Cited by 273Mindfulness and Compassion InterventionsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and Applications

The DOI matches its Crossref record; 93 of the 101 references it cites were found in a registry or an index; 15 of the 54 sources its claims cite were checked for support.

Acceptance and Commitment Therapy as a Treatment for Anxiety and Depression

Open access
Twohig, Michael P., Levin, Michael E.·2017·Psychiatric Clinics of North America

Abstract

Acceptance and commitment therapy (ACT) is a modern form of cognitive behavioral therapy based on a distinct philosophy and basic science of cognition. This article reviews the core features of ACT's theoretic model of psychopathology and treatment and its therapeutic approach. It provides a systematic review of randomized controlled trials (RCTs) evaluating ACT for depression and anxiety disorders. Summarizing 36 RCTs, ACT appears to be more efficacious than waitlist conditions and treatment-as-usual, with largely equivalent effects relative to traditional cognitive behavioral therapy. Evidence indicates that ACT treatment outcomes are mediated through increases in psychological flexibility, its theorized process of change. © 2017

Overview

AI snapshot

Written from the paper’s full text.

TL;DR

This review outlines acceptance and commitment therapy’s theoretical foundations and systematically examines randomized trials for anxiety and depression. Across 36 trials, ACT generally outperformed waitlist and treatment-as-usual conditions and was largely comparable to traditional cognitive behavioral therapy, with psychological flexibility often acting as a mediator.

Key findings

  • Across 36 randomized controlled trials, ACT was more effective than waitlist and treatment-as-usual for anxiety and depression, and largely equivalent to traditional cognitive behavioral therapy.
  • For depression, all 7 waitlist comparisons favored ACT up to 6-month follow-up (Cohen’s d = .32–1.18); 4 of 5 treatment-as-usual comparisons favored ACT up to 18 months (d = .38–1.45); among 5 CT/CBT comparisons, 4 of 5 found equivalent post-treatment effects, with mixed follow-up results.
  • Anxiety findings included panic disorder (between-group d = .72 for panic, d = .89 for general functioning; 70% response at post-treatment and 80% at 6-month follow-up), GAD (ABBT vs waitlist d = 1.02; 76% vs 16% no longer meeting GAD criteria at post), and mixed anxiety, social anxiety, OCD, and health anxiety trials showing generally positive outcomes.
  • Process analyses in several trials indicated that increases in psychological flexibility mediated ACT outcomes; for depression, 12 of 17 trials examined processes, and formal mediation supported psychological flexibility in three waitlist comparisons and cognitive defusion in one ACT-vs-CT comparison.

Methods

  • Narrative/systematic review of published randomized controlled trials of ACT for anxiety disorders and depression, alongside a conceptual review of contextual behavioral science, functional contextualism, relational frame theory, and the psychological flexibility model.
  • The abstract reports 36 RCTs total; tables organize trials by anxiety disorder and depression, including comparison conditions such as waitlist, treatment-as-usual, minimal/placebo conditions, and CT/CBT, as well as individual, group, self-help, online, and workshop formats.
  • Main analysis is qualitative synthesis of between-group effect sizes, response and recovery rates, quality-of-life outcomes, and mediation/process findings; no pooled meta-analytic effect estimate is reported.

Limitations

  • The paper states that many trials have small samples, that research is limited for panic disorder, health anxiety, and specific phobias, and that it remains unclear which clients benefit more from ACT versus traditional CBT or how to match treatments.
  • The paper states that ACT’s comparison with CBT for depression is unclear because of the number of trials and small samples, and that follow-up findings are mixed; it also notes inconsistent differential effects on psychological inflexibility relative to CT/CBT.
  • Evident from the text: this is a narrative review rather than a meta-analysis, effect sizes are not pooled, included studies vary in protocols, comparators, and outcome measures, and five depression RCTs were excluded because they were not available in English, which may limit generalizability.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1016/j.psc.2017.08.009

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Verification

Claims the paper makes

15 of 54 cited sources checked · 9 supported · 1 flagged · accuracy not yet measured

Show all 58 claims

  • It may state two separate claims as one. 36
  • Probably not a substantial claim. 12
45 of 45
  • The paper relies on this without support.

    Psychological inflexibility is a core concern in mixed anxiety disorders.

    “ACT has always been a unified treatment protocol for issues where psychological inflexibility is a core concern.”
  • The paper relies on this without support.

    Most primary outcome measures used in ACT treatment outcome work mix changes to internal events and overt actions.

    “However, most primary outcome measures used in treatment outcome work have a mix of changes to internal events and overt actions.”
  • The paper relies on this without support.

    The six processes of change in ACT all work together.

    “Psychological flexibility is made up of six processes of change that all work together.”
  • The paper relies on this without support.

    ACT is a unified treatment protocol.

    “As ACT is a unified treatment protocol and there is a growing number of trials testing ACT across anxiety and depression issues.”
4 of 4

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • The same trial has two sample sizes

    Minor

    The anxiety and depression tables describe the Forman et al. (2007) ACT comparison with different sample sizes: 101 and 132 participants.

  • A CBT comparison is cited as a waitlist trial

    Minor

    The social anxiety summary places reference 44 among waitlist comparisons, but reference 44 describes a trial comparing CBT with ACT.

2 of 2

Citations

Cites

Flagged first, then by citations

Show all 101 references

8 of the 101 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. Baghooli, 2014, Effectiveness of acceptance and commitment therapy in reduction of severity symptoms of patients with obsessive–compulsive disorder, Adv Environ Biol, 8, 2519
  2. Vakili, 2014, The comparison of acceptance and commitment therapy with selective serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder, Zahedan Journal of Research in Medical Sciences, 16, 10

Cited by

Sorted by citations

Items 101–200 of 273

Metadata

Authors
Twohig, M. P., & Levin, M. E.
Affiliations
Utah State University (US)
Corresponding author
Twohig, Michael P.
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
2017-12
Volume
40
Issue
4
Pages
751-770
ISSN
0193-953X (ISSN-L)
OpenAlex
W2725508837
Cited by
268
References
101
Citations by year
2026: 28 · 2025: 33 · 2024: 37 · 2023: 33 · 2022: 42 · 2021: 39 · 2020: 27 · 2019: 20 · 2018: 8 · 2017: 1
FWCI
2.34
Type
journal article
Language
en
Open access
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Commons - USU (Utah State University) (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords
acceptance and commitment therapy, anxiety disorders, depression, psychological flexibility, cognitive behavioral therapy, change processes, treatment efficacy, psychopathology models
MeSH terms
Anxiety Disorders, Depressive Disorder, Humans, Acceptance and Commitment Therapy

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