Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice

Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A. A., Ogurtsova, K., et al. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107843 · Cited by 10,792 · see citing works

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814 · see citing works

Mitochondrial Fission, Fusion, and Stress

Youle, R. J., & van der Bliek, A. M. (2012) · Science · doi:10.1126/science.1219855 · Cited by 3,674 · see citing works

Risk of dementia in diabetes mellitus: a systematic review

Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., & Scheltens, P. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70284-2 · Cited by 2,187 · see citing works

Diabetes mellitus and the risk of dementia: The Rotterdam Study

Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175 · see citing works

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works

Mitochondrial dysfunction and type 2 diabetes

Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works

Mitochondrial fusion and fission in cell life and death

Westermann, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3013 · Cited by 2,002 · see citing works

Mitochondria: Dynamic Organelles in Disease, Aging, and Development

Chan, D. C. (2006) · Cell · doi:10.1016/j.cell.2006.06.010 · Cited by 1,987 · see citing works

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703 · see citing works

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655 · see citing works

Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease

Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357 · see citing works

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

Murphy, M. P., & Smith, R. A. J. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105110 · Cited by 1,173 · see citing works

Regulation of mitochondrial biogenesis

Jornayvaz, F. R., & Shulman, G. I. (2010) · Essays in Biochemistry · doi:10.1042/bse0470069 · Cited by 1,119 · see citing works

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1

Ventura-Clapier, R., Garnier, A., & Veksler, V. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn098 · Cited by 932 · see citing works

Global and regional estimates and projections of diabetes-related health expenditure: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

Williams, R., Karuranga, S., Malanda, B., Saeedi, P., Basit, A., Besançon, S., Bommer, C., Esteghamati, A., Ogurtsova, K., Zhang, P., et al. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108072 · Cited by 865 · see citing works

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents

Morino, K. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25151 · Cited by 811 · see citing works

Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury

Zhao, K., Zhao, G.-M., Wu, D., Soong, Y., Birk, A. V., Schiller, P. W., & Szeto, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402999200 · Cited by 782 · see citing works

Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2·3 million people comprising more than 100,000 cases of dementia

Chatterjee, S., Peters, S. A. E., Woodward, M., Mejia Arango, S., Batty, G. D., Beckett, N., Beiser, A., Borenstein, A. R., Crane, P. K., Haan, M., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1588 · Cited by 711 · see citing works

Mortality attributable to diabetes in 20–79 years old adults, 2019 estimates: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

Saeedi, P., Salpea, P., Karuranga, S., Petersohn, I., Malanda, B., Gregg, E. W., Unwin, N. C., Wild, S. H., & Williams, R. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108086 · Cited by 666 · see citing works

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

Rovira-Llopis, S., Bañuls, C., Diaz-Morales, N., Hernandez-Mijares, A., Rocha, M., & Victor, V. M. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.013 · Cited by 657 · see citing works

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

Felice, F. G. D., & Ferreira, S. T. (2014) · Diabetes · doi:10.2337/db13-1954 · Cited by 647 · see citing works

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

Calkins, M. J., Manczak, M., Mao, P., Shirendeb, U., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr381 · Cited by 646 · see citing works

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600 · see citing works

Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes

Mogensen, M., Sahlin, K., Fernström, M., Glintborg, D., Vind, B. F., Beck-Nielsen, H., & Højlund, K. (2007) · Diabetes · doi:10.2337/db06-0981 · Cited by 573 · see citing works

Diabetes and global ageing among 65–99-year-old adults: Findings from the International Diabetes Federation Diabetes Atlas, 9th edition

Sinclair, A. J., Saeedi, P., Kaundal, A., Karuranga, S., Malanda, B., & Williams, R. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108078 · Cited by 524 · see citing works

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

Liu, Y. M., Liu, F., Grundke, I., Iqbal, K., & Gong, C. (2011) · The Journal of Pathology · doi:10.1002/path.2912 · Cited by 505 · see citing works

Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes

Green, K., Brand, M. D., & Murphy, M. P. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s110 · Cited by 490 · see citing works

Mitochondria-targeted antioxidants protect against amyloid-β toxicity in Alzheimer's disease neurons

Manczak, M., Mao, P., Calkins, M. J., Cornea, A., Reddy, A. P., Murphy, M. P., Szeto, H. H., Park, B., & Reddy, P. H. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100564 · Cited by 469 · see citing works

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

Hauptmann, S., Scherping, I., Dröse, S., Brandt, U., Schulz, K. L., Jendrach, M., Leuner, K., Eckert, A., & Müller, W. E. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.005 · Cited by 469 · see citing works

Differential Expression of Oxidative Phosphorylation Genes in Patients With Alzheimer's Disease: Implications for Early Mitochondrial Dysfunction and Oxidative Damage

Mańczak, M., Park, B. S., Jung, Y., & Reddy, P. H. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:2:147 · Cited by 432 · see citing works

Mitochondrial dysfunction in Alzheimer's disease: role in pathogenesis and novel therapeutic opportunities

Perez Ortiz, J. M., & Swerdlow, R. H. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14585 · Cited by 426 · see citing works

Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents

Szeto, H. H. (2006) · The AAPS Journal · doi:10.1208/aapsj080362 · Cited by 332 · see citing works

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

Montaigne, D., Marechal, X., Coisne, A., Debry, N., Modine, T., Fayad, G., Potelle, C., El Arid, J.-M., Mouton, S., Sebti, Y., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.008476 · Cited by 322 · see citing works

Does insulin dysfunction play a role in Alzheimer's disease?

Gasparini, L. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02037-0 · Cited by 314 · see citing works

Joslinʼs Diabetes Mellitus

Kahn, C. R., & Weir, G. C. (1995) · The Endocrinologist · doi:10.1097/00019616-199503000-00013 · Cited by 314 · see citing works

Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators

Busik, J. V., Mohr, S., & Grant, M. B. (2008) · Diabetes · doi:10.2337/db07-1520 · Cited by 312 · see citing works

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

Li, X., Leng, S. X., & Song, D. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s74042 · Cited by 294 · see citing works

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity

Chen, Z., Guo, L., Zhang, Y., L. Walzem, R., Pendergast, J. S., Printz, R. L., Morris, L. C., Matafonova, E., Stien, X., Kang, L., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72517 · Cited by 277 · see citing works

Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis

Pal, K., Mukadam, N., Petersen, I., & Cooper, C. (2018) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-018-1581-3 · Cited by 276 · see citing works

Dysregulation of Insulin Signaling, Glucose Transporters, O-GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain

Deng, Y., Li, B., Liu, Y. M., Iqbal, K., Grundke, I., & Gong, C. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090157 · Cited by 233 · see citing works

Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease

Nand, S., Singh, C., Singh, A., Singh, M. P., & Singh, S. P. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01945-y · Cited by 213 · see citing works

Mitochondrial Hormesis and Diabetic Complications

Sharma, K. (2015) · Diabetes · doi:10.2337/db14-0874 · Cited by 193 · see citing works

Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease

Sun, Y., Ma, C., Sun, H. J., Wang, H., Wei, P., Zhou, Z., Wang, H., Pi, C., Shi, Y., & He, X. (2020) · Journal of Diabetes Research · doi:10.1155/2020/4981814 · Cited by 172 · see citing works

Cell‐permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis

Petri, S., Kiaei, M., Damiano, M., Hiller, A., Wille, E., Manfredi, G., Calingasan, N. Y., Szeto, H. H., & Beal, M. F. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04018.x · Cited by 166 · see citing works

Genetic Analysis of a New Mouse Model for Non-Insulin-Dependent Diabetes

Kim, J. H., Sen, Ś., Avery, C., Simpson, E., Chandler, P., Nishina, P. M., Churchill, G. A., & Naggert, J. Κ. (2001) · Genomics · doi:10.1006/geno.2001.6569 · Cited by 157 · see citing works

Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes.

