Orbitofrontal cortex and impulsivity in borderline personality disorder: an MRI study of baseline brain perfusion
Abstract
Behavioral and neuroimaging studies in patients with borderline personality disorder (BPD) have associated orbitofrontal cortex (OFC) dysfunction with distinct symptom clusters such as impulsivity. It is unclear, however, whether abnormal patterns of OFC activity are also present during resting-state conditions and whether OFC dysfunction is specifically associated with impulsivity in BPD. This study tested the hypothesis that BPD patients would exhibit changes of OFC baseline perfusion and explored the relationship between regional cerebral blood flow and distinct BPD symptom clusters, such as impulsivity, dissociation tension and depressive symptoms. Using continuous arterial spin labeling magnetic resonance imaging at 3 Tesla, we investigated 16 women with BPD according to DSM-IV criteria and 16 healthy female control participants during resting-state conditions. Between-group comparisons were conducted using an analysis of variance (p < 0.05 cluster corrected). Compared to controls, BPD patients exhibited decreased blood flow in the medial OFC, whereas increased blood flow was found in the left and right lateral OFC. Correlation analyses revealed a positive relationship between medial and lateral orbitofrontal blood flow and impulsivity scores, whereas measures of dissociation tension and depression did not exhibit a significant correlation with OFC perfusion. These data suggest that dysfunction of medial and lateral regions of the OFC could specifically mediate symptoms of impulsivity in BPD.
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Wolf et al. (2012) found that compared to healthy controls, BPD patients exhibited decreased blood flow in the medial OFC and increased blood flow in the lateral OFC bilaterally, with no significant correlation with self-reported dissociation (DSS); instead, medial and lateral OFC blood flow was positively correlated with impulsivity.
“Compared to HCs, patients exhibited decreased blow flow in the medial OFC, while increased blood flow was found in the lateral OFC bilaterally. Like in the study by Sar and colleagues [132], no significant correlation with self-reported dissociation (DSS) was observed. Instead, medial and lateral OFC blood flow was positively correlated with impulsivity, as measured with the Barratt impulsiveness”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [133]
Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
The control of the false discovery rate in multiple testing under dependency
Benjamini, Y., & Yekutieli, D. (2001) · The Annals of Statistics · doi:10.1214/aos/1013699998 · Cited by 10,490 · see citing works
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070 · cited 1× · see citing works
“It is possible that the positive relationship between medial OFC blood flow and attentional impulsivity could be related to different levels of arousal [56] or that it may signify decreased levels of intrinsic alertness [57] in BPD compared to healthy controls.”
BackgroundForman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202 · see citing works
Separate neural systems value immediate and delayed monetary rewards
McClure, S. M., Laibson, D. I., Loewenstein, G., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1100907 · Cited by 3,089 · see citing works
KRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977 · see citing works
Borderline personality disorder
Lieb, K., Zanarini, M. C., Schmahl, C., Linehan, M. M., & Bohus, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16770-6 · Cited by 1,369 · see citing works
The functions of the orbitofrontal cortex
Rolls, E. T. (2004) · Brain and Cognition · doi:10.1016/s0278-2626(03)00277-x · Cited by 1,327 · see citing works
Elliott, R. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.308 · Cited by 887 · see citing works
A Model for the Coupling between Cerebral Blood Flow and Oxygen Metabolism during Neural Stimulation
Buxton, R. B., & Frank, L. R. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199701000-00009 · Cited by 808 · see citing works
The borderline diagnosis I: psychopathology, comorbidity, and personaltity structure
Skodol, A. E., Gunderson, J. G., Pfohl, B., Widiger, T. A., Livesley, W. J., & Siever, L. J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01324-0 · Cited by 769 · cited 1× · see citing works
“However, most BPD patients have an additional axis I disorder such as depression [65, 66], and thus, fully excluding participants with a co-ocurrent axis I disorder may reduce generalizability to the larger BPD population.”
BackgroundRolls, E. T. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0128 · Cited by 755 · see citing works
Bohus, M., Kleindienst, N., Limberger, M. F., Stieglitz, R., Domsalla, M., Chapman, A. L., Steil, R., Philipsen, A., & Wolf‐Arehult, M. (2008) · Psychopathology · doi:10.1159/000173701 · Cited by 738 · see citing works
Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making
Clark, L., Bechara, A., Damasio, H., Aitken, M. R. F., Sahakian, B. J., & Robbins, T. W. (2008) · Brain · doi:10.1093/brain/awn066 · Cited by 613 · see citing works
Berlin, H. A. (2004) · Brain · doi:10.1093/brain/awh135 · Cited by 541 · see citing works
Evidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study
Herpertz, S. C., Dietrich, T., Wenning, B., Krings, T., Erberich, S. G., Willmes, K., Thron, A. K., & Saß, H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01075-7 · Cited by 503 · see citing works
Silbersweig, D., Clarkin, J. F., Goldstein, M., Kernberg, O. F., Tuescher, O., Levy, K. N., Brendel, G., Pan, H., Beutel, M., Pavony, M. T., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06010126 · Cited by 411 · cited 2× · see citing works
“roimaging studies in BPD have revealed abnormalities of OFC volume [13, 14], metabolism [15, 16] and activation [2, 4, 5, 17].”
