GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation
Open accessAbstract
The role of granulocyte-macrophage colony-stimulating factor (GM-CSF) was sequentially redefined during the past decades. Originally described as a hematopoietic growth factor for myelopoiesis, GM-CSF was recognized as a central mediator of inflammation bridging the innate and adaptive arms of the immune system. Phagocytes sensing GM-CSF adapt an inflammatory phenotype and facilitate pathogen clearance. However, in the context of chronic tissue inflammation, GM-CSF secreted by tissue-invading lymphocytes has detrimental effects by licensing tissue damage and hyperinflammation. Accordingly, therapeutic intervention at the T cell-phagocyte interface represents an attractive target to ameliorate disease progression and immunopathology. Although GM-CSF is largely dispensable for steady state myelopoiesis, dysregulation, as seen in chronic inflammatory diseases, may however lead to disrupted haematopoiesis and long-term effects on bone marrow output. Here, we will survey the role of GM-CSF during inflammation, discuss the extent to which GM-CSF-secreting T cells, debate their introduction as a separate T cell lineage and explore current and future clinical implications of GM-CSF in human disease settings.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the Il10−/− model of colitis, Th17 cells are the main immune population mediating the inflammatory response.
“In the Il10−/− model of colitis, in which IL-10-deficient mice develop spontaneous microbiota-dependent colitis, Th17 cells were identified as the main immune population mediating the inflammatory immune response [43, 133].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [133]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Retracted: Increasing Prevalence of Antinuclear Antibodies in the United States
Dinse, G. E., Parks, C. G., Weinberg, C. R., Co, C. A., Wilkerson, J., Zeldin, D. C., Chan, E. K. L., & Miller, F. W. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41214 · Cited by 195 · see citing works
RetractedCOVID-19: consider cytokine storm syndromes and immunosuppression
Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., & Manson, J. J. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30628-0 · Cited by 9,664 · see citing works
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,438 · see citing works
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129 · see citing works
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099 · see citing works
Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., & Steinman, R. M. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1693 · Cited by 3,741 · see citing works
Simultaneous epitope and transcriptome measurement in single cells
Stoeckius, M., Hafemeister, C., Stephenson, W., Houck-Loomis, B., Chattopadhyay, P. K., Swerdlow, H., Satija, R., & Smibert, P. (2017) · Nature Methods · doi:10.1038/nmeth.4380 · Cited by 3,098 · see citing works
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works
Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K. P., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00070-4 · Cited by 2,819 · see citing works
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
Liao, M., Liu, Y., Yuan, J., Wen, Y., Xu, G., Zhao, J., Cheng, L., Li, J., Wang, X., Wang, F., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0901-9 · Cited by 2,614 · see citing works
Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure
Giamarellos-Bourboulis, E. J., Netea, M. G., Rovina, N., Akinosoglou, K., Antoniadou, A., Antonakos, N., Damoraki, G., Gkavogianni, T., Adami, M.-E., Katsaounou, P., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.04.009 · Cited by 2,045 · see citing works
Cytokine release syndrome in severe COVID-19
Moore, J. B., & June, C. H. (2020) · Science · doi:10.1126/science.abb8925 · Cited by 1,912 · see citing works
Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012
Mayer-Davis, E. J., Lawrence, J. M., Dabelea, D., Divers, J., Isom, S., Dolan, L., Imperatore, G., Linder, B., Marcovina, S., Pettitt, D. J., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1610187 · Cited by 1,476 · see citing works
Norelli, M., Camisa, B., Barbiera, G., Falcone, L., Purevdorj, A., Genua, M., Sanvito, F., Ponzoni, M., Doglioni, C., Cristofori, P., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0036-4 · Cited by 1,406 · see citing works
Channappanavar, R., Fehr, A. R., Vijay, R., Mack, M., Zhao, J., Meyerholz, D. K., & Perlman, S. M. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.01.007 · Cited by 1,400 · see citing works
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
Krausgruber, T., Blazek, K. D., Smallie, T., Alzabin, S., Lockstone, H. E., Sahgal, N., Hussell, T., Feldmann, M., & Udalova, I. A. (2011) · Nature Immunology · doi:10.1038/ni.1990 · Cited by 1,296 · see citing works
Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients
Zhou, Y., Fu, B., Zheng, X., Wang, D., Zhao, C., Qi, Y., Sun, R., Tian, Z., Xu, X., & Wei, H. (2020) · National Science Review · doi:10.1093/nsr/nwaa041 · Cited by 1,295 · see citing works
