Cited by 65Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

Role of cytokines in atypical depression

Yoon, Ho-Kyoung, Kim, Yong-Ku, Lee, Heon-Jeong, Kwon, Do-Young, Kim, Leen·2012·Nordic Journal of Psychiatry

Abstract

BACKGROUND: Atypical depression (AD) is considered a biologically and psychologically distinct subtype of depression. AD, contrary to melancholic depression (MD), may have different alteration in cytokine activity. AIMS: We aimed to investigate the differences of cytokine activity between AD patients and MD patients. Among psychiatric patients visited to the Psychiatry Department, Korea University Medical Center, 105 patients with major depression who met the Diagnostic and Statistical Manual (DSM-IV) criteria based on clinical interviews using a Structured Clinical Interview for DSM-IV were recruited. Among 105 patients, 35 patients had atypical feature. We measured in vitro cytokines (interleukins) IL-2, IL-4, IL-6 and tumor necrosis factor-α (TNF-α). RESULTS: Decreased IL-4 and increased IL-2 was observed in AD patients. IL-6 and TNF-α level of AD patients showed no difference from the controls. CONCLUSIONS: Contrary to MD, AD has reversed vegetative symptoms, i.e. hypersomnia and hyperphagia. It is assumed that the phenotype difference between AD and MD might be related to Th1 cytokines (IL-2) and Th2 cytokines (IL-4) and not related to monocytic cytokines (IL-6, and TNF-α).

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Crossref · 10.3109/08039488.2011.611894

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Authors
Yoon, H.-K., Kim, Y.-K., Lee, H.-J., Kwon, D.-Y., & Kim, L.
Affiliations
Korea University (KR)
Corresponding author
Kim, Leen
Venue
Nordic Journal of Psychiatry
Published
2011-09-22
Volume
66
Issue
3
Pages
183-188
ISSN
  • 0029-1455 (ISSN-L)
  • 0803-9488
  • 1502-4725
OpenAlex
W2056755341
Cited by
65
References
49
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 9 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 2 · 2012: 3
FWCI
1.11
Type
journal article
Language
en
Open access
closed
Locations
  • Nordic Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
atypical depression, endogenous depression, cytokines, interleukin-2, IL-4, interleukin-6, TNF-α, Th1/Th2 balance, major depressive disorder, hypersomnia, hyperphagia, depression subtypes
MeSH terms
Adult, Aged, Feeding and Eating Disorders, Depression, Depressive Disorder, Major, Major Depressive Disorder, Depressive Disorder, Female, Humans, Inflammation, Interleukin-2, Korea, Male, Middle Aged, Monocytes, Sleep Wake Disorders, Tumor Necrosis Factor-alpha, Interleukin-4, Interleukin-6, Cytokines, Th1 Cells, Th2 Cells, Diagnostic and Statistical Manual of Mental Disorders, Young Adult

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