mTORC1 signaling controls multiple steps in ribosome biogenesis

Iadevaia, Valentina; Liu, Rui; Proud, Christopher G.

doi:10.1016/j.semcdb.2014.08.004

Cited by 248PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanismsBiochemical and Molecular Research

mTORC1 signaling controls multiple steps in ribosome biogenesis

Iadevaia, Valentina, Liu, Rui, Proud, Christopher G.·2014·Seminars in Cell & Developmental Biology

DOI 10.1016/j.semcdb.2014.08.004

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Abstract

Ribosome biogenesis is critical for cells to generate the ribosomes they need for protein synthesis in order to survive, grow and proliferate. It is a complex process, involving the coordinated production of four different RNA species and about 80 proteins, as well as their assembly into functional ribosomal subunits. Given its high demand for amino acids and nucleotides, it is also a metabolically expensive process for the cell. The mammalian target of rapamycin complex 1 (mTORC1) is a protein kinases which is activated by nutrients, anabolic hormones and oncogenic signaling pathways. mTORC1 positively regulates several steps in ribosome biogenesis, including ribosomal RNA transcription, the synthesis of ribosomal proteins and other components required for ribosome assembly. mTORC1 can thus coordinate stimuli which promote ribosome production with the various steps involved in this process. Although important advances have been made in our understanding of mTORC1 signaling, major questions remain about the molecular mechanisms by which it regulates ribosome biogenesis.

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mTORC1 increases ribosomal biogenesis.
“However, mTORC1 increases not only protein synthesis from existing ribosomes but also the synthesis of more ribosomes, a process known as ribosomal biogenesis [176].”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [176]

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Matthew, E. M., Hart, L. S., Astrinidis, A., Navaraj, A., Dolloff, N. G., Dicker, D. T., Henske, E. P., & El-Deiry, W. S. (2009) · Cell Cycle · doi:10.4161/cc.8.24.10800 · Cited by 67 · see citing works
Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway
Havel, J. J., Li, Z., Cheng, D., Peng, J., & Fu, H. (2014) · Oncogene · doi:10.1038/onc.2014.91 · Cited by 57 · see citing works
Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells.
Shama, S., Avni, D., Frederickson, R., Sonenberg, N., & Meyuhas, O. (1995) · Europe PMC (PubMed Central) · Cited by 55 · see citing works
The Species-Specific RNA Polymerase I Transcription Factor SL-1 Binds to Upstream Binding Factor
Hempel, W. M., Cavanaugh, A. H., Hannan, R. D., Taylor, L. J., & Rothblum, L. I. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.2.557 · Cited by 54 · see citing works
Transcription inhibitors stimulate translation of 5′ TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway
Loreni, F., Thomas, G., & Amaldi, F. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01753.x · Cited by 50 · see citing works
Transcription from the rat 45S ribosomal DNA promoter does not require the factor UBF.
Sd, S., O’Mahony, D. J., Kinsella, B. T., & Li, R. (1993) · Europe PMC (PubMed Central) · Cited by 46 · see citing works
Pharmacological and Genetic Evaluation of Proposed Roles of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK), Extracellular Signal-regulated Kinase (ERK), and p90RSK in the Control of mTORC1 Protein Signaling by Phorbol Esters
Fonseca, B. D., Alain, T., Finestone, L. K., Huang, B., Rolfe, M. J., Jiang, T., Yao, Z., Hernández, G., Bennett, C. F., & Proud, C. G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.260794 · Cited by 45 · see citing works
Self-citation
Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors
Liu, R., Iadevaia, V., Avérous, J., Taylor, P. M., Zhang, Z., & Proud, C. G. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku130 · Cited by 44 · see citing works
Self-citation
Translational Regulation of Terminal Oligopyrimidine mRNAs Induced by Serum and Amino Acids Involves Distinct Signaling Events
Caldarola, S., Amaldi, F., Proud, C. G., & Loreni, F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310574200 · Cited by 36 · see citing works
Self-citation
Expression of yeast high mobility group protein HMO1 is regulated by TOR signaling
Xiao, L., Kamau, E. T., Donze, D., & Grove, A. (2011) · Gene · doi:10.1016/j.gene.2011.08.017 · Cited by 29 · see citing works

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2 of the 95 references couldn’t be matched to a known paper.

