Subtle gene-environment interactions driving paranoia in daily life

Simons, C. J. P.; Wichers, M.; Derom, C.; Thiery, E.; Myin‐Germeys, I.; Krabbendam, L.; Van Os, J.

doi:10.1111/j.1601-183x.2008.00434.x

Cited by 82Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatmentGenetic Associations and Epidemiology

Subtle gene-environment interactions driving paranoia in daily life

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Simons, C. J. P., Wichers, M., Derom, C., Thiery, E., Myin‐Germeys, I., Krabbendam, L., Van Os, J.·2009·Genes, Brain and Behavior

DOI 10.1111/j.1601-183x.2008.00434.x

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Abstract

It has been suggested that genes impact on the degree to which minor daily stressors cause variation in the intensity of subtle paranoid experiences. The objective of the present study was to test the hypothesis that catechol‐O‐methyltransferase (COMT) Val 158 Met and brain‐derived neurotrophic factor (BDNF) Val 66 Met in part mediate genetic effects on paranoid reactivity to minor stressors. In a general population sample of 579 young adult female twins, on the one hand, appraisals of (1) event‐related stress and (2) social stress and, on the other hand, feelings of paranoia in the flow of daily life were assessed using momentary assessment technology for five consecutive days. Multilevel regression analyses were used to examine moderation of daily life stress‐induced paranoia by COMT Val 158 Met and BDNF Val 66 Met genotypes. Catechol‐O‐methyltransferase Val carriers displayed more feelings of paranoia in response to event stress compared with Met carriers. Brain‐derived neurotrophic factor Met carriers showed more social‐stress‐induced paranoia than individuals with the Val/Val genotype. Thus, paranoia in the flow of daily life may be the result of gene–environment interactions that can be traced to different types of stress being moderated by different types of genetic variation.

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These particular single-item measures have been used in several ESM studies in our research group and have demonstrated predictive and ecological validity.
“These particular single-item measures items have been used in several ESM studies in our research group (e.g. [31]) and have demonstrated predictive and ecological validity.”
From Putting a Hold on the Downward Spiral of Paranoia in the Social World: A Randomized Controlled Trial of Mindfulness-Based Cognitive Therapy in Individuals with a History of Depression (2013) · cites this paper as [31]
The Measures and Paranoia sections show that this study used single-item ESM measures in daily life; the Paranoia section also refers to earlier studies using that item. The Measures section reports a validation correlation for the social-stress item, but our copy does not establish predictive validity for these particular measures as a group. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Momentary paranoia was measured with the ESM item 'I feel suspicious'.
“momentary paranoia was measured with the ESM item I feel suspicious.”
From Putting a Hold on the Downward Spiral of Paranoia in the Social World: A Randomized Controlled Trial of Mindfulness-Based Cognitive Therapy in Individuals with a History of Depression (2013) · cites this paper as [31]

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[69]69. Snijders, T. & Bosker, R. (1999) Multilevel Analysis: An Introduction to Basic and Advanced Multilevel Modeling. SAGE Publications Ltd, London.

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Everyday emotional experience of adults with attention deficit hyperactivity disorder: evidence for reactive and endogenous emotional lability
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COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making
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Brain derived neurotrophic factor Val66Met polymorphism and psychotic symptoms in Alzheimer's disease
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Catechol-o-Methyltransferase Genotype and Childhood Trauma May Interact to Impact Schizotypal Personality Traits
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Putting a Hold on the Downward Spiral of Paranoia in the Social World: A Randomized Controlled Trial of Mindfulness-Based Cognitive Therapy in Individuals with a History of Depression
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“In accordance with previous work [31], momentary paranoia was measured with the ESM item I feel suspicious.”
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Psychiatry beyond labels: introducingcontextual precision diagnosisacross stages of psychopathology
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Comparable emotional dynamics in women with ADHD and borderline personality disorder
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Serum Brain-Derived Neurotrophic Factor Levels and Cocaine-Induced Transient Psychotic Symptoms
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Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia.
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Wandering minds in attention-deficit/hyperactivity disorder and borderline personality disorder
Moukhtarian, T. R., Reinhard, I., Morillas-Romero, A., Ryckaert, C., Mowlem, F. D., Bozhilova, N. S., Moran, P., Ebner‐Priemer, U., & Asherson, P. J. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.07.005 · Cited by 20 · see citing works
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The experience sampling methodology in psychosis risk states: A systematic review
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Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding
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Progressive Structural Brain Changes and NRG1 Gene Variants in First-Episode Nonaffective Psychosis
Suárez‐Pinilla, P., Roiz‐Santiáñez, R., Mata, I. F., de la Foz, V. O., Brambilla, P., Fañanás, L., Román, N. V. S., & Crespo‐Facorro, B. (2015) · Neuropsychobiology · doi:10.1159/000370075 · Cited by 12 · see citing works
COMTVal158Met andMTHFRC677T moderate risk of schizophrenia in response to childhood adversity
Debost, J.-C., Debost, M., Grove, J., Mors, O. N., HOUGAARD, D. M., Børglum, A. D., Mortensen, P. B., & Petersen, L. V. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12761 · Cited by 13 · see citing works
The Influence of the Val158Met Catechol-O-Methyltransferase Polymorphism on the Personality Traits of Bipolar Patients
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Ambulatory Monitoring in the Genetics of Psychosomatic Medicine
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Ambulatory assessment as a means of longitudinal phenotypes characterization in psychiatric disorders
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BDNF val66met genotype and schizotypal personality traits interact to influence probabilistic association learning
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Izmir Mental Health Cohort for Gene-Environment Interaction in Psychosis (TürkSch): Assessment of the Extended and Transdiagnostic Psychosis Phenotype and Analysis of Attrition in a 6-Year Follow-Up of a Community-Based Sample
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Psychosocial functioning in individuals with advanced oesophago-gastric cancer: a mixed methods systematic review
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Childhood traumatic events and the dopaminergic theory of psychosis: A mini-review of studies investigating gene – environment interactions
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Authors: Simons, C. J. P., Wichers, M., Derom, C., Thiery, E., Myin‐Germeys, I., Krabbendam, L., & Van Os, J.
Affiliations: Maastricht University Medical Centre (NL)
KU Leuven (BE)
ORCID: Simons, C. J. P.
Wichers, M.
Derom, C.
Myin‐Germeys, I.
Venue: Genes, Brain and Behavior
Publisher: Wiley
Published: 2009-01-28
Volume: 8
Issue: 1
Pages: 5-12
ISSN: 1601-183X (ISSN-L)
1601-1848
DOI: 10.1111/j.1601-183x.2008.00434.x
OpenAlex: W1984789704
Cited by: 82
References: 90
Citations by year: 2024: 2 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 13 · 2012: 8
FWCI: 2.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Genes Brain & Behavior (publishedVersion)
PubMed (publishedVersion)
VU Research Portal (publishedVersion)
Lirias (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Vlaamse regering
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: paranoia, gene-environment interaction, COMT Val158Met, BDNF Val66Met polymorphism, daily stress, social stress, momentary assessment, young adult women, twins
MeSH terms: Adolescent, Adult, Catechol O-Methyltransferase, DNA, Environment, Female, Genotype, Humans, Male, Middle Aged, Paranoid Disorders, Prospective Studies, Social Environment, Stress, Psychological, Genetic Variation, Brain-Derived Neurotrophic Factor, Young Adult

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Subtle gene-environment interactions driving paranoia in daily life

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