Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
Abstract
Data suggest that both neurotrophic and hypothalamic-pituitary-adrenocortical (HPA) systems are involved in the pathophysiology of depression. The aim of the present study was to investigate whether the non-conservative brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has an impact on HPA axis activity in depressed patients. At admission, the dexamethasone/CRH (DEX/CRH) test was performed in 187 drug-free in-patients suffering from major depression or depressed state of bipolar disorder (DSM-IV criteria). Moreover, genotyping of BDNF Val66Met polymorphism was carried out using the fluorescence resonance energy transfer method (FRET). Homozygous carriers of the Met/Met genotype showed a significantly higher HPA axis activity during the DEX/CRH test than patients carrying the Val/Val or Val/Met genotype (ACTH, cortisol). Our results further contribute to the hypothesized association between HPA axis dysregulation and reduced neuroplasticity in depression and are consistent with the assumption that BDNF is a stress-responsive intercellular messenger modifying HPA axis activity.
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A study of depressed inpatients found that those with two copies of the Met allele of BDNF Val66Met had elevated adrenocorticotropic hormone and cortisol responses to the Dex/CRH test.
“A study of depressed inpatients found that those with two copies of the Met allele of BDNF Val66Met had elevated adrenocorticotropic hormone and cortisol responses to the Dex/CRH text (Schule et al. 2006).”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Schule et al. 2006
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- Authors
- Schüle, C., Zill, P., Baghai, T. C., Eser, D., Zwanzger, P., Wenig, N., Rupprecht, R., & Bondy, B.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Schüle, Cornelius
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 31
- Issue
- 8
- Pages
- 1019-1025
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2026863929
- Cited by
- 94
- References
- 3
- Citations by year
- 2025: 3 · 2024: 1 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, major depressive disorder, bipolar disorder, hypothalamic-pituitary-adrenal axis, HPA axis dysregulation, ACTH, cortisol, neuroplasticity, stress response
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Bipolar Disorder, Corticotropin-Releasing Hormone, Major Depressive Disorder, Depressive Disorder, Dexamethasone, Female, Genotype, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Polymorphism, Genetic, Psychiatric Status Rating Scales, Brain-Derived Neurotrophic Factor, Amino Acid Substitution
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