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Adverse Effects of Psychotropic Medications on Sleep

Doghramji, Karl, Jangro, William C.·2016·Psychiatric Clinics of North America
DOI 10.1016/j.psc.2016.04.009
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Abstract

Psychotropic medications such as antidepressants, antipsychotics, stimulants, and benzodiazepines are widely prescribed. Most of these medications are thought to exert their effects through modulation of various monoamines as well as interactions with receptors such as histamine and muscarinic cholinergic receptors. Through these interactions, psychotropics can also have a significant impact on sleep physiology, resulting in both beneficial and adverse effects on sleep.

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  • According to the FDA clinical trial register, the rate of treatment-emergent insomnia complaints or somnolence during vortioxetine therapy is lower than with SSRI and SNRI drugs.

    “According to the FDA clinical trial register, the rate of treatment-emergent insomnia complaints or somnolence during the therapy with vortioxetine is lower when compared to SSRI and SNRI drugs [17 ·· ].”

    From Effects of Antidepressants on Sleep (2017) · cites this paper as [17]

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Metadata

Authors
Doghramji, K., & Jangro, W. C.
Affiliations
Thomas Jefferson University (US)
Corresponding author
Doghramji, Karl
ORCID
Doghramji, Karl
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
2016-09
Volume
39
Issue
3
Pages
487-502
ISSN
0193-953X (ISSN-L)
DOI
10.1016/j.psc.2016.04.009
OpenAlex
W2471693769
Cited by
69
References
2
Citations by year
2026: 4 · 2025: 11 · 2024: 7 · 2023: 11 · 2022: 6 · 2021: 14 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 1
FWCI
0.34
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
psychotropic drugs, sleep, adverse drug reactions, antidepressants, antipsychotic drugs, stimulants, benzodiazepines, monoamines, histamine receptors, muscarinic receptors, sleep physiology
MeSH terms
Humans, Psychotropic Drugs, Sleep Wake Disorders

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