BackgroundResultPRICE, J. L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.008 · Cited by 395 · see citing works
Canli, T., Omura, K., Haas, B. W., Fallgatter, A. J., Constable, R. T., & Lesch, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503880102 · Cited by 353 · see citing works
Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques
Petersen, E. T., Zimine, I., Ho, Y.-C. L., & Golay, X. (2006) · British Journal of Radiology · doi:10.1259/bjr/67705974 · Cited by 351 · see citing works
Frontolimbic brain abnormalities in patients with borderline personality disorder
van Elst, L. T., Heßlinger, B., Thiel, T., Geiger, E. V., Haegele, K., Lemieux, L., Lieb, K., Bohus, M., Hennig, J., & Ebert, D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01743-2 · Cited by 349 · see citing works
Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex
Noonan, M. P., Walton, M. E., Behrens, T. E. J., Sallet, J., Buckley, M. J., & Rushworth, M. F. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012246107 · Cited by 340 · see citing works
Neural Correlates of Antinociception in Borderline Personality Disorder
Schmahl, C. G., Bohus, M., Esposito, F., Treede, R., Salle, F. D., Greffrath, W., Ludäscher, P., Jochims, A., Lieb, K., Scheffler, K., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.6.659 · Cited by 300 · see citing works
Technical aspects and utility of fMRI using BOLD and ASL
Detre, J. A., & Wang, J. (2002) · Clinical Neurophysiology · doi:10.1016/s1388-2457(02)00038-x · Cited by 291 · see citing works
Amygdala–Prefrontal Disconnection in Borderline Personality Disorder
New, A. S., Hazlett, E. A., Buchsbaum, M. S., Goodman, M. S., Mitelman, S. A., Newmark, R. E., Trisdorfer, R., Haznedar, M. M., Koenigsberg, H. W., Flory, J. D., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301283 · Cited by 282 · see citing works
Epidemiologic and clinical updates on impulse control disorders: a critical review
Dell’Osso, B., Altamura, A. C., Allen, A., Marazziti, D., & Hollander, E. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-0668-0 · Cited by 272 · see citing works
Wang, J., Zhang, Y., Wolf, R. L., Roc, A. C., Alsop, D. C., & Detre, J. A. (2005) · Radiology · doi:10.1148/radiol.2351031663 · Cited by 271 · see citing works
Self-citationNeuronal correlates of cognitive reappraisal in borderline patients with affective instability
Schulze, L., Domes, G., Krüger, A., Berger, C., Fleischer, M., Prehn, K., Schmahl, C., Grossmann, A., Hauenstein, K., & Herpertz, S. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.025 · Cited by 266 · cited 2× · see citing works
“roimaging studies in BPD have revealed abnormalities of OFC volume [13, 14], metabolism [15, 16] and activation [2, 4, 5, 17].”
