Role of Nuclear Factor κB in Ovarian Hormone-Mediated Stress Hypersensitivity in Female Mice
Open accessAbstract
Background The molecular mechanisms of stress-induced depressive behaviors have been characterized extensively in male rodents; however, much less is known about female subjects, despite the fact that human depression is far more prevalent in women.Methods To gain insight into these mechanisms, we performed microarray analysis in nucleus accumbens (NAc), a key brain reward region implicated in depression, in ovariectomized (OVX) and gonadally intact female mice after chronic unpredictable stress and measured stress-induced depression-like behavior in the forced swim test (FST). Male mice were studied in the FST for comparison.Results We find that stress regulation of genes in NAc of gonadally intact female mice is blunted in OVX mice. This pattern of gene regulation is consistent with behavioral findings on the FST: the pro-depression-like effect of stress in intact female mice is absent in OVX female and gonadally intact male mice. We identified, among many genes regulated by stress, several nuclear factor kappaB (NFkappaB) subunits-a pro-survival transcription factor involved in cellular responses to stress-as being highly upregulated in NAc of OVX mice. Given the role of NFkappaB during stress, we hypothesized that upregulation of NFkappaB by OVX decreases susceptibility to stress. Indeed, we show that inhibition of NFkappaB in NAc of OVX animals increases susceptibility to stress-induced depressive behaviors, whereas activation of NFkappaB in NAc of intact female subjects blocks susceptibility.Conclusions These results suggest a hormonal mechanism of NFkappaB regulation that contributes to stress-induced depressive behaviors in female subjects and might represent a mechanism for gender differences in prevalence rates of these disorders in humans.
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Only one study has examined stress effects on the nucleus accumbens in female animals with medium spiny neuron subtype specificity.
“Currently, only a handful of studies addressed how stress differentially affects the NAc of female animals (52, 94–97) and only one provides a MSN subtype specific examination.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [96]
Only a small number of studies have examined how stress differentially affects the nucleus accumbens in female animals.
“Currently, only a handful of studies addressed how stress differentially affects the NAc of female animals (52, 94–97) and only one provides a MSN subtype specific examination.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [96]
Sub-chronic unpredictable stress induces anhedonia, increased immobility on the forced swim test, and increased anxiety in rodents.
“sub–chronic unpredictable stress induces anhedonia (decreased sucrose preference), increased immobility on the forced swim test, and increased anxiety (greater latency to feed in a novel environment and decreased time grooming in the splash test).”
From Neurobiology of resilience (2012) · cites this paper as [85]
Females are more sensitive than males to sub-chronic unpredictable stress in emotional domains.
“The data clearly show that females are more sensitive than males in these domains85”
From Neurobiology of resilience (2012) · cites this paper as [85]
Removal of ovarian hormones in rodents decreases the pro-depressant or anxiogenic effects of stress while simultaneously increasing the negative effects of stress on spatial and non-spatial memory.
“removal of ovarian hormones decreases the pro–depressant or anxiogenic effects of stress, while simultaneously increasing the negative effects of stress on spatial and non–spatial memory85, 91, 92”
From Neurobiology of resilience (2012) · cites this paper as [85]
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 1× · see citing works
“The FST was performed according to previously published protocols (29,42).”
MethodSelf-citationEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Self-citationMAQC Consortium, Shi, L., Shi, L., Reid, L. H., Jones, W. D., Shippy, R., Warrington, J. A., Baker, S. C., Collins, P. J., de Longueville, F., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1239 · Cited by 2,126 · see citing works
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
Self-citationIKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M. S., Mann, M., Manning, A. M., et al. (1997) · Science · doi:10.1126/science.278.5339.860 · Cited by 2,042 · see citing works
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Self-citationChronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · see citing works
Gonadal Steroid Hormone Receptors and Sex Differences in the Hypothalamo-Pituitary-Adrenal Axis
Handa, R. J., Burgess, L. H., Kerr, J. E., & O'Keefe, J. A. (1994) · Hormones and Behavior · doi:10.1006/hbeh.1994.1044 · Cited by 793 · see citing works
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S., Yanagisawa, M., Elmquist, J. K., Nestler, E. J., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2139 · Cited by 644 · see citing works
