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A Review of Treating Depression in Diabetes: Emerging Findings
Open accessAbstract
Background Depression in patients with diabetes is associated with poorer adherence and worse health outcomes, however treating depression may help improve these outcomes.Objective The present systematic review identified published papers to evaluate treatments for depression in patients with diabetes.Results Seventeen studies that met criteria were identified, indicating that psychosocial interventions, particularly cognitive-behavior therapy, anti-depressant medications, and collaborative care are effective in the treatment of depression in patients with diabetes.Conclusion Evidence for the efficacy of these interventions in improving glycemic control was mixed. No study targeted adherence to treatment or health behaviors in addition to depression, which may be necessary to maximize improvement in diabetes outcomes such as glycemic control.
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“Moreover, they have failed to show compelling evidence that amelioration of MDD leads to improved diabetes management or glycemic control (9).”
From Depression in diabetes: have we been missing something important? (2011) · cites this paper as [9]
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“Numerous treatment studies have shown positive effects for the improvement of MDD in diabetic patients, but evidence for resulting glycemic benefit is, at best, weak (9).”
From Depression in diabetes: have we been missing something important? (2011) · cites this paper as [9]
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“Numerous treatment studies have shown positive effects for the improvement of MDD in diabetic patients, but evidence for resulting glycemic benefit is, at best, weak (9).”
From Depression in diabetes: have we been missing something important? (2011) · cites this paper as [9]
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1 of the 108 references couldn’t be matched to a known paper.
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Goldstein, B. I., Carnethon, M. R., Matthews, K. A., McIntyre, R. S., Miller, G. E., Raghuveer, G., Stoney, C. M., Wasiak, H., & McCrindle, B. W. (2015) · Circulation · doi:10.1161/cir.0000000000000229 · Cited by 519
Depression in type 2 diabetes mellitus: prevalence, impact, and treatment
Semenkovich, K., Brown, M. E., Svrakic, D. M., & Lustman, P. J. (2015) · Drugs · doi:10.1007/s40265-015-0347-4 · Cited by 447
van Dooren, F. E. P., Nefs, G., Schram, M. T., Verhey, F. R. J., Denollet, J., & Pouwer, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057058 · Cited by 441
Safren, S. A., O’Cleirigh, C. M., Tan, J. Y., Raminani, S. R., Reilly, L. C., Otto, M. W., & Mayer, K. H. (2009) · Health Psychology · doi:10.1037/a0012715 · Cited by 404
Self-citationGonzalez, J. S., Tanenbaum, M. L., & Commissariat, P. V. (2016) · American Psychologist · doi:10.1037/a0040388 · Cited by 354
Self-citation
Metadata
- Authors
- Markowitz, S. M., Gonzalez, J. S., Wilkinson, J. L., & Safren, S. A.
- Affiliations
- Harvard University (US)
- Albert Einstein College of Medicine (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Markowitz, Sarah M.
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 52
- Issue
- 1
- Pages
- 1-18
- ISSN
- 0033-3182 (ISSN-L)
- PMC
- PMC3043600
- OpenAlex
- W1992579306
- Cited by
- 230
- References
- 108
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 8 · 2023: 11 · 2022: 18 · 2021: 10 · 2020: 14 · 2019: 9 · 2018: 16 · 2017: 19 · 2016: 24 · 2015: 28 · 2014: 20 · 2013: 22 · 2012: 11
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1r01mh078571-01)
- National Institute of Mental Health (1R01MH078571-01, R01 MH-078571)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- depression, diabetes mellitus, depression treatment, psychosocial interventions, cognitive behavioral therapy, antidepressants, collaborative care, glycemic control, medication adherence
- MeSH terms
- Adolescent, Adult, Antidepressive Agents, Child, Cooperative Behavior, Depressive Disorder, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Health Education, Humans, Mental Health Services, Patient Education as Topic, Psychotherapy, Self Care, Cognitive Behavioral Therapy, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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