Wada, J., & Nakatsuka, A. (2016) · PubMed · doi:10.18926/amo/54413 · Cited by 157 · see citing works

Small molecules as therapeutic drugs for Alzheimer's disease

Oliver, D., & Reddy, P. H. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.03.001 · Cited by 156 · see citing works

Mitochondrial Oxidative Damage in Aging and Alzheimer′s Disease: Implications for Mitochondrially Targeted Antioxidant Therapeutics

Reddy, P. H. (2006) · BioMed Research International · doi:10.1155/jbb/2006/31372 · Cited by 153 · see citing works

Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus

Abdul-Ghani, M. A., & DeFronzo, R. A. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0030-1 · Cited by 146 · see citing works

Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease

Bhatti, G. K., Reddy, A. P., Reddy, P. H., & Bhatti, J. S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00369 · Cited by 145 · see citing works

Potent mitochondria-targeted peptides reduce myocardial infarction in rats

Cho, J., Won, K., Wu, D., Soong, Y., Liu, S., Szeto, H. H., & Hong, M. K. (2007) · Coronary Artery Disease · doi:10.1097/01.mca.0000236285.71683.b6 · Cited by 144 · see citing works

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease

Yin, X., Mańczak, M., & Reddy, P. H. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw045 · Cited by 142 · see citing works

Vascular viewpoint

Razak, F. A., & Anand, S. S. (2004) · Vascular Medicine · doi:10.1191/1358863x04vm568xx · Cited by 134 · see citing works

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer’s disease

Reddy, P. H., Mańczak, M., & Kandimalla, R. J. L. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx052 · Cited by 134 · see citing works

Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets

Vieira, M. N. N., Lima‐Filho, R. A. S., & Felice, F. G. D. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.014 · Cited by 131 · see citing works

Mitochondrial dysfunction in pancreatic β-cells in Type 2 Diabetes

Mulder, H., & Ling, C. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.05.015 · Cited by 111 · see citing works

Phenotypic characterization of polygenic type 2 diabetes in TALLYHO/JngJ mice

Kim, J. H., Stewart, T. P., Soltani‐Bejnood, M., Wang, L., Fortuna, J. M., Mostafa, O. A., Moustaïd‐Moussa, N., Shoieb, A. M., McEntee, M. F., Wang, Y., et al. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06647 · Cited by 104 · see citing works

Mitochondrial regulation of β-cell function: Maintaining the momentum for insulin release

Kaufman, B. A., Li, C., & Soleimanpour, S. A. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.01.004 · Cited by 103 · see citing works

Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer’s Disease

Reddy, P. H., Mańczak, M., Yin, X., & Reddy, A. P. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170988 · Cited by 96 · see citing works

Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy

Saxena, S., Mathur, A., & Kakkar, P. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28712 · Cited by 96 · see citing works

Mitochondrial Targeting with Antioxidant Peptide SS-31 Prevents Mitochondrial Depolarization, Reduces Islet Cell Apoptosis, Increases Islet Cell Yield, and Improves Posttransplantation Function

Thomas, D. A., Stauffer, C., Zhao, K., Yang, H., Sharma, V. K., Szeto, H. H., & Suthanthiran, M. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006080825 · Cited by 84 · see citing works

Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis

Men, X., Wang, H., Li, M., Cai, H., Xu, S., Zhang, W., Xu, Y., Ye, L., Yang, W., Wollheim, C. B., et al. (2009) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2008.08.031 · Cited by 83 · see citing works

Mitochondrial dysfunction and type 2 diabetes

Parish, R., & Petersen, K. F. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0006-3 · Cited by 83 · see citing works

Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway

Yang, S., Han, Y., He, J., Yang, M., Zhang, W., Zhan, M., Li, A., Li, L., Na-Song, Liu, Y., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110521 · Cited by 83 · see citing works

Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes

Morino, K., Petersen, K. F., Sono, S., Choi, C. S., Samuel, V. T., Lin, A., Gallo, A. E., Zhao, H., Kashiwagi, A., Goldberg, I. J., et al. (2012) · Diabetes · doi:10.2337/db11-1391 · Cited by 77 · see citing works

The TALLYHO Mouse as a Model of Human Type 2 Diabetes

Kim, H. J., & Saxton, A. M. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-068-7_6 · Cited by 75 · see citing works

Mitochondria-Targeted Antioxidant SS31 Prevents Amyloid Beta-Induced Mitochondrial Abnormalities and Synaptic Degeneration in Alzheimer’s Disease

Calkins, M. J., Mańczak, M., & Reddy, P. (2012) · Pharmaceuticals · doi:10.3390/ph5101103 · Cited by 71 · see citing works

The machinery of mitochondrial fusion, division, and distribution, and emerging connections to apoptosis

Hales, K. G. (2004) · Mitochondrion · doi:10.1016/j.mito.2004.05.007 · Cited by 70 · see citing works

Mitochondrial dysfunction in diabetes and the regulatory roles of antidiabetic agents on the mitochondrial function

Yaribeygi, H., Atkin, S. L., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27754 · Cited by 68 · see citing works

Mitochondria-targeted antioxidant mitoquinone attenuates liver inflammation and fibrosis in cirrhotic rats

Türkseven, S., Bolognesi, M., Brocca, A., Pesce, P., Angeli, P., & Pascoli, M. D. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00135.2019 · Cited by 68 · see citing works

Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus

Yoon, S. J., Cho, H., Kim, J., Lee, D.-W., Kim, G. H., Hong, Y. S., Moon, S., Park, S., Lee, S., Lee, S. L., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4266-7 · Cited by 65 · see citing works

Combined Therapy with SS31 and Mitochondria Mitigates Myocardial Ischemia-Reperfusion Injury in Rats

Lee, F.-Y., Shao, P., Wallace, C. G., Chua, S. O., Sung, P., Ko, S., Chai, H., Chung, S., Chen, K., Lu, H., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092782 · Cited by 65 · see citing works

Mitochondrial dysfunction plays a key role in the development of neurodegenerative diseases in diabetes

Cheng, H., Gang, X., Liu, Y., Wang, G., Zhao, X., & Wang, G. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00179.2019 · Cited by 62 · see citing works

Therapeutic Strategies for Mitochondrial Dysfunction and Oxidative Stress in Age-Related Metabolic Disorders

Bhatti, J. S., Kumar, S., Vijayan, M., Bhatti, G. K., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.012 · Cited by 60 · see citing works

Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer’s disease and a novel protective role for ascorbate

Dixit, S., Fessel, J. P., & Harrison, F. E. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.021 · Cited by 58 · see citing works

Type 2 diabetes mouse model TallyHo carries an obesity gene on chromosome 6 that exaggerates dietary obesity

Kim, J. H., Stewart, T. P., Zhang, W., Kim, H. Y., Nishina, P. M., & Naggert, J. Κ. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00197.2004 · Cited by 57 · see citing works

Muscular mitochondrial dysfunction and type 2 diabetes mellitus

Schrauwen‐Hinderling, V. B., Roden, M., Kooi, M. E., Hesselink, M. K. C., & Schrauwen, P. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f0eca9 · Cited by 56 · see citing works

Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10Lt/J and TALLYHO/JngJ

Leiter, E. H., Strobel, M. C., O’Neill, A. C., Schultz, D. W., Schile, A. J., & Reifsnyder, P. C. (2013) · Journal of Diabetes Research · doi:10.1155/2013/165327 · Cited by 56 · see citing works

The antioxidant peptide SS31 prevents oxidative stress, downregulates CD36 and improves renal function in diabetic nephropathy

Hou, Y., Shi, Y., Han, B., Liu, X., Qiao, X., Qi, Y. A., & Wang, L. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy021 · Cited by 54 · see citing works

Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels

Méndez, D., Arauna, D., Fuentes, F., Araya‐Maturana, R., Palomo, I. F., Alarcón, M. A., Sebastián, D., Zorzano, A., & Eduardo Fuentes, Q. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176192 · Cited by 53 · see citing works

Molecular and cellular bases of diabetes: Focus on type 2 diabetes mouse model-TallyHo

Tamarai, K., Bhatti, J. S., & Reddy, P. H. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.05.004 · Cited by 47 · see citing works

Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using (C57BL/6J × TALLYHO/JngJ) F2 mice

Stewart, T. P., Kim, H. Y., Saxton, A. M., & Kim, J. H. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-713 · Cited by 45 · see citing works

Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I

Davis, W. A., Zilkens, R., STARKSTEIN, S. E., Davis, T. M. E., & Bruce, D. G. (2016) · Diabetologia · doi:10.1007/s00125-016-4127-9 · Cited by 44 · see citing works

Mitochondria-Targeted Small Peptide, SS31 Ameliorates Diabetes Induced Mitochondrial Dynamics in Male TallyHO/JngJ Mice

Bhatti, J. S., Thamarai, K., Kandimalla, R., Manczak, M., Yin, X., Kumar, S., Vijayan, M., & Reddy, P. H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02142-7 · Cited by 41 · see citing works

Metformin Supports the Antidiabetic Effect of a Sodium Glucose Cotransporter 2 Inhibitor by Suppressing Endogenous Glucose Production in Diabetic Mice

Neschen, S., Scheerer, M. F., Seelig, A., Huypens, P., Schultheiß, J., Wu, M., Wurst, W., Rathkolb, B., Suhre, K., Wolf, E., et al. (2014) · Diabetes · doi:10.2337/db14-0393 · Cited by 40 · see citing works

Mitochondria-Targeted Antioxidant Peptide SS31 Protects the Retinas of Diabetic Rats

Huang, J., Li, X., Li, M., Li, J., Xiao, W., Ma, W., Chen, X.-M., Liang, X., Tang, S., & Luo, Y. (2013) · Current Molecular Medicine · doi:10.2174/15665240113139990049 · Cited by 38 · see citing works

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice

Frankó, A., Neschen, S., Rozman, J., Rathkolb, B., Aichler, M., Feuchtinger, A., Brachthäuser, L., Neff, F., Kovářová, M., Wolf, E., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2016.12.007 · Cited by 34 · see citing works

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Imai, T., Matsubara, H., Nakamura, S., Hara, H., & Shimazawa, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.044 · Cited by 33 · see citing works

Glucose intolerance in young TallyHo mice is induced by leptin-mediated inhibition of insulin secretion

Sung, Y.-Y., Lee, Y., Jung, W. H., Kim, H.-Y., Cheon, H. G., Yang, S., & Rhee, S. D. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.160 · Cited by 32 · see citing works

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Czigler, A., Tóth, L., Szarka, N., Berta, G., Amrein, K., Czeiter, E., Lendvai-Emmert, D., Bodó, K., Tarantini, S., Koller, Á., et al. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6439 · Cited by 32 · see citing works

Mitochondrial oxidative phosphorylation is impaired in TALLYHO mice, a new obesity and type 2 diabetes animal model

Hunter, C. A., Kartal, F., Koc, Z. C., Murphy, T., Kim, H. J., Denvir, J., & Koc, E. C. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105616 · Cited by 32 · see citing works

Mitochondrial dysfunction and Alzheimer's disease: prospects for therapeutic intervention

Lim, J. W., Lee, J., & Pae, A. N. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.1.279 · Cited by 28 · see citing works

Obesity of TallyHO/JngJ Mouse Is Due to Increased Food Intake with Early Development of Leptin Resistance

Rhee, S. D., Sung, Y., Lee, Y. J., Kim, J., Jung, W., Kim, M., Lee, M.-S., Lee, M., Yang, S., & Cheon, H.-R. (2010) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0030-1267202 · Cited by 19 · see citing works

Canagliflozin, an SGLT2 inhibitor, corrects glycemic dysregulation in TallyHO model of T2D but only partially prevents bone deficits

Thrailkill, K. M., Bunn, R. C., Uppuganti, S., Ray, P. D., Popescu, I. R., Kalaitzoglou, E., Fowlkes, J. L., & Nyman, J. S. (2020) · Bone · doi:10.1016/j.bone.2020.115625 · Cited by 19 · see citing works

Adiponectin partially rescues high glucose/high fat-induced impairment of mitochondrial biogenesis and function in a PGC-1α dependent manner.