Souza, L., Boone, T., Gabrilove, J., Lai, P., Zsebo, K., Murdock, D., Chazin, V., Bruszewski, J., Lu, H.-B., Chen, K.-K., et al. (1986) · Science · doi:10.1126/science.2420009 · Cited by 1,286 · see citing works
Codarri, L., Gyülvészi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T., & Becher, B. (2011) · Nature Immunology · doi:10.1038/ni.2027 · Cited by 1,191 · see citing works
BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis
Kaufmann, E., Sanz, J., Dunn, J. L., Khan, N., Mendonça, L. E., Pacis, A., Tzelepis, F., Pernet, E., Dumaine, A., Grenier, J.-C., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.031 · Cited by 1,191 · see citing works
Dai, X.-M., Ryan, G. R., Hapel, A. J., Dominguez, M. G., Russell, R. G., Kapp, S., Sylvestre, V., & Stanley, E. R. (2002) · Blood · doi:10.1182/blood.v99.1.111 · Cited by 1,184 · see citing works
Monocyte-Mediated Defense Against Microbial Pathogens
Serbina, N. V., Jia, T., Hohl, T. M., & Pamer, E. G. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090326 · Cited by 1,116 · see citing works
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity
Mitroulis, I., Ruppova, K., Wang, B., Chen, L.-S., Grzybek, M., Grinenko, T., Eugster, A., Troullinaki, M., Palladini, A., Kourtzelis, I., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.034 · Cited by 1,100 · see citing works
El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G.-X., Dittel, B. N., & Rostami, A. (2011) · Nature Immunology · doi:10.1038/ni.2031 · Cited by 1,071 · see citing works
Wiktor-Jedrzejczak, W., Bartocci, A., Ferrante, A. W., Ahmed-Ansari, A., Sell, K. W., Pollard, J. W., & Stanley, E. R. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4828 · Cited by 1,031 · see citing works
Lieschke, G. J., Grail, D., HODGSON, G. S., Metcalf, D., Stanley, E. G., Cheers, C., Fowler, K., Basu, S., Zhan, Y., & Dunn, A. (1994) · Blood · doi:10.1182/blood.v84.6.1737.1737 · Cited by 956 · see citing works
Origin of the Lamina Propria Dendritic Cell Network
Bogunovic, M., Ginhoux, F., Helft, J., Shang, L., Hashimoto, D., Greter, M., Liu, K., Jakubzick, C., Ingersoll, M. A., Leboeuf, M., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.010 · Cited by 859 · see citing works
Differential roles of microglia and monocytes in the inflamed central nervous system
Yamasaki, R., Lu, H., Butovsky, O., Ohno, N., Rietsch, A. M., Cialic, R., Wu, P. M., Doykan, C. E., Lin, J., Cotleur, A. C., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132477 · Cited by 855 · see citing works
Manz, M. G., & Boettcher, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3660 · Cited by 855 · see citing works
Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis
Mortha, A., Chudnovskiy, A., Hashimoto, D., Bogunovic, M., Spencer, S. P., Belkaid, Y., & Merad, M. (2014) · Science · doi:10.1126/science.1249288 · Cited by 820 · see citing works
Helft, J., Böttcher, J. P., Chakravarty, P., Zelenay, S., Huotari, J., Schraml, B. U., Goubau, D., & Sousa, C. R. E. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.018 · Cited by 818 · see citing works
Lineage tracing on transcriptional landscapes links state to fate during differentiation
Weinreb, C., Rodriguez-Fraticelli, A., Camargo, F. D., & Klein, A. M. (2020) · Science · doi:10.1126/science.aaw3381 · Cited by 730 · see citing works
Stability of the Regulatory T Cell Lineage in Vivo
Rubtsov, Y. P., Niec, R. E., Josefowicz, S., Li, L., Darce, J., Mathis, D., Benoist, C., & Rudensky, A. Y. (2010) · Science · doi:10.1126/science.1191996 · Cited by 730 · see citing works
Pietras, E. M., Reynaud, D., Kang, Y.-A., Carlin, D., Calero-Nieto, F. J., Leavitt, A. D., Stuart, J. M., Göttgens, B., & Passegué, E. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.003 · Cited by 723 · see citing works
Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells
Liu, Z., Gu, Y., Chakarov, S., Bleriot, C., Kwok, I., Chen, X., Shin, A., Huang, W., Dress, R. J., Dutertre, C.-A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.009 · Cited by 719 · see citing works
Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions
Varol, C., Vallon-Eberhard, A., Elinav, E., Aychek, T., Shapira, Y., Luche, H., Fehling, H. J., Hardt, W., Shakhar, G., & Jung, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.025 · Cited by 710 · see citing works
Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity
Kalafati, L., Kourtzelis, I., Schulte-Schrepping, J., Li, X., Hatzioannou, A., Grinenko, T., Hagag, E., Sinha, A., Has, C., Dietz, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.058 · Cited by 648 · see citing works
Sterner, R. M., Sakemura, R. L., Cox, M. J., Yang, N., Khadka, R. H., Forsman, C. L., Hansen, M. J., Jin, F., Ayasoufi, K., Hefazi, M., et al. (2018) · Blood · doi:10.1182/blood-2018-10-881722 · Cited by 632 · see citing works
GM-CSF Regulates Alveolar Macrophage Differentiation and Innate Immunity in the Lung through PU.1
Shibata, Y., Berclaz, P., Chroneos, Z. C., Yoshida, M., Whitsett, J. A., & Trapnell, B. C. (2001) · Immunity · doi:10.1016/s1074-7613(01)00218-7 · Cited by 613 · see citing works
Schneider, C., Nobs, S. P., Kurrer, M. O., Rehrauer, H., Thiele, C., & Köpf, M. (2014) · Nature Immunology · doi:10.1038/ni.3005 · Cited by 603 · see citing works
GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation
Becher, B., Tugues, S., & Greter, M. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.026 · Cited by 593 · see citing works
Self-citationPettinelli, C. B., & McFarlin, D. E. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.4.1420 · Cited by 589 · see citing works
Single-cell genomics unveils critical regulators of Th17 cell pathogenicity
Gaublomme, J. T., Yosef, N., Lee, Y., Gertner, R. S., Yang, L. V., Wu, C., Pandolfi, P. P., Mak, T., Satija, R., Shalek, A. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.009 · Cited by 575 · see citing works
Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response
King, K. Y., & Goodell, M. A. (2011) · Nature reviews. Immunology · doi:10.1038/nri3062 · Cited by 565 · see citing works
The nature and action of granulocyte-macrophage colony stimulating factors
Burgess, A. W., & Metcalf, D. (1980) · Blood · doi:10.1182/blood.v56.6.947.947 · Cited by 536 · see citing works
The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity
Croxford, A. L., Lanzinger, M., Hartmann, F. J., Schreiner, B., Mair, F., Pelczar, P., Clausen, B. E., Jung, S., Greter, M., & Becher, B. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.010 · Cited by 484 · see citing works
Self-citationExtramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions
Robbins, C. S., Chudnovskiy, A., Rauch, P. J., Figueiredo, J., Iwamoto, Y., Gorbatov, R., Etzrodt, M., Weber, G. F., Ueno, T., van Rooijen, N., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.061986 · Cited by 483 · see citing works
Granulocyte Macrophage Colony-Stimulating Factor
McQualter, J. L., Darwiche, R., Ewing, C., Onuki, M., Kay, T. W., Hamilton, J. A., Reid, H. H., & Bernard, C. C. A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.7.873 · Cited by 477 · see citing works
Yáñez, A., Coetzee, S. G., Olsson, A., Muench, D. E., Berman, B. P., Hazelett, D. J., Salomonis, N., Grimes, H. L., & Goodridge, H. S. (2017) · Immunity · doi:10.1016/j.immuni.2017.10.021 · Cited by 470 · see citing works
Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy
Li, R., Rezk, A., Miyazaki, Y., Hilgenberg, E., Touil, H., Shen, P., Moore, C. S., Michel, L., Althekair, F., Rajasekharan, S., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab4176 · Cited by 455 · see citing works
Identification of proliferating dendritic cell precursors in mouse blood.
Inaba, K., Steinman, R. M., Pack, M., et al. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.5.1157 · Cited by 451 · see citing works
Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma.
Billiau, A., Heremans, H., Vandekerckhove, F., Dijkmans, R., Sobis, H., Meulepas, E., & Carton, H. (1988) · Journal of Immunology · doi:10.4049/jimmunol.140.5.1506 · Cited by 447 · see citing works
Mildner, A., Mack, M., Schmidt, H., Brück, W., Djukic, M., Zabel, M. D., Hille, A., Priller, J., & Prinz, M. (2009) · Brain · doi:10.1093/brain/awp144 · Cited by 445 · see citing works
Gough, N. M., Gough, J., Metcalf, D., Kelso, A., Grail, D., Nicola, N. A., Burgess, A. W., & Dunn, A. R. (1984) · Nature · doi:10.1038/309763a0 · Cited by 436 · see citing works
Greter, M., Helft, J., Chow, A., Hashimoto, D., Mortha, A., Agudo-Cantero, J., Bogunovic, M., Gautier, E. L., Miller, J., Leboeuf, M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.027 · Cited by 433 · see citing works
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
Haak, S., Croxford, A. L., Kreymborg, K., Heppner, F. L., Pouly, S., Becher, B., & Waisman, A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35997 · Cited by 398 · see citing works
Self-citationLang, R. A., Metcalf, D., Cuthbertson, R. A., Lyons, I. G., Stanley, E. G., Kelso, A., Kannourakis, G., Williamson, D. J., Klintworth, G. K., Gonda, T. J., et al. (1987) · Cell · doi:10.1016/0092-8674(87)90136-x · Cited by 366 · see citing works
van de Laar, L., Coffer, P. J., & Woltman, A. M. (2012) · Blood · doi:10.1182/blood-2011-11-370130 · Cited by 362 · see citing works
Okada, Y., Terao, C. C., Ikari, K., Kochi, Y., Ohmura, K., Suzuki, A., Kawaguchi, T., Stahl, E. A., Kurreeman, F. A. S., Nishida, N., et al. (2012) · Nature Genetics · doi:10.1038/ng.2231 · Cited by 332 · see citing works
Hercus, T. R., Thomas, D., Guthridge, M. A., Ekert, P. G., King-Scott, J., Parker, M. W., & Lopez, A. F. (2009) · Blood · doi:10.1182/blood-2008-12-164004 · Cited by 311 · see citing works
The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation
Hansen, G., Hercus, T. R., McClure, B. J., Stomski, F. C., Dottore, M., Powell, J. A., Ramshaw, H. S., Woodcock, J. M., Xu, Y., Guthridge, M. A., et al. (2008) · Cell · doi:10.1016/j.cell.2008.05.053 · Cited by 311 · see citing works
Molecular analysis of the granulocyte colony-stimulating factor receptor
Avalos, B. (1996) · Blood · doi:10.1182/blood.v88.3.761.bloodjournal883761 · Cited by 293 · see citing works
Menezes, S., Melandri, D., Anselmi, G., Perchet, T., Loschko, J., Dubrot, J., Patel, R., Gautier, E. L., Hugues, S., Longhi, M. P., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.12.001 · Cited by 288 · see citing works