Sorted by citations

The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
Hoxhaj, G., & Manning, B. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0216-7 · Cited by 2,137 · see citing works
Targeting mTOR for cancer therapy
Hua, H., Kong, Q.-B., Zhang, H., Wang, J., Luo, T., & Jiang, Y.-F. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0754-1 · Cited by 772 · see citing works
Ribosome biogenesis in cancer: new players and therapeutic avenues
Pelletier, J., Thomas, G., & Volarević, S. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.104 · Cited by 802 · see citing works
mTORC1 signaling and the metabolic control of cell growth
Ben‐Sahra, I., & Manning, B. D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.02.012 · Cited by 641 · see citing works
“Enhancing ribosome biogenesis is a major function of mTORC1 [33].”
Background
mTOR in Brain Physiology and Pathologies
Bockaert, J., & Marin, P. (2015) · Physiological Reviews · doi:10.1152/physrev.00038.2014 · Cited by 360 · see citing works
“In addition, mTORC1, via S6K1, promotes the expression of ribosomal RNA (rRNA), the transcription of 5S rRNA, and transfer RNA (tRNA) and thereby contributes to ribosome biogenesis (109).”
Background
Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability
Stepanenko, A. A., & Dmitrenko, V. V. (2015) · Gene · doi:10.1016/j.gene.2015.08.009 · Cited by 321 · see citing works
Ribosome biogenesis in disease: new players and therapeutic targets
Jiao, L., Liu, Y., Yu, X., Pan, X., Zhang, Y., Tu, J., Song, Y., & Li, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01285-4 · Cited by 317 · see citing works
“2).(22) Ribosomal protein S6 kinase 1 (S6K1) is under the control of mTORC1 signaling.”
Background
Molecular logic of mTORC1 signalling as a metabolic rheostat
Valvezan, A. J., & Manning, B. D. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0038-7 · Cited by 295 · see citing works
Drosophila as a model for ageing
Piper, M. D. W., & Partridge, L. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.016 · Cited by 273 · see citing works
“In addition to its effects on translation and autophagy, mTOR signals to control other cellular functions, including transcription, through all three RNA polymerases (Ghosh et al., 2014; Iadevaia et al., 2014; Marshall et al., 2012).”
Background
MTOR inhibitors in cancer therapy
Xie, J., Wang, X., & Proud, C. G. (2016) · F1000Research · doi:10.12688/f1000research.9207.1 · Cited by 266 · see citing works
The mTORC1 signaling network senses changes in cellular purine nucleotide levels
Hoxhaj, G., Hughes-Hallett, J., Timson, R. C., Ilagan, E., Yuan, M., Asara, J., Ben-Sahra, I., & Manning, B. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.029 · Cited by 184 · see citing works
“As part of its program to stimulate ribosome biogenesis, mTORC1 has been found to promote the action of both Pol I and Pol III, the RNA polymerases that transcribe rRNA (Iadevaia et al., 2014).”
Background
Gene expression hallmarks of cellular ageing
Frenk, S., & Houseley, J. M. (2018) · Biogerontology · doi:10.1007/s10522-018-9750-z · Cited by 180 · see citing works
“In fact, accumulation of ribosomal proteins is a predictor of shortened lifespan in yeast (Janssens et al. 2015; Janssens and Veenhoff 2016) and fibroblasts derived from Hutchinson–Gilford progeria syndrome (HGPS) patients show unusually high ribosome synthesis (Buchwalter and Hetzer 2017), while…”
Background
Regulation of ribosomal protein genes: An ordered anarchy
Petibon, C., Ghulam, M. M., Catala, M., & Elela, S. A. (2020) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1632 · Cited by 164 · see citing works
“The most studied mechanism of translation regulation is that controlled by the TOR pathway, which links translation to nutrients availability, cell size, and cell division (Caron et al., 2010; Gingras et al., 2004; Iadevaia et al., 2014; Masvidal et al., 2017; Mayer & Grummt, 2006).”
BackgroundMethod
The Lysosome Signaling Platform: Adapting With the Times
Inpanathan, S., & Botelho, R. J. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00113 · Cited by 157 · see citing works
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
Valvezan, A. J., Turner, M., Belaïd, A., Lam, H. C., Miller, S. K., McNamara, M. C., Baglini, C. V., Housden, B. E., Perrimon, N., Kwiatkowski, D. J., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.09.013 · Cited by 160 · see citing works
“also stimulates rRNA synthesis through coordinated regulation of three essential RNA polymerase I (Pol I)-specific transcription factors, UBF, SL1, and TIF1A, and by relieving MAF1-mediated inhibition of RNA polymerase III (Pol III) transcription (Iadevaia et al., 2014; Mayer and Grummt, 2006; Michels et al., 2010; Sh…”
BackgroundInfluential
Lysosomal quality control of cell fate: a novel therapeutic target for human diseases
Zhu, S.-Y., Yao, R.-Q., Li, Y., Zhao, P.-Y., Ren, C., Du, X.-H., & Yao, Y.-M. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03032-5 · Cited by 124 · see citing works
mTOR Cross-Talk in Cancer and Potential for Combination Therapy
Conciatori, F., Ciuffreda, L., Bazzichetto, C., Falcone, I., Pilotto, S., Bria, E., Cognetti, F., & Milella, M. (2018) · Cancers · doi:10.3390/cancers10010023 · Cited by 140 · see citing works