Wang, H., Yan, W.-J., Zhang, J., Zhang, F.-Y., Gao, C., Wang, Y.-J., Law, W. B., & Tao, L. (2017) · PubMed · Cited by 16 · see citing works

Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling

Yan, Y., Wang, J., Chaudhry, M. A., Nie, Y., Sun, S., Carmon, J., Shah, P. T., Bai, F., Pratt, R. D., Brickman, C., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143495 · Cited by 15 · see citing works

Systemic inhibition of miR-451 increases fibrotic signaling and diminishes autophagic response to exacerbate renal damage in Tallyho/Jng mice

Fluitt, M. B., Shivapurkar, N., Kumari, M., Singh, S., Li, L., Tiwari, S., & ECELBARGER, C. A. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00594.2019 · Cited by 15 · see citing works

Mitochondrial dysfunction in adipocytes: the culprit in type 2 diabetes?

Maassen, J. A. (2006) · Diabetologia · doi:10.1007/s00125-006-0165-z · Cited by 14 · see citing works

Mitochondrial dysfunction manifests in the early stages of Alzheimer disease

Wood, H. B. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0353-3 · Cited by 14 · see citing works

Aging and diabetes: Mitochondrial dysfunction

Irving, B. A., & Nair, K. S. (2007) · Current Diabetes Reports · doi:10.1007/s11892-007-0039-x · Cited by 13 · see citing works

Are TallyHo Mice A True Mouse Model for Type 2 Diabetes and Alzheimer’s Disease?

Ramasubramanian, B., & Reddy, P. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190613 · Cited by 13 · see citing works

Subcongenic analysis of tabw2obesity QTL on mouse chromosome 6

Stewart, T. P., Mao, X., Aqqad, M. N., Uffort, D., Dillon, K. D., Saxton, A. M., & Kim, J. H. (2012) · BMC Genetics · doi:10.1186/1471-2156-13-81 · Cited by 12 · see citing works

TallyHo Diabetic Phenotype Limited to Male Mice

Wagner, I. J. (2012) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e318245eaff · Cited by 4 · see citing works

Plexin B2 aids wound sealing and healing after spinal cord injury

Wood, H. B. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0352-4 · Cited by 3 · see citing works

Untitled work

Alberti (1998) · doi:10.1002/(sici)1096-9136(199807)15:7

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works

Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria

Gowda, P., Reddy, P. H., & Kumar, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101529 · Cited by 166 · see citing works

MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapy

Li, Y.-B., Fu, Q., Guo, M., Du, Y., Chen, Y., & Cheng, Y. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03075-8 · Cited by 123 · see citing works

Cholinergic Neuron Targeting Nanosystem Delivering Hybrid Peptide for Combinatorial Mitochondrial Therapy in Alzheimer’s Disease

Qian, K., Bao, X., Li, Y., Wang, P., Guo, Q., Yang, P., Xu, S., Yu, F., Meng, R., Cheng, Y., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c05795 · Cited by 87 · see citing works

Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease

Ding, X.-W., Robinson, M., Li, R., Aldhowayan, H., Geetha, T., & Babu, J. R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105783 · Cited by 73 · see citing works

Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases

Bhatti, G. K., Gupta, A., Pahwa, P., Khullar, N., Singh, S., Navik, U., Kumar, S., Mastana, S. S., Reddy, A. P., Reddy, P. H., et al. (2022) · Biomedical Journal · doi:10.1016/j.bj.2022.05.002 · Cited by 65 · see citing works

Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction

Du, X., Zeng, Q., Luo, Y., He, L., Zhao, Y., Li, N., Han, C., Zhang, G., & Liu, W. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101846 · Cited by 60 · see citing works

Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways

Gao, T., Wang, T., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107779 · Cited by 59 · see citing works

Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer’s disease

Reddy, A. P., Sawant, N. A., Morton, H., Kshirsagar, S., Bunquin, L. E., Yin, X., & Reddy, P. H. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab091 · Cited by 55 · see citing works

Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus

Veselov, I. M., Vinogradova, D. V., Maltsev, A. V., Shevtsov, P. N., Spirkova, E. A., Бачурин, С. О., & Shevtsova, E. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914450 · Cited by 55 · see citing works

Common methods in mitochondrial research (Review)

Yin, Y., & Shen, H. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5182 · Cited by 52 · see citing works

Mitophagy in Alzheimer's disease and other metabolic disorders: A focus on mitochondrial-targeted therapeutics

Skawratananond, S., Xiong, D. X., Zhang, C., Tonk, S. S., Pinili, A., Delacruz, B., Pham, P., Smith, S. C., Navab, R., & Reddy, P. H. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102732 · Cited by 39 · see citing works

The emerging significance of mitochondrial targeted strategies in NAFLD treatment

Zhang, T., Nie, Y., & Wang, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121943 · Cited by 21 · see citing works

Research Advances of Mitochondrial Dysfunction in Perioperative Neurocognitive Disorders

Chen, M., Yan, R., Ding, L., Luo, J.-S., Ning, J., & Zhou, R. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03962-4 · Cited by 13 · see citing works

Pathophysiology Associated with Diabetes-induced Tauopathy and Development of Alzheimer’s Disease

Sur, D., Sarkar, P., Banu, S., Bhattacharya, S., & Bala, A. (2022) · Current Diabetes Reviews · doi:10.2174/1573399818666220513142030 · Cited by 9 · see citing works

Methods to Study Mitochondria: Techniques Used to Study the Effects of Age‐Related Diseases Including Alzheimer's

Baig, J., Pradeepkiran, J. A., & Reddy, P. H. (2023) · Current Protocols · doi:10.1002/cpz1.631 · Cited by 8 · see citing works

The past-tense debate

Pinker, S. A., & Ullman, M. T. (2002) · Cited by 8 · see citing works

Elucidating the molecular targets in Alzheimer's disease: Advances and therapeutic implications

Soni, U., & Pujari, R. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111660 · Cited by 7 · see citing works

Targeting mitochondria: a great boon to fight type 2 diabetes

Marañón, A., Rovira‐Llopis, S., Rocha, M., & Víctor, V. M. (2022) · Redox Experimental Medicine · doi:10.1530/rem-22-0012 · Cited by 6 · see citing works

Mitochondrial targeted therapies in MAFLD

Lai, S., Tang, D., & Feng, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151498 · Cited by 9 · see citing works

Altered mitochondrial function: a clue therapeutic strategies between metabolic dysfunction-associated steatotic liver disease and chronic kidney disease?

Bai, J., Zhang, L., He, L., & Zhou, Y. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1613640 · Cited by 6 · see citing works

Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO

Ramasubramanian, B., Griffith, C., Hanson, M., Bunquin, L. E., Reddy, A. P., Hegde, V. K., & Reddy, P. H. (2022) · Cells · doi:10.3390/cells11040744 · Cited by 4 · see citing works

Cobalt Protoporphyrin Downregulates Hyperglycemia-Induced Inflammation and Enhances Mitochondrial Respiration in Retinal Pigment Epithelial Cells

Fang, P.-H., Lin, T., Huang, C.-C., Lin, Y.-C., Lai, C., & Cheng, B. (2025) · Antioxidants · doi:10.3390/antiox14010092 · Cited by 2 · see citing works

Protein and peptide based nanotherapeutics for the management of Alzheimer’s disease: Current insights and future directions