BackgroundResultLanius, R. A., Williamson, P. C., Bluhm, R. L., Densmore, M., Boksman, K., Neufeld, R. W. J., Gati, J. S., & Menon, R. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.011 · Cited by 260 · see citing works
A voxel‐based morphometry study of frontal gray matter correlates of impulsivity
Matsuo, K., Nicoletti, M., Nemoto, K., Hatch, J. P., Peluso, M. A. M., Nery, F. G., & Soares, J. C. (2008) · Human Brain Mapping · doi:10.1002/hbm.20588 · Cited by 253 · see citing works
Impulsivity and prefrontal hypometabolism in borderline personality disorder
Soloff, P. H., MELTZER, C. C., Becker, C. R., Greer, P. J., Kelly, T. M., & Constantine, D. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00064-7 · Cited by 248 · see citing works
Borderline Personality Disorder, Impulsivity, and the Orbitofrontal Cortex
Berlin, H. A., Rolls, E. T., & Iversen, S. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.12.2360 · Cited by 242 · see citing works
Test–retest reliability of arterial spin labeling with common labeling strategies
Chen, Y., Wang, D. J. J., & Detre, J. A. (2011) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22345 · Cited by 238 · see citing works
The Latest Neuroimaging Findings in Borderline Personality Disorder
Mauchnik, J., & Schmahl, C. G. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-009-0089-7 · Cited by 229 · see citing works
Neuroimaging in borderline personality disorder
Schmahl, C. G., & Bremner, J. D. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.08.011 · Cited by 194 · see citing works
Structural brain abnormalities in borderline personality disorder: a voxel-based morphometry study
Soloff, P., Nutche, J., Goradia, D., & Diwadkar, V. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2008.02.003 · Cited by 177 · see citing works
Neuropsychological assessment of the orbital and ventromedial prefrontal cortex
Zald, D. H., & Andreotti, C. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.08.012 · Cited by 174 · see citing works
Asllani, I., Habeck, C., Scarmeas, N., Borogovac, A., Brown, T. R., & Stern, Y. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600570 · Cited by 172 · see citing works
Schnell, K., & Herpertz, S. C. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.08.011 · Cited by 166 · see citing works
Positron emission tomography in female patients with Borderline personality disorder
Juengling, F. D., Schmahl, C. G., Heßlinger, B., Ebert, D., Bremner, J. D., Gostomzyk, J., Bohus, M., & Lieb, K. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00084-5 · Cited by 142 · see citing works
A brain MRI study in subjects with borderline personality disorder
Lyoo, I. K., Han, M. H., & Cho, D. Y. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00104-9 · Cited by 136 · see citing works
Ludäscher, P., Valerius, G., Stiglmayr, C., Mauchnik, J., Lanius, R. A., Bohus, M., & Schmahl, C. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.090022 · Cited by 131 · see citing works
Aberrant connectivity of resting-state networks in borderline personality disorder
Wolf, R. C., Sambataro, F., Vasic, N., Schmid, M., Thomann, P. A., Bienentreu, S. D., & Wolf, N. D. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100150 · Cited by 130 · see citing works
Self-citationNeuroimaging and genetics of borderline personality disorder: a review
Lis, E., Greenfield, B. J., Henry, M., Guilé, J. M., & Dougherty, G. E. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0716 · Cited by 129 · see citing works
Floyd, T. F., Ratcliffe, S. J., Wang, J., Resch, B., & Detre, J. A. (2003) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10416 · Cited by 126 · see citing works
Potentials and Challenges for Arterial Spin Labeling in Pharmacological Magnetic Resonance Imaging
Wang, D. J. J., Chen, Y., Fernández‐Seara, M. A., & Detre, J. A. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.172577 · Cited by 105 · see citing works
Völlm, B., Richardson, P., McKie, S., Elliott, R., Dolan, M., & Deakin, B. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.04.008 · Cited by 92 · cited 2× · see citing works
“roimaging studies in BPD have revealed abnormalities of OFC volume [13, 14], metabolism [15, 16] and activation [2, 4, 5, 17].”
BackgroundResultMedial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder
Ruocco, A. C., Medaglia, J. D., Tinker, J. R., Ayaz, H., Forman, E. M., Newman, C. F., Williams, J. M., Hillary, F. G., Platek, S. M., Onaral, B., et al. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.12.001 · Cited by 89 · see citing works
Kraus, A., Valerius, G., Seifritz, E., Ruf, M., Bremner, J. D., Bohus, M., & Schmahl, C. G. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01417.x · Cited by 87 · see citing works
Development and Psychometric Characteristics of the Dissociation Tension Scale
Stiglmayr, C., Schimke, P., Wagner, T., Braakmann, D., Schweiger, U., Sipos, V., Fydrich, T., Schmahl, C., Ebner-Priemer, U., Kleindienst, N., et al. (2010) · Journal of Personality Assessment · doi:10.1080/00223891003670232 · Cited by 80 · cited 3× · see citing works
“Correlations between CBF and clinical symptom clusters For the patient group, Spearman correlations were calculated between CBF values and psychometric scores obtained by the DTS, BDI, BIS total score and the BIS subscales (BIS-A, BIS-M, BIS-N).”
