Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program
Open accessAbstract
OBJECTIVE—To assess the association between elevated depression symptoms or antidepressant medicine use on entry to the Diabetes Prevention Program (DPP) and during the study and the risk of developing diabetes during the study. RESEARCH DESIGN AND METHODS—DPP participants (n = 3,187) in three treatment arms (intensive lifestyle [ILS], metformin [MET], and placebo [PLB]) completed the Beck Depression Inventory (BDI) and reported their use of antidepressant medication at randomization and throughout the study (average duration in study 3.2 years). RESULTS—When other factors associated with the risk of developing diabetes were controlled, elevated BDI scores at baseline or during the study were not associated with diabetes risk in any arm. Baseline antidepressant use was associated with diabetes risk in the PLB (hazard ratio 2.25 [95% CI 1.38–3.66]) and ILS (3.48 [1.93–6.28]) arms. Continuous antidepressant use during the study (compared with no use) was also associated with diabetes risk in the same arms (PLB 2.60 [1.37–4.94]; ILS 3.39 [1.61–7.13]), as was intermittent antidepressant use during the study in the ILS arm (2.07 [1.18–3.62]). Among MET arm participants, antidepressant use was not associated with developing diabetes. CONCLUSIONS—A strong and statistically significant association between antidepressant use and diabetes risk in the PLB and ILS arms was not accounted for by measured confounders or mediators. If future research finds that antidepressant use independently predicts diabetes risk, efforts to minimize the negative effects of antidepressant agents on glycemic control should be pursued.
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A history of depression, current depression, and antidepressant use are risk factors for type 2 diabetes, especially with other risk factors such as obesity and family history.
“History of depression, current depression, and antidepressant medication use are risk factors for the development of type 2 diabetes, especially if the individual has other risk factors such as obesity and family history of type 2 diabetes (53–55).”
From Psychosocial care for people with diabetes: a position statement of the American Diabetes Association (2016) · cites this paper as [55]
History of depression, current depression, and antidepressant medication use are risk factors for the development of type 2 diabetes, especially if the individual has other risk factors such as obesity and family history of type 2 diabetes.
“History of depression, current depression, and antidepressant medication use are risk factors for the development of type 2 diabetes, especially if the individual has other risk factors such as obesity and family history of type 2 diabetes (387)(388)(389).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:<i>Standards of Care in Diabetes—2023</i> (2023) · cites this paper as [389]
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- Authors
- Rubin, R. R., Ma, Y., Marrero, D. G., Peyrot, M., Barrett-Connor, E. L., Kahn, S. E., Haffner, S. M., Price, D. W., Knowler, W. C., & for the Diabetes Prevention Program Research Group
- Affiliations
- Johns Hopkins University (US)
- George Washington University (US)
- Indiana University School of Medicine (US)
- University of California San Diego (US)
- University of Washington (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Colorado Denver (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2008-03-01
- Volume
- 31
- Issue
- 3
- Pages
- 420-426
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC2373986
- OpenAlex
- W2098858396
- Cited by
- 242
- References
- 41
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 12 · 2023: 12 · 2022: 4 · 2021: 10 · 2020: 12 · 2019: 6 · 2018: 18 · 2017: 11 · 2016: 16 · 2015: 12 · 2014: 16 · 2013: 18 · 2012: 18
- FWCI
- 16.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (U01DK048489)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- depressive symptoms, antidepressant use, diabetes risk, Diabetes Prevention Program, metformin, intensive lifestyle intervention, glycemic control, antidepressant side effects, Beck Depression Inventory
- MeSH terms
- Adult, Antidepressive Agents, Depression, Diabetes Mellitus, Female, Humans, Hypoglycemic Agents, Life Style, Male, Metformin, Middle Aged, Risk Factors
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