Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

Yamazaki, S., Iwama, A., Takayanagi, S., Morita, Y., Eto, K., Ema, H., & Nakauchi, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601236 · Cited by 270

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570

The bone marrow niche for haematopoietic stem cells

Morrison, S. J., & Scadden, D. T. (2014) · Nature · doi:10.1038/nature12984 · Cited by 2,451

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Takubo, K., Goda, N., Yamada, W., Iriuchishima, H., Ikeda, E., Kubota, Y., Shima, H., Johnson, R. S., Hirao, A., Suematsu, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.020 · Cited by 891

Adult haematopoietic stem cell niches

Crane, G. M., Jeffery, E., & Morrison, S. J. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.53 · Cited by 712

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K.-L., Liu, Y., & Zheng, P. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081297 · Cited by 682

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Walter, D., Lier, A., Geiselhart, A., Thalheimer, F. B., Huntscha, S., Sobotta, M. C., Moehrle, B., Brocks, D., Bayindir, I., Kaschutnig, P., et al. (2015) · Nature · doi:10.1038/nature14131 · Cited by 619

p53 Regulates Hematopoietic Stem Cell Quiescence

Liu, Y., Elf, S. E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J. M., Deblasio, A., Menendez, S., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.11.006 · Cited by 547

Osteoimmunology: The conceptual framework unifying the immune and skeletal systems

Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., & Takayanagi, H. (2017) · Physiological Reviews · doi:10.1152/physrev.00036.2016 · Cited by 534

JAK/STAT signaling in hematological malignancies

Vainchenker, W., & Constantinescu, S. N. (2013) · Oncogene · doi:10.1038/onc.2012.347 · Cited by 528

Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine

Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095919 · Cited by 462

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age

Gekas, C., & Graf, T. (2013) · Blood · doi:10.1182/blood-2012-09-457929 · Cited by 352

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity

Laurenti, E., Varnum-Finney, B., Wilson, A., Ferrero, I., Blanco-Bose, W. E., Ehninger, A., Knoepfler, P. S., Cheng, P.-F., MacDonald, H. R., Eisenman, R. N., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.005 · Cited by 305

p57Kip2 and p27Kip1 Cooperate to Maintain Hematopoietic Stem Cell Quiescence through Interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. I., & Suda, T. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.003 · Cited by 289

Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis

Rodriguez-Fraticelli, A. E., Weinreb, C., Wang, S.-W., Migueles, R. P., Jankovic, M., Usart, M., Klein, A. M., Lowell, S., & Camargo, F. D. (2020) · Nature · doi:10.1038/s41586-020-2503-6 · Cited by 280

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

Lee, S. C.-W., North, K., Kim, E., Jang, E., Obeng, E., Lu, S. X., Liu, B., Inoue, D., Yoshimi, A., Ki, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.07.003 · Cited by 219

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

Tang, D., Tao, S., Chen, Z., Koliesnik, I. O., Calmes, P. G., Hoerr, V., Han, B., Gebert, N., Zörnig, M., Löffler, B., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151100 · Cited by 133

Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms

Fisher, D. A. C., Fowles, J. S., Zhou, A., & Oh, S. T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.683401 · Cited by 115

The role of interferon-gamma in hematopoietic stem cell development, homeostasis, and disease

Morales-Mantilla, D. E., & King, K. Y. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0139-3 · Cited by 99

The Majority of Multipotent Epidermal Stem Cells Do Not Protect Their Genome by Asymmetrical Chromosome Segregation

Sotiropoulou, P. A., Candi, A., & Blanpain, C. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0634 · Cited by 67

Noncanonical NF-κB Signaling Regulates Hematopoietic Stem Cell Self-Renewal and Microenvironment Interactions

Zhao, C., Xiu, Y., Ashton, J., Xing, L., Morita, Y., Jordan, C. T., & Boyce, B. F. (2012) · Stem Cells · doi:10.1002/stem.1050 · Cited by 65

tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis

Mahony, C. B., Fish, R. J., Pasche, C., & Bertrand, J. Y. (2016) · Blood · doi:10.1182/blood-2016-04-710137 · Cited by 58

Chronic interleukin-1 exposure triggers selection for Cebpa -knockout multipotent hematopoietic progenitors

Higa, K. C., Goodspeed, A., Chavez, J. S., De Dominici, M., Danis, E., Zaberezhnyy, V., Rabe, J. L., Tenen, D. G., Pietras, E. M., & DeGregori, J. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20200560 · Cited by 57

Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival

Holmfeldt, P., Pardieck, J., Saulsberry, A. C., Nandakumar, S. K., Finkelstein, D., Gray, J. T., Persons, D. A., & McKinney-Freeman, S. (2013) · Blood · doi:10.1182/blood-2013-04-493973 · Cited by 55

The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing

Pucella, J. N., Upadhaya, S., & Reizis, B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-114601 · Cited by 53

Homeodomain Transcription Factor Meis1 Is a Critical Regulator of Adult Bone Marrow Hematopoiesis

Ariki, R., Morikawa, S., Mabuchi, Y., Suzuki, S., Nakatake, M., Yoshioka, K., Hidano, S., Nakauchi, H., Matsuzaki, Y., Nakamura, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087646 · Cited by 53

Adult Hematopoiesis is Regulated by TIF1γ, a Repressor of TAL1 and PU.1 Transcriptional Activity

Kusy, S., Gault, N., Ferri, F., Lewandowski, D., Barroca, V., Jaracz-Ros, A., Losson, R., & Romeo, P.-H. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.005 · Cited by 47

Bone marrow niches for hematopoietic stem cells: Life span dynamics and adaptation to acute stress

Hofmann, J., & Kokkaliaris, K. D. (2024) · Blood · doi:10.1182/blood.2023023788 · Cited by 45

Thrombopoietin signaling to chromatin elicits rapid and pervasive epigenome remodeling within poised chromatin architectures

Comoglio, F., Park, H. J., Schoenfelder, S., Barozzi, I., Bode, D., Fraser, P., & Green, A. R. (2018) · Genome Research · doi:10.1101/gr.227272.117 · Cited by 41

DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells

Ramabadran, R., Wang, J. H., Reyes, J. M., Guzman, A. G., Gupta, S., Rosas, C., Brunetti, L., Gundry, M. C., Tovy, A., Long, H., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01109-9 · Cited by 35

Pten loss in the bone marrow leads to G-CSF–mediated HSC mobilization

Tesio, M., Oser, G. M., Baccelli, I., Blanco-Bose, W., Wu, H., Göthert, J. R., Kogan, S. C., & Trumpp, A. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20122768 · Cited by 35

Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3

Ishihara, J., Umemoto, T., Yamato, M., Shiratsuchi, Y., Takaki, S., Petrich, B. G., Nakauchi, H., Eto, K., Kitamura, T., & Okano, T. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1534-x · Cited by 28

TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling

Yang, Y., Cathelin, S., Liu, A. C. H., Subedi, A., Maher, A., Hosseini, M., Manikoth Ayyathan, D., Vanner, R., & Chan, S. M. (2025) · Nature Communications · doi:10.1038/s41467-025-57614-y · Cited by 14

Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

Defour, J.-P., Leroy, E., Dass, S., Balligand, T., Levy, G., Brett, I. C., Papadopoulos, N., Mouton, C., Genet, L., Pecquet, C., et al. (2023) · eLife · doi:10.7554/elife.81521 · Cited by 10