MethodInfluentialBrain perfusion SPECT in impulsivity-related personality disorders
Goethals, I., Audenaert, K., Jacobs, F., den Eynde, F. V., Bernagie, K., Kolindou, A., Vervaet, M., Dierckx, R. A. J. O., & Heeringen, C. V. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.06.022 · Cited by 75 · see citing works
Prevention and early intervention for borderline personality disorder
Chanen, A. M., McCutcheon, L., Jovev, M., Jackson, H. J., & McGorry, P. D. (2007) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2007.tb01330.x · Cited by 74 · see citing works
Wolf, R. C., Grön, G., Sambataro, F., Vasić, N., Wolf, N. D., Thomann, P. A., Carsten Saft, C., Landwehrmeyer, G. B., & Orth, M. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.60 · Cited by 62 · see citing works
Self-citationWang, J., Li, L. Z., Roc, A. C., Alsop, D. C., Tang, K. Z., Butler, N. S., Schnall, M. D., & Detre, J. A. (2004) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(03)00210-8 · Cited by 58 · see citing works
Abnormal prefrontal cortical response during affective processing in borderline personality disorder
Ruocco, A. C., Medaglia, J. D., Ayaz, H., & Chute, D. L. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.01.011 · Cited by 58 · see citing works
Perfusion Magnetic Resonance Imaging in Psychiatry
Théberge, J. (2008) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0b013e3181808140 · Cited by 54 · see citing works
Empirical analyses of null-hypothesis perfusion FMRI data at 1.5 and 4 T
Wang, J., Aguirre, G. K., Kimberg, D. Y., & Detre, J. A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00255-6 · Cited by 54 · see citing works
Measurement of cerebral perfusion territories using arterial spin labelling
Paiva, F. F., Tannús, A., & Silva, A. C. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1177 · Cited by 50 · see citing works
Salavert, J., Gasol, M., Vieta, E., Cervantes, A., Trampal, C., & Gispert, J. D. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.01.001 · Cited by 50 · see citing works
Pavić, L. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0411-z · Cited by 42 · see citing works
Lee, A. K. W., Jerram, M. W., Fulwiler, C., & Gansler, D. A. (2011) · Brain Imaging and Behavior · doi:10.1007/s11682-010-9112-1 · Cited by 25 · see citing works
Temporal glucose metabolism in borderline personality disorder
la Fuente, J. D., Lotstra, F., Goldman, S., Biver, F., Luxen, A., Bidaut, L. M., Stanus, E., & Mendlewicz, J. (1994) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(94)90017-5 · Cited by 22 · see citing works
Dual Brain Pathology in Patients With Affective Aggressive Episodes
van Elst, L. T., Trimble, M. R., Ebert, D., et al. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.12.1187 · Cited by 21 · see citing works
Díaz‐Marsá, M., Carrasco, J. L., López‐Ibor, M. I., Moratti, S., Montes, A., Ortiz, T., & López-Ibor, J. J. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.04.034 · Cited by 17 · see citing works
Factor structure of the Barratt impulsiveness scale
Patton, J. H., Stanford, M. S., & Barratt, E. S. (1995) · Journal of Clinical Psychology · doi:10.1002/1097-4679(199511)51:6
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Krause-Utz, A., Winter, D., Niedtfeld, I., & Schmahl, C. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0438-z · Cited by 235 · see citing works
Krause-Utz, A., Frost, R., Winter, D., & Elzinga, B. M. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0757-y · Cited by 116 · see citing works
“Studies including both functional and structural measures may give additional insight into this relationship [106].”
BackgroundNeural responses to monetary incentives among self-injuring adolescent girls
Sauder, C. L., Derbidge, C. M., & Beauchaine, T. P. (2016) · Development and Psychopathology · doi:10.1017/s0954579415000449 · Cited by 89 · see citing works
Beauchaine, T. P., Hinshaw, S. P., & Bridge, J. A. (2019) · Clinical Psychological Science · doi:10.1177/2167702618818474 · Cited by 80 · see citing works
Quattrini, G., Pini, L., Pievani, M., Magni, L. R., Lanfredi, M., Ferrari, C., Boccardi, M., Bignotti, S., Magnaldi, S., Cobelli, M., et al. (2019) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2018.12.010 · Cited by 48 · see citing works
- Authors
- Wolf, R. C., Thomann, P. A., Sambataro, F., Vasic, N., Schmid, M., & Wolf, N. D.
- Affiliations
- Heidelberg University (DE)
- Italian Institute of Technology (IT)
- Universität Ulm (DE)
- Central Institute of Mental Health (DE)
- Corresponding author
- Wolf, Robert Christian
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2012-03-11
- Volume
- 262
- Issue
- 8
- Pages
- 677-685
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W2007780783
- Cited by
- 54
- References
- 67
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 5
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Universität Ulm
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- borderline personality disorder, impulsivity, orbitofrontal cortex, cerebral blood flow, arterial spin labeling, depressive symptoms, medial orbitofrontal cortex, lateral orbitofrontal cortex, symptom clusters
- MeSH terms
- Adult, Borderline Personality Disorder, Female, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Magnetic Resonance Imaging, Oxygen, Psychiatric Status Rating Scales, Psychometrics, Statistics as Topic, Prefrontal Cortex, Young Adult
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