The arcuate fasciculus in auditory-verbal hallucinations: A meta-analysis of diffusion-tensor-imaging studies
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Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy controls (HCs). Five studies were retained gathering 256 DTI data points, divided into AVHs (n=106) and HCs (n=150). The meta-analysis demonstrated a reduced fractional anisotropy in the left Arcuate Fasciculus (AF) of hallucinators (hg= -0.42; CI[-0.69,-0.16]; p<10(-3)). The current meta-analysis confirmed disruptions of white matter integrity in the left AF bundle of schizophrenia patients with AVHs.
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Auditory hallucinations are associated with impaired connectivity of large-scale networks at both functional and structural levels.
“Auditory hallucinations are also associated with impaired connectivity of large-scale networks at both the functional 34 and structural level.35”
From Are hallucinations due to an imbalance between excitatory and inhibitory influences on the brain? (2016) · cites this paper as [35]
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- Authors
- Geoffroy, P. A., Houenou, J., Duhamel, A., Amad, A., De Weijer, A. D., Ćurčić-Blake, B., Linden, D. E. J., Thomas, P., & Jardri, R.
- Affiliations
- Inserm (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Université de Lille (FR)
- Cardiff University (GB)
- Corresponding author
- Jardri, Renaud
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 159
- Issue
- 1
- Pages
- 234-237
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2100037361
- Cited by
- 90
- References
- 26
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 17 · 2015: 7 · 2014: 2
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- GDR-CNRS 3557 'Institut de Recherche en Psychiatrie
- BCB (UMCG grant (No.689901), ERC grant (ERC StG 2012-312787_DRASTIC))
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- auditory verbal hallucinations, arcuate fasciculus
- MeSH terms
- Hallucinations, Humans, Anisotropy, Subthalamus, Diffusion Tensor Imaging, White Matter
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