Siegler, E. L., & Kenderian, S. S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01973 · Cited by 284 · see citing works
Kwok, I., Becht, É., Xia, Y., Ng, M. S. F., Teh, Y. C., Tan, L., Evrard, M., Li, J. L. Y., Tran, H. T., Tan, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.005 · Cited by 263 · see citing works
Guilliams, M., Lambrecht, B. N., & Hammad, H. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.14 · Cited by 261 · see citing works
Targeting GM-CSF in inflammatory diseases
Wicks, I. P., & Roberts, A. W. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.161 · Cited by 261 · see citing works
GM-CSF mediates autoimmunity by enhancing IL-6–dependent Th17 cell development and survival
Sonderegger, I., Iezzi, G., Maier, R., Schmitz, N., Kurrer, M. O., & Köpf, M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071119 · Cited by 240 · see citing works
Vremec, D., Lieschke, G. J., Dunn, A. R., Robb, L. G., Metcalf, D., & Shortman, K. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270107 · Cited by 240 · see citing works
The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis
Kingston, D., Schmid, M., Onai, N., Obata-Onai, A., Baumjohann, D., & Manz, M. G. (2009) · Blood · doi:10.1182/blood-2009-02-206318 · Cited by 236 · see citing works
Campbell, I. K., Rich, M. J., Bischof, R. J., Dunn, A. R., Grail, D., & Hamilton, J. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3639 · Cited by 233 · see citing works
GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches
Lang, F. M., Lee, M.-C., Teijaro, J. R., Becher, B., & Hamilton, J. A. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0357-7 · Cited by 232 · see citing works
Self-citationHandman, E., & Burgess, A. W. (1979) · The Journal of Immunology · doi:10.4049/jimmunol.122.3.1134 · Cited by 228 · see citing works
Stimulation of macrophage plasminogen activator activity by colony‐stimulating factors
Hamilton, J. A., Stanley, E. R., Burgess, A. W., & Shadduck, R. K. (1980) · Journal of Cellular Physiology · doi:10.1002/jcp.1041030309 · Cited by 222 · see citing works
Dieckgraefe, B. K., & Korzenik, J. R. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11437-1 · Cited by 212 · see citing works
The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes
Anzai, A., Choi, J. L., He, S., Fenn, A. M., Nairz, M., Rattik, S., McAlpine, C. S., Mindur, J. E., Chan, C. T., Iwamoto, Y., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170689 · Cited by 210 · see citing works
Self-citationSheng, W., Yang, F., Zhou, Y., Yang, H., Low, P. Y., Kemeny, D. M., Tan, P., Moh, A., Kaplan, M. H., Zhang, Y., et al. (2014) · Cell Research · doi:10.1038/cr.2014.154 · Cited by 203 · see citing works
De Luca, G., Cavalli, G., Campochiaro, C., Della-Torre, E., Angelillo, P., Tomelleri, A., Boffini, N., Tentori, S., Mette, F., Farina, N., et al. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30170-3 · Cited by 202 · see citing works
Komuczki, J., Tuzlak, S., Friebel, E., Hartwig, T., Spath, S., Rosenstiel, P., Waisman, A., Opitz, L., Oukka, M., Schreiner, B., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.006 · Cited by 201 · see citing works
Self-citationGriseri, T., McKenzie, B. S., Schiering, C., & Powrie, F. M. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.025 · Cited by 197 · see citing works
Brummelman, J., Haftmann, C., Núñez, N. G., Alvisi, G., Mazza, E. M. C., Becher, B., & Lugli, E. (2019) · Nature Protocols · doi:10.1038/s41596-019-0166-2 · Cited by 196 · see citing works
Self-citationMechanism of Activation of the GM‐CSF, IL‐3, and IL‐5 Family of Receptors
Guthridge, M. A., Stomski, F. C., Thomas, D., Woodcock, J. M., Bagley, C. J., Berndt, M. C., & Lopez, A. F. (1998) · Stem Cells · doi:10.1002/stem.160301 · Cited by 192 · see citing works
A Single-Cell Sequencing Guide for Immunologists
See, P., Lum, J., Chen, J., & Ginhoux, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02425 · Cited by 187 · see citing works
Cook, A. D., Braine, E. L., Campbell, I. K., Rich, M. J., & Hamilton, J. A. (2001) · Arthritis Research & Therapy · doi:10.1186/ar318 · Cited by 186 · see citing works
Griseri, T., Arnold, I., Pearson, C., Krausgruber, T., Schiering, C., Franchini, F., Schulthess, J., McKenzie, B., Crocker, P., & Powrie, F. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.008 · Cited by 183 · see citing works
Hirota, K., Hashimoto, M., Ito, Y., Matsuura, M., Ito, H., Tanaka, M., Watanabe, H., Kondoh, G., Tanaka, A., Yasuda, K., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.009 · Cited by 181 · see citing works
GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis
Galli, E., Hartmann, F. J., Schreiner, B., Ingelfinger, F., Arvaniti, E., Diebold, M., Mrdjen, D., van der Meer, F., Krieg, C., Nimer, F. A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0521-4 · Cited by 180 · see citing works
Self-citationLin, C., Bradstreet, T. R., Schwarzkopf, E. A., Sim, J. E., Carrero, J. A., Chou, C., Cook, L. E., Egawa, T., Taneja, R., MURPHY, K. M. M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4551 · Cited by 179 · see citing works
Juarrero, M. G., Hattle, J. M., Izzo, A. A., Junqueira‐Kipnis, A. P., Shim, T. S., Trapnell, B. C., Cooper, A. M., & Orme, I. M. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204723 · Cited by 178 · see citing works
