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Cited by 363

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

The comorbidity of insomnia, chronic pain, and depression: Dopamine as a putative mechanism

Open access
Finan, Patrick H., Smith, Michael T.·2013·Sleep Medicine Reviews
DOI 10.1016/j.smrv.2012.03.003
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Abstract

Epidemiological, cross-sectional, and prospective studies suggest that insomnia, chronic pain, and depression frequently co-occur and are mutually interacting conditions. However, the mechanisms underlying these comorbid disorders have yet to be elucidated. Overlapping mechanisms in the central nervous system suggest a common neurobiological substrate(s) may underlie the development and interplay of these disorders. We propose that the mesolimbic dopamine system is an underappreciated and attractive venue for the examination of neurobiological processes involved in the interactions, development, exacerbation, and maintenance of this symptom complex. In the present article, studies from multiple disciplines are reviewed to highlight the role of altered dopaminergic function in the promotion of arousal, pain sensitivity, and mood disturbance. We argue that studies aiming to elucidate common factors accounting for the comorbidity of insomnia, chronic pain, and depression should evaluate functioning within the mesolimbic dopaminergic system and its effect on common processes known to be dysregulated in all three disorders.

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Metadata

Authors
Finan, P. H., & Smith, M. T.
Venue
Sleep Medicine Reviews
Publisher
Elsevier BV
Published
2013-06
Volume
17
Issue
3
Pages
173-183
ISSN
1087-0792 (ISSN-L)
DOI
10.1016/j.smrv.2012.03.003
OpenAlex
W2156931908
Cited by
363
References
34
FWCI
15.71
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.