From Social Structural Factors to Perceptions of Relationship Quality and Loneliness: The Chicago Health, Aging, and Social Relations Study
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OBJECTIVE: The objective of this study was to test a conceptual model of loneliness in which social structural factors are posited to operate through proximal factors to influence perceptions of relationship quality and loneliness. METHODS: We used a population-based sample of 225 White, Black, and Hispanic men and women aged 50 through 68 from the Chicago Health, Aging, and Social Relations Study to examine the extent to which associations between sociodemographic factors and loneliness were explained by socioeconomic status, physical health, social roles, stress exposure, and, ultimately, by network size and subjective relationship quality. RESULT: Education and income were negatively associated with loneliness and explained racial/ethnic differences in loneliness. Being married largely explained the association between income and loneliness, with positive marital relationships offering the greatest degree of protection against loneliness. Independent risk factors for loneliness included male gender, physical health symptoms, chronic work and/or social stress, small social network, lack of a spousal confidant, and poor-quality social relationships. DISCUSSION: Longitudinal research is needed to evaluate the causal role of social structural and proximal factors in explaining changes in loneliness.
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Chronic stress associated with loneliness dysregulates biological systems, including the HPA axis and immune system, which are crucial in the onset and persistence of anxiety and depression.
“Moreover, the chronic stress associated with loneliness dysregulates biological systems, including the hypothalamic-pituitary-adrenal (HPA) axis and the immune system, which are crucial in the onset and persistence of anxiety and depression [80–82].”
From The prospective association of adolescent loneliness and low resilience with anxiety and depression in young adulthood: The HUNT study (2025) · cites this paper as [81]
The Discussion (page unavailable) reports prior findings linking loneliness to a greater morning rise in cortisol and to gene-transcription changes favoring inflammation. The Results section on stress exposure associates chronic stress with loneliness, but the paper does not establish that loneliness-related chronic stress dysregulates those systems or that this pathway causes the onset or persistence of anxiety and depression. (LLM, conf=0.85)
Experimental — accuracy not yet measuredObjective social isolation can influence perceptions of isolation, but perceived isolation relates more to interaction quality than quantity.
“Studies using these assessments indicate that objective social isolation can affect perceptions of isolation,23,24 but show that perceived social isolation is more closely related to the quality than the quantity of social interactions.25”
From Social isolation (2011) · cites this paper as [23]
Objective social isolation can influence perceptions of isolation, but perceived isolation relates more to interaction quality than quantity.
“Studies using these assessments indicate that objective social isolation can affect perceptions of isolation,23,24 but show that perceived social isolation is more closely related to the quality than the quantity of social interactions.25”
From Social isolation (2011) · cites this paper as [25]
Perceived social isolation (or loneliness) reflects the quality of an individual's social interactions rather than their quantity or frequency.
“Perceived social isolation (or loneliness) reflects the quality of an individual’s social interactions (Hawkley et al., 2008, Peplau, 1978) rather than their quantity or frequency.”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Hawkley et al., 2008
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- Authors
- Hawkley, L. C., Hughes, M. E., Waite, L. J., Masi, C. M., Thisted, R. A., & Cacioppo, J. T.
- Affiliations
- University of Chicago (US)
- Johns Hopkins University (US)
- University of Chicago Medical Center (US)
- Corresponding author
- Hawkley, L. C.
- Venue
- The Journals of Gerontology Series B: Psychological Sciences and Social Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-11-01
- Volume
- 63
- Issue
- 6
- Pages
- S375-S384
- ISSN
- 1079-5014 (ISSN-L)
- 1758-5368
- PMC
- PMC2769562
- OpenAlex
- W2135570695
- Cited by
- 666
- References
- 49
- Citations by year
- 2026: 28 · 2025: 58 · 2024: 56 · 2023: 58 · 2022: 78 · 2021: 70 · 2020: 47 · 2019: 42 · 2018: 35 · 2017: 29 · 2016: 26 · 2015: 43 · 2014: 20 · 2013: 21 · 2012: 21
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series B (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- John Templeton Foundation
- University of Chicago
- National Institute on Aging (P01AG18911, P01AG018911)
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
- Keywords
- loneliness, socio-structural factors, relationship quality, socioeconomic status, marital relationships, social network size, racial and ethnic differences, physical health, occupational stress, social stress, middle-aged and older adults
- MeSH terms
- Aged, Chicago, Chronic Disease, Health Status, Humans, Loneliness, Middle Aged, Models, Psychological, Risk Factors, Social Behavior, Social Support, Socioeconomic Factors, Stress, Psychological
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