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth
Gschwend, J., Sherman, S., Ridder, F., Feng, X., Liang, H.-E., Locksley, R. M., Becher, B., & Schneider, C. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210745 · Cited by 176 · see citing works
Self-citationG-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis
Cornish, A. L., Campbell, I., McKenzie, B., Chatfield, S., & Wicks, I. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.178 · Cited by 172 · see citing works
Kobayashi, S. D., Voyich, J. M., Whitney, A. R., & DeLeo, F. R. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0605289 · Cited by 172 · see citing works
Achuthan, A. A., Cook, A. D., Lee, M.-C., Saleh, R., Khiew, H. W., Chang, M. W., Louis, C., Fleetwood, A. J., Lacey, D. C., Christensen, A. D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87828 · Cited by 172 · see citing works
Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells
Hartmann, F. J., Khademi, M., Aram, J., Ammann, S., Kockum, I. S., Constantinescu, C. S., Gran, B., Piehl, F., Olsson, T. P., Deak, L. C., et al. (2014) · Nature Communications · doi:10.1038/ncomms6056 · Cited by 171 · see citing works
Self-citationT follicular helper cells and T follicular regulatory cells in rheumatic diseases
Deng, J., Wei, Y., Fonseca, V. R., Graça, L., & Yu, D. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0254-2 · Cited by 169 · see citing works
Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells
Jain, R., Chen, Y., Kanno, Y., Joyce-Shaikh, B., Vahedi, G., Hirahara, K., Blumenschein, W. M., Sukumar, S., Haines, C. J., Sadekova, S., et al. (2016) · Immunity · doi:10.1016/j.immuni.2015.11.009 · Cited by 167 · see citing works
Castro‐Dopico, T., Fleming, A., Dennison, T. W., Ferdinand, J. R., Harcourt, K., Stewart, B. J., Cader, M. Z., Tuong, Z. K., Jing, C., Lok, L. S. C., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107857 · Cited by 159 · see citing works
Spath, S., Komuczki, J., Hermann, M., Pelczar, P., Mair, F., Schreiner, B., & Becher, B. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.007 · Cited by 157 · see citing works
Self-citationExpression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy
Rasouli, J., Ćirić, B., Imitola, J., GONNELLA, P. A., Hwang, D. H., Mahajan, K. R., Mari, E. R., Safavi, F., Leist, T. P., Zhang, G., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403243 · Cited by 156 · see citing works
Zhao, Y., Kilian, C., Turner, J., Bosurgi, L., Roedl, K., Bartsch, P., Gnirck, A.-C., Cortesi, F., Schultheiß, C., Hellmig, M., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abf6692 · Cited by 156 · see citing works
Carrieri, P. B., Provitera, V., Rosa, T. D., Tartaglia, G. G., Gorga, F., & Perrella, O. (1998) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979809034820 · Cited by 155 · see citing works
Behrens, F., Tak, P. P., Østergaard, M., Stoilov, R. M., Wiland, P., Huizinga, T. W. J., Berenfus, V. Y., Vladeva, S., Rech, J., Rubbert‐Roth, A., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204816 · Cited by 148 · see citing works
GM-CSF: A Promising Target in Inflammation and Autoimmunity
Lee, M.-C., Achuthan, A. A., & Hamilton, J. A. (2020) · ImmunoTargets and Therapy · doi:10.2147/itt.s262566 · Cited by 146 · see citing works
Hazenberg, B., van Leeuwen, M., van Rijswijk, M., Ac, S., & Vellenga, E. (1989) · Blood · doi:10.1182/blood.v74.8.2769.2769 · Cited by 144 · see citing works
Zhan, Y., Lieschke, G., Grail, D., Dunn, A., & Cheers, C. (1998) · Blood · doi:10.1182/blood.v91.3.863 · Cited by 141 · see citing works
Mehta, P., Porter, J. C., Manson, J. J., Isaacs, J. D., Openshaw, P., McInnes, I. B., Summers, C., & Chambers, R. C. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30267-8 · Cited by 131 · see citing works
Ivo, P. T. (2006) · Frontiers in bioscience · doi:10.2741/2103 · Cited by 130 · see citing works
Giladi, A., Wagner, L. K., Li, H., Dörr, D., Medaglia, C., Paul, F., Shemer, A., Jung, S., Yona, S., Mack, M., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0661-1 · Cited by 130 · see citing works
Burmester, G. R., McInnes, I. B., Kremer, J. M., Miranda, P., Korkosz, M., Vencovský, J., Rubbert‐Roth, A., Mysler, E., Sleeman, M. A., Godwood, A., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-210624 · Cited by 127 · see citing works
Regan-Komito, D., Swann, J. W., Demetriou, P., Cohen, E. S., Horwood, N. J., Sansom, S. N., & Griseri, T. (2020) · Nature Communications · doi:10.1038/s41467-019-13853-4 · Cited by 121 · see citing works
Inflammasome-Derived IL-1β Regulates the Production of GM-CSF by CD4+ T Cells and γδ T Cells
Lukens, J. R., Barr, M., Chaplin, D., Chi, H., & Kanneganti, T. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103308 · Cited by 117 · see citing works
GM-CSF–Responsive Monocyte-Derived Dendritic Cells Are Pivotal in Th17 Pathogenesis
Ko, H., Brady, J. L., Ryg-Cornejo, V., Hansen, D. S., Vremec, D., Shortman, K., Zhan, Y., & Lew, A. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302040 · Cited by 115 · see citing works
IL-17 controls central nervous system autoimmunity through the intestinal microbiome
