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Cited by 657Mitochondrial Function and PathologyAutophagy in Disease and TherapyAdipose Tissue and Metabolism

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

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Rovira-Llopis, Susana, Bañuls, Celia, Diaz-Morales, Noelia, Hernandez-Mijares, Antonio, Rocha, Milagros, Victor, Victor M.·2017·Redox Biology
DOI 10.1016/j.redox.2017.01.013PMC PMC5284490
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Abstract

Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is characterised by mitochondrial dysfunction, high production of reactive oxygen species (ROS) and low levels of ATP. Mitochondrial fusion is modulated by different proteins, including mitofusin-1 (MFN1), mitofusin-2 (MFN2) and optic atrophy (OPA-1), while fission is controlled by mitochondrial fission 1 (FIS1), dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF). PARKIN and (PTEN)-induced putative kinase 1 (PINK1) participate in the process of mitophagy, for which mitochondrial fission is necessary. In this review, we discuss the molecular pathways of mitochondrial dynamics, their impairment under type 2 diabetes, and pharmaceutical approaches for targeting mitochondrial dynamics, such as mitochondrial division inhibitor-1 (mdivi-1), dynasore, P110 and 15-oxospiramilactone. Furthermore, we discuss the pathophysiological implications of impaired mitochondrial dynamics, especially in type 2 diabetes.

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  • Mitochondrial dysfunction, characterized by reduced mitochondrial size and activity, is prevalent in individuals with obesity and T2DM.

    “Mitochondrial dysfunction, characterized by reduced mitochondrial size and activity, is prevalent in individuals with obesity and T2DM and is a known contributor to muscle wasting in ageing and some chronic diseases.”

    From The Effects of Glucagon-Like Peptide-1 Receptor Agonists on Mitochondrial Function Within Skeletal Muscle: A Systematic Review (2025) · cites this paper as [31]

    The ‘Type 2 diabetes and mitochondrial dynamics’ section reports smaller mitochondria in people with T2DM and impaired mitochondrial function in insulin-resistant patients. It also reports reduced expression of mitochondrial oxidative pathways in obese patients, but does not establish reduced mitochondrial size in obesity. No page number is available in our copy. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Rovira-Llopis, S., Bañuls, C., Diaz-Morales, N., Hernandez-Mijares, A., Rocha, M., & Victor, V. M.
Affiliations
  • Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
  • Universitat de València (ES)
ORCID
Venue
Redox Biology
Publisher
Elsevier BV
Published
2017-04
Volume
11
Pages
637-645
ISSN
2213-2317 (ISSN-L)
DOI
10.1016/j.redox.2017.01.013
PMC
PMC5284490
OpenAlex
W2572344066
Cited by
657
References
18
Citations by year
2026: 60 · 2025: 95 · 2024: 102 · 2023: 91 · 2022: 92 · 2021: 82 · 2020: 54 · 2019: 35 · 2018: 33 · 2017: 13
FWCI
3.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Redox Biology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • European Regional Development Fund (UGP15-193, UGP15-220)
  • Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (GV/2016/169)
  • Instituto de Salud Carlos III
  • Ministerio de Economía y Competitividad (FJCI-2015–25040)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
mitochondrial dynamics, type 2 diabetes, mitochondrial fusion, mitochondrial fission, mitophagy, mitochondrial biogenesis, reactive oxygen species, mitochondrial dysfunction, mitofusin 1, mitofusin 2, OPA1, Drp1, PINK1, Parkin, Mdivi-1, dynasore, p110, metabolic homeostasis
MeSH terms
Adenosine Triphosphate, Diabetes Mellitus, Type 2, Humans, Mitochondria, Reactive Oxygen Species, Mitochondrial Proteins, Mitochondrial Dynamics, Mitophagy

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