Self-citationD, M. F. M., & Kendler, K. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00112-4 · Cited by 619 · see citing works
Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli
Renthal, W., Maze, I., Krishnan, V., Covington, H. E., Xiao, G., Kumar, A., Russo, S. J., Graham, A., Tsankova, N., Kippin, T. E., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.032 · Cited by 599 · see citing works
Self-citationPliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509 · see citing works
Self-citationBarrot, M., Olivier, J. D. A., Perrotti, L. I., DiLeone, R. J., Berton, O., Eisch, A. J., Impey, S., Storm, D. R., Neve, R. L., Yin, J. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172091899 · Cited by 508 · see citing works
Self-citationMonteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502 · see citing works
Self-citationShors, T. J., Chua, C., & Falduto, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06292.2001 · Cited by 496 · see citing works
Walf, A. A., & Frye, C. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301067 · Cited by 461 · see citing works
Eisch, A. J., Bolaños, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.003 · Cited by 420 · see citing works
Self-citationRat toxicogenomic study reveals analytical consistency across microarray platforms
Guo, L., Lobenhofer, E. K., Wang, C., Shippy, R., Harris, S., Zhang, L., Mei, N., Chen, T., Herman, D., Goodsaid, F. M., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1238 · Cited by 406 · see citing works
Induction of ΔFosB in Reward-Related Brain Structures after Chronic Stress
Perrotti, L. I., Hadeishi, Y., Ulery, P. G., Barrot, M., Monteggia, L. M., Duman, R. S., & Nestler, E. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2542-04.2004 · Cited by 330 · see citing works
Self-citationIκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex
Mercurio, F., Murray, B. W., Shevchenko, A., Bennett, B. L., Young, D. B., Li, J. W., Pascual, G., Motiwala, A., Zhu, H., Mann, M., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1526 · Cited by 325 · see citing works
Chen, A. C. H., Shirayama, Y., Shin, K.-H., Neve, R. L., & Duman, R. S. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01114-8 · Cited by 311 · see citing works
Self-citationConstitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival
Bhakar, A. L., Tannis, L.-L., Zeindler, C., Russo, M. P., Jobin, C., Park, D. S., MacPherson, S., & Barker, P. A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08466.2002 · Cited by 310 · see citing works
Statistical implications of pooling RNA samples for microarray experiments
Peng, X., Wood, C. L., Blalock, E. M., Chen, K. C., Landfield, P. W., & Stromberg, A. J. (2003) · BMC Bioinformatics · doi:10.1186/1471-2105-4-26 · Cited by 297 · see citing works
Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression
Galea, L. A. M., Wide, J. K., & Barr, A. M. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00170-x · Cited by 280 · see citing works
Deecher, D., Andree, T. H., Sloan, D., & Schechter, L. E. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.10.006 · Cited by 270 · see citing works
Orexin Signaling Mediates the Antidepressant-Like Effect of Calorie Restriction
Lutter, M., Krishnan, V., Russo, S. J., Jung, S., McClung, C. A., & Nestler, E. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5584-07.2008 · Cited by 234 · see citing works
Self-citationBowman, R. E., Ferguson, D., & Luine, V. N. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00156-2 · Cited by 224 · see citing works
Bowman, R. E., MacLusky, N. J., Sarmiento, Y., Frankfurt, M., Gordon, M., & Luine, V. N. (2004) · Endocrinology · doi:10.1210/en.2003-1759 · Cited by 216 · see citing works
Sex differences in the conditioned rewarding effects of cocaine
Russo, S. J., Jenab, S., Fabian, S. J., Festa, E. D., Kemen, L. M., & Quiñones-Jenab, V. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02346-1 · Cited by 182 · see citing works
Self-citationRachman, I. M., Unnerstall, J. R., Pfaff, D. W., & Cohen, R. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13941 · Cited by 182 · see citing works
Russo, S. J., Festa, E. D., Fabian, S. J., Gazi, F. M., Kraish, M., Jenab, S., & Quiñones-Jenab, V. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00317-8 · Cited by 179 · see citing works
Self-citationSex differences in the effects of two stress paradigms on dopaminergic neurotransmission
Dalla, C., Antoniou, K., Kokras, N., Drossopoulou, G., Papathanasiou, G., Bekris, S., Daskas, S., & Papadopoulou‐Daifoti, Z. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.020 · Cited by 177 · see citing works
Chronic Stress and Neural Function: Accounting for Sex and Age
Luine, V. N., Beck, K. D., Bowman, R. E., Frankfurt, M., & MacLusky, N. J. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01594.x · Cited by 173 · see citing works
Walf, A., & Frye, C. (2007) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.003 · Cited by 166 · see citing works
Walf, A. A., & Frye, C. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300708 · Cited by 160 · see citing works
Stress and Disease: Is Being Female a Predisposing Factor?
