Increased amygdala and parahippocampal gyrus activation in schizophrenic patients with auditory hallucinations: An fMRI study using independent component analysis
Open accessAbstract
Objective Hallucinations in patients with schizophrenia have strong emotional connotations. Functional neuroimaging techniques have been widely used to study brain activity in patients with schizophrenia with hallucinations or emotional impairments. However, few of these studies have investigated the association between hallucinations and emotional dysfunctions using an emotional auditory paradigm. Independent component analysis (ICA) is an analysis method that is especially useful for decomposing activation during complex cognitive tasks in which multiple operations occur simultaneously. Our aim in this study is to analyze brain activation after the presentation of emotional auditory stimuli in patients with schizophrenia with and without chronic auditory hallucinations using ICA methodology. It was hypothesized that functional connectivity differences in limbic regions responsible for emotional processing would be demonstrated.Methods The present functional magnetic resonance imaging (fMRI) study compared neural activity in 41 patients with schizophrenia (27 with auditory hallucinations, 14 without auditory hallucinations) with 31 controls. Neural activity data was generated while participants were presented with an auditory paradigm containing emotional words. The comparison was performed using a multivariate approach, ICA. Differences in temporo-spatial aspects of limbic network were examined in three study groups.Results Limbic networks responded differently in patients with auditory hallucinations compared to healthy controls and patients without auditory hallucinations. Unlike control subjects and non-hallucinators, the group of hallucinatory patients showed an increase of activity in the parahippocampal gyrus and the amygdala during the emotional session.Conclusions These findings may reflect an increase in parahippocampal gyrus and amygdala activity during passive listening of emotional words in patients with schizophrenia and auditory hallucinations.
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- Authors
- Escartí, M. J., de la Iglesia-Vayá, M., Martí-Bonmatí, L., Robles, M., Carbonell, J., Lull, J. J., García-Martí, G., Manjón, J. V., Aguilar, E. J., Aleman, A., & Sanjuán, J.
- Affiliations
- Universitat Politècnica de València (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- University Medical Center Groningen (NL)
- Universitat de València (ES)
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 117
- Issue
- 1
- Pages
- 31-41
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2122934770
- Cited by
- 80
- References
- 59
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 7
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Ministerio de Ciencia e Innovación (P.I. 02/0018, P.I. 05/2332)
- Centro de Investigación Biomédica en Red de Salud Mental
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- schizophrenia, auditory hallucinations
- MeSH terms
- Adult, Amygdala, Hallucinations, Humans, Magnetic Resonance Imaging, Male, Schizophrenia, Severity of Illness Index, Parahippocampal Gyrus
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