Ribosome biogenesis adaptation in resistance training-induced human skeletal muscle hypertrophy
Figueiredo, V. C., Caldow, M. K., Massie, V., Markworth, J. F., Cameron-Smith, D., & Blazevich, A. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00050.2015 · Cited by 133 · see citing works
“In fact, ribosomal content dictates the upper limit of protein synthesis of a cell (12), and thus it may be speculated that RE not only activates translational initiation but also increases the total muscle capacity for protein synthesis through de novo ribosome biogenesis.”
Background
Aging microglia
Antignano, I., Liu, Y., Offermann, N., & Capasso, M. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04775-y · Cited by 117 · see citing works
The ribosome, (slow) beating heart of cancer (stem) cell
Bastide, A., & David, A. (2018) · Oncogenesis · doi:10.1038/s41389-018-0044-8 · Cited by 119 · see citing works
Phosphorylation and Signal Transduction Pathways in Translational ControlPreprint
Proud, C. G. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033050 · Cited by 121 · see citing works
Self-citation
Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases
Liu, R., & Proud, C. G. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.123 · Cited by 117 · see citing works
Self-citation
Signaling, metabolism, and cancer: An important relationship for therapeutic intervention
Vaghari‐Tabari, M., Ferns, G. A., Qujeq, D., Andevari, A. N., Sabahi, Z., & Moein, S. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30276 · Cited by 117 · see citing works
“acids, so that by stimulating the biogenesis of ribosomes, it increases protein synthesis (Bar‐Peled & Sabatini, 2014; Iadevaia et al., 2014).”
Background
Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number
Farley‐Barnes, K. I., McCann, K. L., Ogawa, L. M., Merkel, J., Surovtseva, Y. V., & Baserga, S. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.056 · Cited by 115 · see citing works
“This process is subject to complex regulation because it must be highly responsive to various cellular stimuli, such as nutrient availability (Iadevaia et al., 2014; Jastrzebski et al., 2007; Mitchell et al., 2015).”
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4
Castets, P., Rion, N., Théodore, M., Falcetta, D., Lin, S., Reischl, M., Wild, F., Guérard, L., Eickhorst, C., Brockhoff, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11227-4 · Cited by 112 · see citing works
The DDX5/Dbp2 subfamily of DEAD‐box RNA helicases
Xing, Z., Ma, W. K., & Tran, E. J. (2018) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1519 · Cited by 108 · see citing works
Ribosomal biogenesis as an emerging target of neurodevelopmental pathologies
Hetman, M., & Słomnicki, Ł. P. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14576 · Cited by 110 · see citing works
Coupling of Ribosome Synthesis and Translational Capacity with Cell Growth
Dai, X., & Zhu, M. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.04.010 · Cited by 110 · see citing works
Ribosome biogenesis restricts innate immune responses to virus infection and DNA
Bianco, C., & Mohr, I. (2019) · eLife · doi:10.7554/elife.49551 · Cited by 101 · see citing works
“Introduction The minting of ribosomes, the molecular machines that synthesize polypeptides, is subject to stringent controls that coordinate demand for ribosomes with intracellular processes and environmental cues, including nutritional status and responses to physiological stress (Iadevaia et al., 2014).”
Background
Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan
Chen, S., Brunskill, E. W., Potter, S. S., Dexheimer, P. J., Salomonis, N., Aronow, B. J., Hong, C. I., Zhang, T., & Kopan, R. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.09.009 · Cited by 98 · see citing works
Regulation of CD8+ T memory and exhaustion by the mTOR signals
Chen, Y., Xu, Z., Sun, H., Ouyang, X.-X., Han, Y.-H., Yu, H., Wu, N.-B., Xie, Y., & Su, B. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-01064-3 · Cited by 91 · see citing works
“Over several decades of research, mTOR has been characterized as a key regulator of multiple metabolic processes, including ribosome biogenesis [160], protein [161]/ nucleotide [162, 163]/fatty acid/lipid [164] synthesis and negative regulation of autophagy [165]. mTOR forms at least two distinct…”
Background
Regulation of rDNA transcription in response to growth factors, nutrients and energy
Kusnadi, E. P., Hannan, K. M., Hicks, R. J., Hannan, R. D., Pearson, R. B., & Kang, J. (2014) · Gene · doi:10.1016/j.gene.2014.11.010 · Cited by 95 · see citing works
PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis
Chen, Q. Y., & Costa, M. (2018) · Molecular Pharmacology · doi:10.1124/mol.118.112268 · Cited by 92 · see citing works
“through an increased number of ribosomes and accelerated protein translation (Iadevaia et al., 2014).”
Background
A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
Cheng, Y., Wang, S., Zhang, H., Lee, J.-S., Ni, C., Guo, J., Chen, E., Wang, S., Acharya, A., Chang, T.-C., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.019 · Cited by 92 · see citing works
“51 Additionally, EPB41L4A-AS1 , the SNORA13 host gene, was reported to be strongly induced in human ﬁbroblasts upon serum starvation or contact-induced growth arrest, conditions where SNORA13-mediated inhibition of ribosome biogenesis might be advantageous.”
Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes
Brunkard, J. O. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.022 · Cited by 84 · see citing works
“…monomeric metabolites required for ribosome synthesis (amino acids and nucleotides) and the energy stores required to transcribe, translate, and assemble ribosomes, to ensure that ribosome production does not deplete available resources (Figure 1) (Iadevaia et al., 2014; Pelletier et al., 2018).”
Background
mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases
Walters, H. E., & Cox, L. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082325 · Cited by 85 · see citing works
“Ribosomal biogenesis (and hence subsequent protein synthesis) requires the coordination of transcription of ribosomal RNAs (rRNA) within the nucleolus by RNA polymerase I, protein-encoding messenger RNAs (mRNA) by RNA polymerase II and transfer RNAs (tRNA) and a further 5S ribosomal RNA by RNA polymerase III, and is p…”
Background
The homeostatic regulation of ribosome biogenesis
Ni, C., & Buszczak, M. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.043 · Cited by 82 · see citing works
Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism
Saare, M., Tserel, L., Haljasmägi, L., Taalberg, E., Peet, N., Eimre, M., Vetik, R., Kingo, K., Saks, K., Tamm, R., et al. (2020) · Aging Cell · doi:10.1111/acel.13127 · Cited by 79 · see citing works
Emerging Role of Eukaryote Ribosomes in Translational Control
Venezia, N. D., Vincent, A., Marcel, V., Catez, F., & Diaz, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051226 · Cited by 77 · see citing works
“Since all of the mRNAs coding for RPs contain a 5′-TOP, mTOR positively regulates synthesis of RPs allowing a coordinated synthesis of the different components of the ribosome [51].”
Background
TERT accelerates BRAF mutant–induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis
Yu, P., Qu, N., Zhu, R., Hu, J., Han, P., Wu, J., Tan, L., Gan, H., He, C., Fang, C., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg7125 · Cited by 79 · see citing works
“5) ( 42 ).”
Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity
Szaflarski, W., Leśniczak-Staszak, M., Sowiński, M., Ojha, S., Aulas, A., Dave, D., Malla, S., Anderson, P., Ivanov, P. V., & Lyons, S. M. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1231 · Cited by 78 · see citing works
“…synthesis. mTOR integrates multiple aspects of ribosome biogenesis to allow for coordinative regulation of different components [Reviewed in (72)]. mTOR inactivation represses ribosomal protein synthesis through dephosphorylation of LARP1 (31) and represses the transcription of both 47S and…”
Canonical signaling and nuclear activity of mTOR —a teamwork effort to regulate metabolism and cell growth
Giguère, V. (2018) · FEBS Journal · doi:10.1111/febs.14384 · Cited by 77 · see citing works
Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression
Rad, E., Murray, J. T., & Tee, A. R. (2018) · Cancers · doi:10.3390/cancers10010005 · Cited by 73 · see citing works
Altered ribosomal function and protein synthesis caused by tau
Evans, H. T., Taylor, D. W., Kneynsberg, A., Bodea, L., & Götz, J. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01208-4 · Cited by 70 · see citing works
Enhanced skeletal muscle ribosome biogenesis, yet attenuated mTORC1 and ribosome biogenesis-related signalling, following short-term concurrent versus single-mode resistance training
Fyfe, J. J., Bishop, D. J., Bartlett, J. D., Hanson, E. D., Anderson, M. J., Garnham, A. P., & Stepto, N. K. (2018) · Scientific Reports · doi:10.1038/s41598-017-18887-6 · Cited by 69 · see citing works
“In addition to mediating transient changes in translational efficiency, accumulating evidence suggests mTORC1 also plays a key role in regulating ribosome biogenesis (and therefore translational capacity) in skeletal muscle by regulating all three classes of RNA polymerases (RNA Pol-I to -III) 25 .”
BackgroundInfluential
Polystyrene nanoplastics induce profound metabolic shift in human cells as revealed by integrated proteomic and metabolomic analysis
Wang, H., Shi, X., Gao, Y., Zhang, X., Zhao, H., Wang, L., Zhang, X., & Chen, R. (2022) · Environment International · doi:10.1016/j.envint.2022.107349 · Cited by 69 · see citing works
PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans
Wu, J., Jiang, X., Li, Y., Zhu, T., Zhang, J., Zhang, Z., Zhang, L., Zhang, Y., Wang, Y., Zou, X., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03531-2 · Cited by 60 · see citing works
Induction of metabolic quiescence defines the transitional to follicular B cell switch
Farmer, J. R., Allard‐Chamard, H., Sun, N., Ahmad, M., Bertocchi, A., Mahajan, V. S., Aicher, T. P., Arnold, J., Benson, M. D., Morningstar, J. E., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aaw5573 · Cited by 62 · see citing works
Synergistic antileukemic therapies in NOTCH1 -induced T-ALL
Sánchez-Martín, M., Ambesi‐Impiombato, A., Qin, Y., Herranz, D., Bansal, M., Girardi, T., Paietta, E. M., Tallman, M. S., Rowe, J. M., Keersmaecker, K. D., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611831114 · Cited by 61 · see citing works
