Abnormalities in functional connectivity in borderline personality disorder: Correlations with metacognition and emotion dysregulation
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A few studies reported functional abnormalities at rest in borderline personality disorder (BPD), but their relationship with clinical aspect is unclear. We aimed to assess functional connectivity (FC) in BPD patients and its association with BPD clinical features. Twenty-one BPD patients and 14 healthy controls (HC) underwent a multidimensional assessment and resting-state fMRI. Independent component analysis was performed to identify three resting-state networks: default mode network (DMN), salience network (SN), and executive control network (ECN). FC differences between BPD and HC were assessed with voxel-wise two-sample t-tests. Additionally, we investigated the mean FC within each network and the relationship between connectivity measures and BPD clinical features. Patients showed significant lower mean FC in the DMN and SN, while, at the local level, a cluster of lower functional connectivity emerged in the posterior cingulate cortex of the DMN. The DMN connectivity was positively correlated with the anger-state intensity and expression, while the SN connectivity was positively correlated with metacognitive abilities and a negative correlation emerged with the interpersonal aggression. The dysfunctional connectivity within these networks might explain clinical features of BPD patients.
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Another case-control study with 21 BPD patients and 14 healthy controls found evidence among the BPD cohort of lower functional connectivity within the brain's Salience Network and the Default Mode Network.
“Another case-control study with 21 BPD patients and 14 healthy controls [137] found evidence among the BPD cohort of lower functional connectivity within the brain’s Salience Network (i.e., the limbic stress reactivity and PfC executive function sites) and the Default Mode Network (DMN) (i.e., midline sites from front to back of the brain that are involved in self-referential processing).”
From Complex PTSD and borderline personality disorder (2021) · cites this paper as [137]
Reduced connectivity in the DMN was associated with heightened levels of anger and its interpersonal expression.
“Reduced connectivity in the DMN was associated with heightened levels of anger and its interpersonal expression.”
From Complex PTSD and borderline personality disorder (2021) · cites this paper as [137]
Reduced connectivity in the salience network was associated with impairment in higher order cognitive abilities and in the ability to inhibit interpersonal aggression.
“Reduced connectivity in the salience network was associated with impairment in higher order cognitive abilities and in the ability to inhibit interpersonal aggression.”
From Complex PTSD and borderline personality disorder (2021) · cites this paper as [137]
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Complex PTSD and borderline personality disorder
Ford, J. D., & Courtois, C. A. (2021) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-021-00155-9 · Cited by 209 · see citing works
“Another case-control study with 21 BPD patients and 14 healthy controls [137] found evidence among the BPD cohort of lower functional connectivity within the brain’s Salience Network (i.”
Background
- Authors
- Quattrini, G., Pini, L., Pievani, M., Magni, L. R., Lanfredi, M., Ferrari, C., Boccardi, M., Bignotti, S., Magnaldi, S., Cobelli, M., Rillosi, L., Beneduce, R., Rossi, G., Frisoni, G. B., & Rossi, R.
- Affiliations
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- University of Geneva (CH)
- Fondazione Poliambulanza Istituto Ospedaliero (IT)
- Corresponding author
- Rossi, Roberta
- ORCID
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 283
- Pages
- 118-124
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2906465404
- Cited by
- 48
- References
- 59
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 11 · 2020: 4 · 2019: 6
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Italian Ministry of Health (GR-2011-02351347)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- borderline personality disorder, functional connectivity, resting-state networks, default mode network, salience network, frontoparietal network, metacognition, emotional dysregulation, anger, interpersonal aggression, posterior cingulate cortex, independent component analysis
- MeSH terms
- Metacognition, Adult, Affective Symptoms, Borderline Personality Disorder, Brain, Brain Mapping, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Case-Control Studies
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