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Cited by 99Diabetes Management and EducationDiabetes Management and ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Changes in depressive symptoms and glycemic control in diabetes mellitus

Georgiades, Anastasia, Zucker, Nancy, Friedman, Kelli E., Mosunic, Christopher J., Applegate, Katherine, Lane, James D., Feinglos, Mark N., Surwit, Richard S.·2007·Psychosomatic Medicine
DOI 10.1097/psy.0b013e318042588d
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Abstract

OBJECTIVE: To investigate if changes in depressive symptoms would be associated with changes in glycemic control over a 12-month period in patients with Type 1 and Type 2 diabetes. METHODS: Ninety (Type 1 diabetes, n = 28; Type 2 diabetes, n = 62) patients having Beck Depression Inventory (BDI) levels of >10 were enrolled in the study. Of those 90 patients, 65 patients completed a 12-week cognitive behavioral therapy intervention. BDI was assessed at baseline and thereafter biweekly during 12 months. Hemoglobin (HbA1c) and fasting blood glucose levels were assessed at baseline and at four quarterly in-hospital follow-up visits. Linear mixed-model analysis was applied to determine the effects of time and diabetes type on depressive symptoms, HbA1c levels, and fasting glucose levels. RESULTS: Mean and standard deviation baseline BDI and HbA1c levels were 17.9 +/- 5.8 and 7.6 +/- 1.6, respectively, with no significant difference between patients with Type 1 and Type 2 diabetes. Mixed-model regression analysis found no difference between the groups with Type 1 and Type 2 diabetes in the within-subject effect of BDI score on HbA1c or fasting glucose levels during the study. Depressive symptoms decreased significantly (p = .0001) and similarly over a 12-month period in both patients with Type 1 and Type 2 diabetes, whereas HbA1c and fasting glucose levels did not change significantly over time in either group. CONCLUSION: Changes in depressive symptoms were not associated with changes in HbA1c or fasting glucose levels over a 1-year period in either patients with Type 1 or Type 2 diabetes.

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Authors
Georgiades, A., Zucker, N., Friedman, K. E., Mosunic, C. J., Applegate, K., Lane, J. D., Feinglos, M. N., & Surwit, R. S.
Affiliations
Duke University (US)
Corresponding author
Surwit, Richard S.
ORCID
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-04
Volume
69
Issue
3
Pages
235-241
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/psy.0b013e318042588d
OpenAlex
W2061477278
Cited by
99
References
45
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 11 · 2012: 8
FWCI
4.38
Type
journal article
Language
en
Open access
closed
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01dk057841-04)
  • U.S. Public Health Service
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK57841)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
depressive symptoms, glycemic control, type 1 diabetes, type 2 diabetes, HbA1c, fasting blood glucose, cognitive behavioral therapy, depression and diabetes comorbidity, Beck Depression Inventory
MeSH terms
Adult, Aged, Blood Glucose, C-Peptide, Energy Intake, Combined Modality Therapy, Depression, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diet, Diabetic, Exercise Therapy, Fasting, Female, Follow-Up Studies, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Personality Inventory, Prospective Studies, Self Care, Cognitive Behavioral Therapy, Diet Records, Body Mass Index, Diabetes Complications

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