“Key oncogenes and signaling pathways involved in the pathogenesis of T-ALL, including NOTCH1, MYC, and the PI3K-AKTmTOR pathway, participate in the regulation of ribosome biogenesis and translation (9, 28, 29).”
Background
Role of mTORC1 Controlling Proteostasis after Brain Ischemia
Pérez-Álvarez, M. J., Villa-González, M., Benito‐Cuesta, I., & Wandosell, F. G. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00060 · Cited by 60 · see citing works
“In addition, mTORC1 upregulates several steps of ribosome biogenesis including transcription of ribosomal RNA and ribosomal protein synthesis (Iadevaia et al., 2014).”
Background
Ribosome profiling and dynamic regulation of translation in mammals
Gobet, C., & Naef, F. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.03.005 · Cited by 56 · see citing works
p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
Bora, P., Gahurová, L., Mašek, T., Hauserová, A., Potěšil, D., Jansová, D., Šušor, A., Zdráhal, Z., Ajduk, A., Pospíšek, M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02290-z · Cited by 57 · see citing works
Ribosome biogenesis in skeletal muscle: coordination of transcription and translation
von Walden, F. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00963.2018 · Cited by 57 · see citing works
Identification of key candidate genes and pathways in multiple myeloma by integrated bioinformatics analysis
Yan, H., Zheng, G., Qu, J., Yang, L., Huang, X., Zhang, E., & Cai, Z. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28947 · Cited by 56 · see citing works
The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1
Rodríguez‐López, M., Gonzalez, S., Hillson, O., Tunnacliffe, E., Codlin, S., Tallada, V. A., Bähler, J., & Rallis, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.058 · Cited by 55 · see citing works
“Our results reveal a transcription factor that not only controls RNA Pol II-mediated expression of genes functioning in translation- and metabolism-related processes but also globally inhibits RNA Pol III-mediated expression of tRNAs.”
BackgroundInfluential
Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation
Doty, R. T., Yan, X. S., Lausted, C. G., Munday, A. D., Yang, Z., Yi, D., Jabbari, N., Liu, L., Keel, S., Tian, Q., et al. (2018) · Blood · doi:10.1182/blood-2018-05-850412 · Cited by 54 · see citing works
FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors
Paul, R., Luo, M., Mo, X., Lu, J. L., Yeo, S. K., & Guan, J. (2020) · Breast Cancer Research · doi:10.1186/s13058-020-01298-3 · Cited by 52 · see citing works
“In addition, mTOR has been indicated to control multiple steps in ribosome biogenesis [44].”
Evaluation of energy metabolism and calcium homeostasis in cells affected by Shwachman-Diamond syndrome
Ravera, S., Dufour, C., Cesaro, S., Bottega, R., Faleschini, M., Cuccarolo, P., Corsolini, F., Usai, C., Columbaro, M., Cipolli, M., et al. (2016) · Scientific Reports · doi:10.1038/srep25441 · Cited by 51 · see citing works
Fine‐Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation
Lu, Z., Huang, L., Li, Y., Xu, Y., Zhang, R., Zhou, Q., Sun, Q., Lu, Y., Chen, J., Shen, Y., et al. (2021) · Advanced Science · doi:10.1002/advs.202102669 · Cited by 47 · see citing works
XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis
Zhu, Z., Liu, J., Yang, C., Zhao, M., & Xiong, Z. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1627-9 · Cited by 45 · see citing works
Translational control by oncogenic signaling pathways.
Gao, B., & Roux, P. P. (2015) · Biochimica et Biophysica Acta · doi:10.1016/j.bbagrm.2014.11.006 · Cited by 48 · see citing works
Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis
Kaiser, M. S., Milan, G., Ham, D. J., Lin, S., Oliveri, F., Chojnowska, K., Tintignac, L. A. J., Mittal, N., Zimmerli, C. E., Glass, D. J., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04097-y · Cited by 46 · see citing works
Reduced Expression of APUM24, Encoding a Novel rRNA Processing Factor, Induces Sugar-Dependent Nucleolar Stress and Altered Sugar Responses in Arabidopsis thaliana
Maekawa, S., Ishida, T., & Yanagisawa, S. (2017) · The Plant Cell · doi:10.1105/tpc.17.00778 · Cited by 45 · see citing works
“…et al., 2008; Ishida et al., 2016), while exogenous sugar application increases the expression levels of a number of genes associated with ribosome biogenesis in Arabidopsis thaliana (Kojima et al., 2007), as well as yeast andmammalian cells (Powers andWalter, 1999; Iadevaia et al., 2014).”
Background
An RNA damage response network mediates the lethality of 5-FU in colorectal cancer
Chen, J.-K., Merrick, K. A., Kong, Y. W., Izrael-Tomasevic, A., Eng, G. M., Handly, E. D., Patterson, J. C., Cannell, I. G., Suárez-López, L., Hosios, A. M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101778 · Cited by 44 · see citing works
“Conversely, inhibition of mTORC1, a kinase complex that positively regulates ribosome biogenesis, 62 greatly decreased the cytotoxicity to 5-FUR (Figure S7B).”
Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq–guided combination with sapanisertib
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A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis
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Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors
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Self-citation

