The DOI matches its Crossref record; 51 of the 53 references it cites were found in a registry or an index.
Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study
Abstract
Purpose Major depressive disorder (MDD) is a devastating disease that afflicts large populations and has also been accepted to be an independent risk factor for cardiovascular disease (CVD). Oxidative stress seems to play an essential role in the relationship of MDD and CVD. We aimed to determine the level of oxidative stress in patients with MDD and to investigate the effects of long-term antidepressant (AD) treatment on the oxidative-antioxidative system parameters and CVD risk factors.Method Fifty patients who fully met the fourth Diagnostic and Statistical Manual of Mental Disorders criteria for MDD and 44 healthy control subjects were included in the study. Control visits of the patients were repeated 6weeks, 12weeks and 24weeks after beginning of the AD treatment. Lipid profiles, oxidation and oxidizability of apolipoprotein B-containing lipoproteins (expressed as apo B-b-MDA and apo B-Δ-MDA, respectively), levels of plasma malondialdehyde (p-MDA), total antioxidative capacity (TAOC), antioxidant molecules and antioxidant enzyme activities including paraoxonase/arylesterase, red blood cell superoxide dismutase (RBC-SOD) and glutathione peroxidase were determined during 24-week of follow-up period.Results According to the results of the study, p-MDA, apo B-b-MDA and RBC-SOD activity were increased and arylesterase activity was decreased in MDD patients. Body mass index (BMI), vitamin A and total cholesterol levels in MDD patients increased after 24-weeks of AD treatment. RBC-SOD activity, TAOC, p-MDA and apo B-b-MDA levels were decreased; paraoxonase/arylesterase activities and apo B-Δ-MDA were increased at the end of 24th week.Conclusion Oxidative stress, demonstrated in MDD patients, was partly improved during 24weeks of AD treatment. Increase in paraoxonase/arylesterase activities and decrease in p-MDA and apo B-b-MDA levels after 24weeks seem to be beneficial for reduction of CVD risk in MDD patients. However increased BMI and apo B-Δ-MDA levels are negative cardiovascular effects of long-term AD treatment.
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“However, TAC was also found decreased after 24-week treatment with antidepressants”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [33]
In the citing paper
“Plasmatic MDA, serum oxidized LDL (OxLDL) levels, and erythrocyte SOD activity were increased in MDD patients before treatment”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [33]
In the citing paper
“After 24-weeks of treatment, MDA and SOD levels decreased.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [33]
In the citing paper
“and MDA levels were positively correlated with the severity of MDD.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [33]
In the citing paper
“Patients on venlafaxine were also compared with patients on SSRIs in the aspect of oxidative stress parameters in the follow-up period, but no significant differences were found [33].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [33]
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Cited by
Sorted by citations
A Meta-analysis of oxidative stress markers in depression
Liu, T., Zhong, S., Liao, X., Chen, J., He, T., Lai, S., & Jia, Y. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138904 · Cited by 485
“Sensitivity analysis of serum TAC in the comparison of before and after the treatment (CBAT) was performed by removing two studies [34, 40], the heterogeneity was no longer significant, and the result remained unchanged.”
BackgroundMethodOxidative stress, inflammation and treatment response in major depression
Lindqvist, D., Dhabhar, F. S., James, S. J., Hough, C. M., Jain, F. A., Bersani, F. S., Reus, V. I., Verhoeven, J. E., Epel, E. S., Mahan, L., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.031 · Cited by 473
“…(GSSG), reduced glutathione (GSH), and antioxidants, GPx, and Vitamin C, have often produced negative results (Jimenez-Fernandez et al., 2015; Kotan et al., 2011; Sarandol et al., 2007), these biomarkers were not part of the a priori hypotheses, but were included in an exploratory analysis.”
BackgroundLopresti, A. L., Maker, G. L., Hood, S. D., & Drummond, P. D. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.017 · Cited by 371
“…and antioxidant defence biomarkers Malondialdehyde (MDA) – MDA concentrations in depressed patients are by-and-large increased compared to healthy control groups (Bilici et al., 2001, Galecki et al., 2009a, Khanzode et al., 2003, Kotan et al., 2011, Ozcan et al., 2004, Sarandol et al., 2007).”
BackgroundMethodInfluentialCzarny, P., Wigner, P., Galecki, P., & Sliwinski, T. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.036 · Cited by 310
“Enzymatic antioxidants including, inter alia, catalase (CAT), superoxide dismutase (SOD), peroxidase, reductase and S-transferase, are also found to have some abnormalities in the patients with DD [Gałecki et al. 2009, Kotan et al. 2011, Szebeni et al. 2014].”
BackgroundDepression and Oxidative Stress: Results From a Meta-Analysis of Observational Studies
Palta, P., Samuel, L. J., Miller, E. R., & Szanton, S. L. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000009 · Cited by 277
“Most studies included in this meta-analysis resulted in positive and significant effect estimates for the association between depression and oxidative stress (11Y18,20Y24,26Y28,30Y33), whereas a few did not (19,25,29).”
Metadata
- Authors
- Kotan, V. O., Sarandol, E., Kirhan, E., Ozkaya, G., & Kirli, S.
- Corresponding author
- Kotan, Vahap Ozan
- ORCID
- Kotan, Vahap Ozan
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 35
- Issue
- 5
- Pages
- 1284-1290
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2016056242
- Cited by
- 149
- References
- 53
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 16 · 2019: 9 · 2018: 5 · 2017: 16 · 2016: 11 · 2015: 13 · 2014: 11 · 2013: 11 · 2012: 9
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Bursa Uludag University - AVESIS (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, antidepressant treatment, oxidative stress, malondialdehyde, apolipoprotein B, lipid peroxidation, superoxide dismutase, glutathione peroxidase, total antioxidant capacity, cardiovascular risk, body mass index, vitamin A, cholesterol
- MeSH terms
- Adult, Antidepressive Agents, Antioxidants, Apolipoproteins, Blood Cell Count, Carboxylic Ester Hydrolases, Cardiovascular Diseases, Major Depressive Disorder, Female, Follow-Up Studies, Hormones, Humans, Lipids, Liver Function Tests, Long-Term Care, Male, Malondialdehyde, Psychiatric Status Rating Scales, Risk Factors, Superoxide Dismutase, Body Mass Index, Oxidative Stress, Aryldialkylphosphatase, Young Adult
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