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Cited by 103Posttraumatic Stress Disorder ResearchMemory Processes and InfluencesMemory and Neural Mechanisms

Increased anterior cingulate cortex and hippocampus activation in Complex PTSD during encoding of negative words

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Thomaes, Kathleen, Dorrepaal, Ethy, Draijer, Nel, de Ruiter, Michiel B., Elzinga, Bernet M., Sjoerds, Zsuzsika, van Balkom, Anton J., Smit, Johannes H. +1 more·2013·Social Cognitive and Affective Neuroscience
DOI 10.1093/scan/nsr084PMC PMC3575721
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Abstract

Post-traumatic stress disorder (PTSD) is associated with impaired memory performance coupled with functional changes in brain areas involved in declarative memory and emotion regulation. It is not yet clear how symptom severity and comorbidity affect neurocognitive functioning in PTSD. We performed a functional magnetic resonance imaging (fMRI) study with an emotional declarative memory task in 28 Complex PTSD patients with comorbid depressive and personality disorders, and 21 healthy non-trauma-exposed controls. In Complex PTSD patients--compared to controls--encoding of later remembered negative words vs baseline was associated with increased blood oxygenation level dependent (BOLD) response in the left ventral anterior cingulate cortex (ACC) and dorsal ACC extending to the dorsomedial prefrontal cortex (dmPFC) together with a trend for increased left hippocampus activation. Patients tended to commit more False Alarms to negative words compared to controls, which was associated with enhanced left ventrolateral prefrontal and orbitofrontal cortex (vlPFC/OFC) responses. Severity of child abuse was positively correlated with left ventral ACC activity and severity of depression with (para) hippocampal and ventral ACC activity. Presented results demonstrate functional abnormalities in Complex PTSD in the frontolimbic brain circuit also implicated in fear conditioning models, but generally in the opposite direction, which may be explained by severity of the trauma and severity of comorbid depression in Complex PTSD.

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  • In cPTSD there is evidence of heightened dorsolateral and ventromedial PfC and anterior cingulate activation in reaction to negatively valenced emotional stimuli.

    “in cPTSD there is evidence of heightened dorsolateral and ventromedial PfC and anterior cingulate activation in reaction to negatively valenced emotional stimuli [71, 168].”

    From Complex PTSD and borderline personality disorder (2021) · cites this paper as [168]

    The Conclusion (Fig. 1 and Table 2; page not provided) reports heightened ventral and dorsal anterior cingulate activation extending to the dorsomedial prefrontal cortex during encoding of negative words in Complex PTSD patients versus controls. It does not report heightened dorsolateral or ventromedial prefrontal activation; the additional prefrontal finding is ventrolateral activation during false alarms to negative words. (LLM, conf=0.88)

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Research works printed but not linked: 3

  1. APA. (2000). Diagnostic and Statistical Manual of Mental Disorders IV -Text Revision (DSM-IV-TR). Washington DC: American Psychiatric Press Incorporated.
  2. First, M.B., Spitzer, R.L., Williams, J.B.W., Gibbon, M. (1995). Structured Clinical Interview for DSM-IV diagnoses (SCID-I). Washington DC: American Psychiatric Press Incorporated.
  3. Hovens, J.E., van der Ploeg, H.M., Klaarenbeek, M.T., Bramsen, I., Schreuder, J.N., Rivero, V.V. (1994). The assessment of posttraumatic stress disorder: with the Clinician Administered PTSD Scale: Dutch re- sults. Journal of Clinical Psychology, 50, 325-40.

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Authors
Thomaes, K., Dorrepaal, E., Draijer, N., de Ruiter, M. B., Elzinga, B. M., Sjoerds, Z., van Balkom, A. J., Smit, J. H., & Veltman, D. J.
Affiliations
  • Leiden University (NL)
  • Department of Psychiatry, GGZ InGeest/VU University Medical Center, Amsterdam, 2Neuroscience Campus, VU, Amsterdam, 3AMC Academic Psychiatric Center, AIAR, Amsterdam, and 4Department of Clinical and Health Psychology, Leiden University, The Netherlands
ORCID
Venue
Social Cognitive and Affective Neuroscience
Publisher
Oxford University Press (OUP)
Published
2011-12-07
Volume
8
Issue
2
Pages
190-200
ISSN
  • 1749-5016 (ISSN-L)
  • 1749-5024
DOI
10.1093/scan/nsr084
PMC
PMC3575721
OpenAlex
W2137560959
Cited by
103
References
82
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 11 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 9 · 2013: 9 · 2012: 8
FWCI
8.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • VU Research Portal (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
complex PTSD, anterior cingulate cortex, hippocampus, negative words, comorbid depression, personality disorders, child abuse, false alarm errors, dorsomedial prefrontal cortex, orbitofrontal cortex, fear conditioning, injury severity
MeSH terms
Adult, Child, Child Abuse, Depressive Disorder, Female, Gyrus Cinguli, Hippocampus, Humans, Magnetic Resonance Imaging, Memory, Personality Disorders, Psychiatric Status Rating Scales, Psycholinguistics, Stress Disorders, Post-Traumatic, Comorbidity, Recognition, Psychology

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