Authors: Iadevaia, V., Liu, R., & Proud, C. G.
Affiliations: University of Southampton (GB)
Corresponding author: Proud, Christopher G.
ORCID: Iadevaia, Valentina
Liu, Rui
Proud, Christopher G.
Venue: Seminars in Cell & Developmental Biology
Publisher: Elsevier BV
Published: 2014-12
Volume: 36
Pages: 113-120
ISSN: 1084-9521 (ISSN-L)
DOI: 10.1016/j.semcdb.2014.08.004
OpenAlex: W1965611273
Cited by: 248
References: 95
Citations by year: 2026: 10 · 2025: 25 · 2024: 19 · 2023: 28 · 2022: 29 · 2021: 29 · 2020: 20 · 2019: 21 · 2018: 26 · 2017: 18 · 2016: 11 · 2015: 9 · 2014: 3
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Open Research (University of Surrey) (submittedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Funders: Cancer Research UK
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: mTORC1 signaling, ribosome biogenesis, rDNA transcription, ribosomal protein synthesis, ribosome assembly, nutrient signaling, kinase regulation
MeSH terms: Mechanistic Target of Rapamycin Complex 1, Humans, Ribosomal Proteins, Ribosomes, RNA Polymerase I, RNA Polymerase III, RNA, Ribosomal, Protein Biosynthesis, Signal Transduction, Multiprotein Complexes, TOR Serine-Threonine Kinases

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mTORC1 signaling controls multiple steps in ribosome biogenesis

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