive correlation between the severity of the disease and serum TOS and OSI (r = 0.58, and r = 0.63, respectively) at the pretreatment stage.
“Furthermore, the authors found a positive correlation between the severity of the disease and serum TOS and OSI (r = 0.58, and r = 0.63, resp.).”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [32]
There was a negative correlation between the severity of the disease and serum TAC (r = −0.553) at the pretreatment stage.
“Also, a negative correlation was found between the severity of the disease and serum TAC (r = −0.553) at the pretreatment stage.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [32]
After 3 months of treatment with escitalopram, paroxetine, or sertraline, TOS and OSI were decreased and TAC was increased compared with pretreatment values.
“After 3 months of treatment with escitalopram, 10–20 mg/day, n = 10; paroxetine, 20–40 mg/day, n = 20; or sertraline, 50–100 mg/day, n = 27, TOS and OSI were decreased and TAC was increased compared with pretreatment values [32].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [32]

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Authors: Cumurcu, B. E., Ozyurt, H., Etikan, I., Demir, S., & Karlidag, R.
Venue: Psychiatry and Clinical Neurosciences
Publisher: Wiley
Published: 2009-09-23
Volume: 63
Issue: 5
Pages: 639-645
ISSN: 1323-1316 (ISSN-L)
1440-1819
DOI: 10.1111/j.1440-1819.2009.02004.x
OpenAlex: W1540420232
Cited by: 165
References: 29
Citations by year: 2026: 5 · 2025: 6 · 2024: 8 · 2023: 13 · 2022: 12 · 2021: 11 · 2020: 6 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 12 · 2014: 13 · 2013: 9 · 2012: 12
FWCI: 8.87
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Psychiatry and Clinical Neurosciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, total antioxidant capacity, total oxidant status, oxidative stress, antidepressant treatment, oxidative stress index, depression severity, serum antioxidants
MeSH terms: Adult, Major Depressive Disorder, Female, Humans, Male, Oxidation-Reduction, Severity of Illness Index, Time Factors, Case-Control Studies, Oxidants, Selective Serotonin Reuptake Inhibitors, Reactive Oxygen Species, Oxidative Stress

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Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment

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