Regen, T., Isaac, S., Amorim, A., Núñez, N. G., Hauptmann, J., Shanmugavadivu, A., Klein, M., Sankowski, R., Mufazalov, I. A., Yogev, N., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.aaz6563 · Cited by 111 · see citing works
Self-citationGranulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice
Campbell, I. K., Bendele, A. M., Smith, D. A., & Hamilton, J. A. (1997) · Annals of the Rheumatic Diseases · doi:10.1136/ard.56.6.364 · Cited by 110 · see citing works
Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis
Constantinescu, C. S., Asher, A., Fryze, W., Kozubski, W. P., Wagner, F. D., Aram, J., Tănăsescu, R., Korolkiewicz, R. P., Dirnberger‐Hertweck, M., Steidl, S., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000117 · Cited by 105 · see citing works
GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia
Temesgen, Z., Assi, M., Shweta, F., Vergidis, P. I., Rizza, S. A., Bauer, P. R., Pickering, B. W., Razonable, R. R., Libertin, C. R., Burger, C. D., et al. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.08.038 · Cited by 102 · see citing works
Kreutmair, S., Unger, S., Núñez, N. G., Ingelfinger, F., Alberti, C., Feo, D. D., Krishnarajah, S., Kauffmann, M., Friebel, E., Babaei, S., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.002 · Cited by 102 · see citing works
Self-citationThe biology of GM-CSF: Regulation of production and interaction with its receptor
Griffin, J. D., Cannistra, S. A., Demetri, G. D., Ernst, T. J., Kanakura, Y., & Sullivan, R. (1990) · Stem Cells · doi:10.1002/stem.5530080705 · Cited by 97 · see citing works
GM‐CSF promotes migration of human monocytes across the blood brain barrier
Vogel, D. Y. S., Kooij, G., Heijnen, P. D. A. M., Breur, M., Peferoen, L. A. N., van der Valk, P., de Vries, H. E., Amor, S., & Dijkstra, C. D. (2015) · European Journal of Immunology · doi:10.1002/eji.201444960 · Cited by 94 · see citing works
Hamilton, J. A. (2015) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2015.1024110 · Cited by 93 · see citing works
Cao, Y., Amezquita, R. A., Kleinstein, S. H., Stathopoulos, P., Nowak, R. J., & O’Connor, K. C. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501339 · Cited by 91 · see citing works
for the NEXUS Study Group, Taylor, P. C., Saurigny, D., Vencovský, J., Takeuchi, T., Nakamura, T., Matsievskaia, G., Hunt, B., Wagner, T., & Souberbielle, B. E. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1879-x · Cited by 90 · see citing works
Arnold, I. C., Artola-Borán, M., Gurtner, A., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190706 · Cited by 90 · see citing works
IFN-γ–Expressing Th17 Cells Are Required for Development of Severe Ocular Surface Autoimmunity
Chen, Y., Chauhan, S. K., Shao, C., Omoto, M., Inomata, T., & Dana, R. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602144 · Cited by 89 · see citing works
Reynolds, G., Gibbon, J. R., Pratt, A., Wood, M. J., Coady, D., Raftery, G., Lorenzi, A., Gray, A., Filer, A., Buckley, C., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-206578 · Cited by 87 · see citing works
NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS
Louis, C., Souza-Fonseca-Guimarães, F., Yang, Y., D'Silva, D. B., Kratina, T., Dagley, L., Hediyeh-zadeh, S., Rautela, J., Masters, S., Davis, M., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191421 · Cited by 87 · see citing works
Real-world incidence and prevalence of systemic lupus erythematosus in Alberta, Canada
Fatoye, F., Gebrye, T., & Svenson, L. W. (2018) · Rheumatology International · doi:10.1007/s00296-018-4091-4 · Cited by 86 · see citing works
Corbin, A., Gomez-Vazquez, M., Berthold, D. L., Attar, M., Arnold, I. C., Powrie, F. M., Sansom, S. N., Udalova, I. A., Sansom, S. N., & Udalova, I. A. (2020) · Science Immunology · doi:10.1126/sciimmunol.aax6085 · Cited by 85 · see citing works
Specific Contributions of CSF-1 and GM-CSF to the Dynamics of the Mononuclear Phagocyte System
Louis, C., Cook, A. D., Lacey, D. C., Fleetwood, A. J., Vlahos, R., Anderson, G. P., & Hamilton, J. A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500369 · Cited by 82 · see citing works
Hirata, Y., Egea, L., Dann, S. M., Eckmann, L., & Kagnoff, M. F. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.01.006 · Cited by 82 · see citing works
Bernasconi, E., Favre, L., Maillard, M. H., Bachmann, D., Pythoud, C., Bouzourène, H., Croze, E., Velichko, S., Parkinson, J. F., Michetti, P., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21072 · Cited by 80 · see citing works
Local Delivery of GM-CSF Protects Mice from Lethal Pneumococcal Pneumonia
Steinwede, K., Tempelhof, O., Bolte, K., Maus, R., Bohling, J., Ueberberg, B., Länger, F. P., Christman, J. W., Paton, J. C., Ask, K., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101413 · Cited by 80 · see citing works
Tugues, S., Amorim, A., Spath, S., Martin‐Blondel, G., Schreiner, B., Feo, D. D., Lutz, M., Guscetti, F., Apostolova, P., Haftmann, C., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat8410 · Cited by 80 · see citing works
Self-citationThe detection and initial characterization of colony-stimulating factors in synovial fluid.