Das, S. K., Bashir, B., Kolekar, K. A., Harish, V., Patle, D., Vishwas, S., Mittal, N., Jha, S. K., Kumar, P., Gupta, G. K., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.103000 · Cited by 2 · see citing works

Use and Reuse of Animal Behavioral, Molecular, and Biochemical Data in Alzheimer’s Disease Research: Focus on 3Rs and Saving People’s Tax Dollars

Islam, M. A., Kshirsagar, S., Reddy, A. P., Sehar, U., & Reddy, P. H. (2024) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-240126 · Cited by 2 · see citing works

Mitochondria-Targeted SS31-Conjugated Liposome Attenuates Oxidative Stress in Endothelial and Skeletal Muscle Cells

Kim, E., Han, Y., Oh, P., Wang, Q., Lim, S. T., & Jeong, H. (2025) · Journal of Vascular Research · doi:10.1159/000547281 · Cited by 1 · see citing works

Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models

Annepaka, E., Rangasmy, M., Panakala, S., & Sayana, S. B. (2024) · Cureus · doi:10.7759/cureus.55400

SS31 Mitigates Subarachnoid Hemorrhage-Induced Early Brain Injury via Nrf2/Keap1 Pathway ActivationPreprint

Liu, M., Shen, J., Wu, L., Liu, M., Zeng, C., Cai, Z., Yin, J., & Guanghui, W. (2025) · Research Square · doi:10.21203/rs.3.rs-6797139/v1

Advances in the Core Role and Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease

Gu, T., Guo, H., Guo, Z., & Hua, S. (2026) · Brain and Behavior · doi:10.1002/brb3.71418

The Role of Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha in Type 2 Diabetes Mellitus and Neurodegenerative Diseases: A Systematic Review of Preclinical Evidence

Olaokun, O. O., & Olaokun, F. D. (2026) · Sci · doi:10.3390/sci8080211

Mitochondrial Dysfunctioning Induced by Hyperglycemia in the Liver Tissues of Diabetic Mice, TALLYHO/JngJ Strain and Ameliorative Action of a Small Peptide, SS31

Bhatti, J. S., Tamarai, K., Kandimalla, R. J. L., Mańczak, M., Yin, X., Ramasubramanian, B., Sawant, N. A., Pradeepkiran, J. A., Vijayan, M., Kumar, S., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2020.154608 · Cited by 2 · see citing works

Mitochondria-Targeted Small Peptide, SS31 Ameliorates Diabetes Induced Mitochondrial Dynamics in Male TallyHO/JngJ Mice

Bhatti, J. S., Thamarai, K., Kandimalla, R., Manczak, M., Yin, X., Kumar, S., Vijayan, M., & Reddy, P. H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02142-7 · Cited by 41 · see citing works

Mitochondria-Targeted Peptide SS31 Attenuates Renal Tubulointerstitial Injury via Inhibiting Mitochondrial Fission in Diabetic Mice

Yang, S., Li, A., Han, Y., Peng, C., Song, N., Yang, M., Zhan, M., Zeng, L., Song, P., Zhang, W., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2346580 · Cited by 50 · see citing works

The Mitochondrial Antioxidant SS-31 Modulates Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Type 2 Diabetes

Escribano‐López, I., Marañón, A., Iannantuoni, F., López‐Domènech, S., Abad‐Jiménez, Z., Díaz-Pozo, P., Solá, E., Apostolova, N., Rocha, M., & Víctor, V. M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091322 · Cited by 32 · see citing works

The Effect of S-15176 Difumarate Salt on Ultrastructure and Functions of Liver Mitochondria of C57BL/6 Mice with Streptozotocin/High-Fat Diet-Induced Type 2 Diabetes

Belosludtseva, N. V., Starinets, V. S., Pavlik, L. L., Mikheeva, I. B., Dubinin, M. V., & Belosludtsev, K. N. (2020) · Biology · doi:10.3390/biology9100309 · Cited by 14 · see citing works