Adult mental health disorders and their age at onset
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Summary: The study of age at onset of mental health disorders is technically and conceptually difficult. It is important to consider these age distributions in order to understand causes and mechanisms of illness and to intervene at an appropriate juncture for primary and secondary prevention. This article reviews some of the approaches to studying age at onset, sets out the evidence to support the assertion that adult mental disorders begin in adolescence, and finds that perhaps half of all adult mental health disorders have begun by the teenage years. The paper then discusses whether this fits what is known about the developmental neurobiology of the brain and introduces the implications for mental health services.
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A further phase of significant neurobiological changes is from mid-childhood through pubescence to mid-20s (second-wave hits), when the risk of disorder onset is the highest.
“A further phase of significant neurobiological changes is from mid-childhood through pubescence to mid-20s (second-wave hits) 47 , when the risk of disorder onset is the highest.”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [47]
Neurobiologically, it takes as long as three decades for mature human brain development, which coincides with the age of onset of psychopathology for young people.
“Neurobiologically, it takes as long as three decades for mature human brain development, which coincides with the age of onset of psychopathology for young people 7,47 .”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [47]
Clinical staging models integrate these epidemiological and neurobiological findings.
“Clinical staging models 53 integrate these epidemiological and neurobiological findings (Figure 2) 47 .”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [47]
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- Authors
- Jones, P. B.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Jones, P. B.
- ORCID
- Jones, P. B.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2013-01
- Volume
- 202
- Issue
- s54
- Pages
- s5-s10
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2170279894
- Cited by
- 701
- References
- 53
- Citations by year
- 2026: 39 · 2025: 67 · 2024: 74 · 2023: 72 · 2022: 84 · 2021: 91 · 2020: 76 · 2019: 51 · 2018: 39 · 2017: 35 · 2016: 24 · 2015: 23 · 2014: 12 · 2013: 13
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- National Institute for Health and Care Research (RP-PG-0606-1335, NF-SI-0509-10215)
- Topics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- age of onset, adult mental disorders, adolescence, developmental neuroscience, primary prevention, secondary prevention, mental health services
- MeSH terms
- Adolescent, Adult, Aged, Anxiety Disorders, Mental Disorders, Brain, Child, Depressive Disorder, Epidemiologic Methods, Female, Humans, Male, Mental Health Services, Middle Aged, Risk Factors, Schizophrenia, Age of Onset, Young Adult
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