Williamson, D. J., Begley, C. G., Vadas, M. A., et al. (1988) · PubMed · Cited by 77 · see citing works
Piper, C. J. M., Pesenacker, A. M., Bending, D., Thirugnanabalan, B., Varsani, H., Wedderburn, L. R., & Nistala, K. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38647 · Cited by 68 · see citing works
Cremer, P. C., Abbate, A., Hudock, K. M., McWilliams, C. S., Mehta, J. P., Chang, S. Y., Sheng, C. C., Tassell, B. W. V., Bonaventura, A., Vecchié, A., et al. (2021) · The Lancet Rheumatology · doi:10.1016/s2665-9913(21)00070-9 · Cited by 68 · see citing works
Becht, É., Tolstrup, D., Dutertre, C., Morawski, P. A., Campbell, D., Ginhoux, F., Newell, E. W., Gottardo, R., & Headley, M. B. (2021) · Science Advances · doi:10.1126/sciadv.abg0505 · Cited by 67 · see citing works
Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature
Ingelfinger, F., Krishnarajah, S., Kramer, M. H., Utz, S. G., Galli, E., Lutz, M., Zwicky, P., Akarca, A. U., Jurado, N. P., Ulutekin, C., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02299-y · Cited by 64 · see citing works
Self-citationGM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen
Sheih, A., Parks, W. C., & Ziegler, S. F. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.90 · Cited by 62 · see citing works
Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions
Sudo, T., Motomura, Y., Okuzaki, D., Hasegawa, T., Yokota, T., Kikuta, J., Ao, T., Mizuno, H., Matsui, T., Motooka, D., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20200817 · Cited by 61 · see citing works
GM-CSF but Not IL-17 Is Critical for the Development of Severe Interstitial Lung Disease in SKG Mice
Shiomi, A., Usui, T., Ishikawa, Y., Shimizu, M., Murakami, K., & Mimori, T. (2014) · Journal of Immunology · doi:10.4049/jimmunol.1303255 · Cited by 60 · see citing works
Darrieutort‐Laffite, C., Boutet, M., Chatelais, M., Brion, R., Blanchard, F., Heymann, D., & Goff, B. L. (2014) · Mediators of Inflammation · doi:10.1155/2014/241840 · Cited by 60 · see citing works
A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR)
Patel, J., Bass, D., Beishuizen, A., Ruiz, X. B., Boughanmi, H., Cahn, A. P., Colombo, H. R., Criner, G. J., Davy, K., de Miguel‐Díez, J., et al. (2022) · European Respiratory Journal · doi:10.1183/13993003.01870-2021 · Cited by 58 · see citing works
GM-CSF intrinsically controls eosinophil accumulation in the setting of allergic airway inflammation
Nobs, S. P., Kayhan, M., & Köpf, M. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.08.044 · Cited by 57 · see citing works
Rasouli, J., Casella, G., Yoshimura, S., Zhang, W., Xiao, D., Garifallou, J., Gonzalez, M. V., Wiedeman, A., Kus, A., Mari, E. R., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba9953 · Cited by 57 · see citing works
Subramaniam, R., Barnes, P. F., Fletcher, K., Boggaram, V., Hillberry, Z., Neuenschwander, P. F., & Shams, H. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit830 · Cited by 55 · see citing works
Broughton, S. E., Hercus, T. R., Nero, T. L., Dottore, M., McClure, B. J., Dhagat, U., Taing, H., Gorman, M. A., King-Scott, J., Lopez, A. F., et al. (2016) · Structure · doi:10.1016/j.str.2016.05.017 · Cited by 54 · see citing works
The inflammatory cytokine, GM ‐ CSF , alters the developmental outcome of murine dendritic cells
Zhan, Y., Vega‐Ramos, J., Carrington, E. M., Villadangos, J. A., Lew, A. M., & Xu, Y. (2012) · European Journal of Immunology · doi:10.1002/eji.201242477 · Cited by 52 · see citing works
Sabatino, J. J., Shires, J., Altman, J. D., Ford, M. L., & Evavold, B. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4451 · Cited by 52 · see citing works
Piper, C., Zhou, V. W., Komorowski, R., Szabo, A., Vincent, B., Serody, J., Alegre, M.-L., Edelson, B., Taneja, R., & Drobyski, W. (2019) · Blood · doi:10.1182/blood.2019001696 · Cited by 49 · see citing works
Huang, H., Wang, S.-Y., Jiang, T., Fan, R., Zhang, Z., Mu, J., Li, K., Wang, Y., Jin, L., Lin, F., et al. (2018) · Cellular & Molecular Immunology · doi:10.1038/s41423-018-0164-2 · Cited by 47 · see citing works
GM-CSF Signalling Boosts Dramatically IL-1Production
Khameneh, H. J., Isa, S. A. B. M., Lin, M., Nih, F. W., & Ruedl, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023025 · Cited by 43 · see citing works
Papp, K. A., Gooderham, M., Jenkins, R., Vender, R. B., Szepietowski, J. C., Wagner, T., Hunt, B., Souberbielle, B. E., & on behalf of the NEPTUNE investigators (2018) · British Journal of Dermatology · doi:10.1111/bjd.17195 · Cited by 42 · see citing works
Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development
Tian, L., Tomei, S., Schreuder, J., Weber, T., Amann‐Zalcenstein, D., Lin, D. S. Y., Tran, J., Audiger, C., Chu, M., Jarratt, A., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.03.012 · Cited by 39 · see citing works
Imitola, J., Rasouli, J., Watanabe, F., Mahajan, K., Sharan, A. D., Ćirić, B., Zhang, G., & Rostami, A. M. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.12.017 · Cited by 38 · see citing works
The end of omics? High dimensional single cell analysis in precision medicine
Galli, E., Friebel, E., Ingelfinger, F., Unger, S., Núñez, N. G., & Becher, B. (2019) · European Journal of Immunology · doi:10.1002/eji.201847758 · Cited by 34 · see citing works
Self-citationShaw, O. M., Steiger, S., Liu, X., Hamilton, J. A., & Harper, J. L. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38730 · Cited by 33 · see citing works
Producing GM-CSF: a unique T helper subset?
