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Cited by 147Liver Disease Diagnosis and TreatmentHepatitis C virus researchLiver Disease and Transplantation

Depression in patients with nonalcoholic fatty liver disease and chronic viral hepatitis B and C

Weinstein, Ali A., Kallman Price, Jillian, Stepanova, Maria, Poms, Laura W., Fang, Yun, Moon, Juhi, Nader, Fatema, Younossi, Zobair M.·2011·Psychosomatics
DOI 10.1016/j.psym.2010.12.019
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Abstract

Background Patients with chronic liver disease (CLD) and depression may be at a higher risk for various complications, including impaired quality of life and more advanced liver disease. The purpose of this study was to determine the prevalence of depression in CLD patients (non-alcoholic fatty liver disease (NAFLD), Hepatitis B (HBV), and Hepatitis C (HCV)) and to identify potential clinical and laboratory correlates of depression in these patients.Methods We used a database of CLD patients that contains extensive clinical (including self-reported depression) and laboratory data for each patient. We compared the prevalence of depression in patients with HBV, HCV, and NAFLD. We also used regression models to find independent predictors of depression in these patients.Results Of 878 CLD patients, 207 (23.6%) had a diagnosis of depression (NAFLD 27.2%, HCV 29.8%, and HBV 3.7%). Examination of predictors of depression differed by the type of chronic liver disease. For NAFLD, independent predictors of depression were the presence of hypertension, smoking, history of lung disease, being female, and non-African-American. For HBV patients, the only independent predictor of depression was excessive alcohol consumption (defined as >10 g/d), while for HCV patients, independent predictors were being female and non-Asian, presence of fatigue, and excessive alcohol intake.Conclusions This study demonstrates that individuals with NAFLD and HCV have a higher prevalence of depression than HBV patients and the rates of depression reported for the general population. The most consistent correlates of depression status in CLD patients are being female and excessive alcohol consumption.

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  • Patients with NAFLD were shown to have a significantly higher prevalence of depression compared with those with hepatitis B (3.7%) but not hepatitis C (29.8%).

    “Further, patients with NAFLD were shown to have a significantly higher prevalence of DEP compared with those with hepatitis B (HBV; 3.7%) but not hepatitis C (29.8%).[12]”

    From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [12]

  • Weinstein and colleagues reported the prevalence of depression to be 27.2% in NAFLD when using self-reported diagnoses paired with confirmatory medical record review.

    “For example, Weinstein and colleagues reported the prevalence of DEP to be 27.2% in NAFLD when using self-reported diagnoses paired with confirmatory medical record review.”

    From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [12]

  • The prevalence of depression in patients with hepatitis B virus has been examined, though limited data on rates of anxiety are available.

    “The prevalence of DEP in patients with HBV has been examined, [12,17,23,28,31,32] though limited data on rates of ANX are available.[17,28]”

    From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [12]

  • Comparative investigations commonly show that the prevalence of depression in patients with hepatitis B virus is lower than that in patients with hepatitis C virus, a finding that extends to both self-report-diagnosed and clinician-diagnosed depression.

    “Comparative investigations commonly show that the prevalence of DEP in patients with HBV is lower than that in patients with HCV, [12,17,32] a finding that extends to both self-report-diagnosed and clinician-diagnosed DEP.”

    From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [12]

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Authors
Weinstein, A. A., Kallman Price, J., Stepanova, M., Poms, L. W., Fang, Y., Moon, J., Nader, F., & Younossi, Z. M.
Affiliations
  • Inova Health System (US)
  • George Mason University (US)
Corresponding author
Younossi, Zobair M.
ORCID
Venue
Psychosomatics
Publisher
Elsevier BV
Published
2011-03
Volume
52
Issue
2
Pages
127-132
ISSN
0033-3182 (ISSN-L)
DOI
10.1016/j.psym.2010.12.019
OpenAlex
W2038382356
Cited by
147
References
21
Citations by year
2026: 4 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 19 · 2021: 13 · 2020: 15 · 2019: 9 · 2018: 14 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 9 · 2013: 13 · 2012: 4
FWCI
6.72
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychosomatics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
depression, non-alcoholic fatty liver disease, chronic hepatitis B, chronic hepatitis C, chronic liver disease, depression prevalence, predictors of depression, alcohol consumption, sex differences, fatigue, hypertension, smoking
MeSH terms
Adult, Age Factors, Depression, Fatty Liver, Female, Humans, Male, Middle Aged, Quality of Life, Regression Analysis, Risk Factors, Sex Factors, Prevalence, Chi-Square Distribution, Statistics, Nonparametric, Hepatitis B, Chronic, Hepatitis C, Chronic

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