CoChat
Sign Up
Cited by 191Posttraumatic Stress Disorder ResearchChild Abuse and TraumaIntimate Partner and Family Violence

Functional Activation and Neural Networks in Women with Posttraumatic Stress Disorder Related to Intimate Partner Violence

Open access
Simmons, Alan N., Paulus, Martin P., Thorp, Steven R., Matthews, Scott C., Norman, Sonya B., Stein, Murray B.·2008·Biological Psychiatry
DOI 10.1016/j.biopsych.2008.05.027PMC PMC2634744
Open this paper in CoChat — free account

Abstract

Background Intimate partner violence (IPV) is one of the most common causes of posttraumatic stress disorder (PTSD) in women. Victims of IPV are often preoccupied by the anticipation of impending harm. This investigation tested the hypothesis that IPV-related PTSD individuals show exaggerated insula reactivity to the anticipation of aversive stimuli.Methods Fifteen women with a history of IPV and consequent PTSD (IPV-PTSD) and 15 non-traumatized control (NTC) women performed a task involving cued anticipation to images of positive and negative events during functional magnetic resonance imaging.Results Both groups showed increased activation of bilateral anterior insula during anticipation of negative images minus anticipation of positive images. Activation in right anterior/middle insula was significantly greater in the IPV-PTSD relative to the NTC group. Functional connectivity analysis revealed that changes in activation in right middle insula and bilateral anterior insula were more strongly associated with amygdala activation changes in NTC than in IPV-PTSD subjects.Conclusions This study revealed increased activation in the anterior/middle insula during negative anticipation in women with IPV-related PTSD. These findings in women with IPV could be a consequence of the IPV exposure, reflect pre-existing differences in insular function, or be due to the development of PTSD. Thus, future longitudinal studies need to examine these possibilities.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2008.05.027

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The insula is responsible for interoception, disgust, emotion processing, emotion recall and anticipation of aversive stimuli.

    “an area responsible for interoception,20 disgust,21 emotion processing,22 emotion recall9 and anticipation of aversive stimuli.19”

    From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [19]

  • Functional MRI studies of individuals with PTSD have demonstrated aberrant activity in the insula.

    “Functional MRI studies of individuals with PTSD have also demonstrated aberrant activity in the insula”

    From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [19]

  • Most studies have found diminished strength of connectivity in individuals with PTSD compared with controls, regardless of the direction of connectivity identified.

    “regardless of the direction of the connectivity identified (positive connectivity v. anticorrelation), most studies have found diminished strength of connectivity in individuals with PTSD compared with controls.2,16,18,19”

    From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [19]

  • Recent fMRI studies have reported greater insula activation in anticipation of negative images and negative emotional faces in individuals with PTSD as well as enhanced coupling between the insula and amygdala during negative emotion induction in healthy volunteers and during symptom provocation in recently traumatized individuals.

    “Recent fMRI studies have reported greater insula activation in anticipation of negative images19 and negative emotional faces18 in individuals with PTSD as well as enhanced coupling between the insula and amygdala during negative emotion induction in healthy volunteers26 and during symptom provocation in recently traumatized individuals.16”

    From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [19]

  • Insula responsivity to negative images in individuals with PTSD has been shown to be positively correlated with hyperarousal symptoms, re-experiencing symptoms and flashback intensity.

    “Indeed, insula responsivity to negative images in individuals with PTSD has previously been shown to be positively correlated with hyperarousal symptoms,19 re-experiencing symptoms63 and flashback intensity.64”

    From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [19]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Simmons, A. N., Paulus, M. P., Thorp, S. R., Matthews, S. C., Norman, S. B., & Stein, M. B.
Affiliations
University of California San Diego (US)
Corresponding author
Simmons, Alan N.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2008-10
Volume
64
Issue
8
Pages
681-690
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2008.05.027
PMC
PMC2634744
OpenAlex
W1971041158
Cited by
191
References
86
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 7 · 2020: 11 · 2019: 18 · 2018: 9 · 2017: 14 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 18 · 2012: 18
FWCI
11.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (MH64122, MH65413)
  • U.S. Department of Veterans Affairs
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Health › Intimate Partner and Family Violence
Keywords
post-traumatic stress disorder, intimate partner violence, women, anterior insula, amygdala, functional connectivity, artificial neural networks, threat anticipation
MeSH terms
Adult, Amygdala, Arousal, Brain Mapping, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Mental Processes, Middle Aged, Neural Pathways, Reference Values, Spouse Abuse, Stress Disorders, Post-Traumatic, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review