Becker, J. B., Monteggia, L. M., Perrot-Sinal, T. S., Romeo, R. D., Taylor, J. R., Yehuda, R., & Bale, T. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3565-07.2007 · Cited by 158 · see citing works
ΔFosB Induction in Orbitofrontal Cortex Mediates Tolerance to Cocaine-Induced Cognitive Dysfunction
Winstanley, C., LaPlant, Q., Theobald, D., Green, T., Bachtell, R., Perrotti, L., DiLeone, R., Russo, S., Garth, W. J., Self, D., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2566-07.2007 · Cited by 149 · see citing works
Self-citationGender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in mice
Lagace, D. C., Fischer, S. J., & Eisch, A. J. (2007) · Hippocampus · doi:10.1002/hipo.20265 · Cited by 139 · see citing works
Stressor-induced anhedonia in the mesocorticolimbic system
Zacharko, R. M., & Anisman, H. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80032-6 · Cited by 135 · see citing works
Sex Differences in Cocaine-Stimulated Motor Behavior Disparate Effects of Gonadectomy
Walker, Q. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00248-7 · Cited by 128 · see citing works
Clark, M. S., Sexton, T. J., McClain, M. E., Root, D., Kohen, R., & Neumaier, J. F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04550.2002 · Cited by 119 · see citing works
Sex differences and stress response of WKY rats
Paré, W. P., & Redei, E. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90345-g · Cited by 117 · see citing works
Aged rats: Sex differences and responses to chronic stress
Bowman, R. E., MacLusky, N. J., Weinstein, S. D., Zrull, M. C., & Luine, V. N. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.047 · Cited by 104 · see citing works
Cognition, Mood Disorders, and Sex Hormone
Shively, C. A., & Bethea, C. L. (2004) · ILAR Journal · doi:10.1093/ilar.45.2.189 · Cited by 65 · see citing works
Beckley, E. H., & Finn, D. A. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.05.017 · Cited by 62 · see citing works
Antidepressant-like actions of pregnancy, and progesterone in Wistar rats forced to swim
Molina-Hernández, M., & Téllez-Alcántara, N. P. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00007-5 · Cited by 60 · see citing works
Panagiotaropoulos, T. I., Papaioannou, A., Pondiki, S., Prokopiou, A., Stylianopoulou, F., & Gerozissis, K. (2004) · Neuroendocrinology · doi:10.1159/000076633 · Cited by 57 · see citing works
Factors producing a menopausal depressive-like state in mice following ovariectomy
Bekku, N., Yoshimura, H., & Araki, H. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0395-2 · Cited by 50 · see citing works
Estrada-Camarena, E. M., Contreras, C. M., Saavedra, M., Luna-Baltazar, I., & López‐Rubalcava, C. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00023-2 · Cited by 46 · see citing works
Bethea, C. L., Reddy, A. P., & Smith, L. J. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.03.262 · Cited by 24 · see citing works
Psychiatric epidemiology-a historic review
Robins, L. N. (1990) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/bf00789066 · Cited by 17 · see citing works
Koshibu, K., & Levitt, P. R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301436 · Cited by 8 · see citing works
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Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Self-citationRusso, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206 · see citing works
Self-citationSex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
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Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
Self-citationAnimal Models of Depression: Molecular Perspectives
Krishnan, V., & Nestler, E. J. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2010_108 · Cited by 528 · see citing works
Self-citationSex Differences in Vulnerability and Resilience to Stress Across the Life Span
Hodes, G. E., & Epperson, C. N. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.028 · Cited by 417 · see citing works
Hodes, G. E., Pfau, M. L., Purushothaman, I., Ahn, H. F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1392-15.2015 · Cited by 395 · see citing works
Self-citationStructural and synaptic plasticity in stress-related disorders
Christoffel, D. J., Golden, S. A., & Russo, S. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.044 · Cited by 334 · see citing works
Self-citationWang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., Golden, S. A., Bi, W., Menard, C., Kana, V., Leboeuf, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02794-5 · Cited by 274 · see citing works
Self-citationIκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works
Self-citationWilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0932-09.2009 · Cited by 262 · see citing works
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Robison, A. J., Vialou, V., Mazei-Robison, M., Feng, J., Kourrich, S., Collins, M., Wee, S., Koob, G., Turecki, G., Neve, R., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5192-12.2013 · Cited by 190 · see citing works
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- Authors
- LaPlant, Q., Chakravarty, S., Vialou, V., Mukherjee, S., Koo, J. W., Kalahasti, G., Bradbury, K. R., Taylor, S. V., Maze, I., Kumar, A., Graham, A., Birnbaum, S. G., Krishnan, V., Truong, H.-T., Neve, R. L., Nestler, E. J., & Russo, S. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- The University of Texas Southwestern Medical Center (US)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Russo, Scott J.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 65
- Issue
- 10
- Pages
- 874-880
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2746634
- OpenAlex
- W1973048800
- Cited by
- 136
- References
- 55
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 14 · 2020: 8 · 2019: 8 · 2018: 11 · 2017: 12 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 9 · 2012: 5
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH066172)
- National Institute on Drug Abuse (R01DA014133)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- NF-κB, stress-induced depression, depression in women, ovariectomy, ovarian hormones, nucleus accumbens, chronic unpredictable mild stress, forced swim test, sex differences in depression, gene expression regulation, NF-κB inhibition
- MeSH terms
- Animals, Depression, Female, Gene Expression Regulation, Male, Mice, Inbred C57BL, Mice, Transgenic, Nucleus Accumbens, Ovariectomy, RNA, Sex Factors, Gonadal Steroid Hormones, Stress, Physiological, Time Factors, Signal Transduction, Up-Regulation, NF-kappa B, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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