Herndler-Brandstetter, D., & Flavell, R. (2014) · Cell Research · doi:10.1038/cr.2014.155 · Cited by 32 · see citing works
Temesgen, Z., Burger, C. D., Baker, J. V., Polk, C. M., Libertin, C. R., Kelley, C. F., Marconi, V. C., Orenstein, R., Durrant, C., Chappell, D. B., et al. (2021) · medRxiv · doi:10.1101/2021.05.01.21256470 · Cited by 32 · see citing works
Neutrophil GM-CSF receptor dynamics in acute lung injury
Alessandris, S. D., Ferguson, G. J., Dodd, A., et al. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma0918-347r · Cited by 29 · see citing works
Pietras, E. M., Reynaud, D., Kang, Y.-A., Carlin, D., Calero‐Nieto, F. J., Leavitt, A. D., Stuart, J. M., Göttgens, B., & Passegue, E. A. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.07.003 · Cited by 27 · see citing works
Transgenic Expression of GM-CSF in T Cells Causes Disseminated Histiocytosis
van Nieuwenhuijze, A. E. M., Coghill, E., Gray, D. H. D., Prato, S., Metcalf, D., Alexander, W. S., & Wicks, I. P. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.09.014 · Cited by 26 · see citing works
Gartlan, K. H., Koyama, M., Lineburg, K. E., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000053 · Cited by 23 · see citing works
Zhan, Y., & Cheers, C. (2000) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2000.00891.x · Cited by 22 · see citing works
GM-CSF producing autoreactive CD4+ T cells in type 1 diabetes
Knoop, J., Gavrisan, A., Kuehn, D., Reinhardt, J., Heinrich, M., Hippich, M., Eugster, A., Ockert, C., Ziegler, A., & Bonifacio, E. E. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.12.002 · Cited by 21 · see citing works
Towards the better understanding of myelopoiesis using single-cell technologies
Dress, R. J., Liu, Z., & Ginhoux, F. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.04.020 · Cited by 15 · see citing works
Makris, A., Adamidi, S., Koutsianas, C., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01967 · Cited by 10 · see citing works
Krebs, J., Hillenbrand, A., Tsagogiorgas, C., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218602 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- J.L. McQualter, R. Darwiche, C. Ewing, M. Onuki, T.W. Kay, J.A. Hamilton, H. H. Reid, C.C.A. Bernard, Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis, J. Exp. Med. 194 (2001), https://doi.org/10.1084/jem.194.7.873. · DOI · Paper page
- K. Hirota, M. Hashimoto, Y. Ito, M. Matsuura, H. Ito, M. Tanaka, H. Watanabe, G. Kondoh, A. Tanaka, K. Yasuda, M. Kopf, A.J. Potocnik, B. Stockinger, N. Sakaguchi, S. Sakaguchi, Autoimmune Th17 cells induced synovial stromal and innate lymphoid cell secretion of the cytokine GM-CSF to initiate and augment autoimmune arthritis, Immunity 48 (6) (2018), https://doi.org/10.1016/j. immuni.2018.04.009. · DOI
- J. Patel, A. Beishuizen, X.B. Ruiz, H. Boughanmi, A. Cahn, G.J. Criner, K. Davy, J. de-Miguel-Díez, S. Fernandes, B. François, A. Gupta, K. Hanrott, T. Hatlen, D. Inman, J.D. Isaacs, E. Jarvis, N. Kostina, J.-C. Lacherade, P. Martinez-Ayala, C. McEvoy, R. Muñoz-Bermúdez, J. Neisen, G. Plantefeve, L. Schifano, L. Schwab, Z. Shahid, M. Shirano, J.E. Smith, E. Sprinz, C. Summers, N. Terzi, M.A. Tidswell, R. Williamson, D. Wyncoll, M. Layton, A Randomized Trial of Otilimab in Severe COVID-19 Pneumonia (OSCAR), MedRxiv, 2021.
Cited by
Sorted by citations
TH17 cell heterogeneity and its role in tissue inflammation
Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology · doi:10.1038/s41590-022-01387-9 · Cited by 286 · see citing works
- Authors
- Ingelfinger, F., De Feo, D., & Becher, B.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Becher, Burkhard
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 54
- Pages
- 101518
- ISSN
- 1044-5323 (ISSN-L)
- OpenAlex
- W3214090945
- Cited by
- 61
- References
- 168
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 12 · 2023: 11 · 2022: 15
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Seminars in Immunology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Universität Zürich (K-41302-10-01)
- Horizon 2020 Framework Programme (826121, 847782, 882424)
- Schweizerische Multiple Sklerose Gesellschaft
- European Research Council
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Studienstiftung des Deutschen Volkes
- Israel Ports Company
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- GM-CSF, inflammation, myelopoiesis, phagocyte activation, hyperinflammation, tissue damage, T cell lineage, hematopoiesis, innate-adaptive immune crosstalk, immunopathology, GM-CSF therapy
- MeSH terms
- Hematopoiesis, Humans, Inflammation, Phagocytes, T-Lymphocytes, Granulocyte-Macrophage Colony-Stimulating Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
